Patents Assigned to Genetics Institute
  • Methods of inducting formation of tendon and/or ligament tissue comprising administering BMP-12, BMP-13, and/or MP-52
    Patent number: 5658882
    Abstract: The present invention relates to methods for the induction of tendon/ligament-like tissue formation, wound healing and ligament and other tissue repair, using a composition comprising BMP-12, BMP-13 or MP-52, or combinations of the above.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: August 19, 1997
    Assignees: Genetics Institute, Inc., President and Fellows of Harvard College
    Inventors: Anthony J. Celeste, John M. Wozney, Vicki A. Rosen, Neil M. Wolfman, Gerald H. Thomsen, Douglas A. Melton
  • Mocarhagin, a cobra venom protease, and therapeutic uses thereof
    Patent number: 5659018
    Abstract: Mocarhagin, a cobra venom protease, is disclosed. Pharmaceutical compositions and therapeutic uses of the protease are also provided.
    Type: Grant
    Filed: August 1, 1995
    Date of Patent: August 19, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Michael C. Berndt, Lindsay Dunlop, Robert Andrews, Mariagrazia DeLuca
  • Secreted proteins and polynucleotides encoding them
    Patent number: 5654173
    Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.
    Type: Grant
    Filed: August 23, 1996
    Date of Patent: August 5, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Kenneth Jacobs, John M. McCoy, Edward R. LaVallie, Lisa A. Racie, David Merberg, Maurice Treacy, Vikki Spaulding
  • Natural killer cell stimulatory factor
    Patent number: 5648467
    Abstract: A novel homogeneous human cytokine, Natural Killer Stimulatory Factor, having the ability to induce the production of gamma interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing it.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: July 15, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Gordon G. Wong, Rodney Hewick, Michiko Kobayashi, Stanley F. Wolf
  • Methods of inducing gamma interferon and stimulating blood cell populations using natural killer stimulatory factor
    Patent number: 5648072
    Abstract: Methods of inducing gamma interferon production and stimulating lymphocyte populations using Natural Killer Stimulatory Factor (NKSF) are disclosed.
    Type: Grant
    Filed: March 13, 1995
    Date of Patent: July 15, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Giorgio Trinchieri, Bice Perussia, Steven C. Clark, Michiko Kobayashi, Gordon G. Wong, Rodney Hewick, Stanley F. Wolf
  • Peptide and protein fusions to thioredoxin, thioredoxin-like molecules, and modified thioredoxin-like molecules
    Patent number: 5646016
    Abstract: Provided is a fusion molecule comprising a DNA sequence encoding a thioredoxin-like protein fused to a DNA sequence encoding a second peptide or protein. The peptide or protein may be fused to the amino terminus of the thioredoxin-like molecule, the carboxyl terminus of the thioredoxin-like molecule, or within the thioredoxin-like molecule, for example at the active-site loop of said molecule. The fusion molecule may be modified to introduce one or more metal-binding/chelating amino-acid residues to aid in purification. Expression of this fusion molecule under the control of a regulatory sequence capable of directing its expression in a desired host cell, produces high levels of stable and soluble fusion protein. The fusion protein, located in the bacterial cytoplasm, may be selectively released from the cell by osmotic shock or freeze/thaw procedures. It may be optionally cleaved to liberate the soluble, correctly folded heterologous protein from the thioredoxin-like portion.
    Type: Grant
    Filed: December 10, 1993
    Date of Patent: July 8, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John McCoy, Elizabeth DiBlasio-Smith, Kathleen Grant, Edward R. LaVallie
  • Therapeutic uses of IL-3
    Patent number: 5639453
    Abstract: A method of treating leukopenia, by administering an IL-3 polypeptide, is disclosed.
    Type: Grant
    Filed: January 10, 1995
    Date of Patent: June 17, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Steven C. Clark, Agnes B. Ciarletta, Yu-Chung Yang
  • DNA molecules encoding bone morpogenetic protein-11
    Patent number: 5639638
    Abstract: Purified Bone Morphogenetic Protein-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception, and for the induction of bone, cartilage and/or other connective tissue.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: June 17, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Anthony J. Celeste
  • DNA molecules encoding bone morphogenetic protein-10
    Patent number: 5637480
    Abstract: Purified Bone Morphogenetic Protein-10 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-10 proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 20, 1994
    Date of Patent: June 10, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Anthony J. Celeste, John M. Wozney
  • BMP-15 compositions
    Patent number: 5635372
    Abstract: Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: June 3, 1997
    Assignees: Genetics Institute, Inc., Vanderbilt University
    Inventors: Anthony J. Celeste, Jennifer L. Dube, Karen M. Lyons, Brigid Hogan
  • Bone morphogenic protein-5(BMP-5) and DNA encoding same
    Patent number: 5635373
    Abstract: Purified BMP-5 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and/or cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 3, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. Wozney, Vicki A. Rosen, Elizabeth A. Wang
  • Method of detecting ligand interactions
    Patent number: 5635182
    Abstract: Provided by the present invention are novel methods of detecting ligand interactions, as well as regents useful in the method, including DNA and host cells; and more specifically relates to novel methods for the detection of protein/protein interactions and their application in epitope mapping and the study of ligand/receptor interactions. Also provided are vaccines and kits comprising the expression products and host cells of the invention.
    Type: Grant
    Filed: June 16, 1994
    Date of Patent: June 3, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John M. McCoy, Zhijian Lu
  • Compositions comprising bone morphogenetic protein-2 (BMP-2)
    Patent number: 5631142
    Abstract: Purified BMP-2 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: September 7, 1993
    Date of Patent: May 20, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki A. Rosen
  • Arachidonic acid releasing phospholipase A2 enzyme and methods of use
    Patent number: 5622832
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: February 28, 1990
    Date of Patent: April 22, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • BMP-2 products
    Patent number: 5618924
    Abstract: Purified BMP-2 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: April 8, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Elizabeth A. Wang, John M. Wozney, Vicki Rosen
  • Pharmaceutical formulations of osteogenic proteins
    Patent number: 5597897
    Abstract: A composition comprising a pharmaceutically acceptable admixture of an osteogenic protein; a polymer matrix component selected from the group consisting of poly(lactic acid), poly(glycolic acid), and copolymers of lactic acid and glycolic acid; and an osteogenic protein-sequestering material.
    Type: Grant
    Filed: June 29, 1993
    Date of Patent: January 28, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: Eyal Ron, Thomas J. Turek, Benjamin S. Isaacs, Himakshi Patel, Richard A. Kenley
  • Recombinant phospholipase A.sub.2 enzyme
    Patent number: 5593878
    Abstract: The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
    Type: Grant
    Filed: June 22, 1994
    Date of Patent: January 14, 1997
    Assignee: Genetics Institute, Inc.
    Inventors: John L. Knopf, James Clark
  • Calcium independent cytosolic phospholipase A.sub.2 /B enzymes
    Patent number: 5589170
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A.sub.2 /B enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: December 31, 1996
    Assignee: Genetics Institute, Inc.
    Inventors: Simon Jones, Jin Tang
  • Methods for treating bleeding disorders
    Patent number: 5582821
    Abstract: Provided by the present invention is a method for treating von Willebrand Disease (vWD) by administering IL-11. The present invention relates generally to novel methods for treating bleeding disorders and more specifically relates to methods for treating von Willebrand Disease (vWD) hemophilia A, and various hemostatic disorders such as uremia, cirrhosis, congenital platelet defects, congenital and acquired storage pool deficiency, patients with unexplained prolongations of bleeding time, as well as prophylactic treatment before surgeries.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: December 10, 1996
    Assignee: Genetics Institute, Inc.
    Inventor: James A. Kaye
  • Methods of treating preeclampsia
    Patent number: 5580554
    Abstract: Methods are provided for the diagnosis and treatment of patients with increased risk of gestational hypertension or preeclampsia. The methods involve measuring serum M-CSF levels, and administration of M-CSF.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: December 3, 1996
    Assignees: Genetics Institute, Inc., Virginia Polytechnic Institute and State University
    Inventor: James C. Keith