Patents Assigned to GP Medical
  • Nanoparticles for protein drug delivery
    Patent number: 7867984
    Abstract: The invention discloses the bioactive nanoparticles composed of chitosan, poly-glutamic acid, and at least one appetite-suppressing agent characterized with a positive surface charge and a method of treating obesity in a subject in need via their enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: January 11, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7863257
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: January 15, 2009
    Date of Patent: January 4, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7863259
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antibiotics or equivalent bioactive agent characterized with a positive surface charge and their enhanced permeability in oral drug delivery.
    Type: Grant
    Filed: February 20, 2009
    Date of Patent: January 4, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7863258
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one antineoplastic drug or cancer therapeutic agent characterized with a positive surface charge and their enhanced permeability for paracellular drug and bioactive agent delivery.
    Type: Grant
    Filed: February 2, 2009
    Date of Patent: January 4, 2011
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7858596
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: December 4, 2008
    Date of Patent: December 28, 2010
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7803748
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-?-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: September 28, 2010
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7611690
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: August 7, 2008
    Date of Patent: November 3, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7604795
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: October 20, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7556826
    Abstract: The invention discloses a chewable composition for oral delivery of bioactive agents having nanoparticles that are composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: July 7, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7541046
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one protein drug or bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular protein drug and bioactive agent delivery.
    Type: Grant
    Filed: May 5, 2008
    Date of Patent: June 2, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for monoclonal antibody delivery
    Patent number: 7541028
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent of monoclonal antibody. The nanoparticles are characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: June 2, 2009
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Mei-Chin Chen, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7455830
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: April 24, 2008
    Date of Patent: November 25, 2008
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein/peptide delivery and delivery means
    Patent number: 7449200
    Abstract: The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: November 11, 2008
    Assignees: GP Medical, Inc., National Tsing Hua Univeristy
    Inventors: Hsing-Wen Sung, Mei-Chin Chen, Po-Wei Lee, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7381716
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: June 3, 2008
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7291598
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: November 6, 2007
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hosheng Tu
  • Nanoparticles for protein drug delivery
    Patent number: 7282194
    Abstract: The invention discloses the nanoparticles composed of chitosan, poly-?-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.
    Type: Grant
    Filed: November 21, 2005
    Date of Patent: October 16, 2007
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Yu-Hsin Lin, Hsiang-Fa Liang, Hosheng Tu
  • Nanoparticles for paracellular drug delivery
    Patent number: 7265090
    Abstract: The invention discloses the nanoparticles composed of chitosan/poly-?-glutamic acid characterized with a positive surface charge and their enhanced permeability through Caco-2 cells for paracellular drug delivery.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: September 4, 2007
    Assignees: GP Medical, Inc., National Tsing Hua University
    Inventors: Hsing-Wen Sung, Hsiang-Fa Liang, Hosheng Tu
  • Crosslinkable biological material and medical uses
    Patent number: 7101857
    Abstract: A method for promoting angiogenesis in a patient comprising providing crosslinkable biological solution to the target tissue, wherein the crosslinkable biological solution is loaded with at least one angiogenic agent. In one embodiment, the at least one angiogenic agent is a non-protein factor selected from a group consisting of ginsenoside Rg1, ginsenoside Re, combination thereof and the like. In another embodiment, the crosslinkable biological solution of the present invention is broadly defined in a form or phase of solution, paste, gel, suspension, colloid or plasma that may be solidifiable thereafter.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: September 5, 2006
    Assignee: GP Medical, Inc.
    Inventors: Hsing-Wen Sung, Huang-chien Liang, Hosheng Tu
  • Acellular biological material chemically treated with genipin
    Patent number: 6998418
    Abstract: A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: February 14, 2006
    Assignee: GP Medical, Inc.
    Inventors: Hsing-Wen Sung, Huang-Chien Liang, Hosheng Tu
  • Drug-loaded biological material chemically treated with genipin
    Patent number: 6624138
    Abstract: A method for treating tissue of a patient comprising, in combination, mixing a drug with a solidifiable biological material, chemically treating the drug with the biological material with a crosslinking agent, loading the solidifiable drug-containing biological material onto a medical device, solidifying the drug-containing biological material; and delivering the medical device to a target tissue for treating the tissue.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: September 23, 2003
    Assignee: GP Medical
    Inventors: Hsing-Wen Sung, Hosheng Tu