Patents Assigned to Hamilton Bonaduz AG
  • Patent number: 12072312
    Abstract: A pH combination electrode includes inner and outer tubes, working and reference electrodes, and a hydrogel diaphragm between the tubes. A seal is disposed inside the inner tube closer to a first inner tube end than to the second inner tube end. An extended reference chamber is formed inside the inner tube between the seal and the second inner tube end. A first conductive fluid is contained in the inner tube between the seal and the first inner tube end. A second conductive fluid is contained in the extended reference chamber and in a reference chamber formed between the inner and outer tubes. A through-hole in the inner tube allows the second conductive fluid to flow between the reference chamber and the extended reference chamber. The working electrode extends into the inner tube, through the seal and into the first conductive fluid. The reference electrode contacts the second conductive fluid.
    Type: Grant
    Filed: June 11, 2021
    Date of Patent: August 27, 2024
    Assignee: Hamilton Bonaduz AG
    Inventors: Gabriela Fisch, Theo Gaupp, Dirk Schoenfuss, Claudius-Michael Ortega Schulte
  • Patent number: 11938474
    Abstract: A pipette device comprises a pipette channel filled with compressible working gas, a pipette piston movable along the pipette path, a piston drive, which drives the pipette piston, a control device, a data memory connected to the control device for signal transmission, a pressure sensor which detects the pressure of the working gas and which is connected to the control device, a position sensor which detects a position of the pipette piston and which is connected to the control device. The control device is designed to determine a quality of a dispensing sequence on the basis of a target residual quantity value, which represents the target residual quantity of dosing liquid remaining in the pipette channel, of a working gas pressure and of an end position of the pipette piston, in each case after the end of the dispensing sequence, and to output the determined quality.
    Type: Grant
    Filed: October 8, 2019
    Date of Patent: March 26, 2024
    Assignee: HAMILTON BONADUZ AG
    Inventor: Jonas Hilti
  • Patent number: 11911757
    Abstract: A pipetting device includes a pipetting channel at least partially filled with working gas, a pipetting tip accessible through a pipetting opening such that the volume of dosing liquid drawn into the receiving chamber can be varied by changing the pressure of the working gas in the receiving chamber, a pipetting piston for changing the pressure of the working gas and accommodated in the pipetting channel to be movable along the pipetting channel, a drive driving the pipetting piston to perform a movement along the pipetting channel, a control device controlling the drive, and a pressure sensor sensing the pressure of the working gas. The control device controls the drive to generate a pressure pulse in the pipetting channel based on the pressure signal output by the pressure sensor whereby the pressure of the working gas during the pulse follows a predefined working gas target pressure pulse curve.
    Type: Grant
    Filed: July 9, 2019
    Date of Patent: February 27, 2024
    Assignee: HAMILTON BONADUZ AG
    Inventors: Hanspeter Romer, Reto Ettinger, Fridolin Gysel, Jürg Rast, Jonas Hilti
  • Patent number: 11744980
    Abstract: An exhalation valve arrangement (22) for a ventilation apparatus for artificial ventilation of patients is flow-capable in an exhalation flow direction (E) and encompasses: an upstream respiratory gas conduit (54) that extends along a first conduit path (K1) and is connected or connectable to a portion, coming from the patient, of the exhalation line; a downstream respiratory gas conduit (58) that extends along a second conduit path (K2) and is connected or connectable to a respiratory gas sink (U); a valve subassembly (63) which comprises a valve body (64) and a valve seat (66) and which is provided between the upstream and the downstream respiratory gas conduit (54, 58) in such a way that, in the context of a predetermined first respiratory gas overpressure in the upstream respiratory gas conduit (54) relative to the downstream respiratory gas conduit (58), it permits an expiratory respiratory gas flow from the upstream respiratory gas conduit (54) into the downstream respiratory gas conduit (58); and in
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: September 5, 2023
    Assignee: Hamilton Bonaduz AG
    Inventors: Karolin Franke, Felix Breitruck
  • Patent number: 11726077
    Abstract: A method is provided for calibrating impedance-spectroscopic biomass sensors that are embodied to detect information regarding the quantity and/or size of living cells in a biomass by means of an electric field having a periodically changing field direction A calibration suspension encompasses an electrically conductive viscously flowable or viscoelastic carrier substance and electrically conductive solid particles and/or solid semiconductor particles received therein. An electric field is generated having a periodically changing field direction, which acts on the calibration suspension. At least one permittivity value is detected, respectively representing a permittivity of the calibration suspension, in a context of at least two electric fields having different field direction change frequencies. A difference value is ascertained that represents a difference between the detected permittivity values. The difference value is compared with a reference value associated with the calibration suspension.
    Type: Grant
    Filed: March 1, 2017
    Date of Patent: August 15, 2023
    Assignee: HAMILTON BONADUZ AG
    Inventors: Marlene Frank, Philipp Arquint, Theo Gaupp
  • Patent number: 11668649
    Abstract: A sensor arrangement includes a reaction subassembly having a housing and a detector subassembly. The housing is a layered component arrangement encompassing a luminophore-containing reaction laminate excitable, by irradiation with a first electromagnetic radiation of a first wavelength, to emit a second electromagnetic radiation of a second wavelength different from the first wavelength; and a temperature-detection laminate emitting an infrared radiation. The housing includes an opening for introducing a fluid, a reaction window and a temperature-sensing window. The reaction window transmits the first and second electromagnetic radiation, and the temperature-sensing window is penetrable by infrared radiation.
    Type: Grant
    Filed: July 8, 2021
    Date of Patent: June 6, 2023
    Assignee: HAMILTON BONADUZ AG
    Inventors: Marco Giardina, Bernd Offenbeck, Christoph Schranz, Thomas Laubscher, Dominik Novotni, Dirk Schönfuss
  • Patent number: 11648566
    Abstract: A pipetting device includes pipetting unit(s), a guide assembly with at least one guide rail on which the pipetting unit(s) is guided in order to be moved along a movement axis, and a linear drive assembly, by which the pipetting unit(s) can be driven in order to be moved along the movement axis. The linear drive device has a stationary stator, and the at least one pipetting unit forms a linear drive assembly rotor which can be moved along the movement axis relative to the stator. The pipetting device also has at least two rotor magnet assemblies which interact with the same common stator magnet assembly so as to generate a drive force and which are arranged at a distance from one another along a spacing axis that is orthogonal to the movement axis. The common stator magnet assembly is located between the at least two rotor magnet assemblies.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: May 16, 2023
    Assignee: HAMILTON BONADUZ AG
    Inventors: Hanspeter Romer, Silvio Walpen, Fridolin Gysel
  • Patent number: 11630094
    Abstract: Described is an oxygen permeable layer for detection of molecular oxygen, wherein the layer has a carrier material in which at least one particle is comprised, wherein the carrier material is polyvinylidene fluoride or a copolymer of polyvinylidene fluoride, and the particle comprises a polymer or a copolymer, wherein the polymer or copolymer of the particle has a chemically covalently bonded indicator compound for detection of molecular oxygen. In addition, a multilayer system for detection of molecular oxygen is described. Also described are a method for producing the layer, and the use of the layer or of the multilayer system for detection of molecular oxygen.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 18, 2023
    Assignee: Hamilton Bonaduz AG
    Inventors: Claudius-Michael Ortega Schulte, Dirk Schönfuss, {hacek over (S)}pela Willi, Sara Simonato
  • Patent number: 11608487
    Abstract: A fluid supply interface includes at least one supply coupling configuration, at least one discharge coupling configuration, at least one user coupling configuration, and a fluid conduit that connects the supply, discharge, and user coupling configurations to one another. A supply valve is capable of having fluid flow through it or is blocked for flow through it. A discharge valve is capable of having fluid flow through it or is blocked for flow through it. The supply valve is preloaded into a blocking position that prevents flow, and opens by means of a sufficiently large pressure difference between the two sides of the supply valve, against the preload force, for flow through in a direction from the supply coupling configuration toward the fluid conduit. The discharge valve likewise being preloaded into a closed position that prevents flow through it.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: March 21, 2023
    Assignee: Hamilton Bonaduz AG
    Inventor: Oliver Kühne
  • Patent number: 11561176
    Abstract: A method is provided for degradation-compensated evaluation of detection signals of a sensor arrangement operating on the principle of luminescence quenching, which arrangement has a luminophore that degrades over time, an excitation radiation source, and at least one optical sensor. The luminophore radiates, in accordance with a response characteristic of the sensor arrangement, in reaction to irradiation with a predefined modulated excitation radiation and as a function of the extent of an interaction of the luminophore with a quencher substance that quenches the luminescence of the luminophore. A response radiation is detected by the at least one optical sensor. The sensor arrangement outputs a detected intensity value representing an intensity of the response radiation and a detected phase value representing a phase difference of the response radiation with respect to the modulation of the excitation radiation.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: January 24, 2023
    Assignee: HAMILTON BONADUZ AG
    Inventors: Dirk Schönfuss, Valentin Verschinin
  • Patent number: 11539271
    Abstract: There is provided a method for contactless determination of the position of a driven moving portion (4) of an electric motor (2) by means of a plurality of magnetic field sensors (8), wherein the moving portion is movably arranged with respect to a stator (6) and has a plurality of permanent magnets (40) which generate a moving-portion magnetic field having a plurality of periodically spaced apart maxima, and wherein the plurality of magnetic field sensors are arranged along a movement path (43) of the moving portion.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: December 27, 2022
    Assignee: HAMILTON BONADUZ AG
    Inventors: Reto Ettinger, Jürg Rast, Fridolin Gysel
  • Publication number: 20220379295
    Abstract: The present application relates to a pipetting device and a pipetting method for pipetting, therefore for aspirating and/or dispensing, a metered liquid using a working gas, independently of the flow- and/or wetting characteristics of the metered liquid, wherein a pipetting channel comprises a first working region, of which the known base temperature is in a lower base temperature range, and a second working region, of which the known working temperature is in a working temperature range that is increased with respect to the base temperature range.
    Type: Application
    Filed: October 1, 2020
    Publication date: December 1, 2022
    Applicant: HAMILTON BONADUZ AG
    Inventors: Jonas Hilti, Jürg Rast
  • Patent number: 11504708
    Abstract: A pipetting apparatus and method for pulsed dispensing of small metered-liquid doses of no more than 1 ?l. The apparatus includes a pipetting conduit at least partly filled with working gas, a pressure-modifying apparatus for modifying the pressure of the working gas, and a control apparatus for applying control to the pressure-modifying apparatus. The control apparatus can control the pressure-modifying apparatus so as to generate in the pipetting conduit, with respect to a reference holding pressure in the pipetting conduit which is necessary for immovable holding of the metered-liquid quantity, an overpressure pulse having a pulse duration of no more than 40 ms.
    Type: Grant
    Filed: December 11, 2017
    Date of Patent: November 22, 2022
    Assignee: HAMILTON BONADUZ AG
    Inventors: Hanspeter Romer, Reto Ettinger, Fridolin Gysel, Jürg Rast, Jonas Hilti
  • Patent number: 11485952
    Abstract: A cell separation apparatus a container for reception of a cell suspension and a conduit connected to the container for the conveyance of cell suspension out of the container. The conduit extends along a notional conduit path passing centrally through the conduit, the conduit path defining in the conduit an axial direction proceeding along the conduit path, a radial direction orthogonal to the conduit path, and a circumferential direction proceeding around the conduit path. A segment of the conduit constitutes a turbulent flow segment including a flow configuration. The flow configuration includes at least two axial configuration segments located axially behind one another to accelerate a cell suspension.
    Type: Grant
    Filed: February 9, 2017
    Date of Patent: November 1, 2022
    Assignees: Hamilton Bonaduz AG, Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.
    Inventors: Tom Kissling, Jens Grosch, Thomas Zumstein, Andrea Traube, Carsten Etzold, Tobias Seiler
  • Patent number: 11480536
    Abstract: A method for determining a value indicative of the permittivity of a cell population in the context of impedance spectroscopy comprises the following steps: generating an excitation current through the cell population, which oscillates with an excitation frequency; measuring a voltage in the cell population between a first measuring electrode (12) and a second measuring electrode (14); sampling the excitation current, wherein first sampled values for the excitation current are generated; sampling the voltage between the first measuring electrode (12) and the second measuring electrode (14), wherein second sampled values for the voltage between the first measuring electrode and the second measuring electrode are generated; and determining the value indicative of the permittivity of the cell population on the basis of the first sampled values and the second sampled values.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: October 25, 2022
    Assignee: HAMILTON BONADUZ AG
    Inventor: Manuel Imhof
  • Publication number: 20220268695
    Abstract: A sensor arrangement includes a reaction subassembly having a housing and a detector subassembly. The housing is a layered component arrangement encompassing a luminophore-containing reaction laminate excitable, by irradiation with a first electromagnetic radiation of a first wavelength, to emit a second electromagnetic radiation of a second wavelength different from the first wavelength; and a temperature-detection laminate emitting an infrared radiation. The housing includes an opening for introducing a fluid, a reaction window and a temperature-sensing window. The reaction window transmits the first and second electromagnetic radiation, and the temperature-sensing window is penetrable by infrared radiation.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 25, 2022
    Applicant: Hamilton Bonaduz AG
    Inventors: Marco Giardina, Bernd Offenbeck, Christoph Schranz, Thomas Laubscher, Dominik Novotni, Dirk Schönfuss
  • Patent number: 11413625
    Abstract: A magnetic isolating apparatus (10) for isolating magnetic particles (66) from a suspension has an immersion section (30) which is designed to be temporarily immersed in the suspension, a guide apparatus (16) which extends along a guide path (F), a magnet arrangement (18) which is guided by the guide apparatus (16) such that it can be moved between an active position which is situated close to the immersion section (30) and an inactive position which is positioned further away from the immersion section (30) along the guide path (F), so that a magnetic field in the region of the immersion section (30) can be changed by moving the magnet arrangement (18) between the active position and the inactive position, and a drive apparatus (22, 50) by which the magnet arrangement (18) can be driven to move at least in a direction between the active position and the inactive position, wherein the drive apparatus (22, 50) is coupled in a non-physical manner to the magnet arrangement (18) by a force field and/or a fluid so
    Type: Grant
    Filed: September 25, 2017
    Date of Patent: August 16, 2022
    Assignee: Hamilton Bonaduz AG
    Inventors: Ingo Schwaiger, Hanspeter Romer
  • Patent number: 11291987
    Abstract: A permanent-magnet piston subassembly (10) for a pipetting apparatus, the piston subassembly (10) extending along a piston axis (K) and comprising a plurality of permanent-magnet arrangements (14a to 14m) that are arranged one behind another along the piston axis (K) with alternatingly opposite polarization directions in such a way that for each two permanent-magnet arrangements (14i, 14j) directly successive along the piston axis, it is the case that magnetic poles located closest to one another along the piston axis (K), of different successive permanent-magnetic arrangements (14a to 14m), are like poles, is characterized in that the piston subassembly (10) encompasses a sheath tube (12), extending along the piston axis (K) constituting a tube axis (H), in which the plurality of permanent-magnet arrangements (14a to 14m) are received.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: April 5, 2022
    Assignee: Hamilton Bonaduz AG
    Inventors: Hans-Peter Romer, Heidi Cattaneo
  • Publication number: 20220023852
    Abstract: A liquid-metering device for discharging metered liquid in the nanometer range, includes a pipetting-tip receiving device defining, at least in a metering-ready operating position of the liquid-metering device, a receiving space that runs along a virtual receiving axis and is designed to receive a portion of a pipetting-tip. The liquid-metering device also includes a triggering plunger moveable relative to the pipetting-tip receiving device, between a standby position and a triggering position. The liquid-metering device also includes movement drive, which is coupled to the triggering plunger so as to transmit motion, and a control device for controlling operation of the movement drive. A first and second deformation formation define therebetween an axial longitudinal region of the receiving space as a deformation region, in which region the first and second formations can be brought closer or farther away to/from one another. The triggering plunger is located in the deformation region.
    Type: Application
    Filed: December 2, 2019
    Publication date: January 27, 2022
    Applicants: HAMILTON BONADUZ AG, BIOFLUIDIX GMBH
    Inventors: Jörg Pochert, Andreas Ernst, Nils Lass
  • Publication number: 20210322969
    Abstract: A pipette device comprises a pipette channel filled with compressible working gas, a pipette piston movable along the pipette path, a piston drive, which drives the pipette piston, a control device, a data memory connected to the control device for signal transmission, a pressure sensor which detects the pressure of the working gas and which is connected to the control device, a position sensor which detects a position of the pipette piston and which is connected to the control device. The control device is designed to determine a quality of a dispensing sequence on the basis of a target residual quantity value, which represents the target residual quantity of dosing liquid remaining in the pipette channel, of a working gas pressure and of an end position of the pipette piston, in each case after the end of the dispensing sequence, and to output the determined quality.
    Type: Application
    Filed: October 8, 2019
    Publication date: October 21, 2021
    Applicant: HAMILTON BONADUZ AG
    Inventor: Jonas Hilti