Patents Assigned to Gpi Nil Holdings, Inc.
  • Method of using neurotrophic sulfonamide compounds
    Patent number: 5721256
    Abstract: This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme activity associated with immunophilin proteins, particularly peptidyl-prolyl isomerase, or rotamase, enzyme activity.
    Type: Grant
    Filed: February 12, 1997
    Date of Patent: February 24, 1998
    Assignee: GPI NIL Holdings, Inc.
    Inventors: Gregory S. Hamilton, Jia-He Li, Joseph P. Steiner
  • Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth
    Patent number: 5696135
    Abstract: This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.
    Type: Grant
    Filed: May 28, 1996
    Date of Patent: December 9, 1997
    Assignees: GPI NIL Holdings, Inc., Johns Hopkins Univ. School of Medicines
    Inventors: Joseph P. Steiner, Solomon Snyder, Gregory S. Hamilton