Patents Assigned to GRÜNENTHAL GMBH
  • TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM DIFFERENT PARTICLES
    Publication number: 20160310428
    Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: GRUNENTHAL GMBH
    Inventors: KLAUS WENING, LUTZ BARNSCHEID, ANJA GEISSLER, JANA DENKER, JESSICA REDMER
  • TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER
    Publication number: 20160310427
    Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: KLAUS WENING, LUTZ BARNSCHEID, ANJA GEISSLER, JANA DENKER, JESSICA REDMER
  • TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
    Publication number: 20160310487
    Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.
    Type: Application
    Filed: June 1, 2016
    Publication date: October 27, 2016
    Applicant: GRUNENTHAL GMBH
    Inventors: Klaus WENING, Anja GEIßLER, Jana DENKER, Lutz BARNSCHEID
  • TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES
    Publication number: 20160310437
    Abstract: A tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: KLAUS WENING, LUTZ BARNSCHEID, ANJA GEISSLER, JANA DENKER, JESSICA REDMER
  • TAMPER-RESISTANT DOSAGE FORM WITH IMMEDIATE RELEASE AND RESISTANCE AGAINST SOLVENT EXTRACTION
    Publication number: 20160310429
    Abstract: A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.
    Type: Application
    Filed: April 22, 2016
    Publication date: October 27, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: KLAUS WENING, ANJA GEIßLER, JANA DENKER, LUTZ BARNSCHEID
  • FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES AS CAV2.2 CALCIUM CHANNEL BLOCKERS
    Publication number: 20160289214
    Abstract: The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 6, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Melanie REICH, Stefan SCHUNK, Florian JAKOB, Henning STEINHAGEN, Nils DAMANN, Michael HAURAND, Marc ROGERS, Kathy MACKENZIE
  • TAMPER-RESISTANT DOSAGE FORM COMPRISING PHARMACOLOGICALLY ACTIVE COMPOUND AND ANIONIC POLYMER
    Publication number: 20160271066
    Abstract: The invention relates to a pharmaceutical dosage form having a breaking strength of at least 300 N and comprising a pharmacologically active compound, an anionic polymer bearing carboxylic groups, wherein the content of the anionic polymer is ?20 wt.-%, based on the total weight of the pharmaceutical dosage form, and a nonionic surfactant.
    Type: Application
    Filed: May 27, 2016
    Publication date: September 22, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Lutz BARNSCHEID, Jessica REDMER, Sebastian SCHWIER
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20160263037
    Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: April 19, 2016
    Publication date: September 15, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMAEUS, Heinrich KUGELMANN
  • PREPARATION OF A POWDERY PHARMACEUTICAL COMPOSITION BY MEANS OF CRYO-MILLING
    Publication number: 20160263032
    Abstract: A method for the preparation of a powdery pharmaceutical composition comprising a pharmaceutical excipient and a pharmaceutical component, wherein the pharmaceutical excipient is a polyalkylene glycol, the method comprising the step of grinding a mixture of the pharmaceutical excipient and the pharmaceutical component at a temperature below ambient temperature.
    Type: Application
    Filed: May 25, 2016
    Publication date: September 15, 2016
    Applicant: GRUNENTHAL GMBH
    Inventors: Alessandro GRASSANO, Anna PERACHIOTTI, Matteo MINELLI, Daniele VOLPI
  • Abuse-proofed oral dosage form
    Publication number: 20160220517
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: April 11, 2016
    Publication date: August 4, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich Kugelmann, Elisabeth Arkenau-Maric
  • Tamper-resistant tablet providing immediate drug release
    Publication number: 20160199306
    Abstract: The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a polyalkylene oxide; and form a discontinuous phase within the matrix material; and method of using said tablet to treat pain and other conditions.
    Type: Application
    Filed: March 18, 2016
    Publication date: July 14, 2016
    Applicant: Grünenthal GmbH
    Inventors: Sebastian Schwier, Marcel Haupts, Udo Rüttgers, Lutz Barnscheid, Jana Pätz
  • PHARMACEUTICAL DOSAGE FORM
    Publication number: 20160199305
    Abstract: The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
    Type: Application
    Filed: December 11, 2015
    Publication date: July 14, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: EUGEEN MARIE JOZEF JANS, FILIP RENÉ IRENA KIEKENS, JODY FIRMIN MARCELINE VOORSPOELS, ANNE FAURE, IRIS ZIEGLER, ELISABETH ARKENAU-MARIC, LUTZ BARNSCHEID, JOHANNES BARTHOLOMÄUS, MARC FREVEL, ERIC GALIA, ANDREA SCHÜESSELE
  • CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
    Publication number: 20160184297
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: March 4, 2016
    Publication date: June 30, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes Bartholomäus, Heinrich Kugelmann
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20160184295
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: March 3, 2016
    Publication date: June 30, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20160175256
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: March 1, 2016
    Publication date: June 23, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20160166517
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: February 26, 2016
    Publication date: June 16, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS, HEINRICH KUGELMANN
  • NOVEL SUBSTITUTED CONDENSED PYRIMIDINE COMPOUNDS
    Publication number: 20160152624
    Abstract: Novel substituted condensed pyrimidine compounds of general formula (I) in which the chemical groupings, substituents and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.
    Type: Application
    Filed: February 9, 2016
    Publication date: June 2, 2016
    Applicant: GRÜNENTHAL GMBH
    Inventors: Florian JAKOB, Ingo KONETZKI, Tobias CRAAN, Antonio NARDI, Christian HESSLINGER
  • Reactor array for producing and analyzing products
    Patent number: 9339816
    Abstract: The present invention relates to a reactor array for producing and/or analyzing products, comprising a plurality of vessels in which products can be produced on a preparative or analytical scale.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: May 17, 2016
    Assignee: Grünenthal GmbH
    Inventors: Michael Gruss, Matthias Ridder
  • CRUSH RESISTANT DELAYED-RELEASE DOSAGE FORMS
    Publication number: 20160120810
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: January 13, 2016
    Publication date: May 5, 2016
    Applicant: Grünenthal GmbH
    Inventors: Judy Ashworth, Elisabeth Arkenau-Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • TAMPER RESISTANT DOSAGE FORM COMPRISING INORGANIC SALT
    Publication number: 20160106839
    Abstract: The invention relates to a pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an inorganic salt (B); and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the inorganic salt (B) and the polyalkylene oxide (C) and wherein, under in vitro conditions, the release profile of the pharmacologically active ingredient (A) from said matrix comprises at least a time interval during which the release follows zero order kinetics.
    Type: Application
    Filed: December 28, 2015
    Publication date: April 21, 2016
    Applicant: GRUNENTHAL GMBH
    Inventor: LUTZ BARNSCHEID