Abstract: Provided is a method of using soluble CD14 or peptides derived therefrom for protecting cells from death, specifically from apoptotic cell death. Further provided are compositions including CD14 or CD14 peptides and methods for protecting cells, in particular lymphocytes, from apoptotic cell death. The compositions and methods are relevant, in particular, for the treatment of various immune deficiencies associated, for example, with cell transplantation procedures, autoimmune diseases and infectious diseases such as HIV.
Abstract: A method of treating cancer in an immune-privileged site of a subject in need thereof is provided. The method comprises systemically administering to an area outside the immune-privileged site of the subject, a therapeutically effective amount of naive, viable cells of a tumor of the subject, the tumor being in the immune-privileged site so as to generate an immune response in the subject, thereby treating the cancer in the immune-privileged site of the subject.
Type:
Application
Filed:
September 11, 2008
Publication date:
July 29, 2010
Applicants:
Yeda Research And Development Co. Ltd., The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical Center
Inventors:
Ilan Volovitz, Lea Eisenbach, Irun R. Cohen, Zvi Ram, Shimon Slavin
Abstract: A method of treating a CD24-related medical condition is disclosed. The method comprises administering to a subject in need thereof at least one siRNA molecule selected from the group consisting of SEQ ID NO: 1 to 4. Pharmaceutical compositions comprising same are also disclosed.
Type:
Application
Filed:
November 13, 2007
Publication date:
May 27, 2010
Applicant:
The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical Center