Patents Assigned to Genetics Institute
  • Polynucleotides encoding secreted proteins
    Patent number: 5945302
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: January 13, 1997
    Date of Patent: August 31, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg
  • Human GDP-mannose 4,6 dehydratase
    Patent number: 5942228
    Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
    Type: Grant
    Filed: September 9, 1998
    Date of Patent: August 24, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Francis Sullivan, Ronald Kriz, Ravindra Kumar
  • DNA molecules encoding mammalian cerberus-like proteins
    Patent number: 5935852
    Abstract: DNA molecules are disclosed which encode mammalian Cerberus-Like Proteins.
    Type: Grant
    Filed: July 3, 1997
    Date of Patent: August 10, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Maximillian Follettie, Edward M. DeRobertis
  • Macrophage inflammatory protein variants
    Patent number: 5936067
    Abstract: The present invention provides a Stem Cell Inhibitor (SCT) protein which comprises at least one amino acid alteration from its active form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity. The alteration is preferably a conservative substitution of a charged amino acid residue. Such proteins may be used in treating stem cells in a patient undergoing chemotherapy.
    Type: Grant
    Filed: January 29, 1996
    Date of Patent: August 10, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Gerard Graham, Ian Pragnell
  • Cartilage induction by bone morphogenetic proteins
    Patent number: 5902785
    Abstract: Compositions of proteins with cartilaginous tissue inducing and maintenance activity are disclosed. The compositions are useful in the treatment of osteoarthritis, cartilage defects and in related tissue repair.
    Type: Grant
    Filed: May 7, 1996
    Date of Patent: May 11, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Gary Hattersley, Neil M. Wolfman, Elisabeth A. Morris, Vicki A. Rosen
  • TNF receptor death domain ligand proteins
    Patent number: 5891675
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: April 23, 1997
    Date of Patent: April 6, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Method of producing storage stable M-CSF lyophilizates
    Patent number: 5888495
    Abstract: Lyophilized M-CSF formulations are presented that are free of high molecular weight species and stable to prolonged storage.
    Type: Grant
    Filed: August 18, 1992
    Date of Patent: March 30, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Jay A. Schrier, Donald F. Williams
  • Multidomain hematopoiesis stimulators
    Patent number: 5883230
    Abstract: A noval fusion protein, IL3-X or X-IL3 wherein X is a hematopoietin fused to IL3.
    Type: Grant
    Filed: June 5, 1996
    Date of Patent: March 16, 1999
    Assignee: Genetics Institute, Inc.
    Inventor: Paul Schendel
  • Human GDP-mannose 4,6-dehydratase
    Patent number: 5869307
    Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
    Type: Grant
    Filed: December 3, 1997
    Date of Patent: February 9, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Francis Sullivan, Ronald Kriz, Ravindra Kumar
  • Recombinant bone morphogenetic protein heterodimers
    Patent number: 5866364
    Abstract: The present invention relates to a methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and compositions containing them.
    Type: Grant
    Filed: November 27, 1992
    Date of Patent: February 2, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: David Israel, Neil M. Wolfman
  • HNF3.delta. compositions
    Patent number: 5861278
    Abstract: Purified HNF3.delta. proteins and processes for producing them are disclosed. DNA molecules encoding the HNF3.delta. proteins are also disclosed. The proteins may be used in regulating the transcription of one or more genes involved in the formation, differentiation, proliferation and maintenance of cells which form organ tissues, particularly pancreatic cells, as well as other tissue repair.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: January 19, 1999
    Assignee: Genetics Institute, Inc.
    Inventors: Gordon W. Wong, Kwok-Ming Yao
  • Method for purification of IL-12
    Patent number: 5853714
    Abstract: Methods for the purification of interleukin-12 (IL-12) is provided.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: December 29, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Jeffrey S. Deetz, Bonnie Germain, Brian Hubbard, Lei Shi, Thomas Spitznagel, Dwight Winters
  • Compositions comprising IL-11 and methods of making and using IL-11
    Patent number: 5854028
    Abstract: A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
    Type: Grant
    Filed: March 10, 1997
    Date of Patent: December 29, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Yu-Chung Yang, Frances K. Bennett, Stephan R. Paul
  • TNF receptor death ligand proteins and inhibitors of ligand binding
    Patent number: 5852173
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: September 26, 1995
    Date of Patent: December 22, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Bone morphogenetic protein (BMP)--6
    Patent number: 5849880
    Abstract: Purified bone morphogenetic protein (BMP)-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste
  • TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding
    Patent number: 5849501
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: June 19, 1995
    Date of Patent: December 15, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella
  • DNA molecules encoding human chordin
    Patent number: 5846770
    Abstract: Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.
    Type: Grant
    Filed: November 14, 1996
    Date of Patent: December 8, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Edward R. LaVallie, Lisa A. Racie, Edward M. DeRobertis
  • TNF receptor death domain ligand proteins
    Patent number: 5847099
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: May 17, 1996
    Date of Patent: December 8, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen
  • TNF receptor death domain ligand proteins and inhibitors of ligand binding
    Patent number: 5843675
    Abstract: Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
    Type: Grant
    Filed: February 15, 1996
    Date of Patent: December 1, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Lih-Ling Lin, Jennifer Chen, Andrea R. Schievella, James Graham
  • Nucleic acid encoding a novel P-selectin ligand protein
    Patent number: 5843707
    Abstract: A novel P-selectin ligand glycoprotein is disclosed, comprising the amino acid sequence set forth in SEQ ID NO:2 or by the amino acid sequence set forth in SEQ ID NO:4. DNA sequences encoding the P-selectin ligand protein are also disclosed, along with vectors, host cells, and methods of making the P-selectin ligand protein. Pharmaceutical compositions containing the P-selectin ligand protein and methods of treating inflammatory disease states characterized by P-selectin- and E-selectin-mediated intercellular adhesion are also disclosed.
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: December 1, 1998
    Assignee: Genetics Institute, Inc.
    Inventors: Glenn R. Larsen, Dianne S. Sako, Xiao-Jia Chang, Geertruida M. Veldman, Dale Cumming, Ravindra Kumar, Gray Shaw