Patents Assigned to Gist-Brocades B.V.
  • Patent number: 6010892
    Abstract: Methods and DNA constructs are provided for the expression of a fungal acetyl xylan esterase gene in microbial hosts. A purified fungal acetyl xylan esterase is obtained which is suited for the use as an accessory enzyme in the degradation of acetylated xylans.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: January 4, 2000
    Assignee: Gist-brocades, B.V.
    Inventors: Leendert H. De Graaff, Jacob Visser, Henriette C. Van Den Broeck, Francois Strozyk, Felix J. M. Kormelink, Johannes C. P. Boonman
  • Patent number: 6007851
    Abstract: A flavor enhancer which is low in monosodium glutamate, which is substantially free of 5'-IMP and 5'-GMP and which enhances both meat, vegetable and dairy flavors. The use of the flavor enhancer in flavoring compositions and food and feed applications.
    Type: Grant
    Filed: December 23, 1997
    Date of Patent: December 28, 1999
    Assignee: Gist-Brocades, B.V.
    Inventors: Arie Cornelis Schoenmaker, Johanna Plijter-Schuddemat, Luppo Edens
  • Patent number: 6001375
    Abstract: The present invention discloses the topical application of ceramides. The present invention provides specific cosmetic compositions comprising a ceramide and an agent to target said ceramide to the proper site of the skin. Specifically it is shown that the ceramide-containing compositions have a high capacity for recovering diminished water-retaining properties of preheated or damaged skin. Furthermore, the ceramide-containing compositions are shown to protect the skin again irritation.
    Type: Grant
    Filed: October 16, 1996
    Date of Patent: December 14, 1999
    Assignee: Gist-brocades, B.V.
    Inventors: Johannes Wilhelmus Jacobus Lambers, Ernst-Ludwig Roehl
  • Patent number: 5997926
    Abstract: A complex containing natamycin complexed to one or more proteins. Processes for producing the same. Compositions containing the same. Use of the complexes as a preventative antimycobacterial treatment for natural products. A method for preventing the infection of a natural product by mycobacteria the method containing treating the natural with the complex.
    Type: Grant
    Filed: March 13, 1998
    Date of Patent: December 7, 1999
    Assignee: Gist-brocades B.V.
    Inventors: Ferdinand Theodorus Jozef van Rijn, Jacobus Stark, Edith Magda Lucia Geijp
  • Patent number: 5989877
    Abstract: The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.
    Type: Grant
    Filed: August 23, 1997
    Date of Patent: November 23, 1999
    Assignee: Gist-Brocades B.V.
    Inventors: Robertus M. De Pater, Mieke Sibeyn
  • Patent number: 5972669
    Abstract: The present invention discloses methods to improve the processing and storage stability of dry enzyme preparations. To this extend an inorganic salt, e.g. MgSO.sub.4, is dissolved in an enzyme containing solution which is subsequently dried, using e.g. spray drying. Not only does the addition of salt improve the yield of enzyme activity upon drying, also the storage and processing stability of the obtained solid composition containing the enzyme and the inorganic salt are improved with respect to enzyme activity. The invention further discloses solid compositions comprising enzymes and inorganic salts.
    Type: Grant
    Filed: October 26, 1998
    Date of Patent: October 26, 1999
    Assignee: Gist-brocades, B.V.
    Inventors: Hans-Peter Harz, Roland Jurgen Betz
  • Patent number: 5962510
    Abstract: An aqueous composition is disclosed which comprises 0.1 to 20 g/l of polyene fungicide, 0.5 to 50 g/l of a suitable thickener and optionally 20 to 250 g/l of salt.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: October 5, 1999
    Assignee: Gist-brocades B.V.
    Inventors: Ben Rudolf De Haan, Jacobus Stark, Vincenzo Bozzetti
  • Patent number: 5955458
    Abstract: New solvates of penicillin, in particular amoxycillin glycolate has been provided for together with a simple one-step process to prepare the same.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: September 21, 1999
    Assignee: Gist-Brocades, B.V.
    Inventor: Jagdish C. Kapur
  • Patent number: 5925515
    Abstract: A transformant selection system has been developed, particularly for a .beta.-lactam producing strain, more particularly for P. chrysogenum, by the complementation of a mutation of said .beta.-lactam producing strain by a homologous selection marker without interfering with .beta.-lactam biosynthesis. Particularly, in applying said transformant selection system a positive selection agent, for instance fluoroacetate is used for the isolation of fac mutants of said strain, particularly of said .beta.-lactam producing strain. Furthermore, a gene entitled facA has been isolated from P. chrysogenum.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: July 20, 1999
    Assignee: Gist-brocades B.V.
    Inventors: Willem Van Hartingsveldt, Robert Franciscus Maria Van Gorcom, R. J. Gouka, Roelof Ary Lans Bovenberg
  • Patent number: 5922861
    Abstract: An efficient process for de-esterification has been provided for by application of special tetrahalogenides. By applying this process a new compound, viz. cefesone, and especially the E-isomer thereof, has been prepared.
    Type: Grant
    Filed: April 1, 1998
    Date of Patent: July 13, 1999
    Assignee: Gist-Brocades B.V.
    Inventors: Erik De Vroom, Thomas Van Der Does
  • Patent number: 5919960
    Abstract: The present invention describes phytospringosine-based analogs of ceramides I, as well as cosmetics and pharmaceutical compositions containing these novel compounds and their use.
    Type: Grant
    Filed: April 29, 1996
    Date of Patent: July 6, 1999
    Assignee: Gist-brocades, B.V.
    Inventors: Pieter Gijsbert Weber, Johannes Wilhelmus Jacobus Lambers, Hein Simon Koger, Jan Verweij
  • Patent number: 5916607
    Abstract: The present invention relates to use of cyclodextrin glucanotransferase in the preparation of doughs for baked products, e.g. bread doughs. In particular, the invention provides a process for the preparation of a dough for a baked product which includes incorporating into the dough cyclodextrin glucanotransferase in an amount to increase the volume of the baked product.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: June 29, 1999
    Assignee: Gist-brocades B.V.
    Inventors: Johanna Henrica Gerdina Maria Mutsaers, Johannes Henricus Van Eijk
  • Patent number: 5916609
    Abstract: A process is disclosed for the production of baker's yeast which comprises the fermentation of a baker's yeast strain using a non-molasses carbon source until a fermentation broth having at least 10%, preferably at least 13%, more preferably at least 16% of dry solids content is formed, which can be used directly as a cream yeast without concentration.
    Type: Grant
    Filed: July 28, 1997
    Date of Patent: June 29, 1999
    Assignee: Gist-brocades, B.V.
    Inventor: Pieter Jan Arnoldus Maria Plomp
  • Patent number: 5914259
    Abstract: Aminopeptidases originating from Aspergilli niger are disclosed, which can be produced in a fermentation broth or a liquid concentrate thereof substantially free of endoprotease. Such aminopeptidases may be advantageously employed in the food industry, e.g. in the preparation of bread doughs or cheese.
    Type: Grant
    Filed: January 30, 1997
    Date of Patent: June 22, 1999
    Assignee: Gist-brocades B.V.
    Inventors: Laurent Chevalet, Jerome Souppe, Joel De Leseleuc, Jacky Brunet, Martinus J.M. Warmerdam
  • Patent number: 5897995
    Abstract: An enzymatic process for the conversion of glucose into gluconic acid, uses concentrated glucose solutions. The process employs a combination of glucose oxidase and catalase enzymes which may be obtained from an Aspergilltus niger strain and has a high ratio of catalase;glucose oxidase activity. The enzymatic process requires less time than conventional fermentation processes, the yield of the conversion is close to 100% and the obtained gluconic acid/gluconate solutions do not contain impurities.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: April 27, 1999
    Assignee: Gist-brocades, B.V.
    Inventors: Albert J. Vroemen, Marc Beverini
  • Patent number: 5879927
    Abstract: The present invention provides Phaffia rhodozyma strains having increased levels of astaxantin and a low percentage of 3-hydroxy-3',4'-didehydro-.beta.,.psi.-caroten-4-one (HDCO). Such strains are obtained by a combination of mutagenesis and selection. The invention further provides a method for obtaining such strains. The invention also provides astaxanthin obtained from a mutagenized strain of Phaffia rhodozyma characterized in that it contains a decreased relative amount of HDCO.
    Type: Grant
    Filed: March 28, 1997
    Date of Patent: March 9, 1999
    Assignee: Gist-Brocades, B.V.
    Inventors: Lex De Boer, Bart Van Hell, Andreas Jacobus Johanna Krouwer
  • Patent number: 5849559
    Abstract: Methods and expression constructs are provided for the cloning and overexpression of an arabinoxylan degrading enzyme of fungal origin in a selected microbial host cell. The enzyme is shown to be active in the degradation of water-insoluble solids obtained from maize. The enzyme can be used in the preparation of animal feed compositions, human food or in industrial processes.
    Type: Grant
    Filed: August 5, 1996
    Date of Patent: December 15, 1998
    Assignee: Gist-brocades, B.V.
    Inventors: Monique Josina Andrea Van Der Wouw, Albert Johannes Joseph Van Ooijen, Marcus Matheus Catharina Gielkens, Leendert Hendrik De Graaff, Jacob Visser
  • Patent number: 5840940
    Abstract: The present invention discloses a novel ceramide 3 derivative which is N-linoleoylphytosphingosine (Ceramide IIIA). In addition, a method for preparing this compound is described. The solubility of this diunsaturated ceramide IIIA is much higher than the solubility of ceramide 1 and a saturated ceramide 3 compound. Compositions containing ceramide IIIA are described which are suitable for topical use. Furthermore, a method is given for maintaining the water permeability characteristics of the skin using compositions comprising ceramide IIIA.
    Type: Grant
    Filed: December 12, 1995
    Date of Patent: November 24, 1998
    Assignee: Gist-Brocades B.V.
    Inventors: Robertus Mattheus De Pater, Hein Simon Koger, Johannes Wilhelmus Jacobus Lambers, Jan Verweij
  • Patent number: 5827552
    Abstract: This invention discloses novel methods of making fermented food products such as yogurt. It also discloses novel Lactobacillus bulgaricus organisms for making fermented food products which are conditionally sensitive, that is, operate to metabolize a desired compound normally under the processing conditions for fermented food products but slow or decrease in activity beyond what is normal under the routine storage temperatures for the fermented food products. Such fermented food products exhibits improved shelf life and long-term taste.
    Type: Grant
    Filed: November 3, 1994
    Date of Patent: October 27, 1998
    Assignee: Gist-Brocades B.V.
    Inventors: Stanley E. Mainzer, Sienna Yoast, Robin M. Adams, Tony V. Palombella, Brian F. Schmidt
  • Patent number: 5827709
    Abstract: The present invention discloses methods to improve the processing and storage stability of dry enzyme preparations. To this extent an inorganic salt, e.g. MgSO.sub.4, is dissolved in an enzyme containing solution which is subsequently dried, using e.g. spray drying. Not only does the addition of salt improve the yield of enzyme activity upon drying, also the storage and processing stability of the obtained solid composition containing the enzyme and the inorganic salt are improved with respect to enzyme activity. The invention further discloses solid compositions comprising enzymes and inorganic salts. Preferably the enzymes comprise phytase, protease, hemicellulase, cellulase, and mixtures thereof, and the inorganic salts are divalent cations comprising zinc, magnesium, or calcium. The concentration of the inorganic salt is at least 5%, preferably at least 15%, more preferably at least 30%, still more preferably at least 60%, and most preferably at least 90% (w/w).
    Type: Grant
    Filed: July 29, 1996
    Date of Patent: October 27, 1998
    Assignee: Gist-brocades, B.V.
    Inventors: Rudolf Carolus Maria Barendse, Hans-Peter Harz, Roland Jurgen Betz