Patents Assigned to Gifu University
  • Patent number: 10376544
    Abstract: An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for SSEA-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells. The cell preparation of the present invention is based on a cardiac tissue regeneration mechanism by which Muse cells are made to selectively accumulate in damaged myocardial tissue and differentiate into cardiac muscle in that tissue as a result of intravenous administration of Muse cells to a subject presenting with the aforementioned disorders.
    Type: Grant
    Filed: November 3, 2017
    Date of Patent: August 13, 2019
    Assignees: CLIO, INC., GIFU UNIVERSITY, TOHOKU UNIVERSITY
    Inventors: Masanori Yoshida, Shinya Minatoguchi, Mari Dezawa
  • Patent number: 10377628
    Abstract: An energy carrier system is provided that produces ammonia with high efficiency and that further produces hydrogen as final product and uses the hydrogen as energy. An energy storage transportation method is further provided that is carried out by using energy carrier system. The energy carrier system includes nitric acid production device, an ammonia production device, and hydrogen production device. The nitric acid production device includes a photo-reactor, a gas supply unit that supplies photo-reactor with gas to be treated containing a nitrogen oxide, water, and oxygen, and light source disposed in the photo-reactor. The light source radiates light including ultraviolet of a wavelength shorter than 175 nm. The energy storage transportation method includes nitric acid production step of producing nitric acid from a nitrogen oxide, ammonia production step of producing ammonia through reduction of nitric acid, and hydrogen production step of producing hydrogen through decomposition of the ammonia.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: August 13, 2019
    Assignees: SAWAFUJI ELECTRIC CO., LTD., GIFU UNIVERSITY
    Inventors: Shinji Kambara, Nobuyuki Hishinuma, Tomonori Miura
  • Patent number: 10252125
    Abstract: To provide a lightweight shaft having excellent strength, a shaft has one or a plurality of fiber reinforced resin layers. At least one of the fiber reinforced resin layers is produced by a filament winding method in which one or a plurality of fiber bundles are wound while tension is applied thereto. The fiber bundles each include a plurality of filaments. The tension applied to the fiber bundles is not less than 0.04 (gf) per filament. The tension is great. Preferably, at least one of the fiber reinforced resin layers is produced by a multi-filament winding method in which a plurality of the fiber bundles are simultaneously wound while being arranged side by side. Preferably, fibers forming the filaments are carbon fibers. Preferably, a resin composition included in each fiber reinforced resin layer is an epoxy resin composition.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: April 9, 2019
    Assignees: SUMITOMO RUBBER INDUSTRIES, LTD., GIFU UNIVERSITY
    Inventors: Takehiko Hyodo, Yumi Kanemitsu, Asami Nakai, Akio Ohtani, Tadashi Uozumi
  • Publication number: 20180303409
    Abstract: Provided is an apparatus for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphological index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. An osteoporosis diagnostic support apparatus, wherein the apparatus has a contour extraction unit adapted to extract a mandibular contour from an image of a mandibular cortical bone photographed by a photographic apparatus adapted to photograph the mandibular cortical bone and surroundings thereof, a line segment extraction unit adapted to extract line segments from the image of the mandibular cortical bone photographed by the photographic apparatus; and a cortical bone thickness calculation unit adapted to calculate a thickness of the cortical bone based on the extracted mandibular contour and line segments.
    Type: Application
    Filed: June 25, 2018
    Publication date: October 25, 2018
    Applicants: Media Co., Ltd., Gifu University
    Inventors: Hironobu TSUJI, Yosuke TSUJI, Tatsuro HAYASHI, Hiroshi FUJITA, Takeshi HARA, Chisako MURAMATSU, Kazuki HORIBA, Akitoshi KATSUMATA
  • Patent number: 10065170
    Abstract: To provide a hydrogen generating apparatus that efficiently generates hydrogen from ammonia, and a fuel cell system that generates power using the efficiently generated hydrogen. [Solution] A hydrogen generating apparatus (1) is provided with a plasma reactor (3), a high-voltage electrode (5), a grounding electrode (7), and a gas supply means (15) that supplies a gas containing ammonia to the plasma reactor. The high-voltage electrode (5) is configured with a hydrogen separation membrane (12) included therein. Under the conditions of room temperature and atmospheric pressure, the hydrogen separation membrane (12) of the high-voltage electrode (5) discharges electricity between the grounding electrode (7) and the hydrogen separation membrane with power supplied from a high-voltage pulse power supply (2), and hydrogen is generated by bringing into the plasma state the ammonia contained in the gas thus supplied.
    Type: Grant
    Filed: October 1, 2013
    Date of Patent: September 4, 2018
    Assignees: GIFU UNIVERSITY, SAWAFUJI ELECTRIC CO., LTD., ACTREE CORPORATION
    Inventors: Shinji Kambara, Tomonori Miura, Megumi Masui
  • Patent number: 10006024
    Abstract: Provided is an RNA interference agent, with which a suppression effect on the off-target effect can be obtained with a simple system. The disclosures relate to an RNA interference agent provided with a single-stranded oligonucleotide passenger strand having one or two or more PAZ domain low-affinity units at the 3?-end.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: June 26, 2018
    Assignee: GIFU UNIVERSITY
    Inventors: Yukio Kitade, Remi Nakashima
  • Publication number: 20180094017
    Abstract: The oligonucleotide derivative of the present invention is represented by Formula (1). This derivative is considered to be introduced into cells by binding of its amino sugar chain moiety to a ligand on cell surfaces, and have selective drug delivery function. The oligonucleotide derivative can be easily synthesized and introduced into cells without using a lipofection reagent. wherein—A and B are independently modified or unmodified oligonucleotides whose total chain length is 3 or more, and A and B do not contain hydroxyl groups at 3? and 5? ends of the oligonucleotide; S represents a sugar substituent, a peptide chain, or a tocopherol-binding group; and an alkyl group may be bound instead of hydrogen bound to a benzene ring.
    Type: Application
    Filed: March 24, 2016
    Publication date: April 5, 2018
    Applicant: GIFU UNIVERSITY
    Inventors: Yukio KITADE, Aya SHIBATA
  • Publication number: 20180078834
    Abstract: To provide a lightweight shaft having excellent strength, a shaft has one or a plurality of fiber reinforced resin layers. At least one of the fiber reinforced resin layers is produced by a filament winding method in which one or a plurality of fiber bundles are wound while tension is applied thereto. The fiber bundles each include a plurality of filaments. The tension applied to the fiber bundles is not less than 0.04 (gf) per filament. The tension is great. Preferably, at least one of the fiber reinforced resin layers is produced by a multi-filament winding method in which a plurality of the fiber bundles are simultaneously wound while being arranged side by side. Preferably, fibers forming the filaments are carbon fibers. Preferably, a resin composition included in each fiber reinforced resin layer is an epoxy resin composition.
    Type: Application
    Filed: April 27, 2016
    Publication date: March 22, 2018
    Applicants: SUMITOMO RUBBER INDUSTRIES, LTD., GIFU UNIVERSITY
    Inventors: Takehiko HYODO, Yumi KANEMITSU, Asami NAKAI, Akio OHTANI, Tadashi UOZUMI
  • Patent number: 9919270
    Abstract: A denitration device and a denitration method in which denitration is performed efficiently and in a stable manner in a lower-reaction-temperature region without using a catalyst. The denitration device is provided with a combustion chamber, a denitration agent feed means for feeding a denitration agent into the combustion chamber, an exhaust pipe, and an OH-radical-generating substance feed means for feeding an OH radical-generating substance into the exhaust pipe. The denitration agent feed means feeds a denitration agent into the exhaust gas of the combustion chamber to perform a first denitration reaction step, and the OH-radical-generating substance feed means feeds the OH-radical-generating substance into the exhaust gas in the exhaust pipe to perform a second denitration reaction step.
    Type: Grant
    Filed: October 30, 2014
    Date of Patent: March 20, 2018
    Assignees: GIFU UNIVERSITY, SAWAFUJI ELECTRIC CO., LTD., ACTREE CORPORATION
    Inventors: Shinji Kambara, Tomonori Miura, Tatsuya Ikeda, Sho Arai, Megumi Masui
  • Publication number: 20180050067
    Abstract: An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for SSEA-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells. The cell preparation of the present invention is based on a cardiac tissue regeneration mechanism by which Muse cells are made to selectively accumulate in damaged myocardial tissue and differentiate into cardiac muscle in that tissue as a result of intravenous administration of Muse cells to a subject presenting with the aforementioned disorders.
    Type: Application
    Filed: November 3, 2017
    Publication date: February 22, 2018
    Applicants: CLIO, INC., GIFU UNIVERSITY, TOHOKU UNIVERSITY
    Inventors: Masanori Yoshida, Shinya Minatoguchi, Mari Dezawa
  • Patent number: 9890360
    Abstract: A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: February 13, 2018
    Assignees: GIFU UNIVERSITY, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Kenichi Tezuka, Naritaka Tamaoki, Kazuki Iida, Tomoko Kawaguchi, Hitomi Aoki, Takahiro Kunisada, Toshiyuki Shibata, Naoki Goshima
  • Publication number: 20180009661
    Abstract: An energy carrier system is provided that produces ammonia with high efficiency and that further produces hydrogen as final product and uses the hydrogen as energy. An energy storage transportation method is further provided that is carried out by using energy carrier system. The energy carrier system includes nitric acid production device, an ammonia production device, and hydrogen production device. The nitric acid production device includes a photo-reactor, a gas supply unit that supplies photo-reactor with gas to be treated containing a nitrogen oxide, water, and oxygen, and light source disposed in the photo-reactor. The light source radiates light including ultraviolet of a wavelength shorter than 175 nm. The energy storage transportation method includes nitric acid production step of producing nitric acid from a nitrogen oxide, ammonia production step of producing ammonia through reduction of nitric acid, and hydrogen production step of producing hydrogen through decomposition of the ammonia.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 11, 2018
    Applicants: SAWAFUJI ELECTRIC CO., LTD., GIFU UNIVERSITY
    Inventors: Shinji KAMBARA, Nibuyuki HISHINUMA, Tomonori MIURA
  • Patent number: 9844570
    Abstract: An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for SSEA-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells. The cell preparation of the present invention is based on a cardiac tissue regeneration mechanism by which Muse cells are made to selectively accumulate in damaged myocardial tissue and differentiate into cardiac muscle in that tissue as a result of intravenous administration of Muse cells to a subject presenting with the aforementioned disorders.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: December 19, 2017
    Assignees: CLIO, INC., GIFU UNIVERSITY, TOHOKU UNIVERSITY
    Inventors: Masanori Yoshida, Shinya Minatoguchi, Mari Dezawa
  • Patent number: 9809563
    Abstract: An object of the present invention is to provide an anti-prion compound that has high crystallinity and is highly stable in the crystalline form and to provide a medicament for preventing, ameliorating or treating a prion disease.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: November 7, 2017
    Assignee: GIFU University
    Inventor: Kazuo Kuwata
  • Patent number: 9765457
    Abstract: A braider and a tube body in which braids are arranged on an outer peripheral surface of a mandrel uniformly even if the diameter of the mandrel is uneven. A braider 1 has bobbin carrier conveyance mechanisms 50A and 50B in which bobbin carriers 40A and 40B are conveyed from traveling tracks W1 and W2 to an outside of the traveling tracks W1 and W2 so as to stop winding of braids Y1 and Y2 onto a mandrel 2 and the bobbin carriers 40A and 40B are conveyed from the outside of the traveling tracks W1 and W2 to the traveling tracks W1 and W2 so as to start the winding of the braids Y1 and Y2 onto the mandrel 2.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: September 19, 2017
    Assignees: MURATA MACHINERY, LTD., GIFU UNIVERSITY
    Inventors: Ryosuke Tahara, Tadashi Uozumi, Akio Ohtani
  • Patent number: 9710907
    Abstract: A diagnosis support system includes a diagnosis support computer that includes a model data acquisition unit configured to obtain a plurality of mandible model data, a contour model creation unit configured to create contour model data from the mandible model data, a contour database storage unit configured to construct a contour model database from the contour model data, a diagnosis image data receiving unit configured to receive an input of diagnosis image data of an examinee, an edge extraction unit configured to extract edge data from the diagnosis image data, a similar model searching unit configured to search contour model data based on the edge data, a position judgment unit and an image quality judgment unit configured to judge an imaging position and an image quality based on imaging information, respectively, and a diagnosis support information provision unit configured to provide diagnosis support information based on provider information.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: July 18, 2017
    Assignees: Gifu University, MEDIA CO., LTD.
    Inventors: Hiroshi Fujita, Takeshi Hara, Akitoshi Katsumata, Tatsuro Hayashi
  • Publication number: 20160279570
    Abstract: To apply a denitration device and a denitration method in which denitration is performed efficiently and in a stable manner in a lower-reaction-temperature region without using a catalyst. The denitration device (100) is provided with a combustion chamber (1), a denitration agent feed means (11) for feeding a denitration agent into the combustion chamber (1), an exhaust pipe (2), and an OH-radical-generating substance feed means (21) for feeding an OH-radical-generating substance into the exhaust pipe (2). The denitration agent feed means (11) feeds a denitration agent into the exhaust gas of the combustion chamber to perform a first denitration reaction step, and the OH-radical-generating substance feed means (21) feeds the OH-radical-generating substance into the exhaust gas in the exhaust pipe (2) to perform a second denitration reaction step.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 29, 2016
    Applicant: GIFU UNIVERSITY
    Inventors: Shinji Kambara, Tomonori Miura, Tatsuya Ikeda, Sho Arai, Megumi Masui
  • Publication number: 20160262686
    Abstract: Provided is an apparatus for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphological index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. An osteoporosis diagnostic support apparatus, wherein the apparatus has a contour extraction unit adapted to extract a mandibular contour from an image of a mandibular cortical bone photographed by a photographic apparatus adapted to photograph the mandibular cortical bone and surroundings thereof, a line segment extraction unit adapted to extract line segments from the image of the mandibular cortical bone photographed by the photographic apparatus; and a cortical bone thickness calculation unit adapted to calculate a thickness of the cortical bone based on the extracted mandibular contour and line segments.
    Type: Application
    Filed: May 23, 2016
    Publication date: September 15, 2016
    Applicants: Media Co., Ltd., Gifu University
    Inventors: Hironobu TSUJI, Yosuke TSUJI, Tatsuro HAYASHI, Hiroshi FUJITA, Takeshi HARA, Chisako MURAMATSU, Kazuki HORIBA, Akitoshi KATSUMATA
  • Publication number: 20160208218
    Abstract: A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
    Type: Application
    Filed: August 28, 2014
    Publication date: July 21, 2016
    Applicants: GIFU UNIVERSITY, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Kenichi TEZUKA, Naritaka TAMAOKI, Kazuki IIDA, Tomoko KAWAGUCHI, Hitomi AOKI, Takahiro KUNISADA, Toshiyuki SHIBATA, Naoki GOSHIMA
  • Patent number: 9198682
    Abstract: An endoscope treatment tool includes a flexible sheath, a manipulation wire, and a basket portion constituted by a locking portion and a plurality of elastic wires. A maximum outside diameter portion of the basket portion is at a position closer to the locking portion than an intermediate position between a proximal end of the basket portion and the locking portion. The plurality of elastic wires is formed in a shape of a helix, and a winding pitch of the plurality of elastic wires becomes gradually smaller in a direction from a proximal side to the distal side of the manipulation wire. When a proximal side of the basket portion is reduced, an outside diameter of the maximum outside diameter portion is maintained at substantially a same size as the outside diameter before the proximal side of the basket portion is reduced.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: December 1, 2015
    Assignees: OLYMPUS CORPORATION, GIFU UNIVERSITY
    Inventors: Ichiro Yasuda, Tsukasa Kobayashi, Yutaka Yanuma