Patents Assigned to Genetics Institute
  • Patent number: 5573763
    Abstract: A novel family of primate CSF-1-like polypeptides is provided via recombinant techniques, including compositions and methods for their production and use.
    Type: Grant
    Filed: August 14, 1989
    Date of Patent: November 12, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Steven C. Clark, Gordon G. Wong
  • Patent number: 5573764
    Abstract: The use of interleukin-12 to prevent, to ameliorate, and to treat graft-versus-host disease in a mammal in need of such treatment is disclosed.
    Type: Grant
    Filed: January 21, 1994
    Date of Patent: November 12, 1996
    Assignees: Genetics Institute, Inc., The General Hospital Corporation
    Inventors: Megan Sykes, Stanley F. Wolf
  • Patent number: 5569454
    Abstract: Methods of treating an infection using Natural Killer Stimulatory Factor (NKSF) are disclosed.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: October 29, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf
  • Patent number: 5563045
    Abstract: Provided are porcine factor VIII nucleotide sequences and hybrid sequences encoding human/porcine chimeric factor VIII-type procoagulant proteins. DNAs encoding such chimeric factor VIII-type procoagulant proteins, pharmaceutical compositions containing such chimeric factor VIII-type procoagulant proteins, and methods of treating hemophilia using such chimeric factor VIII-type procoagulant proteins are also provided.
    Type: Grant
    Filed: September 14, 1993
    Date of Patent: October 8, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Debra Pittman, Alnawaz Rehemtulla, John M. Wozney, Randal J. Kaufman
  • Patent number: 5554511
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: September 10, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Simon Jones, Jin Tang
  • Patent number: 5543394
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: August 6, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Vicki A. Rosen, Elizabeth A. Wang
  • Patent number: 5543138
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 10, 1994
    Date of Patent: August 6, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State Univ.
    Inventor: James C. Keith
  • Patent number: 5536637
    Abstract: A novel method of screening for novel secreted mammalian proteins is described in which mammalian secretory leader sequences are detected using the yeast invertase gene as a reporter system.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: July 16, 1996
    Assignee: Genetics Institute, Inc.
    Inventor: Kenneth Jacobs
  • Patent number: 5527698
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: June 18, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • Patent number: 5520923
    Abstract: A formulation is disclosed comprising a pharmaceutically acceptable admixture of an osteogenic protein and a sponge of porous particulate polymer matrix. The sponge may be prepared by treating the porous particulate polymer matrix with a suitable fusing material such as ethanol and a surfactant such as a polysorbate.
    Type: Grant
    Filed: September 19, 1994
    Date of Patent: May 28, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Jane S. Tjia, Brian D. Kelley, Richard P. Northey, C. Michael Philbrook
  • Patent number: 5516654
    Abstract: A process for increasing the yield of recombinant bone-inducing proteins of the BMP-2 family is provided, wherein dextran sulfate is added to the culture medium in which cells expressing the proteins are grown.
    Type: Grant
    Filed: January 27, 1994
    Date of Patent: May 14, 1996
    Assignee: Genetics Institute, Inc.
    Inventor: David I. Israel
  • Patent number: 5466595
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: July 27, 1994
    Date of Patent: November 14, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: Simon Jones, Jin Tang
  • Patent number: 5460810
    Abstract: A method for reducing damage or depletion of gut epithelial cells (e.g., as a result of radiation therapy or chemotherapy) by administration of one or more of the following cytokines: interleukin 11 (IL-11), interleukin 6 (IL-6), leukemia inhibitory factor/cholinergic differentiation factor (LIF/CDF), oncostatin M (OSM), or ciliary neurotrophic factor (CNTF).
    Type: Grant
    Filed: September 2, 1992
    Date of Patent: October 24, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: David A. Williams, Steven C. Clark
  • Patent number: 5460950
    Abstract: Compositions and methods are provided for endopeptidase production and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides, including proteins requiring gamma-carboxylation for biological activity. These compositions and methods utilize recombinant PACE, a mammalian endopeptidase that is specific for dibasic amino acid sites.
    Type: Grant
    Filed: May 20, 1992
    Date of Patent: October 24, 1995
    Assignees: Genetics Institute, Inc., Chiron Corporation
    Inventors: Philip J. Barr, Anthony J. Brake, Randal J. Kaufman, Louise Wasley, Patricia Tekamp-Olson, Polly A. Wong
  • Patent number: 5459047
    Abstract: Purified BMP-6 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: October 17, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Elizabeth A. Wang, Vicki A. Rosen, Anthony J. Celeste
  • Patent number: 5457038
    Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
    Type: Grant
    Filed: September 18, 1990
    Date of Patent: October 10, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: Giorgio Trinchieri, Bice Perussia, Michiko Kobayashi, Steven C. Clark, Gordon G. Wong, Rodney Hewick
  • Patent number: 5451521
    Abstract: This invention relates to recombinant Factor VIII:c variants, methods to produce the variants and pharmaceutical compositions containing same. The variants of this invention are characterized by modification of one or more specific proteolytic cleavage sites encompassing the arginine residues at positions 226, 336, 562, 740, 776, 1313, 1648, or 1721. The variants possess similar procoagulant activity to that of human Factor VIII:c.
    Type: Grant
    Filed: December 9, 1986
    Date of Patent: September 19, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: Randal J. Kaufman, Debra D. Pittman, John J. Toole, Jr.
  • Patent number: 5437863
    Abstract: A method of restoring damaged or depleted cell populations by treating the patient with cytokines, particularly IL-11 and IL-6.
    Type: Grant
    Filed: September 1, 1993
    Date of Patent: August 1, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: David A. Williams, Steven C. Clark
  • Patent number: 5430019
    Abstract: Methods of treating mammalian soft tissue injuries such as thermal and chemical burns, surgical incisions, ulcers, abrasions, skin grafts, and nervous tissue damage by administering a therapeutically effective amount of homogeneous K-fibroblast growth factor are provided. Also provided are methods of treating mammalian musculo-skeletal disorders such as bone grafts, bone fractures, ligament tears, cartilage tears, tendon tears, bursa inflammation and tendon inflammation by administering a therapeutically effective amount of homogeneous K-fibroblast growth factor. In accordance with the methods of the invention, homogeneous K-fibroblast growth factor may be administered to the mammal alone or in combination with other growth factors.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: July 4, 1995
    Assignee: Genetics Institute, Inc.
    Inventors: David T. Rogers, Neil M. Wolfman, Jasbir S. Seehra
  • Patent number: H1532
    Abstract: Methods and nutrient media are disclosed useful for adapting mammalian cell lines to culture at increased cell densities.
    Type: Grant
    Filed: November 3, 1993
    Date of Patent: May 7, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: S. Robert Adamson, Denis Drapeau, Yen-Tung Luan, Douglas A. Miller