Abstract: Various embodiments of a laser illumination system are disclosed. In an example, a system includes one or more lasers, a beam combiner (if multiple lasers are used) configured to direct a combined light beam along a path, a focusing optical element to receive the light beam and focus the received light towards a focus point, a MEMS mirror positioned to receive light from the focusing optical element and output a moving light beam, moving in an angular range ar1 and at a frequency f1, a collimating element configured to receive the beam output by the MEMS mirror and output a beam that is more collimated than the light received from the MEMS mirror, and a CLA positioned to receive the light beam from the collimating optical element, alter the received light beam, and output a substantially flat-top distribution of light that propagates through an objective lens to a target plane.

Abstract: Various embodiments of a laser illumination system are disclosed. In some examples, a system includes one or more lasers and a beam combiner configured to direct a combined light beam along a path. The system can include a polychroic optical assembly that receives the combined light beam and to output a first beam of the first light of the first wavelength and a second beam of the second light of the second wavelength. The second beam can be offset from the first beam. The polychroic optical assembly can be a prism assembly. The system can include one or more optical elements configured alter a distribution of light of the first beam to output a first output line at a sample plane, and to alter a distribution of light of the second beam to output a second output line at the sample plane.

Abstract: A fluid delivery system for continuous fluid flow includes a first inlet in fluidic communication with a first pump, a first pressure sensor for detecting a first fluid pressure downstream from the first pump, a second inlet in fluidic communication with a second pump, a second pressure sensor for detecting a second fluid pressure downstream from the second pump, an outlet, a valve including a first position and a second position, wherein the first position fluidically connects the first inlet with the outlet, and the second position fluidically connects the first inlet, the second inlet, and the outlet, and a controller system including a processor and memory.

Abstract: A method for sampling a liquidous material with a sampling system includes providing the sampling system having a gas/liquid separator. The gas/liquid separator includes a separation chamber having a membrane separating the separation chamber into a retentate portion and a permeate portion. The membrane is gas-permeable and liquid impermeable. The gas/liquid separator includes a pressure regulation system fluidically connected to the permeate portion of the separation chamber. The pressure regulation system is configured to control a gas pressure in the permeate portion. The method includes selectively operating the pressure regulation system in a first mode and a second mode. The first mode establishes a first gas pressure condition in the permeate portion of the separation chamber configured to draw a sample of the liquidous material from a reservoir through a first flow channel to the retentate portion of the separation chamber.

Abstract: A precision volumetric pump with a bellows hermetic seal provides compliance time performance comparable to a conventional pump having a dynamic seal. However, the precision volumetric pump with a bellows hermetic seal is enabled to operate over a very long service life with minimal or no maintenance without a propensity to develop leaks over the long service life.

Abstract: An infusion system includes a primary delivery device, a secondary delivery device, an ancillary device, and a manifold. The manifold includes a primary connection port fluidly coupled with the primary delivery device. A delivery connection port in fluid communication with the primary connection port is fluidly coupled with the ancillary device. A secondary connection port fluidly coupled with the secondary delivery device is in fluid communication with the primary connection port. The primary connection port is operable to permit bidirectional flow so that fluid flows from the primary delivery device through the primary connection port and through the delivery connection port to the ancillary device, and from the secondary delivery device through the secondary connection port and through the primary connection port to be received by the primary delivery device.

Abstract: A magnetic particle suspension system includes a vessel defining a chamber and an opening to the chamber, particles magnetically responsive to a magnetic field disposed in the chamber, and a suspension apparatus for controllably moving the magnetic field along a path having an engagement portion in which the magnetic field effects a magnetic response in the particles, wherein the suspension apparatus includes a motor, an arm movably driven by the motor, and a magnet supported by the arm for movement along the path, wherein the motor rotatably drives the arm about a drive axis so that the magnet travels along a circumaxial path about the drive axis.

Abstract: The present invention is directed to liquid pharmaceutical compositions comprising an active ingredient selected from the group consisting of rasagiline, ropinirole and a pharmaceutically acceptable salt thereof and a liquid vehicle. The present invention is further directed to methods of treating Parkinson's disease or one or more symptoms of Parkinson's disease comprising administering a liquid pharmaceutical composition of the present invention to a subject in need thereof.

Abstract: A structural reinforcement and biocompatible pump head for a pump includes a reinforcement structure having a plurality of ports and fluid pathways therein. The fluid pathways in the reinforcement may be coated or lined with a biocompatible material to form a biocompatible pump head useful for liquid chromatography and other analytical instrument systems. The biocompatible material may be injection molded into the fluid pathways of the reinforcement structure and may be machined after core pins are removed to obtain a desired surface finish and/or size of the biocompatible fluid pathways of the pump head.

Abstract: A method for processing a sample of a cell culture composition includes diluting the sample followed by filtering the diluted sample, wherein the dilution may be at least 10 parts by volume of a diluent to one part sample, and the filter may be a porous membrane with a molecular weight cutoff of less than 20,000 Daltons. The dilution may be carried out at a multiple-port dilution valve having a first condition and a second condition. The sample may be mixed with the diluent at a predetermined dilution ratio when the dilution valve is in the second condition.

Abstract: A fluid immersion control system may use a common electrode along with a plurality of sensor electrodes at a planar surface associated with a distal end of an immersion microscope objective to monitor electrical resistance of a fluid as an indication of presence of a fluid layer having a meniscus greater than a diameter of an optical axis used for immersion microscopy. The fluid immersion control system may activate replenishment of the fluid when the resistance indicates that the diameter is not immersed in the fluid.

Abstract: A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.

Abstract: An apparatus is described for controlling fluid flow and in particular fluid flow through a microfluidic multi-port control valve assembly of a High Pressure Liquid Chromatography (HPLC) unit. The flow control apparatus has a localized data repository for storing cumulative wear indications of components of the apparatus. The stored information travels with the apparatus allowing for more reliable predictive failure of components of the apparatus.

Abstract: A membrane-based fluid degassing system is arranged for automated control to a degassing efficiency set point, so that fluid is degassed only as necessary. The control variable may be assigned as the degassing environment, to provide the gas transfer driving force suitable to appropriately degas the fluid. By avoiding unnecessary degassing of the fluid, mobile phase pervaporation through the membrane is minimized.

Abstract: Various embodiments of a multi-laser system are disclosed. In some embodiments, the multi-laser system includes a plurality of lasers, a plurality of laser beams, a beam positioning system, a thermally stable enclosure, and a temperature controller. The thermally stable enclosure is substantially made of a material with high thermal conductivity such as at least 5 W/(m K). The thermally stable enclosure can help maintain alignment of the laser beams to a target object over a range of ambient temperatures. Various embodiments of an optical system for directing light for optical measurements such laser-induced fluorescence and spectroscopic analysis are disclosed. In some embodiments, the optical system includes a thermally conductive housing and a thermoelectric controller, a plurality of optical fibers, and one or more optical elements to direct light emitted by the optical fibers to illuminate a flow cell. The housing is configured to attach to a flow cell.

Abstract: The pressure fluctuations in a fluid degassing system may be diminished by independently controlling the intake phase and the exhaust phase of an evacuation pump. The speed of the pump's drive element may be modulated at least during the intake phase to more closely align with a pressure set point in a degassing module.

Abstract: Valve with two-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a two-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate.

Abstract: An apparatus for controlling fluid flow, and in particular fluid flow through a microfluidic multi-port control valve assembly of a High Pressure Liquid Chromatography (HPLC) unit includes a localized data repository for storing cumulative wear indications of components of the apparatus. The stored information may travel with the apparatus to enable predictive failure of components of the apparatus.

Abstract: Various claims of a multi-laser system are disclosed. In some claims, the multi-laser system includes a plurality of lasers, a plurality of laser beams, a beam positioning system, a thermally stable enclosure, and a temperature controller. Various claims of an optical system for directing light for optical measurements such laser-induced fluorescence and spectroscopic analysis are disclosed. In some claims, the optical system includes a beam shaping element configured to generate an illumination profile having a flat top.

Abstract: A valve for use with liquid chromatography or other analytical systems may include a separate and removable stator plate. The stator plate may be a with a multi-piece stator plate with different layers. A mounting device mounting device may be adapted to engage the stator plate. The mounting plate may include a plurality of ports for fluidic connections in fluid communication with fluid passageways in the stator plate. Liquid chromatography elements, such as a packed chromatography column, a sample loop, or an electronic device may be formed on one or more layers of the stator plate. A first stator plate may be removed from a valve and replaced by a second stator having additional or different liquid chromatography elements than the first stator plate.