Patents Assigned to GRÜNENTHAL GMBH
  • CRYSTALLINE, ANHYDROUS FORMS OF OXYMORPHONE HYDROCHLORIDE
    Publication number: 20140088132
    Abstract: Crystalline, anhydrous hydrochloride salts of 4,5?-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: Andreas FISCHER, Dagmar PETERS-GROTH, Dagmar LISCHKE
  • DOSAGE FORM THAT IS SAFEGUARDED FROM ABUSE
    Publication number: 20140086847
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: GRUNENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • Substituted 2-oxy-quinoline-3-carboxamides as KCNQ2/3 modulators
    Publication number: 20140080867
    Abstract: The invention relates to substituted 2-oxy-quinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Application
    Filed: November 26, 2013
    Publication date: March 20, 2014
    Applicant: Grünenthal GmbH
    Inventors: Sven KÜHNERT, Gregor BAHRENBERG, Achim KLESS, Wolfgang SCHRÖDER
  • Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 8669399
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: March 11, 2014
    Assignee: Grünenthal GmbH
    Inventors: Helmut Heinrich Buschmann, Joerg Holenz
  • Substituted nicotinamides as KCNQ2/3 modulators
    Patent number: 8586755
    Abstract: Substituted nicotinamides, processes for their preparation, medicaments comprising these compounds and methods of using these compounds to treat pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, and/or dystonia-associated dyskinesias.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: November 19, 2013
    Assignee: Grünenthal GmbH
    Inventors: Sven Kühnert, Beatrix Merla, Gregor Bahrenberg, Wolfgang Schröder
  • TAMPER-RESISTANT DOSAGE FORM COMPRISING PHARMACOLOGICALLY ACTIVE COMPOUND AND ANIONIC POLYMER
    Publication number: 20130225697
    Abstract: The invention relates to a pharmaceutical dosage form having a breaking strength of at least 300 N and comprising a pharmacologically active compound, an anionic polymer bearing carboxylic groups, wherein the content of the anionic polymer is 20 wt.-%, based on the total weight of the pharmaceutical dosage form, and a nonionic surfactant.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 29, 2013
    Applicant: GRUNENTHAL GMBH
    Inventor: Grunenthal GmbH
  • TAMPER-RESISTANT PHARMACEUTICAL DOSAGE FORM COMPRISING NONIONIC SURFACTANT
    Publication number: 20130225625
    Abstract: The invention relates to a pharmaceutical dosage form having a breaking strength of at least 500 N and comprising a pharmacologically active compound, a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol, and a nonionic surfactant; wherein the content of the polyalkylene oxide is within the range of from 20 to 75 wt.-%, based on the total weight of the pharmaceutical dosage form.
    Type: Application
    Filed: February 27, 2013
    Publication date: August 29, 2013
    Applicant: GRUNENTHAL GMBH
    Inventor: Grunenthal GmbH
  • TAMPER RESISTANT DOSAGE FORM COMPRISING INORGANIC SALT
    Publication number: 20130209557
    Abstract: The invention relates to a pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an inorganic salt (B); and a polyalkylene oxide (C) having a weight average molecular weight of at least 200,000 g/mol, wherein the content of the polyalkylene oxide (C) is at least 20 wt.-%, based on the total weight of the dosage form; wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the inorganic salt (B) and the polyalkylene oxide (C) and wherein, under in vitro conditions, the release profile of the pharmacologically active ingredient (A) from said matrix comprises at least a time interval during which the release follows zero order kinetics.
    Type: Application
    Filed: March 1, 2013
    Publication date: August 15, 2013
    Applicant: GRUNENTHAL GMBH
    Inventor: GRUNENTHAL GMBH
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20130195935
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 1, 2013
    Applicant: GRUNENTHAL GMBH
    Inventor: GRUNENTHAL GMBH
  • SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES
    Publication number: 20130197095
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 1, 2013
    Applicant: Grünenthal GmbH
    Inventor: Grünenthal GmbH
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20130171075
    Abstract: The invention relates to a dosage form that is thermoformed without discoloration and is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: December 21, 2012
    Publication date: July 4, 2013
    Applicant: GRUNENTHAL GMBH
    Inventor: GRUNENTHAL GMBH
  • METHOD AND DEVICE FOR SUPPLYING LIQUIDS TO ANALYSIS UNITS AND LIQUID HANDLING SYSTEMS
    Publication number: 20130139894
    Abstract: The invention relates to a method for supplying at least one analysis apparatus with at least one liquid. In the method, the liquid is kept available in a storage tank, from where it is transported into at least one buffer tank. The liquid is fed to the analysis apparatus from the buffer tank, whose filling level is monitored. Here, the buffer tank is arranged above the analysis apparatus and the storage tank is arranged below the analysis apparatus. The invention also relates to a device for carrying out this method as well as to an analysis apparatus in which this device is employed.
    Type: Application
    Filed: August 4, 2011
    Publication date: June 6, 2013
    Applicants: NEVOLAB GMBH, GRUNENTHAL GMBH
    Inventors: Martin Fuhr, Stefan Oberbörsch, Martin Metzger, Manfred Lorenz
  • Substituted indole derivatives
    Publication number: 20130116283
    Abstract: Substituted indole derivatives, processes for the preparation thereof, medicinal products and pharmaceutical compositions containing these compounds and the use of substituted indole derivatives to treat pain and other conditions and for other medical purposes.
    Type: Application
    Filed: December 11, 2012
    Publication date: May 9, 2013
    Applicant: GRÜNENTHAL GMBH
    Inventor: GRÜNENTHAL GMBH
  • Tamper-resistant oral pharmaceutical dosage form comprising opioid agonist and opioid antagonist
    Publication number: 20130090349
    Abstract: A pharmaceutical dosage form for oral administration having a breaking strength of at least 300 N and comprising an opioid agonist, an opioid antagonist, and a polyalkylene oxide having an average molecular weight of at least 200,000 g/mol, wherein in accordance with Ph. Eur. the in vitro release profile of the opioid agonist essentially corresponds to the in vitro release profile of the opioid antagonist, and wherein the opioid agonist and the opioid antagonist are intimately mixed with one another and homogeneously dispersed in the polyalkylene oxide. The pharmaceutical dosage form is useful, for example, to treat pain in a patient in need of such treatment.
    Type: Application
    Filed: October 5, 2012
    Publication date: April 11, 2013
    Applicant: Grünenthal GmbH
    Inventor: Grünenthal GmbH
  • Tamper-resistant tablet providing immediate drug release
    Publication number: 20130028970
    Abstract: The invention relates to a tamper-resistant tablet comprising (i) a matrix material in an amount of more than one third of the total weight of the tablet; and (ii) a plurality of coated particulates in an amount of less than two thirds of the total weight of the tablet; wherein said particulates comprise a pharmacologically active compound and a physiologically acceptable polymer, preferably a polyalkylene oxide; and form a discontinuous phase within the matrix material; which preferably provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.; and method of using said tablet to treat pain and other conditions.
    Type: Application
    Filed: July 27, 2012
    Publication date: January 31, 2013
    Applicant: GRUNENTHAL GMBH
    Inventors: Sebastian Schwier, Marcel Haupts, Lutz Barnscheid, Jana Pätz
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20120308654
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: August 13, 2012
    Publication date: December 6, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMÄUS, HEINRICH KUGELMANN
  • SUBSTITUTED NICOTINAMIDES AS KCNQ2/3 MODULATORS
    Publication number: 20120184550
    Abstract: Substituted nicotinamides, processes for their preparation, medicaments comprising these compounds and methods of using these compounds to treat pain, epilepsy, urinary incontinence, anxiety, dependency, mania, bipolar disorders, migraine, cognitive diseases, and/or dystonia-associated dyskinesias.
    Type: Application
    Filed: March 30, 2012
    Publication date: July 19, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: SVEN Kühnert, Beatrix Merla, Gregor Bahrenberg, Wolfgang Schröder
  • OXIDATION-STABILIZED TAMPER-RESISTANT DOSAGE FORM
    Publication number: 20120136021
    Abstract: A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
    Type: Application
    Filed: January 5, 2012
    Publication date: May 31, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: Lutz Barnscheid, Eric Galia, Sebastian Schwier, Ulrike Bertram, Anja Geissler, Kornelia Griessmann, Johannes Bartholomäus
  • PHARMACEUTICAL SALTS
    Publication number: 20120059066
    Abstract: The invention relates to pharmaceutical salts comprised of a pharmaceutical active substance and of at least one sugar substitute, to medicaments containing these salts, and to the use of these salts for producing medicaments.
    Type: Application
    Filed: November 14, 2011
    Publication date: March 8, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMÄUS, Heinrich Kugelmann
  • Tamper Resistant Dosage Form Comprising An Anionic Polymer
    Publication number: 20120059065
    Abstract: A pharmaceutical dosage form and method of using same, the pharmaceutical dosage form exhibiting a breaking strength of at least 500 N, said dosage form containing a pharmacologically active ingredient (A); an anionic polysaccharide (B) obtainable by introducing anionic functional groups, in protonated form or a physiologically acceptable salt thereof, into a polysaccharide; and a polyalkylene oxide (C); wherein the pharmacologically active ingredient (A) is present in a controlled-release matrix comprising the anionic polysaccharide (B) and the polyalkylene oxide (C).
    Type: Application
    Filed: September 1, 2011
    Publication date: March 8, 2012
    Applicant: Grünenthal GmbH
    Inventors: Lutz Barnscheid, Sebastian Schwier, Johannes Bartholomäus