Abstract: Provided are batteries and fuel cells incorporating a stripline detector for use in nuclear magnetic resonance (NMR). The stripline batteries and fuel cells can be used for in situ NMR measurement of battery or fuel cell chemistry. Also provided are methods for measuring in situ battery and fuel cell NMR using the stripline batteries and fuel cells of the invention.

Abstract: Provided herein are methods of treating or preventing a neurodegenerative disease, a myodegenerative disease or a prion disease in a subject comprising administering a tyrosine kinase inhibitor.

Abstract: Compositions comprising bile acids or their salts and methods of use thereof for the treatment of residual lesions of vascular anomalies.

Abstract: Provided herein are methods for treating a cholecystokinin (CCK) receptor-expressing cancerous tumor in a subject. Also provided are methods for increasing sensitivity of a (CCK) receptor-expressing cancerous tumor in a subject to immunotherapy.

Abstract: A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface (API) and a hypergraph transfer protocol (HGTP), for facilitating communication between the one or more client applications and one or more knowledge representation servers responsive to a client application request. The client application request includes an API call for a specific entity that is received by a first knowledge representation server. If the first knowledge representation server does not manage the specific entity, the first knowledge representation server forwards the specific entity call to a second knowledge representation server via the HGTP using a universal unique identifier (UUID) associated with the specific entity having encoded therein a network address for the second knowledge representation server.

Abstract: Provided herein are methods for detecting a cerebrospinal fluid-specific (CSF-specific) glycoform of Apolipoprotein E (APOE) in a subject.

Abstract: The present invention relates to methods of determining if a subject has an increased risk of suffering from memory impairment. The methods comprise determining the influx of polyunsaturated fatty acids (PUFAs) into the brain from plasma in a test subject and comparing this measured influx to a normal standard influx. An increase in influx of PUFAs from the plasma into the brain is indicative that the subject has an increased risk of suffering from memory impairment compared to a normal individual.

Abstract: Embodiments may provide a cache for query results that can adapt the cache-space utilization to the popularity of the various topics represented in the query stream. For example, a method for query processing may perform receiving a plurality of queries for data, determining at least one topic associated with each query, and requesting data responsive to each query from a data cache comprising a plurality of partitions, including at least a static cache partition, a dynamic cache partition, and a temporal cache partition, the temporal cache partition may store data based on a topic associated with the data, and may be further partitioned into a plurality of topic portions, each portion may store data relating to an associated topic, wherein the associated topic may be selected from among determined topics of queries received by the computer system, and the data cache may retrieve data for the queries from the computer system.

Abstract: A system and method are described for enhancing readability of document images by operating on each document individually. Monochromatic light sources operating at different wavelengths of light can be used to obtain greyscale images. The greyscale images can then be used in any desired image enhancement algorithm. In one example algorithm, an automated method removes image background noise and improves sharpness of the scripts and characters using edge detection and local color contrast computation.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1? are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: Devices including graphene quantum dots yield extremely high performance THz bolometers, by measuring the current of hot electrons formed in the graphene source and drain electrodes of the device and propagating through the graphene quantum dot connected thereto. Devices may also include additional materials such as MoS2, as well as one or more gate electrodes to alter performance as needed.

Abstract: The present invention is directed to analytical methods for determining the concentration, and/or stereoisomeric excess, and/or absolute configuration of chiral analytes in a sample.

Abstract: A system and method are described for enhancing readability of document images by operating on each document individually. Monochromatic light sources operating at different wavelengths of light can be used to obtain greyscale images. The greyscale images can then be used in any desired image enhancement algorithm. In one example algorithm, an automated method removes image background noise and improves sharpness of the scripts and characters using edge detection and local color contrast computation.

Abstract: Disclosed herein are systems and methods for the automatic re-analysis of genetic testing data. A centralized computing system can analyze genetic testing data and automatically re-analyze the genetic testing data when the centralized computing system is updated. In some embodiments, the centralized computing system can be updated with new or updated software, genetic analysis tools, and/or genetic analysis methods. The genetic testing data can then be re-analyzed using the new or updated software, tools, or methods. The genetic testing data can also be re-analyzed if/when available databases or knowledgebases are updated, such as when a new study or report is published. Based on the re-analysis, a suggested diagnoses and/or treatment plans can be revised.

Abstract: The present invention relates to methods of treating hypertension in a subject in need of treatment thereof, with the methods comprising administering a pharmaceutically effective amount of an angiotensin II inhibitor and a pharmaceutically effective amount of a receptor tyrosine kinase inhibitor to the subject.

Abstract: The present invention is directed towards methods of culturing germline pluripotent stem cells (gPSCs), with the methods comprising culturing the cells in a cell culture medium while inhibiting the activity of Rho kinase (ROCK) in the cells during culture. The present invention is also directed towards methods of using these continuously cultured gPSCs.

Abstract: (R)-12-hydroxystearic acid hydrazides as gelators and gels generated therefrom are provided. A series of (R)-12-hydroxystearic acid hydrazides produce gels that are self-standing and self-healing. The (R)-12-hydroxystearic acid hydrazides are capable of exhibiting gelling properties in a wide variety of solvents. The gels have demonstrated good potential for use in drug release.

Abstract: A system and method for connecting one or more client applications with one or more knowledge representation servers and communicating there between includes an application programming interface (API) and a hypergraph transfer protocol (HGTP), for facilitating communication between the one or more client applications and one or more knowledge representation servers responsive to a client application request. The client application request includes an API call for a specific entity that is received by a first knowledge representation server. If the first knowledge representation server does not manage the specific entity, the first knowledge representation server forwards the specific entity call to a second knowledge representation server via the HGTP using a universal unique identifier (UUID) associated with the specific entity having encoded therein a network address for the second knowledge representation server.

Abstract: The invention relates to methods of treating a metabolic disorder in a subject, the method comprising administering fibroblast growth factor binding protein 3 (FGFBP3) or a variant thereof to a subject in need of treatment of a metabolic disorder.

Abstract: Small molecule carbazole compounds for use as androgen receptor inhibitors are provided herein. Also provided herein are methods for using the carbazole compounds in treating prostate cancer, including castration-resistant prostate cancer and enzalutamide-resistant prostate cancer. The methods include administering to a subject an effective amount of a compound or composition as described herein.