Patents Assigned to Health and Human Services, National Institutes of Health
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Patent number: 9303080Abstract: The present invention provides for nucleic acids improved for the expression of interleukin-15 (IL-15) in mammalian cells. The invention further provides for methods of expressing IL-15 in mammalian cells by transfecting the cell with a nucleic acid sequence comprising a codon optimized IL-15 sequence. The present invention further provides expression vectors, and IL-15 and IL 15 receptor alpha combinations (nucleic acid and protein) that increase IL-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of IL-15 after DNA, RNA or protein administration in a subject (e.g. a mammal, a human).Type: GrantFiled: January 12, 2007Date of Patent: April 5, 2016Assignee: The United States of America as Represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: Barbara K. Felber, George N. Pavlakis
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Patent number: 9186406Abstract: This invention encompasses methods of preserving protein function by contacting a protein with a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese). In addition, the invention encompasses methods of treating and/or preventing a side effect of radiation exposure and methods of preventing a side effect of radiotherapy comprising administration of a pharmaceutically effective amount of a composition comprising one or more purine or pyrimidine nucleosides (such as e.g., adenosine or uridine) and an antioxidant (such as e.g., manganese) to a subject in need thereof. The compositions may comprise D. radiodurans extracts.Type: GrantFiled: August 18, 2008Date of Patent: November 17, 2015Assignees: The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc., The United States of America, as Represented by the Secretary, Department of Health and Human Services, National Institutes of HealthInventors: Michael J. Daly, Elena K. Gaidamakova, Vera Y. Matrosova, Rodney L. Levine, Nancy B. Wehr
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Patent number: 9163068Abstract: The present invention includes influenza Hemagglutinin protein fragments that fold properly when expressed in bacteria.Type: GrantFiled: November 2, 2010Date of Patent: October 20, 2015Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology TransferInventors: Surender Khurana, Hana Golding
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Patent number: 9108035Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.Type: GrantFiled: November 8, 2013Date of Patent: August 18, 2015Assignees: University of Maryland, College Park, The United States of America as represented by the Secretary, Department of Health and Human Services, National Institutes of HealthInventors: Benjamin Shapiro, Michael R. Emmert-Buck
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Patent number: 8940700Abstract: The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.Type: GrantFiled: August 18, 2010Date of Patent: January 27, 2015Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: John M. Hallenbeck, Hideaki Wakita
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Patent number: 8841266Abstract: A method of treating a disease associated with a cell population which proliferates abnormally in a subject is disclosed. The method comprises administering to the subject a therapeutically effective amount of at least one modulator capable of modulating in the cell population a level and/or activity of a polypeptide having an amino acid sequence at least 60 percent similar to SEQ ID NO: 5, as determined using the Standard protein-protein BLAST [blastp] software of the NCBI.Type: GrantFiled: November 16, 2006Date of Patent: September 23, 2014Assignees: Tel Hashomer Medical Research Infrastructure and Services Ltd., The United States of America as represented by the Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology TransferInventors: Shai Izraeli, Ilan R. Kirsch, Ayelet Erez, Stefano Campaner
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Patent number: 8703826Abstract: This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding ?2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.Type: GrantFiled: December 21, 2011Date of Patent: April 22, 2014Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: Irving W. Wainer, Weizhong Zhu, Khalid Chakir, Rui Ping Xiao, Darrell R. Abernethy, Farideh M. Beigi
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Patent number: 8579787Abstract: Systems and methods are disclosed for directing magnetizable particles comprising therapeutic agents to a target volume, or for guiding magnetizable particles comprising therapeutic agents from a first target volume to a second target volume, at a distance using a magnetic field, to enable the treatment of diseased areas including areas deep inside a patient's body. The methods may be used to diagnose or treat diseased areas within a patient, for example tumors of the lungs, intestines, and liver, and is also useful in enhancing the permeability of solid tumors to chemotherapeutic agents.Type: GrantFiled: May 19, 2009Date of Patent: November 12, 2013Assignees: University of Maryland College Park, The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: Benjamin Shapiro, Michael R. Emmert-Buck
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Patent number: 8518647Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: August 27, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8507267Abstract: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.Type: GrantFiled: March 8, 2010Date of Patent: August 13, 2013Assignee: U.S. Dept. of Health and Human Services, National Institutes of HealthInventors: John A. Chiorini, Robert M. Kotin, Nancy Safer
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Patent number: 8481048Abstract: Methods for making an immunogenic conjugate that includes a hapten or an antigen covalently linked to a carrier. The methods include reacting a first agent with a dihydrazide resulting in a hydrazine-modified first agent, wherein the first agent is a hapten, an antigen or a carrier; reacting a second agent with a benzaldehyde compound resulting in a benzaldehyde-modified second agent, wherein the second agent is a hapten, an antigen or a carrier, provided that the first agent or the second agent is a carrier; and reacting the hydrazine-modified first agent with the benzaldehyde-modified second agent resulting in an immunogenic conjugate comprising a hapten or an antigen covalently linked to a carrier via a hydrazone linkage.Type: GrantFiled: October 20, 2009Date of Patent: July 9, 2013Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: Rachel Schneerson, Joanna Kubler-Kielb, Fathy Majadly, Stephen H. Leppla, John B. Robbins, Darrell T. Liu, Joseph Shiloach
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Patent number: 8465917Abstract: The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.Type: GrantFiled: June 9, 2008Date of Patent: June 18, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institutes of Health, Office of Technology TransferInventors: Xin Wei Wang, Junfang Ji, Taro Yamashita, Carlo M. Croce
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Patent number: 8445216Abstract: The invention provides high affinity antibodies suitable for forming Immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendroglioma cells, and melanoma cells.Type: GrantFiled: October 18, 2011Date of Patent: May 21, 2013Assignees: Duke University, The United States of America, as represented by the Secretary of Health and Human Services, National Institutes of HealthInventors: Chien-Tsun Kuan, Darell D Bigner, Ira H Pastan
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Patent number: 8394411Abstract: Disclosed herein are methods of detecting tumors, monitoring cancer therapy, and selectively inhibiting the proliferation and/or killing of cancer cells utilizing a papilloma pseudovirus or a papilloma virus-like particle (VLP).Type: GrantFiled: May 1, 2008Date of Patent: March 12, 2013Assignee: The United States of America as represented by the Secretary, Dept. of Health and Human Services National Institutes of HealthInventors: Jeff Roberts, Douglas R. Lowy, John T. Schiller
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Patent number: 8349568Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: January 8, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as Represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8343725Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: January 1, 2013Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8338104Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8338106Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8338105Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 15, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TansferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8338102Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Department of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter