Abstract: This invention relates, e.g., to a method for predicting a subject's response to a chemotherapeutic agent and/or the subject's prognosis, comprising measuring the phosphorylation state of at least one member of the mTOR pathway, and/or of at least one member of an interconnected polypeptide pathway (e.g. a member of the Akt pathway or a member of the IRS pathway), compared to a baseline value, in a cancer tissue or cancer cell sample from the subject, wherein an elevated level of the phosphorylation state compared to the baseline value indicates that the subject is a non-responder to the chemotherapeutic agent and/or has a poor prognosis. Also described is a method for treating a cancer in a subject in need thereof, wherein the subject exhibits an elevated level of the phosphorylation state, comprising administering one or more inhibitors of the mTOR and/or an interconnected pathway.

Abstract: An apparatus for detecting a cavity comprising a signal receiver, a signal analyzer and a threshold excedent determination processor. The signal receiver receives a reflected signal resulting from an interaction of multi-frequency irradiating signal(s) with at least one cavity. The irradiating signal may include an electromagnetic or acoustic signal above a cavity dependent cutoff frequency with a randomized spectral component. The signal analyzer computes cavity detecting statistic(s) of the reflected signal. The cavity detecting statistic(s) may include an autocorrelation function. The autocorrelation function may be a Fourier transform of the power spectral density of the reflected signal. The threshold excedent determination processor generates a notification when cavity detecting statistic(s) exceed a threshold. The threshold may include a multi-variable function. The cavity may be the bore of a weapon. The apparatus may be configured to determine the bearing from the cavity to the apparatus.

Abstract: The invention involves developing and stabilizing cultivating droplets within a matrix of a porous medium. A cultivation medium may be selected, prepared and mixed with a surfactant. Where cells are desired to be cultured in droplets, cells may be added. The mixture may be converted into cultivating droplets. The cultivating droplets may be stabilized by introducing them to a porous medium. The porous medium may contain hydrophobic particles. Stabilized, cultivating droplets having one or more cells may form an aseptic microenvironment for the concentrated growth of cells.

Abstract: An apparatus and method for assigning subchannel(s) for communication between frequency agile mobile station(s) and a frequency agile base station. A received power level may be identified for each subcarrier in a set of subcarriers available for data transmission. A minimum power level needed to establish communications may be allocated. A detection threshold set to avoid interference with other devices currently transmitting on the set of subcarriers may be determined using the minimum uplink power level. A subset of subcarriers not already assigned may be selected where each subcarrier in the subset of subcarriers has a received power level that is less than the detection threshold. A subchannel that satisfies a bandwidth requirement may be formed where the subchannel consists of selected subcarriers in the set of subcarriers available for data transmission between the frequency agile mobile station(s) and the frequency agile base station.

Abstract: An attack graph analysis tool that includes a network configuration information input module, a domain knowledge input module, a network configuration information storage module, a domain knowledge storage module, and a result generation module. The network configuration information input module inputs network configuration information. The domain knowledge input module inputs domain knowledge for the network. The network configuration information storage module stores network configuration information in a network database table. The domain knowledge storage module stores the domain knowledge in an exploit database table. The result generation module generates a result using the network database table and exploit database table. The result may be generated in response to a query to a database management system that has access to the network database table and exploit database table.

Abstract: An attention assistance device for providing attention assistance including various features that help maintain a user's focus on a given task. The attention assistance device may include an activity sensor that generates an activity output in response to detection of a user generated activity. The attention assistance device may also have a timer that increments a counter at regular time intervals, resets the counter in response to the activity output, and generates a timer output when the counter reaches a threshold. Further, the attention assistance device may include a stimulation unit that alerts a user in response to the timer output.

Abstract: An attention assistance device configured to help maintain a user's focus on a given task. In one embodiment, text is presenting to a user on a touchscreen. The user tracking the text using a finger is monitored. The user is stimulated when the finger stops tracking the text for a predetermined period of time. In another embodiment, an electronic device presents an output configured to be tracked by a user. A monitoring device observes the user tracking the output. A sensory stimulating device stimulates the user when the “tracking” falls below an attention threshold.

Abstract: Embodiments treat cyclical behaviors based on behavioral data describing physiological factors affecting the behaviors. According to various embodiments, a processor or probe produce, from the behavioral data, factor data concerning the factors. Using a processor or recommendation engine that analyzes the factor data, treatment data is recommended based on an estimate of how the at least one factor affects the at least one cyclical behavior. A processor or feedback engine determines, from the treatment data, behavioral feedback configured to produce new behavioral data and to harness the effects of the factors to improve the cyclical behaviors.

Abstract: This invention relates, e.g., to a composition that, at room temperature, when contacted with a sample comprising phosphoproteins, can fix and stabilize cellular phosphoproteins, preserve cellular morphology, and allow the sample to be frozen to generate a cryostat frozen section suitable for molecular analysis. The composition comprises (1) a fixative that is effective to fix the phosphoproteins, and that has a sufficient water content to be soluble for a stabilizer and/or a permeability enhancing agent); (2) a stabilizer, comprising (a) a kinase inhibitor and (b) a phosphatase inhibitor and, optionally, (c) a protease (e.g., proteinase) inhibitor; and (3) a permeability enhancing agent (e.g. PEG). Methods are described for preserving phosphoproteins, using such a composition. Also described are endogenous surrogate markers for monitoring protein degradation, including the loss of posttranslational modifications (such as phosphorylation), e.g.

Abstract: A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human ?-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.

Abstract: The invention relates to a one-step chemical composition that preserves animal tissue, cells, and biomolecules, such as human tissue, human cells, and biomolecules therein. It improves the fidelity and morphologic structure of cells, organelles, and nuclear chromatin, and maintains and enhances the cellular antigenicity for immunohistochemistry and flow cytometry, while preserving proteins, post-translational modifications of proteins, and nucleic acids. In one embodiment, the composition comprises a) a non-aldehyde precipitating fixative at a concentration below 25% (volume/volume), b) a reversible/cleavable protein cross-linker that targets lipid-associated molecules, and c) a c reversible/cleavable protein cross-linker that targets water soluble molecules. In another embodiment, the composition further includes a kinase inhibitor, a phosphatase inhibitor, and a permeation enhancer.

Abstract: A Montgomery multiplication device calculates a Montgomery product of an operand X and an operand Y with respect to a modulus M and includes a plurality of processing elements. In a first clock cycle, two intermediate partial sums are created by obtaining an input of length w?1 from a preceding processing element as w?1 least significant bits. The most significant bit is configured as either zero or one. Then, two partial sums are calculated using a word of the operand Y, a word of the modulus M, a bit of the operand X, and the two intermediate partial sums. In a second clock cycle, a selection bit is obtained from a subsequent processing element and one of the two partial sums is selected based on the value of the selection bit. Then, the selected partial sum is used for calculation of a word of the Montgomery product.

Abstract: Embodiments locate a botmaster on a network. A honeynet host is configured to join a botnet and generate a watermarked packet flow by applying a watermark to an outgoing packet flow in response to commands from the botmaster. The watermark is applied to the outgoing packet flow by: choosing distinct packets from the outgoing packet flow; forming packet pair(s) from the distinct packets, that include a reference packet and an encoding packet; and encoding bits in the watermark to the packet pair(s) by increasing the length of the encoding packet when watermark bits have a predetermined value. The cooperating node(s) are configured to: inspect passing packet flows for the watermarked packet flow and generate tracking information related to detection of the watermarked packet flow. The path determination processor is configured to analyze the tracking information to locate a path taken by the watermarked packet flow.

Abstract: A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human ?-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.

Abstract: A Montgomery multiplication device calculates a Montgomery product of an operand X and an operand Y with respect to a modulus M and includes a plurality of processing elements. In a first clock cycle, two intermediate partial sums are created by obtaining an input of length w?1 from a preceding processing element as w?1 least significant bits. The most significant bit is configured as either zero or one. Then, two partial sums are calculated using a word of the operand Y, a word of the modulus M, a bit of the operand X, and the two intermediate partial sums. In a second clock cycle, a selection bit is obtained and one of the two partial sums is selected based on the value of the selection bit. Then, the selected partial sum is used for calculation of a word of the Montgomery product.

Abstract: A system and method for determining if a computer user is a human or a computer program. A computer user is presented with a series of images, the series of images including: at least two related images of an object, at least one of the at least two related images independently processed using an image modifying algorithm; and at least one unrelated image. The computer user is then requested to identify the related images from the series of images. These image identifications are received from the computer user. A determination is made that the computer user is: a human if the image identifications only identify the related images from the series of images; and a non-human if the image identifications do not only identify the related images from the series of images.

Abstract: A service-oriented system architecture includes a computer-implemented search method and computer-implemented agent system for enabling efficient information searches on, for example, on XML databases, relational databases, and files located on intranets, the Internet, or other computer network systems. Referred to as the Knowledge Sifter architecture, the architecture may comprise, in one embodiment, a community of cooperating agents. The system architecture may be employed using a variety of methodologies, such as a case-based framework, collaborative filtering, or hybrid filtering. The case-based framework may be configured to recommend query specifications and refinements based on previously-stored user-query cases. Collaborative filtering involves the architecture recommending a set of unseen items that are preferred by other users to the active user. Hybrid filtering combines collaborative filtering and content-based filtering.

Abstract: A new robust human authentication system, device, and instructions, embeddable in a physical and tangible computer readable medium, for determining if at least one test image obtained using an imaging device matches at least one training image in an enrollment database, are disclosed. This invention applies the concepts of appearance (PCA or PCA+LDA) and holistic anthropometrics that include head, face, neck, and shoulder linear and non-linear geometric measurements. The appearance (“eigen”) coefficients and holistic anthropometric measurements selected may be used as feature vectors. A boosting algorithm ranks features as “weak learners” and combines their outputs for “strong” recognition.

Abstract: Non-invasive methods for detecting non-alcoholic fatty liver disease (NAFLD) and identifying the presence or absence of non-alcoholic steatohepatitis (NASH) in a subject utilize one or more biomarkers. The methods can differentiate between subjects with NASH and those with simple steatosis. Kits containing one or more agents for measuring the level of the biomarkers can be utilized to perform the described methods.

Abstract: An attention assistance device configured to help maintain a user's focus on a given task. In one embodiment, text is presenting to a user on a touchscreen. The user tracking the text using a finger is monitored. The user is stimulated when the finger stops tracking the text for a predetermined period of time. In another embodiment, an electronic device presents an output configured to be tracked by a user. A monitoring device observes the user tracking the output. A sensory stimulating device stimulates the user when the “tracking” falls below an attention threshold.