Patents Assigned to GP Medical
  • Pharmaceutical composition of nanoparticles
    Patent number: 8038985
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: October 18, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 8007768
    Abstract: The invention discloses a pharmaceutical composition of the nanoparticles composed of chitosan, a negatively charged substrate, a transition metal ion, and at least one bioactive agent for drug delivery. The nanoparticles are characterized with a positive surface charge configured for promoting enhanced permeability for bioactive agent delivery.
    Type: Grant
    Filed: January 15, 2011
    Date of Patent: August 30, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7998458
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one anti-hemophilic factor or bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: February 15, 2011
    Date of Patent: August 16, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 7998459
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: August 16, 2011
    Assignees: GP Medical, Inc., National Tsing Huu University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7993624
    Abstract: The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge. The bioactive agent is hydrophobic or lipophilic in nature and is associated with micelles before being encapsulated in nanoparticles.
    Type: Grant
    Filed: January 26, 2011
    Date of Patent: August 9, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Pharmaceutical composition of nanoparticles
    Patent number: 7993625
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a pegylated bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: February 17, 2011
    Date of Patent: August 9, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7988949
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: January 27, 2011
    Date of Patent: August 2, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7919072
    Abstract: The invention discloses the bioactive nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: April 5, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7919293
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: March 6, 2009
    Date of Patent: April 5, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7910086
    Abstract: The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: March 22, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7901666
    Abstract: The invention discloses a pharmaceutical composition for treating a subject comprising two or more bioactive nanoparticles, thus treating the subject by co-administering the bioactive nanoparticles to the subject, wherein a first and a second bioactive nanoparticles comprise a shell portion that is dominated by positively charged chitosan, a core portion that contains negatively charged substrate, and at least a first bioactive agent in the first nanoparticle and a second bioactive agent in the second nanoparticle.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: March 8, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein/peptide delivery and delivery means thereof
    Patent number: 7901711
    Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins, peptides or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate, negatively charged core substrate complexed with chitosan, and encapsulated bioactive agents.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: March 8, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Po-Wei Lee, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7897585
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one anti-hemophilic factor or bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: March 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for drug delivery
    Patent number: 7879361
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of HMG-CoA reductase inhibitors or erythropoietin. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: May 26, 2006
    Date of Patent: February 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7879313
    Abstract: The invention discloses nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge. The bioactive agent is hydrophobic or lipophilic in nature and is associated with micelles before being encapsulated in nanoparticles.
    Type: Grant
    Filed: May 24, 2010
    Date of Patent: February 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7879819
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: February 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7879312
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one DNA/RNA or bioactive agent characterized with a positive surface charge and their enhanced permeability for gene delivery and bioactive agent delivery.
    Type: Grant
    Filed: May 23, 2009
    Date of Patent: February 1, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Shu-Fen Peng, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7871988
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: January 18, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7871989
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid as drug carriers, and encapsulating at least one bioactive agent. The nanoparticles are characterized with a positive surface charge configured for promoting enhanced permeability for bioactive agent delivery.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: January 18, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7871990
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: June 24, 2009
    Date of Patent: January 18, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu