Patents Assigned to Gist-Brocades
  • Patent number: 4761282
    Abstract: Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemoilogy under the numbers CNCTC AO 17/81 and CNCTC AO18/82 and at the Collection Nationale de Cultures de Microorganismes d'Institut Pasteur, under Nos. I-168 and I-202 and combined infectious-bronchitis vaccines derived from the IBV H. 120 or the IBV H. 52 of the Massachusetts type strain together with the novel before-mentioned virus strain; the infectious-bronchitis virus strain itself, and a process for preventing infectious-bronchitis in poultry by vaccination with a vaccine derived from the before-mentioned strains. Preferably, live infectious bronchitis vaccines are prepared, which contain a virus content of at least 10.sup.4.0 EID.sub.
    Type: Grant
    Filed: August 6, 1986
    Date of Patent: August 2, 1988
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4746517
    Abstract: A process for improving the filterability of wort or beer comprising treating said wort or beer with an enzymatic product produced by Disporotrichum dimorphosporm exhibiting xylanase activity in an amount effective to improve the filterability.
    Type: Grant
    Filed: December 2, 1986
    Date of Patent: May 24, 1988
    Assignee: Gist-Brocades S.A.
    Inventor: Paul Ducroo
  • Patent number: 4735723
    Abstract: Waste water containing sulfate and organic material is purified by anaerobic biological waste water treatment where at least 80% of the sulfate is converted into hydrogen sulfide in an acidification process and at least 70% of the resulting hydrogen sulfide is removed from the waste water.
    Type: Grant
    Filed: April 3, 1987
    Date of Patent: April 5, 1988
    Assignee: Gist Brocades N. V.
    Inventor: Arnold Mulder
  • Patent number: 4711777
    Abstract: Novel tablets comprising (a) 80 to 98% by weight of a mixture of trimethoprim and/or an acid addition salt thereof and a sulfonamide and/or a salt thereof in a weight ratio of 1:20 to 20:1 and (b) a pharmaceutically acceptable synthetic ion exchange resin having improved disintegration times and other properties and a process for their preparation.
    Type: Grant
    Filed: April 30, 1986
    Date of Patent: December 8, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Hong S. Tan, Bernardus B. M. Wegman
  • Patent number: 4710571
    Abstract: Novel sebum synthesis inhibiting compositions comprising a sebum inhibiting effective amount of at least one compound selected from the group consisting of compounds of the formula ##STR1## wherein R is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid free of additional carboxyl group and their non-toxic, pharmaceutically acceptable acid addition salts and an inert pharmaceutical carrier and to a novel method of inhibiting sebum synthesis in warm-blooded animals and novel 1H-imidazol-1-ethanol esters.
    Type: Grant
    Filed: August 25, 1986
    Date of Patent: December 1, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Petrus S. Hofman, David W. R. Hall, Kapil D. Jaitly
  • Patent number: 4696901
    Abstract: Hydrocarbon utilizing microorganisms are immobilized on a plastic carrier in an aqueous nutrient medium to which a minor amount of a water-immiscible hydrocarbon substrate has been added. The water-immiscible hydrocarbon is preferably hexadecane or dodecylcyclohexane and the plastic carrier is preferably polytetrafluoroethylene. Presence of the water-immiscible hydrocarbon substrate results in increased loading of microorganisms on the carrier.
    Type: Grant
    Filed: December 7, 1983
    Date of Patent: September 29, 1987
    Assignees: Shell Internationale Research Maatschappij B.V., Gist Brocades N.V.
    Inventors: Brian W. Robertson, Gareth T. Phillips
  • Patent number: 4695627
    Abstract: A process for the preparation of 7.beta.-acylamino-3-substituted-3-cephem-4-carboxylic acid compounds comprising reacting at -70.degree. C. to 0.degree. C. in an inert organic solvent phosphorus pentachloride with a cephalosporin compound in the presence of an olefinic compound having at least one carbon-carbon double bond having not more than three hydrogen atoms attached thereto capable of removing chlorine at least in part by addition to a carbon-carbon double bond.
    Type: Grant
    Filed: September 21, 1984
    Date of Patent: September 22, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Jan Verweij, Herman H. Grootveld, Henri G. J. Hirs, Gerardus J. Van Veen, Jan Kalter, Peter W. Henniger
  • Patent number: 4695628
    Abstract: A process for the preparation of 6-amino-pencillanic acid-1,1-dioxide without protecing either the amino group or the carboxy group during oxidation, by oxidation of 6-amino-penicillanic acid or 6-amino penicillanic acid sulfoxide with an alkali metal permanganate in an aqueous medium.
    Type: Grant
    Filed: September 5, 1986
    Date of Patent: September 22, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Jacobus J. Bos, Rinze Cuperus, Rudolf Wielinga
  • Patent number: 4692410
    Abstract: Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology under the numbers CNCTC AO 17/81 and CNCTC AO18/82 and at the Collection Nationale de Cultures de Microorganismes D'Institut Pasteur, under Nos. I-169 and I-202 and combined infectious-bronchitis vaccines derived from the IBV H. 120 or the IBV H. 52 of the Massachusetts type strain together with the novel before-mentioned virus strain; the infectious-bronchitis virus strain itself, and a process for preventing infectious-bronchitis in poultry by vaccination with a vaccine derived from the before-mentioned strains. Preferably, live infectious bronchitis vaccines are prepared, which contain a virus content of at least 10.sup.4..sup.0 EID.sub.
    Type: Grant
    Filed: June 15, 1984
    Date of Patent: September 8, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4677198
    Abstract: Process for the preparation of oligosaccharides-containing products from biomass involving the use of hydrochloric acid for partly hydrolyzing biomass to easily fermentable oligosaccharides-containing products and easy recovery of the hydrochloric acid and the oligosaccharides containing products. The oligosaccharides-containing products themselves and use of the latter for the preparation of useful products like ethanol and penicillin by fermentation.
    Type: Grant
    Filed: November 15, 1984
    Date of Patent: June 30, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Paul E. Linnett, Johan P. M. Sanders
  • Patent number: 4663287
    Abstract: Water-soluble, biologically active conjugates comprising residues of (1) a biologically active protein or glycoprotein having primary amino groups, (2) a heteropolymer of D-mannuronic acid and L-guluronic acid and (3) an alkyleneglycol of 2 to 6 carbon atoms, the said residue (2) being linked to (1) by an amide linkage and to (3) by an ester linkage, which conjugates have increased activity at higher pH values and higher temperatures and a process for their preparations.
    Type: Grant
    Filed: June 14, 1984
    Date of Patent: May 5, 1987
    Assignee: Gist-Brocades N.V.
    Inventor: Sydney A. Barker
  • Patent number: 4655924
    Abstract: In a process for the production and maintenance of well-adhering biomass attached to carrier particles capable of decomposing contaminants in waste water containing both well-adhering and non-adhering microorganisms wherein a granular carrier is contacted in a reaction space with a continuous stream of waste water containing both well-adhering and non-adhering microorganisms and nutrients for the growth and the maintenance of the microorganisms in an adherent layer until a sufficiently thick, well-adhering layer of microorganisms is formed and maintained on the carrier, the improvement comprising maintaining the residence time of the waste water in the reaction space lower than the reciprocal maximum growth rate of the microorganisms on carrier particles of at least 0.1 mm while generating in the reaction liquid shear forces caused by liquid motion and circulation caused by gas bubbles and washing out of the reaction space all non-adhering microorganisms.
    Type: Grant
    Filed: September 30, 1985
    Date of Patent: April 7, 1987
    Assignee: Gist-Brocades N.V.
    Inventor: Joseph J. Heijnen
  • Patent number: 4652374
    Abstract: A solid organic waste is fermented in water in two phases, a hydrolysis/acidification phase and a methane fermentation phase. Solid organic waste is introduced in the first phase, of which waste at least 80% of the volume has a particle size larger than x mm, x being between 0.25 and 1.5 mm dependent on the introduced solid organic waste. The waste in the first phase is continuously or periodically stirred and is screened for the removal of particles smaller than x mm with liquid, whereafter the smaller particles are separated from the liquid and the so-separated liquid is at least mainly supplied to the methane fermentation space, while the separated smaller particles are recirculated to the first phase reactor and/or discharged.
    Type: Grant
    Filed: September 7, 1984
    Date of Patent: March 24, 1987
    Assignee: Gist-Brocades N.V.
    Inventor: Alberto Cohen
  • Patent number: 4647410
    Abstract: Novel 17-(formamidosulfonylmethylene)-steroids of the formula ##STR1## useful as intermediates for the novel 17-(isocyanosulfonylmethylene)-steroids of the formula ##STR2## which are useful intermediates for 21-hydroxy-20-keto-.DELTA..sup.16 -steroids and 20-keto-.DELTA..sup.16 -steroids.
    Type: Grant
    Filed: April 27, 1984
    Date of Patent: March 3, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Albert M. van Leusen, Adriaan M. van Leusen
  • Patent number: 4645665
    Abstract: Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology under the numbers CNCTC AO 17/81 and CNCTC AO 18/82 and at the Collection Nationale de Cultures de Microorganismes d'Institut Pasteur, under Nos. I-168 and I-202 and combined infectious-bronchitis vaccines derived from the IBV H. 120 or the IBV H. 52 of the Massachusetts type strain together with the novel before-mentioned virus strain; the infectious-bronchitis virus strain itself, and a process for preventing infectious-bronchitis in poultry by vaccination with a vaccine derived from the before-mentioned strains. Preferably, live infectious bronchitis vaccines are prepared, which contain a virus content of at least 10.sup.4..sup.0 EID.sub.
    Type: Grant
    Filed: June 15, 1984
    Date of Patent: February 24, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: 4619786
    Abstract: A process for the preparation of at least one compound of a formula selected from the group consisting of ##STR1## and their salts and esters wherein X is selected from the group consisting of hydrogen and a substituent such as halogen and acetoxy comprising diazotizing a compound of the formula ##STR2## and salts and esters thereof wherein X has the above definition and brominating the resulting diazotized compound with at least an equimolar amount of a nitrosating agent in the presence of 1 to 5 equivalents of a strong acid in solution or suspension in a mixture of water and an at least partially water-miscible organic solvent with the amount of water being 1 to 20% by volume containing at least equimolar amounts of hydrogen bromide and bromine which bromo compounds are useful intermediates for the preparation of penicillanic acid-1,1-dioxide and its derivatives and novel 6-diazo-intermediates.
    Type: Grant
    Filed: April 19, 1983
    Date of Patent: October 28, 1986
    Assignee: Gist-Brocades N.V.
    Inventors: Peter W. Henniger, Johannes K. van der Drift
  • Patent number: 4618418
    Abstract: A single unit fluidized-bed reactor having a reaction space for purification of waste water with biomass attached to carrier particles, comprising a liquid distribution device above the bottom of the reaction space particularly suited for introduction of waste water in wide reactors to achieve uniform fluidization therein, said device consisting of a number of substantially horizontal pipes, each having in the under-surface a number of regularly distributed openings for downward introduction of the liquid, and on top of the reaction space united therewith a multifunctional separation compartment for complete separation of the gas-liquid-solids mixture leaving the reaction space and for complete return of attached biomass into the reaction space, the separation compartment being construction so as to handle treatments involving large or small gas fractions in reactors of varying width.
    Type: Grant
    Filed: December 26, 1984
    Date of Patent: October 21, 1986
    Assignee: Gist-Brocades N.V.
    Inventors: Joseph J. Heijnen, Pieter A. Lourens, Albertus J. Vixseboxse
  • Patent number: RE32283
    Abstract: Infectious bronchitis vaccines for poultry derived from at least a virus strain of a novel serotype of the infectious-bronchitis virus (IBV), identified by the internal indication Gelderland. 901 and Brabant. 802, which have been deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology under the numbers CNCTC AO 17/81 and CNCTC AO 18/82 and at the Collection Nationale de Cultures de Microorganismes d'Institut Pasteur, under Nos. I-168 and I-202 and combined infectious-bronchitis vaccines derived from the IBV H. 120 or the IBV H. 52 of the Massachusetts type strain together with the novel before-mentioned virus strain; the infectious-bronchitis virus strain itself, and a process for preventing infectious-bronchitis in poultry by vaccination with a vaccine derived from the before-mentioned strains. Preferably, live infectious bronchitis vaccines are prepared, which contain a virus content of at least 10.sup.4..sup.0 EID.sub.
    Type: Grant
    Filed: December 18, 1984
    Date of Patent: November 11, 1986
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: RE32423
    Abstract: Infectious bronchitis (IB) vaccines for poultry derived from at least one novel virus strain of novel infectious bronchitis serotypes, selected from the group consisting of culture Nos. CNCTC A 07/80, CNCTC A 08/80, CNCTC A 09/80, CNCTC A 010/80, CNCTC A 011/80, CNCTC A 013/80, CNCTC A 014/80, CNCTC A 015/80 and CNCTC A 016/80 deposited at the Czechoslovak National Collection of Type Cultures of the Institute of Hygiene and Epidemiology in Prague, Czechoslovakia and the novel viruses per se, combined virus vaccines and a novel method of protecting poultry from infectious bronchitis.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: May 19, 1987
    Assignee: Gist-Brocades N.V.
    Inventors: Peter Apontoweil, Manfred M. Krasselt
  • Patent number: RE32597
    Abstract: In apparatus for the anaerobic purification of waste water the invention aims at improving the structure and the operation. In known apparatus of this kind there is a reactor tank with one or more aftersettling compartments in the upper part thereof, with inlet and outlet openings for water and sludge into and from the aftersettling compartments from and into the reactor tank respectively.
    Type: Grant
    Filed: February 27, 1986
    Date of Patent: February 9, 1988
    Assignee: Gist-Brocades N.V.
    Inventor: Kees C. Pette