Patents Assigned to Gachon University of Industry-Academic Cooperation Foundation
  • Patent number: 10209333
    Abstract: A flipped fitting method that performs a flipped curve fitting on a maximum of 256 MRI images obtained at different echo times using an EPI image which obtains a plurality of MRI images at a plurality of different echo times within a TR period after application of an excitation RF pulse. Then, T2* values are fitted based on a sufficient amount of acquired TE images, such that it is possible to provide much more accurate T2* values than these provided by underestimated or overestimated fitting by the existing method which is based on only 12 images and to obtain rapid and accurate data without nerve stimulation or acoustic noise. Further, the flipped fitting method is more suitable and accurate for showing the real T2* values.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: February 19, 2019
    Assignee: Gachon University of Industry-Academic Cooperation Foundation
    Inventors: Jun Young Chung, Hyun Wook Park, Ye Ji Han
  • Patent number: 10143549
    Abstract: Disclosed is an artificial valved conduit that is a composite valved graft comprising double sewing cuffs, which can be easily used in aortic root replacement. The composite valved graft comprises a valve and a conduit part connected to the valve. The conduit part comprises a sewing cuff positioned on the outer circumference thereof. The sewing cuff comprises a first sewing cuff and a second sewing cuff positioned below the first sewing cuff. Accordingly, a double suture is easily performed, so that it is possible to prevent the loss of blood after a surgery and to reduce surgical time at the same time.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: December 4, 2018
    Assignees: GIL MEDICAL CENTER, GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventor: Chul Hyun Park
  • Publication number: 20180327370
    Abstract: The present invention relates to a novel spiroquinone derivative compound, a production method thereof, and a pharmaceutical composition for preventing or treating neurological disorders which contains the compound as an active ingredient
    Type: Application
    Filed: July 24, 2018
    Publication date: November 15, 2018
    Applicants: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION, GIL MEDICAL CENTER
    Inventors: Mi-hyun Kim, Sun Yeou Kim, Venkanna Arramshetti, Kang Kim, Kyohee Cho, Prema Dhorma Lama, Sang-Yoon Lee
  • Publication number: 20180303954
    Abstract: Provided are a stem cell-nano anticancer drug complex in which an anticancer drug based on carbon nanotubes (CNT) and gold (Au) nano particles is loaded on the surface of stem cells, which can overcome side effects of conventional stem cells and targeting limitations of nano anticancer drugs and whose anticancer effect is very excellent, the use thereof, and a method for preparing the same.
    Type: Application
    Filed: April 19, 2018
    Publication date: October 25, 2018
    Applicant: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Dong Woo Khang, Yeon Kyung Lee, Sang-Woo Kim, Jeong Hee Hong, Jun-Young Park
  • Patent number: 10090389
    Abstract: A semiconductor memory device and a method of fabrication of the same are provided. The semiconductor memory device comprises a two-terminal memory cell sequentially joined together with a first high concentration doping region doped with a first conductive dopant, a second base region doped with a second conductive type dopant, a first base region doped with the first conductive type dopant, and a second high concentration doping region doped with the second conductive type dopant, wherein a write voltage of the memory cell is controlled by adjusting the lengths or doping concentrations of the first and second base regions.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: October 2, 2018
    Assignee: Gachon University of Industry-Academic Cooperation Foundation
    Inventors: Hoon Heo, Seongjae Cho
  • Patent number: 10068971
    Abstract: A junctionless field-effect transistor is provided and has an ultra-thin low-crystalline silicon channel. A fabrication method thereof also is provided for enabling greatly improved economics by significantly reducing the process costs while having electrical characteristics similar to those of the one formed on an SOI substrate by source/channel/drain regions formed in a junctionless ultra-thin low-crystalline silicon layer that has lower crystallinity than that of single-crystal silicon and that has a thickness of 20 nm or less on a bulk silicon substrate instead of an expensive SOI substrate.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: September 4, 2018
    Assignee: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Seongjae Cho, Youngmin Kim
  • Patent number: 9980682
    Abstract: A curved movable beam-stop array which has a generator, a curved grid and a controller. The generator generates radiation beams while rotating to a gantry angle. The curved grid is positioned in the radiation direction of the radiation beams generated from the generator. The controller controls operations of the grid. A plurality of slits of the grid are spaced apart from each other at a predetermined distance and allow at least a portion of the radiation beams generated from the generator to pass through. The controller moves the slit by a predetermined distance when the generator moves by a predefined angle.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: May 29, 2018
    Assignees: GIL MEDICAL CENTER, GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: So Hyun Ahn, Kyu Chan Lee
  • Publication number: 20180127276
    Abstract: A method for preparing a three-dimensional graphene structure, and an energy storage device are provided, the method including forming a graphene precursor by heating a carbohydrate and a gas generator, forming a graphene structure having a cavity therein by carbonizing the graphene precursor, and forming nanopores in the graphene structure, wherein the nanopores pass through an outer surface and an inner surface of the graphene structure, and are connected with the cavity.
    Type: Application
    Filed: November 3, 2017
    Publication date: May 10, 2018
    Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, Gachon University of Industry-Academic Cooperation Foundation
    Inventors: Tae-Young KIM, In-Kyu YOU, Bit Na KIM, In Gyoo KIM, Sung-Hoon JUNG, Seung-Jun PARK
  • Patent number: 9943497
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating pulmonary fibrosis comprising an isothiocyanate-based compound and a biguanide agent as active ingredients, a method for preventing or treating pulmonary fibrosis using the composition, and use of the isothiocyanate-based compound and the biguanide agent for the preparation of the prophylactic or therapeutic agent for preventing or treating pulmonary fibrosis. The pharmaceutical composition comprising the isothiocyanate-based compound and the biguanide agent as active ingredients of the present invention can be used to stably prevent or treat pulmonary fibrosis for which specific therapeutic agents have not yet been known, and thus it can be widely used for health and welfare improvement through treatment of pulmonary fibrosis.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: April 17, 2018
    Assignees: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION, GIL MEDICAL CENTER
    Inventor: Sung Hwan Jeong
  • Patent number: 9849589
    Abstract: A mobile robot employing a method and a system for localizing the mobile robot using external surveillance cameras acquires images from the surveillance cameras installed indoors adjacent to each other, recognizes objects included in the images by removing shadows from the images and performing a homography scheme, and avoids the recognized objects. The mobile robot employing the method and the system for localizing the mobile robot using the external surveillance cameras enables rapider localization and lower price as compared with a conventional image-based autonomous robot, so that the commercialization of a service robot is accelerated.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: December 26, 2017
    Assignee: Gachon University of Industry-Academic Cooperation Foundation
    Inventor: Young-Im Cho
  • Patent number: 9795336
    Abstract: The present invention relates to a device for measuring bladder pressure, comprising: a measurement rod inserted into the abdomen of a user to measure both abdomen pressure and bladder pressure; and a body unit provided to be worn on the waist of the user and electrically connected to the measurement rod so as to calculate and store urinary detrusor pressure measured by subtracting a measurement abdomen pressure from a measurement bladder pressure measured by the measurement rod.
    Type: Grant
    Filed: April 18, 2014
    Date of Patent: October 24, 2017
    Assignees: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION, GIL MEDICAL CENTER
    Inventor: Kyung Jin Chung
  • Patent number: 9799706
    Abstract: A resistive random access memory device is provided with a tunneling insulator layer between a resistance change layer and a bottom electrode. Thus, it is possible: to raise the selection (on/off) ratio by the current of a direct tunneling induced by low voltage in the unselected cell and the current of an F-N tunneling induced by high voltage in the selected cell, to efficiently suppress the leakage current in the read operation, to make a low current operation less ?A level by controlling the thickness of the tunneling insulator layer, and to be simultaneously fabricated together with circuit devices by forming the bottom electrodes (word lines) with a semiconductor material.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: October 24, 2017
    Assignees: Seoul National University R&DB Foundation, Gachon University of Industry-Academic Cooperation Foundation
    Inventors: Byung-Gook Park, Seongjae Cho, Sungjun Kim
  • Patent number: 9783893
    Abstract: A method of manufacturing a microarray substrate having improved reliability and mass-production properties uses a vapor of a surface-reforming material, and includes washing a base substrate, supplying the vapor of the surface-reforming material into a container to which the base substrate is provided, and coupling the vapor of the surface-reforming material to a surface of the base substrate to form a self-assembled monolayer.
    Type: Grant
    Filed: July 8, 2015
    Date of Patent: October 10, 2017
    Assignees: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION, GIL MEDICAL CENTER
    Inventors: Young Soo Yoon, Seung Hyun Jee, Seon Tae Kim
  • Patent number: 9757342
    Abstract: The present invention relates to a method for preparing a protein cage which comprises: a 1st step of preparing an amphiphilic polymer comprising a 1st hydrophobic polymer and a 1st hydrophilic functional group; a 2nd step of preparing a hydrophilic protein comprising a 2nd functional group binding to the 1st functional group; a 3rd step of forming an amphiphilic polymer-protein hybrid by the binding of the 1st functional group and the 2nd functional group, and forming core-shell structured particles comprising a protein shell and an amphiphilic polymer core by the self-assembly of the amphiphilic polymer in a hydrophilic solvent; and a fourth step of removing some or all of the hydrophobic polymer of the core part from the core-shell structured particles.
    Type: Grant
    Filed: October 11, 2013
    Date of Patent: September 12, 2017
    Assignees: Pusan National University Industry-University Cooperation Foundation, Korea Research Institute of Chemical Technology, Gachon University of Industry-Academic Cooperation Foundation
    Inventors: Hyun Jong Paik, Jae Kwang Song, Seong Soo An, Chae Yeon Lee, Jong Hwa Jeong, Mohammad Abdul Kadir, Tae Heon Lee
  • Publication number: 20170252546
    Abstract: Discloses is a method of manufacturing a micro-needle. The method includes a step of preparing a medicinal solution, a step of forming a plurality of tips with the medicinal solution, and a step of forming a cavity in each of the tips. In accordance with such a configuration, a micro-needle in which cavities are formed is provided, whereby it is possible to administer a fixed amount of medicine in a short time.
    Type: Application
    Filed: March 2, 2017
    Publication date: September 7, 2017
    Applicant: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Jung Hwan PARK, Ji Yeon KIM, Jee Hyun PARK, Won Jun LEE
  • Patent number: 9662347
    Abstract: The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: May 30, 2017
    Assignee: Gachon University of Industry-Academic Cooperation Foundation
    Inventors: Bong Hee Lee, Kyung Hee Byun
  • Publication number: 20170149004
    Abstract: A method of manufacturing a thin film according to an exemplary embodiment of the present invention includes preparing an ink in which nickel oxide nanoparticles are uniformly dispersed, coating the ink on a base layer, and curing the ink to form a thin film including nickel oxide nanoparticles.
    Type: Application
    Filed: November 18, 2016
    Publication date: May 25, 2017
    Applicants: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION, AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Daeho LEE, Hui Joon PARK, Uisik KWON
  • Patent number: 9606211
    Abstract: A first off resonance radio frequency (RF) pulse and a second off resonance RF pulse having a phase difference of 180 degrees from the first off resonance RF pulse are applied, one or more auxiliary gradient magnetic fields for offsetting inhomogeneity of a main magnetic field generated by applying the first and second off resonance RF pulses are applied, and magnitudes and signs of the auxiliary gradient magnetic fields are appropriately adjusted. Therefore, artifacts generated due to inhomogeneity of a main magnetic field in an imaging method using an off resonance RF pulse may be removed. When this method is applied to an imaging method using a spatial pre-saturation RF pulse, the phenomenon in which spins excited by the pre-saturation RF pulse are excited again by the off resonance RF pulse to return signals, such that undesired signals overlap and appear in an ultimately-obtained signal, may be removed.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: March 28, 2017
    Assignee: Gachon University of Industry-Academic cooperation Foundation
    Inventors: Jun Young Chung, Hyun Wook Park
  • Publication number: 20160298241
    Abstract: The present invention relates to a method of manufacturing a microarray substrate having improved reliability and mass-production properties using a vapor of a surface-reforming material, and the method of manufacturing the microarray substrate according to the present invention includes washing a base substrate, supplying the vapor of the surface-reforming material into a container to which the base substrate is provided, and coupling the vapor of the surface-reforming material to a surface of the base substrate to form a self-assembed monolayer.
    Type: Application
    Filed: July 8, 2015
    Publication date: October 13, 2016
    Applicants: Gachon University of Industry-Academic Cooperation Foundation, Gil Medical Center
    Inventors: Young Soo YOON, Seung Hyun JEE, Seon Tae KIM
  • Publication number: 20160232309
    Abstract: Disclosed is a network-based drug efficacy-assessing method, and an apparatus. The method comprises: computing a score for association between drugs and diseases by means of at least one of drug-adjacency-based inference, disease-adjacency-based inference, and module-distance-based inference; building a classifier for determining whether the drug is associated with the disease, using machine learning in which the score is employed as a feature; and determining the association between the drug and the disease by use of the classifier. The method and apparatus can search for drug-disease relation in which a drug can exert its pharmaceutical efficacy on a disease on the basis of a network constructed from protein interaction databases and protein-gene association databases, and can evaluate the molecular interaction of the drug to find out new pharmaceutical effects of the drug with higher precision and sensitivity, whereby a time and cost for the development of new drugs can be reduced.
    Type: Application
    Filed: October 29, 2015
    Publication date: August 11, 2016
    Applicant: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Youngmi YOON, Min OH, Jaegyoon AHN