Patents Assigned to Georgetown University
  • COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
    Publication number: 20190262323
    Abstract: Provided herein are methods of treating or preventing a neurodegenerative disease in a subject using an inhibitor of discoidin domain receptor (DDR) tyrosine kinase.
    Type: Application
    Filed: October 31, 2017
    Publication date: August 29, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: Charbel Moussa
  • CD99 Inhibitors and Their Uses
    Publication number: 20190262370
    Abstract: Provided herein are methods of treating cancer in a subject. Also provided are methods of treating autoimmune disorders. The methods comprise administering to the subject an effective amount of a CD99 inhibitor.
    Type: Application
    Filed: October 12, 2017
    Publication date: August 29, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Aykut Üren, Haydar Celik, Jeffrey A. Toretsky
  • Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies
    Patent number: 10376597
    Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: August 13, 2019
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, GEORGETOWN UNIVERSITY
    Inventors: Siang-Yo Lin, Joseph R. Bertino, Chen-Yong Lin
  • Electronic devices with organic nanoparticles
    Patent number: 10374198
    Abstract: An organic field effect transistor includes a semiconductor substrate having an insulating layer and a source electrode and a drain electrode located on the insulating layer, where the source electrode and drain electrode are spaced apart and define a channel region. The organic field effect transistor also includes an organic semiconductor located in the channel region.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: August 6, 2019
    Assignee: Georgetown University
    Inventors: Edward Van Keuren, George Burton
  • Biomarkers for Carcinogenesis and Uses Thereof
    Publication number: 20190227072
    Abstract: Provided herein are methods of reducing the recurrence of liver cancer in a subject.
    Type: Application
    Filed: August 11, 2017
    Publication date: July 25, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Fung-Lung Chung, Ying Fu, Aiwu Ruth He
  • Compositions and methods for identification of relapse risk and treatment in patients with colorectal cancer
    Patent number: 10351913
    Abstract: In certain aspects, the disclosure relates to methods of predicting recurrence of colorectal cancer by using a combination of microRNAs in the circulation, wherein the microRNAs are selected from the group consisting of miR-15a, miR-103, miR-148a, miR-320a, miR-451 and miR-596. In other aspects, the disclosure relates to methods of treating colorectal cancer by administering a therapeutic agent after determining an increased risk of recurrence.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: July 16, 2019
    Assignee: Georgetown University
    Inventors: Anton Wellstein, Narayan Shivapurkar
  • Manganese-oxo clusters as contrast agents for magnetic resonance imaging
    Patent number: 10342881
    Abstract: Nanoparticles for use as magnetic resonance imaging contrast agents are described. The nanoparticles are made up of a polymeric support and a manganese-oxo or manganese-iron-oxo cluster having magnetic properties suitable of a contrast agent. The manganese-oxo clusters may be Mn-12 clusters, which have known characteristics of a single molecule magnet. The polymer support may form a core particle which is coated by the clusters, or the clusters may be dispersed within the polymeric agent.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: July 9, 2019
    Assignee: Georgetown University
    Inventors: Sarah Stoll, Julie Quinn, Edward Van Keuren, Christopher Albanese, Stanley Fricke
  • METHODS OF IDENTIFYING NOVEL PROTEINS AND ANTIGENS IN CANCER CELLS
    Publication number: 20190204327
    Abstract: The present invention provides methods of identifying neopeptides in abnormal cells, with the methods comprising sequencing long-read messenger RNA (mRNA) isolated from the abnormal cells, identifying splice variants that could be generated from the sequenced long-read mRNA, determining if the abnormal cells contain neopeptides that correlate with the identified splice variants. The methods may also comprise identifying at least one neoantigen on the neopeptides that are present in the abnormal cells.
    Type: Application
    Filed: August 2, 2017
    Publication date: July 4, 2019
    Applicant: Georgetown University
    Inventor: Anton Wellstein
  • Process and framework for facilitating information sharing using a distributed hypergraph
    Patent number: 10331644
    Abstract: A knowledge model “overlay” for organizing and analyzing large, dynamic data volumes is implemented as a hypergraph that manifests as a result of a distributed theory-driven data source transformation process. This process maps exponentially growing data into an asymptotically limited information space. Within this space, real-world entities (e.g. people, computers, cities, Earth) and their complex interdependencies (e.g. social networks, connectivity, causal relationships) are represented as attributed hypergraph elements (i.e. both hypervertices and hyperedges). Attributes are represented as state vectors affixed to any hypergraph element. Transformation of source system data into this overlay structure is accomplished with minimal data movement and replication using a universal “pointer” like mechanism that is managed in a decentralized fashion by the respective transformation components.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: June 25, 2019
    Assignee: Georgetown University
    Inventor: J. Cory Smart
  • PROCESS FOR CONTINUOUS CELL CULTURE OF CANCER CELLS AND CANCER STEM CELLS
    Publication number: 20190161737
    Abstract: The present invention is directed towards compositions and methods of culturing cancer cells, with the methods comprising culturing cancer cells in the presence a cell culture medium while inhibiting the activity of Rho kinase (ROCK) in the cells during culturing.
    Type: Application
    Filed: July 26, 2017
    Publication date: May 30, 2019
    Applicant: Georgetown University
    Inventors: Maria Laura Aventaggiati, Giuseppe Giaccone
  • PROCESS FOR CONTINUOUS CELL CULTURE OF ISLET CELLS
    Publication number: 20190151371
    Abstract: The present invention is directed towards methods of culturing pancreatic islet cells, with the methods comprising culturing pancreatic islet cells in the presence a cell culture medium while inhibiting the activity of Rho kinase (ROCK) in the cells during culturing.
    Type: Application
    Filed: June 9, 2017
    Publication date: May 23, 2019
    Applicant: Georgetown University
    Inventors: Ian Gallicano, Samiksha Mahapatra
  • SYSTEM AND METHOD OF APPLYING STATE OF BEING TO HEALTH CARE DELIVERY
    Publication number: 20190131004
    Abstract: A system for assisting a subject to select a proper form of treatment. The system comprises: a monitoring section that remotely monitors a health status of the subject; an inference section that infers medical information about the subject based on information subject posted on social networks; a subject database that stores subject's information; and a symptom engine that stores symptoms of medical situations. The inference section applies the health status and the medical information against symptoms stored in the symptom engine to determine a proper form of treatment.
    Type: Application
    Filed: November 13, 2018
    Publication date: May 2, 2019
    Applicant: Georgetown University
    Inventors: Howard Federoff, Ophir Frieder, Eric Burger
  • Radioprotector compounds
    Patent number: 10266490
    Abstract: Radioprotector compounds including 3,3?-diindolylmethane (DIM) analogs, are provided. Further provided are methods for their use in reducing or preventing radiation damage, killing a tumor cell and protecting a non-tumor cell, and treating cancer.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 23, 2019
    Assignee: Georgetown University
    Inventors: Eliot M. Rosen, Milton Brown, Saijun Fan, Thomas Walls, Kathryn E. Ditmer
  • SYSTEM AND METHOD FOR DETERRING MALICIOUS NETWORK ATTACKS
    Publication number: 20190108141
    Abstract: A system and method for deterring malicious network attacks. The system and method is configured to execute instructions on at least one of the processors to generate a plurality of random blocks of data; generate a first XOR result by using the XOR function with the plurality of random blocks of data as the XOR function inputs; generate a tail value by using the XOR function with the first XOR result and a random encryption key as the XOR function inputs; encrypt a designated file using the random encryption key; write the plurality of random blocks and tail value to at least one storage medium; and write the encrypted designated file to at least one storage medium.
    Type: Application
    Filed: November 29, 2018
    Publication date: April 11, 2019
    Applicant: Georgetown University
    Inventor: Thomas Clay Shields
  • Exonuclease cycling assay
    Patent number: 10246739
    Abstract: The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising hybridizing the target polynucleotide with a probe to form a hybrid; exposing the hybrid to a 5? exonuclease so that the probe in the hybrid is digested and the target polynucleotide is dissociated from the digested probe; repeating the hybridization step and the digestion step; and detecting the digested probes. The presence of the digested probes indicates the presence of the target polynucleotide.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: April 2, 2019
    Assignee: GEORGETOWN UNIVERSITY
    Inventors: Mark Danielsen, Berenice Alfonso, Bolor Tumurpurev
  • SMALL MOLECULE ANDROGEN RECEPTOR INHIBITORS AND METHODS OF USE THEREOF
    Publication number: 20190077755
    Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.
    Type: Application
    Filed: November 7, 2018
    Publication date: March 14, 2019
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton L. Brown, Shujie Hou, Partha Banerjee, Karishma Amin
  • NANOPARTICLE TO TARGET CANCER
    Publication number: 20190076457
    Abstract: A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
    Type: Application
    Filed: March 15, 2017
    Publication date: March 14, 2019
    Applicants: Georgetown University, The United States of America, as represented by the Secretary, Department of Health & Human Servic
    Inventors: Jill P. Smith, Stephan Stern, Abdullah Mahmud
  • Amino-substituted polysiloxanes combined with polymerizable and unpolymerizable organic acids
    Patent number: 10221283
    Abstract: Provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant amines and (ii) an acid. Also provided is a composition comprising (i) a polysiloxane comprising a plurality of pendant acids and (ii) an amine. The compositions are useful inter alia for chemical or oil spill cleanup, drug delivery systems, transparent films, adhesives, binding agents, conductors, membranes, cross-linking agents, or opticoelectronic applications. Also provided are methods for making the compositions of the invention, as well as a battery and a composition for controlled release of a compound, each comprising a composition of the invention.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: March 5, 2019
    Assignee: Georgetown University
    Inventors: Richard G. Weiss, Ajaya M. V. Mallya, Yong He, Tao Yu
  • ENHANCING THE LEGIBILITY OF IMAGES USING MONOCHROMATIC LIGHT SOURCES
    Publication number: 20190066273
    Abstract: A system and method are described for enhancing readability of document images by operating on each document individually. Monochromatic light sources operating at different wavelengths of light can be used to obtain greyscale images. The greyscale images can then be used in any desired image enhancement algorithm. In one example algorithm, an automated method removes image background noise and improves sharpness of the scripts and characters using edge detection and local color contrast computation.
    Type: Application
    Filed: October 30, 2018
    Publication date: February 28, 2019
    Applicant: Georgetown University
    Inventors: Ophir Frieder, Gideon Frieder, Jon Parker
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF AGE-RELATED MACULAR DEGENERATION
    Publication number: 20190049465
    Abstract: The present invention is related to diagnostic, treatment and compound screening methods related to dry age-related macular degeneration (dry AM D). In select embodiments, the methods comprise determining expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SI RT-1), AM P-activated protein kinase (AM PK), poly(adenosine diphosphate ribose) poly-merase-2 (PARP2), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-I?) and/or mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3). In general, higher levels of PARP2, lower levels of PGC-I? or AKT3 and/or higher acetylation levels of PGC-I? in the samples are indicative that the subject or cells from which the samples are obtained are susceptible or are suffering from dry AMD.
    Type: Application
    Filed: February 6, 2017
    Publication date: February 14, 2019
    Applicant: Georgetown University
    Inventor: Nady GOLESTANEH