Patents Assigned to GRÜNENTHAL GMBH
  • 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES I
    Publication number: 20150307507
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors. to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ANTONIO NARDI, PAUL RATCLIFFE, TOBIAS CRAAN, TORSTEN HERTRAMPF, BERNHARD LESCH, ROBERT KIME, HENNING STEINHAGEN
  • 3-OXO-TETRAHYDRO-FURO[3,2-B]PYRROL-4(5H)-YL) DERIVATIVES II
    Publication number: 20150307506
    Abstract: The invention relates to amidic oxotetrahydro-2H-furo[3.2-b]pyrrol-4(5H)-yl) derivatives as dual CatS/K inhibitors exhibiting a pronounced CatK-inhibition, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 23, 2015
    Publication date: October 29, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Antonio NARDI, Paul RATCLIFFE, Tobias CRAAN, Torsten HERTRAMPF, Bernhard LESCH, Henning STEINHAGEN
  • Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
    Patent number: 9168259
    Abstract: Substituted 6-amino-nicotinamides, pharmaceutical compositions containing these compounds and also use of these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: October 27, 2015
    Assignee: GRÜNENTHAL GMBH
    Inventors: Sven Kühnert, Gregor Bahrenberg, Achim Kless, Wolfgang Schröder, Simon Lucas
  • Process for the preparation of a solid dosage form, in particular a tablet, for pharmaceutical use and process for the preparation of a precursor for a solid dosage form, in particular a tablet
    Patent number: 9161917
    Abstract: Process for preparing a powder comprising the steps of providing at least one first component in liquid form at ambient temperature, providing at least one second component having a melting point or melting range in the range from above ambient temperature to below the degradation temperature of said first component, forming a homogenous liquid mixture comprising the at least one first component and the at least one second component by stirring and heating the mixture to or keeping the mixture at a temperature in the range from above the melting point or melting range of the second component and below the degradation temperature of the first component, transferring the liquid mixture to at least one spray congealing unit, spray congealing the mixture, and isolating the powder obtained upon spray congealing.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: October 20, 2015
    Assignee: GRÜNENTHAL GMBH
    Inventors: Anne Faure, Jody Firim Marceline Voorspoels, Roel Jos M. Mertens, Filip René Irena Kiekens
  • HETEROARYL SUBSTITUTED HETEROCYCLYL SULFONES
    Publication number: 20150291572
    Abstract: The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 14, 2015
    Publication date: October 15, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: STEFAN SCHUNK, MELANIE REICH, FLORIAN JAKOB, NILS DAMANN, MICHAEL HAURAND, ACHIM KLESS, MARC ROGERS, KATHY SUTTON
  • TREATMENT AND/OR PROPHYLAXIS OF TSPO MEDIATED DISEASES AND/OR DISORDERS
    Publication number: 20150290203
    Abstract: The invention relates to certain compounds for the use in the treatment and/or prophylaxis of diseases and/or disorders that are, at least partially, mediated by TSPO activity.
    Type: Application
    Filed: October 11, 2013
    Publication date: October 15, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Petra Bloms-Funke, Gregor Bahrenberg, Wolfgang Schröder, Sven Kühnert, Simon Lucas
  • ARYL SUBSTITUTED HETEROCYCLYL SULFONES
    Publication number: 20150291573
    Abstract: The invention relates to aryl substituted heterocyclyl sulfones as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: April 14, 2015
    Publication date: October 15, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: STEFAN SCHUNK, MELANIE REICH, FLORIAN JAKOB, RENÉ MICHAEL KOENIGS, NILS DAMANN, MICHAEL HAURAND, MARC ROGERS, KATHY SUTTON, RICHARD HAMLYN
  • Crush resistant delayed-release dosage forms
    Publication number: 20150290138
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: June 25, 2015
    Publication date: October 15, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150283086
    Abstract: The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
    Type: Application
    Filed: June 22, 2015
    Publication date: October 8, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS
  • TAMPER-RESISTANT DOSAGE FORM COMPRISING PHARMACOLOGICALLY ACTIVE COMPOUND AND ANIONIC POLYMER
    Publication number: 20150238422
    Abstract: The invention relates to a pharmaceutical dosage form having a breaking strength of at least 300 N and comprising a pharmacologically active compound, an anionic polymer bearing carboxylic groups, wherein the content of the anionic polymer is ?20 wt.-%, based on the total weight of the pharmaceutical dosage form, and a nonionic surfactant.
    Type: Application
    Filed: March 3, 2015
    Publication date: August 27, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Lutz BARNSCHEID, Jessica REDMER, Sebastian SCHWIER
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20150216821
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: April 14, 2015
    Publication date: August 6, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150164811
    Abstract: The present invention relates to a process for the production of abuse-proofed, thermoformed dosage forms containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N.
    Type: Application
    Filed: December 23, 2014
    Publication date: June 18, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS
  • TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE MANUFACTURED BY CO-EXTRUSION
    Publication number: 20150164807
    Abstract: The invention relates to a monolithic pharmaceutical dosage form comprising a hot melt-extruded first segment (S1) and a second segment (S2); wherein the first segment (S1) contains at least a first pharmacologically active ingredient (A1) and/or the second segment (S2) contains at least a second pharmacologically active ingredient (A2); and the segment (S1) and/or the segment (S2) is tamper-resistant and/or exhibits a breaking strength of at least 300 N.
    Type: Application
    Filed: December 15, 2014
    Publication date: June 18, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ANJA GEISSLER, KLAUS WENING, LUTZ BARNSCHEID, JANA PÄTZ
  • PYRIDINYL-SUBSTITUTED PYRAZOLYL CARBOXAMIDES
    Publication number: 20150166505
    Abstract: The invention relates to pyrazolyl-based carboxamide compounds useful as ICRAC inhibitors, to pharmaceutical compositions containing these compounds and to methods of using these compounds for the treatment and/or prophylaxis of diseases and/or disorders, in particular inflammatory diseases and/or inflammatory disorders.
    Type: Application
    Filed: December 18, 2014
    Publication date: June 18, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: FELIX VOSS, SONJA NORDHOFF, SEBASTIAN WACHTEN, ANDRÉ WELBERS, STEFANIE RITTER
  • DOSAGE THAT IS SAFEGUARDED FROM ABUSE
    Publication number: 20150150978
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: February 10, 2015
    Publication date: June 4, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • CRYSTALLINE, ANHYDROUS FORMS OF OXYMORPHONE HYDROCHLORIDE
    Publication number: 20150148368
    Abstract: Crystalline, anhydrous hydrochloride salts of 4,5?-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.
    Type: Application
    Filed: February 4, 2015
    Publication date: May 28, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: Andreas FISCHER, Dagmar Peters-Groth, Dagmar Lischke
  • PROCESS FOR THE PRODUCTION OF AN ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150091201
    Abstract: The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
    Type: Application
    Filed: December 9, 2014
    Publication date: April 2, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: ELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS
  • Crystalline, anhydrous forms of oxymorphone hydrochloride
    Patent number: 8969368
    Abstract: Crystalline, anhydrous hydrochloride salts of 4,5?-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: March 3, 2015
    Assignee: Grünenthal GmbH
    Inventors: Andreas Fischer, Dagmar Peters-Groth, Dagmar Lischke
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150056147
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 26, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMAEUS, HEINRICH KUGELMANN
  • Method for the production of a form of administration of a medicament
    Patent number: 8939748
    Abstract: The present invention relates to a device for cutting a strand to a length with regard to a weight and to the use of such device in a method for producing a medicament dosage form of at least one piece composed of at least one medicament and at least one additive, the medicament and the additive being mixed and extruded from a die as a strand and the strand being cut into pieces of precise weight using the device.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: January 27, 2015
    Assignee: Grünenthal GmbH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Dieter Schateikis, Kai-Uwe Ustorf