Patents Assigned to Gpi Nil Holdings, Inc.
  • N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders
    Patent number: 7410995
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using N-linked sulfonamides of heterocyclic thioesters.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: August 12, 2008
    Assignee: GPI Nil Holdings Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Heterocyclic esters or amides for vision and memory disorders
    Patent number: 7338976
    Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using heterocyclic esters and amides.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: March 4, 2008
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Douglas T. Ross, Gregory S. Hamilton, Joseph P. Steiner
  • Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
    Patent number: 7265150
    Abstract: This invention relates to novel compositions and uses of N-heterocyclic carboxylic acids and carboxylic acid isosteres for treating a vision disorder, improving vision, treating memory impairment or enhancing memory performance in an animal.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: September 4, 2007
    Assignee: GPI NIL Holdings Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
    Patent number: 7153883
    Abstract: This invention relates to novel N-heterocyclic carboxylic acids and carboxylic acid isosteres, their preparation and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, for treating alopecia and promoting hair growth, for treating vision disorders and/or improving vision, and for treating memory impairment and/or enhancing memory performance by administering such compounds.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: December 26, 2006
    Assignee: GPI NIL Holdings Inc.
    Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
  • N-linked sulfonamides of N-heterocyclic carboxylic acids or carboxylic acid isosteres
    Patent number: 7078424
    Abstract: This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: July 18, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
  • Rotamase enzyme activity inhibitors
    Patent number: 7056935
    Abstract: This invention relates to methods of using neurotrophic compounds having an affinity for FKBP-type immunophilins to stimulate or promote neuronal growth or regeneration and to prevent neuronal degeneration.
    Type: Grant
    Filed: March 14, 2001
    Date of Patent: June 6, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Patent number: 6984639
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Grant
    Filed: July 10, 2003
    Date of Patent: January 10, 2006
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Pyrrolidine derivative hair growth compositions and uses
    Patent number: 6943187
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using pyrrolidine derivatives.
    Type: Grant
    Filed: May 20, 2002
    Date of Patent: September 13, 2005
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Publication number: 20040106652
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Application
    Filed: July 10, 2003
    Publication date: June 3, 2004
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • Small molecule inhibitors of rotamase enzyme activity
    Publication number: 20040049046
    Abstract: This invention relates to neurotrophic N-glyoxylprolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Application
    Filed: August 16, 2002
    Publication date: March 11, 2004
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity
    Publication number: 20030114365
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Application
    Filed: August 27, 2002
    Publication date: June 19, 2003
    Applicant: GPI NIL Holding, Inc.
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
    Patent number: 6506788
    Abstract: The present invention relates to pharmaceutical compositions comprising and methods of using an N-linked urea or carbamate of a heterocyclic thioester for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: January 14, 2003
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity
    Patent number: 6500843
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: November 5, 1999
    Date of Patent: December 31, 2002
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins University School of Medicine
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton, Ted Dawson
  • Pyrrolidine derivatives and processes for preparing same
    Patent number: 6500959
    Abstract: This invention relates to neurotrophic N-glyoxyl-prolyl ester compounds having an affinity for FKBP-type immunophilins, their preparation and use as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: December 31, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner
  • Heterocyclic ketone and thioester compounds and uses
    Publication number: 20020193420
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Application
    Filed: March 25, 2002
    Publication date: December 19, 2002
    Applicant: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • N-oxides of heterocyclic esters, amides, thioesters, and ketones
    Patent number: 6486151
    Abstract: This invention relates to neurotrophic low molecular weight, small molecule N-oxides of heterocyclic esters amides, thioesters, and ketones having an affinity for FKBP-type immunophilins, and their use as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: November 26, 2002
    Assignee: GPI NIL Holdings Inc.
    Inventors: Gregory S. Hamilton, Joseph P. Steiner, Eric S. Burak
  • Cyclic ester or amide derivatives
    Patent number: 6462072
    Abstract: This invention relates to low molecular weight, small molecule cyclic esters and amides having an affinity for FKBP-type immunophilins, pharmaceutical compositions comprising the same, and methods of using the same to effect a neuronal activity.
    Type: Grant
    Filed: September 21, 1998
    Date of Patent: October 8, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, David C. Limburg
  • N-oxide of heterocyclic ester, amide, thioester, or ketone hair growth compositions and uses
    Patent number: 6429215
    Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using an N-oxide of a heterocyclic ester, amide, thioester, or ketone.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: August 6, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Joseph P. Steiner, Gregory S. Hamilton
  • Heterocyclic ketone and thioester compounds and uses
    Patent number: 6417209
    Abstract: This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.
    Type: Grant
    Filed: December 11, 2000
    Date of Patent: July 9, 2002
    Assignee: GPI Nil Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li
  • AZA compounds, pharmaceutical compositions and methods of use
    Patent number: 6417189
    Abstract: The present invention relates to N-substituted cyclic aza compounds, pharmaceutical compositions comprising such compounds, and methods of their use for effecting neuronal activities.
    Type: Grant
    Filed: April 17, 2000
    Date of Patent: July 9, 2002
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Yong-Qian Wu, Wei Huang, Gregory S. Hamilton