Abstract: Provided is an RNA interference agent, with which a suppression effect on the off-target effect can be obtained with a simple system. The disclosures relate to an RNA interference agent provided with a single-stranded oligonucleotide passenger strand having one or two or more PAZ domain low-affinity units at the 3?-end.

Abstract: The oligonucleotide derivative of the present invention is represented by Formula (1). This derivative is considered to be introduced into cells by binding of its amino sugar chain moiety to a ligand on cell surfaces, and have selective drug delivery function. The oligonucleotide derivative can be easily synthesized and introduced into cells without using a lipofection reagent. wherein—A and B are independently modified or unmodified oligonucleotides whose total chain length is 3 or more, and A and B do not contain hydroxyl groups at 3? and 5? ends of the oligonucleotide; S represents a sugar substituent, a peptide chain, or a tocopherol-binding group; and an alkyl group may be bound instead of hydrogen bound to a benzene ring.

Abstract: To provide a lightweight shaft having excellent strength, a shaft has one or a plurality of fiber reinforced resin layers. At least one of the fiber reinforced resin layers is produced by a filament winding method in which one or a plurality of fiber bundles are wound while tension is applied thereto. The fiber bundles each include a plurality of filaments. The tension applied to the fiber bundles is not less than 0.04 (gf) per filament. The tension is great. Preferably, at least one of the fiber reinforced resin layers is produced by a multi-filament winding method in which a plurality of the fiber bundles are simultaneously wound while being arranged side by side. Preferably, fibers forming the filaments are carbon fibers. Preferably, a resin composition included in each fiber reinforced resin layer is an epoxy resin composition.

Abstract: A denitration device and a denitration method in which denitration is performed efficiently and in a stable manner in a lower-reaction-temperature region without using a catalyst. The denitration device is provided with a combustion chamber, a denitration agent feed means for feeding a denitration agent into the combustion chamber, an exhaust pipe, and an OH-radical-generating substance feed means for feeding an OH radical-generating substance into the exhaust pipe. The denitration agent feed means feeds a denitration agent into the exhaust gas of the combustion chamber to perform a first denitration reaction step, and the OH-radical-generating substance feed means feeds the OH-radical-generating substance into the exhaust gas in the exhaust pipe to perform a second denitration reaction step.

Abstract: An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for SSEA-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells. The cell preparation of the present invention is based on a cardiac tissue regeneration mechanism by which Muse cells are made to selectively accumulate in damaged myocardial tissue and differentiate into cardiac muscle in that tissue as a result of intravenous administration of Muse cells to a subject presenting with the aforementioned disorders.

Abstract: A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.

Abstract: An energy carrier system is provided that produces ammonia with high efficiency and that further produces hydrogen as final product and uses the hydrogen as energy. An energy storage transportation method is further provided that is carried out by using energy carrier system. The energy carrier system includes nitric acid production device, an ammonia production device, and hydrogen production device. The nitric acid production device includes a photo-reactor, a gas supply unit that supplies photo-reactor with gas to be treated containing a nitrogen oxide, water, and oxygen, and light source disposed in the photo-reactor. The light source radiates light including ultraviolet of a wavelength shorter than 175 nm. The energy storage transportation method includes nitric acid production step of producing nitric acid from a nitrogen oxide, ammonia production step of producing ammonia through reduction of nitric acid, and hydrogen production step of producing hydrogen through decomposition of the ammonia.

Abstract: An object of the present invention is to provide a novel medical application for use in regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating myocardial infarction, and particularly serious massive myocardial infarction and heart failure associated therewith, that contains pluripotent stem cells positive for SSEA-3 isolated from biological mesenchymal tissue or cultured mesenchymal cells. The cell preparation of the present invention is based on a cardiac tissue regeneration mechanism by which Muse cells are made to selectively accumulate in damaged myocardial tissue and differentiate into cardiac muscle in that tissue as a result of intravenous administration of Muse cells to a subject presenting with the aforementioned disorders.

Abstract: An object of the present invention is to provide an anti-prion compound that has high crystallinity and is highly stable in the crystalline form and to provide a medicament for preventing, ameliorating or treating a prion disease.

Abstract: A braider and a tube body in which braids are arranged on an outer peripheral surface of a mandrel uniformly even if the diameter of the mandrel is uneven. A braider 1 has bobbin carrier conveyance mechanisms 50A and 50B in which bobbin carriers 40A and 40B are conveyed from traveling tracks W1 and W2 to an outside of the traveling tracks W1 and W2 so as to stop winding of braids Y1 and Y2 onto a mandrel 2 and the bobbin carriers 40A and 40B are conveyed from the outside of the traveling tracks W1 and W2 to the traveling tracks W1 and W2 so as to start the winding of the braids Y1 and Y2 onto the mandrel 2.

Abstract: A diagnosis support system includes a diagnosis support computer that includes a model data acquisition unit configured to obtain a plurality of mandible model data, a contour model creation unit configured to create contour model data from the mandible model data, a contour database storage unit configured to construct a contour model database from the contour model data, a diagnosis image data receiving unit configured to receive an input of diagnosis image data of an examinee, an edge extraction unit configured to extract edge data from the diagnosis image data, a similar model searching unit configured to search contour model data based on the edge data, a position judgment unit and an image quality judgment unit configured to judge an imaging position and an image quality based on imaging information, respectively, and a diagnosis support information provision unit configured to provide diagnosis support information based on provider information.

Abstract: To apply a denitration device and a denitration method in which denitration is performed efficiently and in a stable manner in a lower-reaction-temperature region without using a catalyst. The denitration device (100) is provided with a combustion chamber (1), a denitration agent feed means (11) for feeding a denitration agent into the combustion chamber (1), an exhaust pipe (2), and an OH-radical-generating substance feed means (21) for feeding an OH-radical-generating substance into the exhaust pipe (2). The denitration agent feed means (11) feeds a denitration agent into the exhaust gas of the combustion chamber to perform a first denitration reaction step, and the OH-radical-generating substance feed means (21) feeds the OH-radical-generating substance into the exhaust gas in the exhaust pipe (2) to perform a second denitration reaction step.

Abstract: Provided is an apparatus for measuring the thickness, roughness, and morphology index of the mandibular cortical bone using a dental panorama image to assist in the diagnosis of osteoporosis, wherein the thickness, roughness, and morphological index of the cortical bone is measured more accurately and the diagnosis of osteoporosis can be supported more accurately. An osteoporosis diagnostic support apparatus, wherein the apparatus has a contour extraction unit adapted to extract a mandibular contour from an image of a mandibular cortical bone photographed by a photographic apparatus adapted to photograph the mandibular cortical bone and surroundings thereof, a line segment extraction unit adapted to extract line segments from the image of the mandibular cortical bone photographed by the photographic apparatus; and a cortical bone thickness calculation unit adapted to calculate a thickness of the cortical bone based on the extracted mandibular contour and line segments.

Abstract: A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.

Abstract: An endoscope treatment tool includes a flexible sheath, a manipulation wire, and a basket portion constituted by a locking portion and a plurality of elastic wires. A maximum outside diameter portion of the basket portion is at a position closer to the locking portion than an intermediate position between a proximal end of the basket portion and the locking portion. The plurality of elastic wires is formed in a shape of a helix, and a winding pitch of the plurality of elastic wires becomes gradually smaller in a direction from a proximal side to the distal side of the manipulation wire. When a proximal side of the basket portion is reduced, an outside diameter of the maximum outside diameter portion is maintained at substantially a same size as the outside diameter before the proximal side of the basket portion is reduced.

Abstract: A force sense interface includes a tactile finger base having a plurality of tactile fingers, which are capable of tracking motions of the fingers of a hand of an operator, an arm mechanism, which allow spatial motion of the tactile finger base, and a controller, which controls the arm mechanism in accordance with the position and posture of the hand, and controls the tactile fingers in accordance with the movements of the fingers of the operator. The force sense interface further includes finger holders for attaching the tactile fingers on the fingers of the operator in a state where the tactile finger base is distanced from the back of the hand of the operator (H) so as to face the back of the hand.

Abstract: The present invention provides uracil-requiring Moorella bacteria obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase; and transforming-gene-introduced Moorella bacteria obtained by introducing a gene coding for orotidine-5-phosphate decarboxylase and a transforming-gene to a chromosome of the uracil-requiring Moorella bacteria. The present invention was accomplished by uracil-requiring Moorella bacteria, comprising an MTA-D-pF strain that is obtained by destroying a gene coding for orotidine-5-phosphate decarboxylase on a chromosome of Moorella bacteria.

Abstract: A braider and a tube body in which braids are arranged on an outer peripheral surface of a mandrel uniformly even if the diameter of the mandrel is uneven. A braider 1 has bobbin carrier conveyance mechanisms 50A and 50B in which bobbin carriers 40A and 40B are conveyed from traveling tracks W1 and W2 to an outside of the traveling tracks W1 and W2 so as to stop winding of braids Y1 and Y2 onto a mandrel 2 and the bobbin carriers 40A and 40B are conveyed from the outside of the traveling tracks W1 and W2 to the traveling tracks W1 and W2 so as to start the winding of the braids Y1 and Y2 onto the mandrel 2.

Abstract: Provided are a device (10) and a method for measuring the crispness of a food product. An item to be measured (22) comprising a porous food product is broken apart by causing the blade of a knife (14) to penetrate into the item. A vibration detector (18) attached to the knife (14) detects crack vibrations from cracks that form when the item to be measured (22) is broken apart. In a computer (20), the small crack vibrations of a predetermined vibration power or less that are included in the crack vibrations within an individual cracking duration time are extracted from the detected crack vibrations. Crispness is measured on the basis of the number of extracted small crack vibrations counted (number of cracks).

Abstract: The present invention provides a pharmaceutical composition for treating infarction, such as myocardial infarction or cerebral infarction, with a method that is different from conventional therapeutic methods that use a thrombolytic agent or balloon therapy. An autophagy enhancer such as hsa-miR-145 is used as the active ingredient of the pharmaceutical composition for treating infarction. In particular, an autophagy enhancer such as hsa-miR-145 is used in a liposomal state as an active ingredient of the pharmaceutical composition for treating infarction.