Abstract: A neuronal measurement tool including: an input module, a grouping module, a metric selection module, a statistical test selection module, a raw measurement module, a clustering module and a statistical test module. The input module inputs digitally reconstructed neuronal morphologies. The grouping module groups the digitally reconstructed neuronal morphologies into groups. The metric selection module selects at least one metric of interest. The statistical test selection module selects a statistical test method. The raw measurement module gathers raw measurements associated with the metric(s) of interest on the digitally reconstructed neuronal morphologies. The clustering module clusters the raw measurements into groups and the statistical test module performs the statistical test method between the raw measurements clustered in the groups.

Abstract: This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a likelihood of a poor overall survival. The method comprises the step of determining if one or more of certain identified proteins are activated in tumor cells obtained from the patient's tumor, wherein the activation of one or more of the proteins indicates that the patient has an aggressive N0 tumor and is likely to have a poor overall-survival. The invention also provides a method for selecting a treatment for an NSCLC patient with an N0 tumor and a method for treating such patients. It further provides a kit for identifying an NSCLC patient with an aggressive N0 tumor and a likelihood of a poor overall survival and a pharmaceutical composition for treating such patients.

Abstract: A tangible computer readable medium may include a program of instructions which when executed by one or more processors, may implement a method of managing protocols. Instructions may include agreeing upon one or more protocol specifications. Instructions may include identifying one or more components required to implement one or more protocol specifications. Instructions may include communicating among parties one or more components when one or more components is a missing component. Instructions may include communicating among parties one or more protocol specifications. Instructions may include generating one or more executable codes using one or more protocol specifications. Instructions may include generating one or more executable codes using one or more components.

Abstract: Sensitive data associations for related data values are protected. A set of related data values is received. The set of related data values include at least a first data value and a second data value. The first data value is associated with a first data field and the second data value is associated to a second data field. First encrypted data is created by encrypting the first data value using a first encryption key and a second encrypted data is created by encrypting the second data value using a second encryption key. The first data value is stored in a first data table, the second data value is stored in a second data table, the first encrypted data is stored in the second table, and the second encrypted data is stored in the first table.

Abstract: A recognition-by-parts authentication system for determining if a physical test target represented in test image(s) obtained using an imaging device matches a physical training target represented in training image(s). The system includes a multitude of adaptive and robust correlation filters. Each of the adaptive and robust correlation filters is configured to generate correlation-peak-strength and distance-from-origin data using a multitude of related images. Each of the multitude of related images representing a similar part of a larger image. The related images originate from the test image(s) and training image(s).

Abstract: A data stream change detector including a receiving module, a preprocessor module, a clustering module, a strangeness module, a p-value module, a martingale value determination module, comparison module, and an output module. The receiving module accepts new data vectors that originate from a sequence of data in a data stream. Preprocessor module preprocesses the new data vector using a filter. The clustering module clusters the new data vector with previously received data vectors. Strangeness module computes a strangeness value for each of the previously received data vectors. The p-value module calculates a p-value for the new data vector using the strangeness value. Martingale value determination module calculates a martingale value for the new data vector using the p-value. Comparison module compares the martingale value with a threshold value; and sets an indicator if a change if the martingale is greater than the threshold.

Abstract: To preprocess a tissue sample, a first permeable mesh membrane is tautly stretched out over the tissue sample and overlaid on top of a flat surface. This covering sandwiches and secures the tissue sample in between the first permeable mesh membrane and the flat surface. If it is desired to reinforce the mechanical strength of the first permeable mesh membrane, a second permeable mesh membrane can be tautly stretched out and overlaid on top of the sandwich. Alternatively, the second permeable mesh membrane can be attached onto a third component, such as a disposable solvent resistant frame, to create a framed mesh. Thereafter, the first permeable mesh membrane may be attached to the framed mesh to create a compound framed mesh. The tissue sample may then be sandwiched and secured in between the compound framed mesh and the flat surface. To retain and flatten the tissue sample, gentle pressure may be uniformly applied.

Abstract: The present invention relates to methods and systems for creating secure cookies. The methods can be used to create, receive, and transmit secure cookies, confidential cookies, and authentication cookies.

Abstract: A system and method for determining if a computer user is a human or a computer program. A computer user is presented with a series of images, the series of images including: at least two related images of an object, at least one of the at least two related images independently processed using an image modifying algorithm; and at least one unrelated image. The computer user is then requested to identify the related images from the series of images. These image identifications are received from the computer user. A determination is made that the computer user is: a human if the image identifications only identify the related images from the series of images; and a non-human if the image identifications do not only identify the related images from the series of images.

Abstract: Described are methods and systems for designing target-specific oligonucleotides of L-length. The method comprises a) parsing a polynucleotide target into overlapping sequences of N-length nucleotides, creating a kernel set; b) performing step a) reiteratively for each target until each it is associated with its own kernel set; c) removing N-length kernels from the kernel sets which are redundant; d) concatenating X-length nucleotide suffixes to each N-length nucleotide kernel to create L-length oligonucleotide sets; e) ordering L-length nucleotides within each set of step d) by their nucleotide position within the target; f) retaining or rejecting an L-length oligonucleotide, based on the presence or absence of each of the X consecutive and overlapping N-length kernels; and g) performing step f) reiteratively.

Abstract: The present invention relates to the identification and diagnostic use of biomarkers in primary colorectal cancer tumors whose activation level are predictive of the likelihood of the onset of metastatic disease. These biomarkers may be used to determine the suitability of a patient for aggressive and/or targeted treatments. Kits and compositions of the invention are also provided.

Abstract: A radioactive containment composition may be created for containing radionuclides from a radioactive material by mixing a clay mineral with water. This mixture may form an aqueous clay suspension. The mixture can be refined by filtering to remove coarse material. The aqueous clay suspension may be applied to a radioactive material, allowing the radionuclides to be exchanged with cations in the aqueous clay suspension. The resulting aqueous slurry, a silver-based solution may be added to produce a suspension. The suspension may be collected, heated and analyzed.

Abstract: The present invention grows nanostructures using a microwave heating-based sublimation-sandwich SiC polytype growth method comprising: creating a sandwich cell by placing a source wafer parallel to a substrate wafer, leaving a small gap between the source wafer and the substrate wafer; placing a microwave heating head around the sandwich cell to selectively heat the source wafer to a source wafer temperature and the substrate wafer to a substrate wafer temperature; creating a temperature gradient between the source wafer temperature and the substrate wafer temperature; sublimating Si- and C-containing species from the source wafer, producing Si- and C-containing vapor species; converting the Si- and C-containing vapor species into liquid metallic alloy nanodroplets by allowing the metalized substrate wafer to absorb the Si- and C-containing vapor species; and growing nanostructures on the substrate wafer once the alloy droplets reach a saturation point for SiC.

Abstract: The present invention provides reliable methods to identify subsets of subjects with a cancer of epithelial origin characterized by a high level of phosphorylated c-erbB2 which does not correlate with the over-expression of total c-erbB2 as measured by IHC or FISH, for selection and inclusion for c-erbB2-direct treatment and therapy. Furthermore, the present invention provides a reliable method to determine whether a subject with a cancer of epithelial origin who has been determined to be c-erbB2 positive by IHC and by FISH should be excluded from c-erbB2-direct treatment because of a non-significant level of phosphorylated c-erbB2 in epithelial tumor tissue.

Abstract: A nanowire field effect junction diode constructed on an insulating transparent substrate that allows form(s) of radiation such as visual light, ultraviolet radiation; or infrared radiation to pass. A nanowire is disposed on the insulating transparent substrate. An anode is connected to a first end of the nanowire and a cathode is connected to the second end of the nanowire. An oxide layer covers the nanowire. A first conducting gate is disposed on top of the oxide layer adjacent with a non-zero separation to the anode. A second conducting gate is disposed on top of the oxide layer adjacent with a non-zero separation to the cathode and adjacent with a non-zero separation the first conducting gate. A controllable PN junction may be dynamically formed along the nanowire channel by applying opposite gate voltages. Radiation striking the nanowire through the substrate creates a current the anode and cathode.

Abstract: A sensor manager comprising: a situation information expected value network and an information instantiator. The situation information expected value network includes a probabilistic network configured to generate situation probabilities using situation data; and an expected information gain determination module configured to generate an information request using expected changes in the situation probabilities. The information instantiator is configured to generate a sensor observation request utilizing the information request and the situation data. The situation data includes at least one of the following: a goal lattice structure data; a goal lattice value; a kinematic state estimate; a non-kinematic state estimate; a search probability mass function; a sensor applicable function table; or any combination of the above. The probabilistic network includes: at least one managed evidence node; at least one unmanaged evidence node; and at least one situation evidence node.

Abstract: A promoter comprising nucleotides from positions 2489-3038 of FIG. 3.

Abstract: The present invention provides an active assay method for detecting a biological analyte. According to the method, a probe molecule is immobilized on a surface. An analyte is then placed in fluidic connection with the probe molecule on the surface. A force is then applied to the analyte to move it toward the surface to facilitate contact and possibly binding of the analyte to the probe. Optionally, another force can be applied or the force can be reversed, to remove unbound or weakly bound analyte from the surface. Analyte that remains bound to the surface is then detected. The detection can include rolling or sliding beads over an analyte and/or probe on a substrate, and detecting bound beads. The present invention furthermore, provides devices, such as electrophoresis apparatuses and biochip assemblies, for carrying out the methods of the invention.

Abstract: A flow cell for electrophoretically-assisted capturing analytes from a flow. The flow cell includes a specimen chamber, a first membrane, a second membrane, a first electrode chamber, and a second electrode chamber. The specimen chamber may have a sample inlet and a sample outlet. A first portion of the first membrane may be coupled to a first portion of the specimen chamber. A first portion of the second membrane may be coupled to a second portion of the specimen chamber. The first electrode chamber may be configured to accept a charge. A portion of the first electrode chamber may be coupled to a second portion of the first membrane. A second electrode chamber may be configured to accept an opposite charge. A portion of the second electrode chamber may be coupled to a second portion of the second membrane.

Abstract: A radioactive containment composition may be created for containing radionuclides from a radioactive material by mixing a clay mineral with water. This mixture may form an aqueous clay suspension, which in turn can be refined by filtering to remove coarse material. The aqueous clay suspension may be applied to a radioactive material, allowing the radionuclides to be exchanged with cations in the aqueous clay suspension. The resulting aqueous slurry may be collected, heated and analyzed.