Abstract: A tumbling barrel plasma processing method and apparatus are presented. The tumbling barrel plasma processor includes a vacuum chamber, a plasma source, a power supply, a rotatable barrel which is disposed within the vacuum chamber and a barrel rotation mechanism for rotating the barrel. The plasma source generates a plasma surrounding the rotatable barrel. The barrel is made up of at least one conductive screen of a certain transparency that allows ions to pass therethrough. The power supply provides a negative voltage which is applied to the screens of the barrel to extract ions from a plasma surrounding the rotatable barrel. Alternately a positive voltage can be applied to the screens of the barrel to extract electrons from the plasma surrounding the rotatable barrel. The barrel is rotated by the barrel rotation mechanism such that the samples disposed within the barrel are tumbled, thereby the samples receive plasma treatment on all sides.

Abstract: A call center is adapted to select calls on a preprogrammed basis for possible participation in a survey. Selected calls are transferred to an interrogation point, which may be by Interactive Voice Response, where the callers are asked if they will participate. For those callers who do not wish to participate, the calls are routed by normal routing rules. For those callers who do wish to participate, the calls are transferred according to survey routing rules, and after transaction with an agent, to a survey point where the survey is conducted. In one embodiment callers who indicate a willingness to participate, but hang up before being transferred to a survey point, are automatically called back, and then, if willing, transferred to the survey point.

Abstract: An Internet Protocol Network Telephony (IPNT) call-routing system has a call-routing processor on a wide area network (WAN) such as the Internet, and receives and re-routes incoming calls to remote computer stations adapted to receive such calls. The call-routing processor, upon routing a call to a selected one of remote stations, sets a semaphore that the remote station is busy and routed no more calls to that remote station until the semaphore is reset. In one embodiment, after a return signal that the call is answered, the semaphore is set to continue for a pre-determined average call-duration time, after which it is reset, and further calls may be routed, even though no signal is returned that the call has been completed. In some embodiments the remote stations comprise call centers wherein a central call-center managing processor re-routes calls to computer agent workstations connected to the managing processor on a local area network (LAN).

Abstract: An agent station for a call-in center has a telephone for an agent's use connected by a communication link with a computer workstation adapted for monitoring transaction and status for the telephone and calls received on the telephone. In a preferred embodiment the computer workstation is connected on a local area network (LAN) to a processor running and instance of a telephony server (T-Server) application, and the computer workstation reports telephone transaction and status data to the T-Server, which uses the data to effect call routing at a remote telephony switch. In some embodiments the computer workstations are personal computers (PCs) and the communication link between telephones and PCs is a PC-compatible serial data link.

Abstract: A method is described for controlling the spread of Lyme Disease spirochete from rodents which have been infected. The method involves orally administering to the rodents a composition which includes an antibiotic (e.g., tetracycline) which is capable of killing the spirochete. Bait compositions are described which include an antibiotic. The bait compositions may be solid or liquid.

Abstract: A method for a reporting application to flexibly report the status of an entity in a call center to a requesting application is provided. The entity could be in one or more states. Examples of an entity are a directory number, an agent, a group, a routing point, and an agent place. The requesting application sets the priority of these states belonging to the entity by sending a status priority table to the reporting application. The reporting application reports the status based on the active states of the entity and the priority table. As an example, the reported status could be the active state having the highest priority in the table. This state is reported back to the requesting application. Because different requesting applications could present different priority tables, the reporting application could report different states for the same entity.

Abstract: A software routine for a multimedia-capable call center checks for active status of the telephone, active communication with clients via a computer station available to an agent, and the level of uncompleted tasks in a storage system adapted for listing tasks for an agent to complete, such as messages to answer. The software routine returns Agent Busy if there is an active network call or the level of uncompleted tasks is above a preset level, and Agent Available if there are no active network calls and the level of uncompleted tasks is at or below the preset level. The software routine is adapted to operate with call-center management software including Computer-Telephony Integrated (CTI) systems wherein CTI servers are connected to telephony switches to provide enhanced functionality.

Abstract: A system for routing calls has a plurality of call centers and a central controller for managing activity of the plurality of call centers, including call loading. The central controller utilizes a method for managing loading based on estimates of loading for call centers in the system for which real time loading information is not available during certain time intervals. The method involves retrieving a previous status of the call center for which real time information is not available, and using that previous status to perform and estimate of current loading for management purposes.

Abstract: A telephone call-routing system comprises a routing intelligence adapted to receive real-time activity reports on busy status of remote telephone stations, and to route incoming calls based on the busy status. In a preferred embodiment the routing intelligence sets a busy semaphore for each station to which a call is routed at the time the call is routed, before a real-time signal is returned that the station is in fact busy. The semaphore is initially set to busy for a first period of time substantially equal to the known latency for returning the real-time busy signal. After the first period of time, and with return of a real-time busy signal, the semaphore is reset to busy for a second period of time substantially equal to the historical average elapsed time for calls in the call-routing system, after which the semaphore is released. After the first period of time, and in the absence of the real-time busy signal, the semaphore is immediately released so further calls may be routed to the station.

Abstract: A network-level routing system has a router and a connected information server at network level, the information server linked to a plurality of CTI servers each connected by a CTI link to a telephony switch in a call center. The CTI servers are adapted to monitor and control the telephony switches, which may be of different make and manufacture, and to report switch status to the connected information server at network level on a continuous basis, transaction-by-transaction. Incoming calls are routed to the telephony switches at the call centers by the network-level router based on the continually updated information in the network-level information server.

Abstract: The invention involves using a glow discharge plasma to functionalize a surface of medical devices such as catheters, particularly intracardial catheters, with covalently bound thermochemically reactive groups. The surface is further contacted with a bioactive agent, particularly antithrombogenic coatings, which is thermochemically covalently coupled to the reactive group to form a therapeutically effective coating. The selected bioactive agent is then covalently bound to the surface by thermochemical reaction with the surface reactive groups. In another embodiment, the functionalizing step comprises contacting the surface with a Langmuir-Blodgett film comprising an amphipathic compound and a bioactive agent and using a plasma to covalently crosslink the Langmuir-Blodgett film to the medical device surface and to the bioactive agent. Medical devices prepared by the subject methods are also provided.

Abstract: Regulatory DNA sequences that silence and enhance transcription of coding portions of the CD95 gene, which is instrumental in apoptosis, are disclosed. Proteinaceous transcription factors that bind to the silencer and enhancer regulatory sequences are also disclosed and are useful for modulating the expression of CD95 or other proteins. Methods for regulating apoptosis have therapeutic and prophylactic applications for a variety of disorders, including cancer, viral and retroviral infections, neurodegenerative disorders, immune system dysfunction, and other disorders.

Abstract: Method and device for sealing puncture wounds in a vascular walls wherein a cylinder of compliant material with a coating of hydrophilic material is placed with one end of the cylinder against the side wall of a vessel. Axial pressure is then applied to the other end of the cylinder to deform the cylinder and flatten it into a disk which increases in lateral dimension and becomes embedded in tissue over the wound. The hydrophilic material expands on the disk to seal the wound. A clot promoter in the coating reverses the effects of heparin and accelerates clot formation.

Abstract: A telephone call-routing system includes an initial call-processing system having a first telephone line adapted for receiving calls from customers and a processor system, and a remote call-in center comprising a computerized telephony switch connected to a plurality of telephones at operator workstations. The processor system is adapted to route calls to individual ones of the telephones, and is connected by a telephony line to the initial call processing system. A telephony server is connected to the telephony switch by a first high-speed data link and has a digital network communication link to the processor system. The telephony server is adapted to monitor activity of the telephony switch and to report the activity to the processor system over the digital network link.

Abstract: A needleless injector for injecting medication through the skin of a patient includes a vial which holds a volume of liquid medication. The vial includes a vial piston which moves to force the liquid medication out of the vial. A power mechanism applies force to the vial piston. The power mechanism includes a power piston which has a plurality of ratchets. A spring is positioned to apply force to the power piston. A trigger engages the ratchets on the power piston to hold the power piston in place against the force applied by the spring. The trigger selectively releases the power piston so that the power piston moves in response to the force applied by the spring. The power piston applies the force to the vial piston to cause the vial piston to force the liquid medication out of the vial. A cocking mechanism applies force to the power piston to move the power piston against the force of the spring to engage the ratchets.

Abstract: The invention relates to a workpiece positioner and assembly therefore which optimizes workpiece rotation for manufacturing processes, and specifically for use with an industrial robot. In general, the workpiece positioner assembly is supported on a base. The workpiece positioner assembly is rectangular in shape and includes drive arms and idler arms between which workpieces are supported. Due to the unique shape of the workpiece positioner assembly, the workpiece-to-workpiece rotational clearance can be reduced to zero due in part to the position of cross tubing from the drive end of the workpiece positioner assembly to the idler end of the workpiece positioner assembly. The cross tubing does not interfere with the workpiece rotational area thereby allowing workpiece size and orientation to be increased without affecting positioner swing or operation height.

Abstract: The present invention is directed to novel replication-deficient adenoviral vectors characterized in that they harbor at least two lethal early region gene deletions (E1 and E4) that normally transcribe adenoviral early proteins. These novel recombinant vectors find particular use in human gene therapy treatment whereby the vectors additionally carry a transgene or therapeutic gene that replaces the E1 or E4 regions. The present invention is further directed to novel packaging cell lines that are transformed at a minimum with the adenoviral E1 and E4 gene regions and function to propagate the above novel replication-deficient adenoviral vectors.

Abstract: A medical device for implantation in the tissue of a human body having a biocompatible coating thereon including a foreign body formed of a material which is substantially biocompatible with the tissue of the human body. The foreign body has a surface adapted to come in contact with the tissue of the human body and is capable of being oxidized. An organic linker is carried on the surface and forms an oxidative coupling with the surface. A bioactive agent is bonded to the organic linker by a chemical reaction or photochemical function.

Abstract: The invention provides a novel retroviral packaging system, in which retroviral packaging constructs and packagable vector transcripts are produced from high expression plasmids by transfection in human cells. High titers of recombinant retrovirus are produced in infected cells. The methods of the invention include the use of the novel retroviral constructs to transduce primary human cells, including T cells and human hematopoietic stem cells, with foreign genes by cocultivation at high efficiencies. The invention is useful for the rapid production of high viral supernatants, and to transduce with high efficiency cells that are refractory to transduction by conventional means.

Abstract: A stent including a cylindrical member having an outside diameter, a length and having proximal and distal extremities. The stent is formed of a metal and has a wall defining a central bore having a longitudinal axis extending from the proximal extremity to the distal extremity. The cylindrical member has at least two longitudinally spaced-apart struts extending in the wall and permit radial expansion of the cylindrical member from a contracted condition to an expanded condition. Ribs extending in the wall prevent shrinkage in length of the cylindrical member as it is expanded from a contracted position to an expanded position.