Patents Assigned to Health and Human Services, National Institutes of Health
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Patent number: 8338103Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. In particular, the present invention provides diagnostics and prognostics for colon (including colon adenocarcinoma) cancer patients, wherein the methods related to measuring miR levels can predict poor survival. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: November 14, 2011Date of Patent: December 25, 2012Assignees: The Ohio State University Research Foundation, The United States of America, as represented by the Secretary of the Deparment of Health and Human Services, National Institute of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8313746Abstract: The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.Type: GrantFiled: August 1, 2011Date of Patent: November 20, 2012Assignees: The Henry Jackson Foundation for the Advancement of Military Medicine, Inc., The United States of America, as Represented by the Secretary of the Department of Health and Human Services National Institutes of Health, Office of Technology TransferInventors: Dimiter S. Dimitrov, Zhongyu Zhu, Christopher C. Broder
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Patent number: 8252538Abstract: Provided herein are methods and compositions for the diagnosis, prognosis and treatment of Hepatocellular carcinoma (HCC). Also provided are methods of identifying anti-HCC agents.Type: GrantFiled: November 1, 2007Date of Patent: August 28, 2012Assignees: The Ohio State University, The United States of America as represented by the Secretary of the Department of Health and Human Services National Institute of Health, Office of Technology Transfer, Liver Cancer Institute and Zhongshan Hospital, Fudan UniversityInventors: Carlo M. Croce, Xin W. Wang, Anuradha Budhu, Zhao-you Tang
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Patent number: 8084199Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: GrantFiled: July 12, 2007Date of Patent: December 27, 2011Assignees: The Ohio State University Research Foundation, The United States of America as represented by the Department of Health and Human Services, National Institutes of Health, Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Patent number: 8003112Abstract: This disclosure relates to vaccine formulations comprising an immunogenic composition for inducing antibodies to both S. pneumoniae and N. meningitides in a subject. In a preferred aspect, the immunogenic composition comprises covalently conjugated recombinant PsaA (“rPsaA”) from S. pneumoniae and capsular polysaccharide from N. meningitidis serogroup C. This disclosure further relates to methods for producing the immunogenic composition as well as methods for their use.Type: GrantFiled: April 16, 2009Date of Patent: August 23, 2011Assignees: Howard University, The United States of America as represented by the Secretary, Department of Health and Human Services; National Institutes of Health, Office of Technology TransferInventors: Stanley Shih-Peng Tai, Che-Hung Robert Lee
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Patent number: 7989630Abstract: P-glycoprotein transporter (P-gp) acts as a pump at the blood-brain barrier to exclude a wide range of xenobiotics (e.g., toxins, drugs, etc.) from the brain and is also expressed in a tumor in response to exposure to established or prospective chemotherapeutics (a phenomenon known as multidrug resistance). This invention concerns the preparation and use of radiotracers for imaging P-gp function in vitro and in vivo. Radiotracers of the present invention are avid substrates for P-gp and have structures based on N-Desmethyl-loperamide.Type: GrantFiled: April 30, 2008Date of Patent: August 2, 2011Assignee: National Institutes of Health Represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: Victor W. Pike, Robert B. Innis, Sami S. Zoghbi, Neva Lazarova
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Publication number: 20100257618Abstract: The present invention provides novel methods and compositions for the diagnosis and treatment of colon cancers. The invention also provides methods of identifying inhibitors of tumorigenesis.Type: ApplicationFiled: July 12, 2007Publication date: October 7, 2010Applicants: The Ohio State University Research Foundation, Department of Health and Human Services, National Institutes of Health,Office of Technology TransferInventors: Carlo M. Croce, Curtis C. Harris, Aaron J. Schetter
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Publication number: 20100227407Abstract: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.Type: ApplicationFiled: March 8, 2010Publication date: September 9, 2010Applicant: US Department of Health and Human Services, National Institutes of HealthInventors: John A. Chiorini, Robert M. Kotin, Brian Safer, Nancy Safer
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Publication number: 20090280506Abstract: The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.Type: ApplicationFiled: October 23, 2007Publication date: November 12, 2009Applicants: The Regents of the University of California, of Health and Human Services National Institutes of Health Office of Technology TransferInventors: Charles S. Zuker, Jon E. Adler, Nick Ryba, Ken Mueller, Mark Hoon
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Publication number: 20090227664Abstract: The invention relates to nucleic acids (such as DNA immunization plasmids), encoding fusion proteins containing a destabilizing amino acid sequence attached to an amino acid sequence of interest, in which the immunogenicity of the amino acid sequence of interest is increased by the presence of the destabilizing amino acid sequence. The invention also relates to nucleic acids encoding secreted fusion proteins, such as those containing chemokines or cytokines, and an attached amino acid sequence of interest, in which the immunogenicity of the amino acid sequence of interest is increased as a result of being attached to the secretory sequence. The invention also relates methods of increasing the immunogenicity of the encoded proteins for use as vaccines or in gene therapy.Type: ApplicationFiled: April 20, 2009Publication date: September 10, 2009Applicants: Department of Health and Human Services, National Institute of HealthInventors: George N. Pavlakis, Alexander Gragerov, Barbara K. Felber
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Publication number: 20090201467Abstract: An eye examination device has a fundus observation system and an optical stimulation system. The optical stimulation system has an optical targeting subsystem and an optical stimulation subsystem, wherein the optical stimulation system is structured to be used to provide light stimulation to a portion of a fundus of an eye targeted by the optical targeting subsystem in conjunction with observations made with the fundus observation system.Type: ApplicationFiled: July 28, 2008Publication date: August 13, 2009Applicants: Health and Human Services, National Institutes of HealthInventors: Paul D. Smith, Francisco De Monasterio, Edward Wellner
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Patent number: 7507793Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: GrantFiled: August 20, 2003Date of Patent: March 24, 2009Assignees: The Regents of the University of California, United States of America Dept. of Health and Human Services National Institutes of Health-OTTInventors: Charles S. Zuker, Nicholas J. P. Ryba, Gregory A. Nelson, Mark A. Hoon, Jayaram Chandrashekar, Yifeng Zhang
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Patent number: 7432067Abstract: Disclosed herein are novel nucleic acid and protein sequences that are essential to fertility. In particular, human Mater cDNA and protein sequences are provided. Functional MATER is required for female fertility; zygotes that arise from Mater null oocytes do not progress beyond the two-cell stage. Methods are described for detecting an autoimmune response to MATER in a subject by detecting autoantibodies that recognize an epitope of a MATER protein. Also provided are methods for diagnosis of infertility or reduced fertility by detecting presence of MATER protein autoantibodies in a subject. The disclosure also describes kits for detecting MATER autoantibodies comprising MATER protein.Type: GrantFiled: October 24, 2006Date of Patent: October 7, 2008Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services & The National Institutes of HealthInventors: Lawrence M. Nelson, Zhi-Bin Tong
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Publication number: 20080063345Abstract: A multi-photon microscope has an illumination source, an objective lens unit arranged in an optical path of the illumination source, a first light collection system arranged to collect a first portion of light emitted from a sample when the sample is illuminated by light from the illumination source, and a second light collection system arranged to collect a second portion of light emitted from the sample when the sample is illuminated by light from the illumination source. The first portion of light when collected by the first light collection system and the second portion of light when collected by the second light collection system, together provide a means of collecting as much light from as many angles as possible emanating from an emitting point source. This collection scheme has the potential to approach the total emission collection of light from an emitting point source depending on the optical properties of the sample being imaged.Type: ApplicationFiled: November 6, 2007Publication date: March 13, 2008Applicants: Health and Human Services, National Institutes of HealthInventors: Robert Balaban, Christian Combs, Jay Knutson
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Patent number: 7320991Abstract: A number of thalidomide metabolites having superior anti-angiogenic properties have now been isolated and identified. In addition, thalidomide analogs that mimic the effects of the isolated and identified active thalidomide metabolites, and variations of such thalidomide analogs, have been developed. Such thalidomide analog compounds show enhanced potency in the inhibition of undesirable angiogenesis without the undesirable effects of administration of thalidomide.Type: GrantFiled: February 26, 2002Date of Patent: January 22, 2008Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, National Institutes of HealthInventors: William D. Figg, Kurt Eger, Uwe Teubert, Michael Weiss, Michael Guetschow, Thomas Hecker, Sunna Hauschildt
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Patent number: 7267941Abstract: The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugates of cyanovirin-N variants exhibiting antiviral activity.Type: GrantFiled: December 18, 2003Date of Patent: September 11, 2007Assignees: The Government of the United States of America as represented by The Secretary of The Department of Health and Human Services, The National Institutes of Health, Nektar Therapeutics ALInventors: M. Elizabeth Snell, Michael J. Roberts, Toshiyuki Mori, Barry R. O'Keefe, Michael R. Boyd
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Patent number: 7261896Abstract: The present invention provides a method for reducing stroke-related tissue damage by treating a mammal with E-selectin. Preferably, this treatment induces E-selectin tolerance in the mammal. Another aspect of the invention is a method for inducing E-selectin tolerance in a mammal through intranasal administration of E-selectin, preferably including booster administrations. The present methods are especially adapted for use in patients at increased risk of stroke or who may become at increased risk of stroke.Type: GrantFiled: May 23, 2001Date of Patent: August 28, 2007Assignee: United States of America as represented by the Secretary of the Department of Health and Human Services National Institutes of HealthInventors: John M. Hallenbeck, Hidetaka Takeda, Maria Spatz
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Publication number: 20060018927Abstract: Recombinant respiratory syncytial virus (RSV) having the position of genes shifted within the genome or antigenome of the recombinant virus are infectious and attenuated in humans and other mammals. Gene shifted RSV are constructed by insertion, deletion or rearrangement of genes or genome segments within the recombinant genome or antigenome and are useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a recombinant RSV genome or antigenome wherein a gene or gene segment is shifted to a more promoter-proximal or promoter-distal position within the genome or antigenome compared to a wild type position of the gene in the RSV gene map. Shifting the position of genes in this manner provides for a selected increase or decrease in expression of the gene, depending on the nature and degree of the positional shift.Type: ApplicationFiled: February 8, 2005Publication date: January 26, 2006Applicant: The Govt. of the U.S.A, Department of Health and Human Services National Institutes of HealthInventors: Christine Krempl, Peter Collins, Brian Murphy, Ursula Buchholz, Stephen Whitehead
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Publication number: 20050260599Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet taste receptors.Type: ApplicationFiled: August 20, 2003Publication date: November 24, 2005Applicants: The Regents of the University of California, The Govt. of the U.S.A., Dept. of Health and Human Services National Institutes of Health-OTTInventors: Nicholas Ryba, Mark Hoon, Charles Zuker, Gregory Nelson, Jayaram Chandrashekar, Yifeng Zhang
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Publication number: 20040235043Abstract: This invention relates to novel molecular constructs that act as various logic elements, i.e. gates and flip-flops. The constructs are useful in a wide variety of contexts including, but not limited to, computation and control systems. The basic functional unit of the construct comprises a nucleic acid having at least two protein binding sites that cannot be simultaneously occupied by their cognate binding protein. This basic unit can be assembled in number of formats providing molecular constructs that act like traditional digital logic elements (flip-flops, gates, inverters, etc.).Type: ApplicationFiled: June 21, 2004Publication date: November 25, 2004Applicant: Department of Health and Human Service National Institutes of Health Office of Technology TransferInventors: Thomas Schneider, Paul N. Hengen