Patents Assigned to Health & Science, LLC
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Patent number: 9889098Abstract: The subject invention relates to novel micoparticulate and soluble forms of flavonoids, and their synthesis. The invention also includes novel formulations of such flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.Type: GrantFiled: October 22, 2010Date of Patent: February 13, 2018Assignee: VIZURI HEALTH SCIENCES LLCInventor: Philip J. Birbara
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Patent number: 9861805Abstract: The breakaway assembly includes a first breakaway subassembly and a second breakaway subassembly. The subassemblies are configured to connect, which causes bellows sheaths in each subassembly to compress and open pores, allowing fluid to flow through the subassemblies. The subassemblies can be connected to luer tip. The luer tips can be connected to the an intravenous (IV) fluid line or other types of lines used in the medical field to move fluids. This allows the movement of fluid from a fluid-holding component to a patient. Unless the subassemblies are locked together, the subassemblies will be disconnected under the correct amount of pressure. This disconnection closes the pores on the subassemblies, which keeps fluid from leaking, and prevents the contamination of the IV line. Luer tips may also be connected to the subassemblies. Some of the luer tips allow for the quick connection of the luer tip to the subassembly through a flange being inserted into a notch or flange acceptor.Type: GrantFiled: June 24, 2016Date of Patent: January 9, 2018Assignee: Linear Health Sciences, LLCInventors: Ryan Wayne Dennis, Daniel Lawrence Clark, Adam James Waters
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Patent number: 9829140Abstract: A fluid pulse dampener with automatic pressure-compensation is provided. A system of chambers and channels in the dampener creates an internal feedback mechanism that increases or decreases a compensating pressure on the membrane in response to increases or decreases in the pressure of a fluid moving past the other side of the membrane. Variations of the pulse dampener allow for the input and/or output of gas flow to be restricted or increased as may be desired.Type: GrantFiled: January 8, 2015Date of Patent: November 28, 2017Assignee: IDEX Health & Science LLCInventors: Daniel M. Hartmann, Efthimios Tsirlis
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Patent number: 9829123Abstract: A biocompatible tube and fitting system that can be used in a liquid chromatography system is described. The tube can have a polymer tip and can be used in conjunction with one or more fitting assembly.Type: GrantFiled: May 4, 2015Date of Patent: November 28, 2017Assignee: IDEX Health & Science LLCInventors: Mark Hahn, Scott J. Ellis, Eric Beemer
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Patent number: 9791080Abstract: A microfluidic interconnect system and method for assembly thereof is described. The microfluidic interconnect has a port and a seal, with the port having a reverse taper. The port has a first port end, a second port end, and an inner port surface with a tapered portion. Each port end has an opening with a diameter, and in certain embodiments, the diameter of the first port end is smaller than the diameter of the second port end. The seal has a first end and a second end, and each seal end has a rim and an opening with an inner diameter and an outer diameter. The seal also has an inner surface and an outer surface, where in certain embodiments, each surface has a tapered portion.Type: GrantFiled: November 27, 2012Date of Patent: October 17, 2017Assignee: IDEX Health & Science LLCInventor: Craig Graham
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Patent number: 9764290Abstract: A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.Type: GrantFiled: April 10, 2015Date of Patent: September 19, 2017Assignee: IDEX Health & Science LLCInventors: Daniel M. Hartmann, Carl Sims, David Steckman, Leanne Elson
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Patent number: 9739383Abstract: A multi-path selector valve used in liquid chromatography and other analytical methods for directing fluid along alternate paths of a flowstream. The selector valve has a stator and a rotor. The dynamic face of the stator has a plurality of openings arranged along an inner ring, a plurality of openings arranged along an outer ring, and an annular collection groove formed in the dynamic face. The inner ring, outer ring, and annular collection groove are concentric circles. The rotor's dynamic face is configured to mate with the rear face of the stator, and has two fluid flow paths. One fluid flow path has one end at a rotational center of the rotor and another end of the fluid flow path is configured to be aligned with a stator opening along the inner ring. The second fluid flow path has one end that is configured to be aligned with the annular collection groove and another end that is configured to be aligned with a stator opening along the outer ring.Type: GrantFiled: July 28, 2015Date of Patent: August 22, 2017Assignee: IDEX Health & Science LLCInventors: Jon A. Nichols, James Smyth
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Patent number: 9730953Abstract: The subject invention relates to novel soluble forms of planar ring structured organic compounds including flavonoids, and their production. The invention also includes the use of these novel formulations of planar ring structured organic compounds in the preparation of formulations and products. The invention also relates to a wide variety of applications of the formulations of the invention. The subject invention includes novel soluble forms and various formulations of flavonoids. Further, the invention includes novel methods of manufacturing the flavonoid formulations. The invention also relates to a wide variety of applications of the flavonoid formulations.Type: GrantFiled: December 16, 2013Date of Patent: August 15, 2017Assignee: VIZURI HEALTH SCIENCES LLCInventor: Philip J. Birbara
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Patent number: 9700816Abstract: An elongated fluid degassing apparatus may be employed as a fluid transfer line for fluidly connecting components in a liquid system, while at the same time degassing, or preventing re-gassing of, the fluid. The fluid transfer line degassing apparatus forms a shell and tube degassing arrangement, wherein shell-side fluid flow is facilitated by one or more spacer elements that centrally position a semi-permeable separation membrane in the shell chamber. The degasser may include one or more tubular separation membranes that provide a gas-permeable, liquid-impermeable contact surface to effect the gas-liquid separation of the process fluid.Type: GrantFiled: October 28, 2015Date of Patent: July 11, 2017Assignee: IDEX Health & Science LLCInventors: Quan Liu, Yuri Gerner, Carl Sims
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Patent number: 9683975Abstract: A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.Type: GrantFiled: February 12, 2015Date of Patent: June 20, 2017Assignee: IDEX Health & Science LLCInventor: Carl Sims
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Patent number: 9671048Abstract: A manifold assembly has a manifold and can be located between a block and a plate, and serve as a stator for a valve or other component. The manifold, block or plate can have a plurality of ports either integral thereto or removably connected thereto, with the ports adapted to receive and sealingly engage with a tube having an inner tube layer, an outer tube layer, a sleeve, a tip portion, and a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The ends of the tip portion and inner layer together can define a substantially flat surface which can form a seal in a flat-bottomed port of the manifold, block, or plate, which can be used in a component in an analytical instrument system, including for example a liquid chromatography system.Type: GrantFiled: June 27, 2016Date of Patent: June 6, 2017Assignee: IDEX Health & Science LLCInventors: Craig Graham, Eric Beemer, Scott Ellis, Troy Sanders, Carl Sims, Quan Liu, Nathaniel Nienhuis
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Patent number: 9656186Abstract: An elongated flow-through degassing apparatus includes an elongated gas permeable outer shell and one or more gas-permeable, liquid-impermeable elongated inner conveyance members extending within the outer shell and at least partially through a chamber defined within the outer shell. The apparatus also includes inlet and outlet junctions for securing the outer shell to the inner conveyance member. The outer shell exhibits a first permeance that is substantially greater than a second permeance of the inner conveyance member. The degassing apparatus may be sufficiently flexible so as to be readily manipulatable into desired configurations.Type: GrantFiled: May 29, 2015Date of Patent: May 23, 2017Assignee: IDEX Health and Science, LLCInventors: Carl Sims, Yuri Gerner, Quan Liu
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Patent number: 9546985Abstract: A fitting assembly having a nut, a ferrule, and a ferrule tip that may be assembled by an operator. The fitting assembly includes a nut with first and second ends, with the second end adapted to receive the first end of a ferrule, and a ferrule tip with a first end having an externally tapered portion adapted to abut the second end of the ferrule and a second end adapted to be received in a component or fitting of a liquid chromatography system. The nut, ferrule and ferrule tip of the fitting assembly have passageways therethrough for receiving and removably holding tubing.Type: GrantFiled: September 26, 2013Date of Patent: January 17, 2017Assignee: IDEX Health & Science LLCInventors: Scott J. Ellis, Eric Beemer, Nathaniel Nienhuis, Craig W. Graham, Troy N. Sanders
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Publication number: 20170000744Abstract: This disclosure teaches phospholipid nanoparticle compositions of cannabinoids formed from phospholipids and simpler lipids in an unfired sequential process that encapsulate a high concentration of cannabinoids, and create standardized precision-metered dosage forms of cannabinoids; yielding an increase cannabinoid transport across hydrophobic mucosa; increase the bioavailability of the cannabinoid 2-fold to 8-fold, decrease the dose of cannabinoids 2-fold to 8-fold less than an amount of cannabinoids needed to illicit the same therapeutic effect compared to raw and non-encapsulated cannabinoids; where the nanoparticle dynamic structure reduces the adverse effects of cannabinoids; and enable safe more efficacious cannabinoid therapy.Type: ApplicationFiled: June 4, 2015Publication date: January 5, 2017Applicant: NANOSPHERE HEALTH SCIENCES, LLCInventor: Richard Clark Kaufman
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Publication number: 20170000999Abstract: The breakaway assembly includes a first breakaway subassembly and a second breakaway subassembly. The subassemblies are configured to connect, which causes bellows sheaths in each subassembly to compress and open pores, allowing fluid to flow through the subassemblies. The subassemblies can be connected to luer tip. The luer tips can be connected to the an intravenous (IV) fluid line or other types of lines used in the medical field to move fluids. This allows the movement of fluid from a fluid-holding component to a patient. Unless the subassemblies are locked together, the subassemblies will be disconnected under the correct amount of pressure. This disconnection closes the pores on the subassemblies, which keeps fluid from leaking, and prevents the contamination of the IV line. Luer tips may also be connected to the subassemblies. Some of the luer tips allow for the quick connection of the luer tip to the subassembly through a flange being inserted into a notch or flange acceptor.Type: ApplicationFiled: June 24, 2016Publication date: January 5, 2017Applicant: Linear Health Sciences, LLCInventors: Ryan Wayne Dennis, Daniel Lawrence Clark, Adam James Waters
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Patent number: 9492403Abstract: A formulation or composition contractility comprising jasmonate for modulating bladder and/or treating bladder dysfunction, particularly an overactive bladder in a mammal, particularly a human and use of jasmonate for treating bladder dysfunction is provided.Type: GrantFiled: September 19, 2014Date of Patent: November 15, 2016Assignee: Broady Health Sciences, LLCInventor: Brunde Broady
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Patent number: 9486136Abstract: An apparatus for use in the measurement of the optical density of macular pigment in the human eye, and an apparatus for the use in measuring the lens optical density of a human eye. The apparatus is particularly applicable to flicker photometers, which are used to measure the macular pigment in the human eye.Type: GrantFiled: February 11, 2013Date of Patent: November 8, 2016Assignee: Guardion Health Sciences, LLCInventor: Richard Bone
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Patent number: 9457504Abstract: A connector with a biocompatible fluid passageway to be used as a column filter retainer and the method for manufacturing it is described. The connector has a reinforcement insert and a biocompatible molding covering portions of the reinforcement insert. The reinforcement insert has a first portion, a second portion, and a middle portion between the first portion and the second portion. The first and second portions have threaded sections and each have a plurality of non-threaded sections. For a given portion, the junction of the non-threaded sections forms a lip by which to prevent the molded material from flowing into the threaded sections. In certain embodiments, an interior web is used in the reinforcement insert to provide additional structural support.Type: GrantFiled: March 13, 2014Date of Patent: October 4, 2016Assignee: IDEX Health & Science LLCInventor: Eric Beemer
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Publication number: 20160263047Abstract: Novel process and products thereby emplace nutraceutical factors within nanodelivery vehicles for various indications in mammals, including humans.Type: ApplicationFiled: October 14, 2014Publication date: September 15, 2016Applicant: Nanaspehre Health Sciences, LLCInventor: Richard Clark Kaufman
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Patent number: 9421545Abstract: A springless rotary shear that produces compression forces by utilizing the stiffness properties of polymer seals. The valve is designed to produce an effective spring load, with inherent sealing force, by deflecting polymer elements whose response depends on stiffness that is governed by each component's elastic modulus and geometry. A stator seal protrudes thousandths of an inch beyond a stator seal housing. When a stator is fastened down to the stator seal housing the clamping forces are transmitted to the stator seal, rotor seal, shaft adapter, bearings and housings, and the assembly is deflected to a flush position, resulting in a sealing force between the rotor and stator seal. The transmitted sealing force is as a function of the stiffness of each component and the protrusion distance of the stator seal above the mating surface prior to fastening the stator.Type: GrantFiled: September 22, 2015Date of Patent: August 23, 2016Assignee: IDEX Health & Science LLCInventor: Carl M. Servin