Abstract: A rotating dual-electrode infrared cell for in situ electrochemical attenuated-total-reflection infrared spectroscopy (ATR-IRS) comprising: a first and second prism; a first and second thin metal film, wherein the first thin metal film is coated on a surface of the first prism and the second thin metal film is coated on a surface of the second prism; an ion exchange membrane; and a first and second cell body, wherein each cell body comprises an inlet and outlet.

Abstract: Devices including graphene quantum dots yield extremely high performance THz bolometers, by measuring the current of hot electrons formed in the graphene source and drain electrodes of the device and propagating through the graphene quantum dot connected thereto. Devices may also include additional materials such as MoS2, as well as one or more gate electrodes to alter performance as needed.

Abstract: Technologies are disclosed for computing heavy hitter histograms using locally private randomization. Under this strategy, “agents” can each hold a “type” derived from a large dictionary. By performing an algorithm, an estimate of the distribution of data can be obtained. Two algorithms implement embodiments for performing methods involving differential privacy for one or more users, and usually are run in the local model. This means that information is collected from the agents with added noise to hide the agents' individual contributions to the histogram. The result is an accurate enough estimate of the histogram for commercial or other applications relating to the data collection of one or more agents. Specifically, the proposed algorithms improve on the performance (measured in computation and memory requirements at the server and the agent, as well as communication volume) of previously solutions.

Abstract: The present invention relates to markers and therapeutic targets of abnormal retinal pigment epithelium (RPE).

Abstract: A method and system for contact tracing and alerting anonymously tracks persons within and across digitally modeled areas using registration stations within the area having scannable digital codes which are unique to the area. Upon being alerted to a contagion situation, either from a laboratory or from an area administrator, the system compares electronic visit tickets unique to each person's visit to determine overlap and generates at least one of an exposure event notifications and a contamination event notifications responsive to one or more determinations made by the comparing.

Abstract: The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing.

Abstract: A system for producing dry nanoparticles from a liquid includes a closed tubing system which incorporates a mister, heater and an electrostatic collector therein. The system is able to produce dry nanoparticles from liquid-suspensions and from solvent solutions.

Abstract: Embodiments of the present systems and methods may provide techniques to predict the success or failure of a drug used for disease treatment. For example, a method of determining drug efficacy may include, for a plurality of patients, generating a directed acyclic graph from health related information of each patient comprising nodes representing a medical event of the patient, at least one first edge connecting the first node to an additional node, each additional edge connecting nodes representing two consecutive medical events, the edge having a weight based on a time difference between the two consecutive medical events, capturing a plurality of features from each directed acyclic graph, generating a binary graph classification model on captured features of each directed acyclic graph, determining a probability that a drug or treatment will be effective using the binary graph classification model, and determining a drug to be prescribed to a patient based on the determined probability.

Abstract: Technologies are provided for efficiently querying a database using a plurality of oblivious random-access memories (ORAMs) while providing differential privacy. Subsets of a set of database records can be stored in a plurality of ORAMs. The subsets of database records in the separate ORAMs can be concurrently accessed (for example, by a database query server). When a database query is received, a number of database records that match the query can be identified for each of the ORAMs. A differential privacy constraint can be used to determine an additional number of database records to be retrieved from each ORAM. The differential privacy constraint can specify an upper bound on the number of records to be retrieved from each ORAM to prevent (or reduce the risk of) information leakage. Once all of the identified records are retrieved from the plurality of ORAMs, the additional records can be discarded.

Abstract: A system for carrying out electrochemical nuclear magnetic resonance spectroscopy (EC-NMR) is disclosed, along with methods of manufacturing the EC-NMR system, and methods of using the EC-NMR system to monitor electrochemical reactions. The system comprises interdigitated electrodes arranged in a cylindrically symmetric manner. The system allows for nuclear magnetic resonance spectroscopy to be carried out on a sample during electrolysis with minimal effect to its sensitivity.

Abstract: A method for training vibrotactile speech perception in the absence of auditory speech can comprise selecting a first word, generating a first control signal configured to cause at least one vibrotactile transducer to vibrate against a person's body with a first vibration pattern based on the first word, sampling a second word spoken by the person, generating a second control signal configured to cause at least one vibrotactile transducer to vibrate against the person's body with a second vibration pattern based on the sampled second word, and presenting a comparison between the first word and the second word to the person. An array of vibrotactile transducers can be in contact with the person's body.

Abstract: The present invention relates to assays, methods, and kits to assess traumatic brain injury (TBI) in a subject. The present invention also relates to ultrasensitive assays for GFAP, tau, CKBB, IL-1?, IL-2, IL-6, IL-10, IL-22, IP-10, TNF?, TSLP, NFL, and/or NFH.

Abstract: In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds.

Abstract: Described herein are methods of predicting drug-target interactions and methods of using the information for drug repurposing. The methods described herein combine different descriptors, including, for example, atom pair similarity, shape, topology and chemical signatures, physico-chemical functional descriptors, contact points of the ligand and the target protein, chemical similarity, and docking score.

Abstract: The present invention is directed to analytical methods for determining the concentration, and/or stereoisomeric excess, and/or absolute configuration of chiral analytes in a sample.

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's proteomic profile and comparing the value of the subject's proteomic profile with the value of a normal proteomic profile. A change in the value of the subject's proteomic profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Abstract: A triage system that determines whether a user is likely to have contracted a disease based on sensor data received from a user device (e.g., a smartphone or activity tracker). Each symptom is identified by comparing sensor data to a predetermined baseline and comparing the difference to a predetermined symptom threshold. Because direct measurement of symptoms using the sensors available to the user may not be feasible or sufficiently accurate, the triage system also uses surrogates the identify certain symptoms. For example, a fever may be identified using heart data, a cough or shortness of breath may be identified by analyzing recorded sound, fatigue may be identified by analyzing the movement of the user device, and loss of smell or taste may be identified by recording sound and using speech detection algorithms to identify phrases in the recorded sound indicative of loss of smell or taste.

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Abstract: Provided are methods, kits, and systems useful in the performance of analysis and reporting of highly polymorphic loci, including, in particular, the performance of analysis and reporting of HLA typing. Combining one-step sequencing and sequence-specific oligonucleotide probe hybridization, the methods, kits, and systems offer improved efficiency of HLA typing while providing detailed sequencing information. In certain embodiments the methods and systems comprise one or more software applications to facilitate data acquisition, processing, and reporting.

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise analyzing at least one plasma sample from the subject to determine a value of the subject's metabolite profile and comparing the value of the subject's metabolite profile with the value of a normal metabolite profile. A change in the value of the subject's metabolite profile, over normal values is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.