Patents Assigned to GP Medical
  • Pharmaceutical composition of nanoparticles
    Patent number: 8226928
    Abstract: The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein the bioactive agent may include mitofusin 1, mitofusin 2, and/or anti-diabetic compounds.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: July 24, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Ha Giang Thi Nguyen, Fang Yi Su, Er-Yuan Chuang, Hosheng Tu
  • Composition of imaging nanoparticles
    Patent number: 8221795
    Abstract: The invention relates to a method of managing a tumor of an animal subject comprising imaging the tumor by delivering a dosage of imaging nanoparticles to the tumor site, the imaging nanoparticles consisting of positively charged chitosan, optionally a zero-charge substance or bioactive agent, and a negatively charged substrate having gadolinium (Gd) chelated to the negatively charged substrate.
    Type: Grant
    Filed: December 8, 2011
    Date of Patent: July 17, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8202839
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: January 7, 2012
    Date of Patent: June 19, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles for protein drug delivery
    Patent number: 8202508
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: June 19, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8198246
    Abstract: The invention discloses a pharmaceutical composition of liposome nanoparticles for lodging in a target tissue cell in situ of an animal subject, the nanoparticles comprising at least one thermal triggered phase-transition compound as a targeting drug delivery system for physical cancer therapy.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: June 12, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Disposable ostomy irrigation sleeve
    Patent number: 8192411
    Abstract: Ostomy irrigation sleeve having a tubular shape and a first end with a first opening for receiving ostomy discharge material and a second, opposite end with a second opening for discharge of the ostomy discharge material into a discharge unit, for example a toilet, after guidance through the sleeve. The irrigation sleeve is made of a flexible, water soluble material configured to be water soluble only after a certain time of exposure to liquid, wherein the certain time is at least 3 minutes.
    Type: Grant
    Filed: July 7, 2006
    Date of Patent: June 5, 2012
    Assignee: GP Medical Devices ApS
    Inventors: Lars Lund, Henning Hedegaard
  • Pharmaceutical composition of nanoparticles
    Patent number: 8192718
    Abstract: The invention relates to a method for treating disorders or diseases of a tight junction comprising delivering a pharmaceutical composition of nanoparticles to the tight junction, wherein the nanoparticles consist of positively charged chitosan, a negatively charged substrate, optionally a zero-charge compound, and at least one bioactive agent for treating said disorders or diseases of the tight junction of an animal subject.
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: June 5, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Er-Yuan Chuang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 8187570
    Abstract: The invention discloses particulate complexes composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network enabling improved loading the bioactive agent.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: May 29, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Zi-Xian Liao, Shu-Fen Peng, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 8188042
    Abstract: The invention discloses bioactive nanoparticles composed of chitosan, poly-glutamic acid, and diethylenetriaminepentaacetic acid for use in radionuclide decorporation during radiological emergency. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: May 29, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8187571
    Abstract: The invention discloses a pharmaceutical composition of nanoparticles, wherein each nanoparticle comprises N-palmitoyl chitosan that is conjugated with at least two different moieties, the moieties including a donor moiety and an acceptor moiety having a distance of 10 nm or less enabling Förster resonance energy transfer.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: May 29, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of peptide drug and enzyme-inhibition compounds
    Patent number: 8173106
    Abstract: The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject.
    Type: Grant
    Filed: December 13, 2011
    Date of Patent: May 8, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Pharmaceutical composition of nanoparticles for protein drug delivery
    Patent number: 8153153
    Abstract: The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent, wherein equal moles of the positively charged chitosan and the negatively charged poly-glutamic acid substrate form an electrostatic network with zero surface charge enabling improved loading the bioactive agent.
    Type: Grant
    Filed: June 17, 2011
    Date of Patent: April 10, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Nanoparticles for protein/peptide delivery and delivery means thereof
    Patent number: 8137697
    Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate and the nucleic acid encapsulated within the nanoparticles or electrostatically loaded on the exterior surface of the nanoparticles.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: March 20, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Po-Wei Lee, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8119102
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: February 21, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Ho-Ngoc Nguyen, Hosheng Tu
  • Pharmaceutical composition of nanoparticles for protein drug delivery
    Patent number: 8114380
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: September 8, 2011
    Date of Patent: February 14, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Nanoparticles for drug delivery
    Patent number: 8114842
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent for treating wet AMD. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: February 14, 2012
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of peptide drug and enzyme-inhibition compounds
    Patent number: 8084493
    Abstract: The invention relates to a method of co-administering a peptide or protein drug with an enzyme-resistant PGA-complexone compound orally so to mitigate enzyme attack in the gastrointestinal tract of an animal subject.
    Type: Grant
    Filed: May 13, 2011
    Date of Patent: December 27, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Stool collector
    Publication number: 20110270125
    Abstract: A stool collector adapted for being positioned in a use position in which it is secured to a standard water closet or toilet to collect a stool sample delivered by a user, said stool collector comprising a rear piece adapted for being secured between rear halves of a toilet bowl and a tip-up toilet seat, respectively, of said toilet.
    Type: Application
    Filed: April 14, 2009
    Publication date: November 3, 2011
    Applicant: GP Medical Devices ApS
    Inventors: Morten Høstrup Sønderholm, Erfurt-Hansen Emil Christian, Peter Soren Sogaard, Erik Lars Lund, Hemming Hedegaard
  • Pharmaceutical composition of nanoparticles for protein drug delivery
    Patent number: 8048404
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: November 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu
  • Pharmaceutical composition of nanoparticles for protein drug delivery
    Patent number: 8048453
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: April 4, 2011
    Date of Patent: November 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Kiran Sonaje, Hosheng Tu