Abstract: A method of manufacturing a microarray substrate having improved reliability and mass-production properties uses a vapor of a surface-reforming material, and includes washing a base substrate, supplying the vapor of the surface-reforming material into a container to which the base substrate is provided, and coupling the vapor of the surface-reforming material to a surface of the base substrate to form a self-assembled monolayer.

Abstract: The present invention relates to a method for preparing a protein cage which comprises: a 1st step of preparing an amphiphilic polymer comprising a 1st hydrophobic polymer and a 1st hydrophilic functional group; a 2nd step of preparing a hydrophilic protein comprising a 2nd functional group binding to the 1st functional group; a 3rd step of forming an amphiphilic polymer-protein hybrid by the binding of the 1st functional group and the 2nd functional group, and forming core-shell structured particles comprising a protein shell and an amphiphilic polymer core by the self-assembly of the amphiphilic polymer in a hydrophilic solvent; and a fourth step of removing some or all of the hydrophobic polymer of the core part from the core-shell structured particles.

Abstract: Discloses is a method of manufacturing a micro-needle. The method includes a step of preparing a medicinal solution, a step of forming a plurality of tips with the medicinal solution, and a step of forming a cavity in each of the tips. In accordance with such a configuration, a micro-needle in which cavities are formed is provided, whereby it is possible to administer a fixed amount of medicine in a short time.

Abstract: The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death.

Abstract: A method of manufacturing a thin film according to an exemplary embodiment of the present invention includes preparing an ink in which nickel oxide nanoparticles are uniformly dispersed, coating the ink on a base layer, and curing the ink to form a thin film including nickel oxide nanoparticles.

Abstract: A first off resonance radio frequency (RF) pulse and a second off resonance RF pulse having a phase difference of 180 degrees from the first off resonance RF pulse are applied, one or more auxiliary gradient magnetic fields for offsetting inhomogeneity of a main magnetic field generated by applying the first and second off resonance RF pulses are applied, and magnitudes and signs of the auxiliary gradient magnetic fields are appropriately adjusted. Therefore, artifacts generated due to inhomogeneity of a main magnetic field in an imaging method using an off resonance RF pulse may be removed. When this method is applied to an imaging method using a spatial pre-saturation RF pulse, the phenomenon in which spins excited by the pre-saturation RF pulse are excited again by the off resonance RF pulse to return signals, such that undesired signals overlap and appear in an ultimately-obtained signal, may be removed.

Abstract: The present invention relates to a method of manufacturing a microarray substrate having improved reliability and mass-production properties using a vapor of a surface-reforming material, and the method of manufacturing the microarray substrate according to the present invention includes washing a base substrate, supplying the vapor of the surface-reforming material into a container to which the base substrate is provided, and coupling the vapor of the surface-reforming material to a surface of the base substrate to form a self-assembed monolayer.

Abstract: Disclosed is a network-based drug efficacy-assessing method, and an apparatus. The method comprises: computing a score for association between drugs and diseases by means of at least one of drug-adjacency-based inference, disease-adjacency-based inference, and module-distance-based inference; building a classifier for determining whether the drug is associated with the disease, using machine learning in which the score is employed as a feature; and determining the association between the drug and the disease by use of the classifier. The method and apparatus can search for drug-disease relation in which a drug can exert its pharmaceutical efficacy on a disease on the basis of a network constructed from protein interaction databases and protein-gene association databases, and can evaluate the molecular interaction of the drug to find out new pharmaceutical effects of the drug with higher precision and sensitivity, whereby a time and cost for the development of new drugs can be reduced.

Abstract: Provided is a method of separating carbon nanotubes, the method comprising: forming first carbon nanotubes having a first functional group, forming a substrate having a second functional group, and causing the first carbon nanotubes to adhere to the substrate by a click chemistry reaction between the first functional group and the second functional group.

Abstract: Disclosed is a pharmaceutical composition for the prevention or treatment of ischemic heart diseases, comprising as an active ingredient an inhibitor which acts to restrain mononuclear phagocyte system cells from synthesizing or releasing AGE-albumin, which induces the apoptosis of cardiomyocytes upon the onset of the ischemic heart disease. Also, a method is provided for screening an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells. Inhibitory or suppressive of AGE-albumin-induced cell death, the pharmaceutical composition comprising as an active ingredient an inhibitor against the AGE-albumin synthesis or release of mononuclear phagocyte system cells can be applied to the prevention or treatment of a wide spectrum of ischemic heart diseases including myocardial infarction.

Abstract: A method for acquiring a PET image with ultra high resolution using movement of a PET device is provided. In the related art, there is a limit in lowering of the resolution below a half (d/2) of the width of a detector. According to the provided method, an image with ultra high resolution, which can jump over the limit, can be acquired. Further, since utilization of larger detectors becomes possible without a loss of the resolution, the sensitivity of the PET can be improved, and thus an image of higher quality can be acquired.

Abstract: The present invention provides a silicon-compatible germanium-based high-hole-mobility transistor with high-hole-mobility germanium channel comprising a semiconductor material having a valence band offset instead of the conventional gate insulating film, a germanium channel region, and a quantum well formed by heterojunctions of the upper and lower portions of the germanium channel on a silicon substrate. Thus, the present invention enables to gain maximum hole mobility of the germanium channel by using the two-dimensional hole gas gathered into the quantum well for high-speed and low-power operations and device reliability improvement.

Abstract: The present invention relates to a method for tracking the motion of a subject in real time and for correcting a medical image. The method includes the steps of: (a) a motion detection module outputting real-time motion information of a subject; (b) a motion calculation module receiving and analyzing the real-time motion information, transforming the analyzed result into triaxial motion parameters, and outputting the triaxial motion parameters; (c) a driving module driving a driving motor in response to the triaxial motion parameters; and (d) a medical image data acquisition module moving by as much as the subject moves in response to the driving of the driving motor. According to the present invention, medical image data can be acquired as if a subject has not moved during imaging by calculating the triaxial motion parameters of a subject through motion information acquired from the motion detection module and moving the medical image data acquisition module according to the triaxial motion parameters.

Abstract: A blood glucose measurement unit, a blood glucose measurement method, and a blood glucose measurement system comprising the same are disclosed. According to one aspect of the present invention, provided is a blood glucose measurement unit comprising: a transparent first substrate consisting of a blood inflow region into which blood flows and a reaction region connected to the blood inflow region which are formed on one surface thereof; a transparent second substrate coupled to the first substrate and comprising a blood aperture through which the blood flowing into the blood inflow region passes; and a reagent distributed to the reaction region so as to react with the blood glucose of the blood which has flown into the blood inflow region.

Abstract: A method and system provide personalized dietary compliance rate based on health information. The method may include: (a) transmitting health information from a hospital's information system to a service operating server; (b) identifying a disease using the health information by the service operating server; (c) selecting food in a user's terminal and determining the degree of correlation between the disease and nutrients of the selected food; and (d) determining dietary compliance rate based on the degree of correlation and providing the dietary compliance rate and the nutritional information of the food to the user's terminal. Dietary compliance rate can be provided via a mobile device and web, thus remote patient monitoring is possible, and consultation procedures are simplified using system's care information and on-line real-time Q & A. Additionally, due to continuous care, both physical and mental stability can be provided, increasing a patient's confidence.

Abstract: Provided is a method of separating carbon nanotubes, the method comprising: forming first carbon nanotubes having a first functional group, forming a substrate having a second functional group, and causing the first carbon nanotubes to adhere to the substrate by a click chemistry reaction between the first functional group and the second functional group.

Abstract: The present invention relates to a method for inhibiting the induction of cell death by inhibiting the synthesis or secretion of AGE-albumin in cells of the mononuclear phagocyte system, to an AGE-albumin synthesis inhibitor, and to a pharmaceutical composition comprising the AGE-albumin synthesis inhibitor for preventing or treating degenerative disease and autoimmune disease. The AGE-albumin of the present invention is synthesized and secreted in human microglia or human macrophages in an Alzheimer's model, stroke model, Parkinson's disease model and rheumatoid arthritis model. The AGE-albumin synthesis and secretion are caused by oxidative stress. The expression of RAGE increases in first-order human neurons or cartilage cells to which AGE-albumin is administered, whereupon a MAPK signaling pathway is activated and the expression of Bax increases to induce an increase in calcium in mitochondria, thus finally inducing cell death.