Abstract: A malleable, biodegradable hemostatic agent is provided that can be used for mechanical sealing of bleeding bone tissue, as well as a method for forming a malleable, biodegradable hemostatic agent of this type, and a medical implant having a coating that includes a malleable, biodegradable hemostatic agent of this type. The malleable, biodegradable hemostatic agent contains (a) at least one saturated glycerol-1,2,3-tri-fatty acid ester having a melting temperature above 37° C., (b) at least one filling agent present in particulate form, at least in part, and having a melting temperature above 37° C., and (c) at least one compound having a melting temperature not above 37° C. and a solubility at a temperature of 25° C. of less than 50 grams per liter of water.

Abstract: A device for coating a medical implant includes a container that contains a liquid having at least one pharmaceutically active substance. An elastic head for application of the liquid onto a surface to be coated is connected to an inside of the container through at least one channel.

Abstract: A device for coating at least regions of a medical implant includes an elastically deformable transfer means having a liquid that contains at least one pharmaceutically active substance. The liquid can be transferred to the medical implant when the transfer means is contacted with a surface of the medical implant.

Abstract: A device for coating at least regions of a medical implant including a powder having at least one pharmaceutically active substance or one bone growth-promoting substance such that the powder can be transferred to the medical implant when the medical implant is contacted.

Abstract: A method for coating at least regions of a medical implant includes providing a medical implant having a surface to be coated, and immersing the surface of the medical implant into a liquid including at least one pharmaceutically active substance, whereby the liquid is transferred to the surface of the medical implant due to the immersing. The method also includes pulling the surface of the medical implant out of the liquid, whereby part of the liquid remains adhering to the surface of the medical implant.

Abstract: The invention provides a cartridge for squeezing-out a cartridge content, like a cement, preferably a medical cement, having a one cylindrical hollow space bordered by a cartridge wall, at least one feed plunger arranged in the hollow space to be mobile along the cylinder axis of the hollow space and abuts on the cartridge wall, and at least one snap-in means for locking the feed plunger in place at the cartridge wall, whereby at least one locking device is arranged on the feed plunger and comprises at least one of the snap-in means and which is accessible from outside when the feed plunger is locked. The invention also provides a cartridge system with a cartridge for squeezing out content and a method for dispensing such cartridge content, preferably a cement, through the use of a cartridge of said type.

Abstract: A bone cement system (100) is provided having a mixing facility (10) for mixing and dispensing of bone cement, a reservoir container (112) for a monomer, and a conveyor (122). The mixing facility (10) has a mixing cylinder (20), which stores a bone cement powder. The monomer can be conveyed from the reservoir container (112) into the mixing cylinder (20) by the conveyor (122). A sieve element is (4) is arranged between the reservoir container (112) and the mixing facility (10), in order to preventingress of the bone cement powder from the mixing cylinder (20) into the conveyor (122). The mixing device (10) included a dispensing opening (23) for dispensing a bone cement mixed from the bone cement powder and the monomer. The dispensing opening (23) includes a shield (1) having at least one through-opening (2). The ratio of the area of the through-opening (2) to the area of the sieve element (4) is at least 1 to 3, and the distance between the shield (1) and the sieve element (4) is at least 1 mm.

Abstract: The invention relates to a device for vial opening comprising an external container, in which a closed vial having a vial body and a vial head is arranged, and comprising a hollow space in the region of the vial head, whereby the hollow space comprises at least one opening and a connection to the vial, whereby the vial head, at least regions thereof, is arranged in the connection of the hollow space to the vial, and the walls of the external container comprise at least one deformable region or are altogether made of a deformable material, whereby tilting of the vial with respect to the connection is made feasible, and the diameter of the connection is adapted to the dimensions of the vial head in such a manner that the vial head can be fractured or broken off the vial body when the vial is being tilted with respect to the connection.

Abstract: The invention relates to a method for coating of a medical implant that can be used to apply a calcium salt to the surface of a medical implant easily and without expensive coating equipment and little expenditure of time. Accordingly, a method is provided that includes (i) providing a medical implant that includes at least one surface to be coated; (ii) providing a body that includes at least one calcium salt with a Mohs hardness of no more than 5.5 on at least one of its surfaces; and (iii) rubbing said body having the calcium salt-containing surface onto the at least one medical implant surface to be coated in order to coat said surface of the medical implant with the at least one calcium salt.

Abstract: A kit is provided based on two pastes designed to produce bone cement with high initial stability and therefore low post-cure. The kit includes a paste A and a paste B, wherein paste A contains (a1) a polymerizable monomer having a pH in water in the range of 5-9, (a2) a filling agent insoluble in (a1), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbiturates, 1,3,5-trisubstituted barbiturates, and 1,3,5-tetrasubstituted barbiturates, and paste B contains (b1) a polymerizable monomer having a pH in water in the range of 5-9, (b2) a filling agent insoluble in (b1), (b3) a peroxide soluble in (b1), (b4) a heavy metal compound insoluble in (b1) and selected from the group consisting of heavy metal salts and heavy metal complexes, and wherein at least one of the pastes A and B contains a halide salt.

Abstract: An implant is provided having an antibiotic coating that is inexpensive and easy to manufacture. The antibiotic coating adheres well and in stable manner to the surface of the implant, can be degraded by the body without forming toxic products, prevents the crystallization of the antibiotics in the coating, and ensures a high immediate locally-effective antibiotic concentration at the implant site. A coating solution useful for making the implant and a method for the manufacture of the implant are also described.

Abstract: A cartridge system mixes and applies a mixing ware, such as, for example, a medical cement. The cartridge system has two cartridges that are arranged parallel to each other, and a mixing space having an outlet opening, wherein the cartridges each comprise at least one opening in the cartridge walls that connects the cartridges to the mixing space. The cartridges each comprise a feed plunger for expelling starting components of the mixing ware out of the cartridges through the openings, wherein a closure that can be shifted in the mixing space is arranged in the mixing space in a manner such that it closes the openings of the cartridges in a starting position and in that the openings to the mixing space are opened, at least in part, in a final position of the shiftable closure, wherein the shiftable closure can be shifted from a starting position to a final position.

Abstract: A dispensing device for cartridges having a trigger grip for operating a valve of the dispensing device, a connection for supplying a pressurised gas, a cartridge connector for connecting a cartridge, and a base body, in which at least one passage extends through such that pressurised gas can be guided to the cartridge connector. The cartridge connector comprises an opening towards the passage such that the content can be expelled from the cartridge upon application of the pressurised gas to the floor of a cartridge when the cartridge is arranged in the cartridge connector, and wherein the passage can be closed and opened through the operated valve. The valve has a valve body that is arranged in the base body in a rotatable manner, wherein a motion of the trigger grip leads to a rotation of the valve body in the base body.

Abstract: A dispensing device for cartridges having a connection for supplying a pressurised gas, a base body, in which at least one passage and/or channel extends through which the pressurised gas can be guided to a first cartridge connector for connecting a cartridge. The first cartridge connector has a first opening towards the passage and/or the front channel such that a cartridge content can be expelled from the cartridge through application of the pressurised gas to a cartridge when the cartridge is arranged in the cartridge connector, wherein a second cartridge connector having a larger cross-section and a second opening is arranged at a front edge of the first cartridge connector The second cartridge connector is suitable for connecting a larger cartridge, and wherein the second opening of the second cartridge connector is sufficiently large to allow a cartridge to be connected to the first cartridge connector proceeding through the second opening.

Abstract: A cartridge system for application of a flowable material has at least one cartridge having cartridge walls, one cartridge head, and one feed plunger opposite the cartridge head for expelling a cartridge content. The cartridge has at least one opening in the cartridge head or the cartridge wall that can be closed through a valve, wherein a rotatable valve is mounted in rotatable manner in a bracket on the cartridge head or cartridge heads or a shiftable valve is mounted in shiftable manner in a bracket on the cartridge. The valve has at least one passage through the valve that is connected to an outlet opening, the valve, in a closed position, closes in a sealed manner at least one opening of at least one cartridge, in particular all openings of all cartridges, the passage or passages is/are connected to the opening or openings in an open position of the valve such that a cartridge content can be squeezed from the cartridge or cartridges through the outlet opening.

Abstract: A cartridge system for application of a material has at least one cartridge having at least one cartridge has cartridge walls and one cartridge head each having at least one opening in each cartridge head, and a bracket that is arranged on the cartridge head or cartridge heads. A valve is mounted in rotatable manner in the bracket, wherein the valve has at least one passage through the valve that is connected to an outlet opening, wherein the valve, in a closed position, closes at least one opening of at least one cartridge, in particular all openings of all cartridges, in a sealed manner. The at least one passage is connected to the opening or openings in an open position of the valve such that the cartridge content can be squeezed out of the at least one cartridge through the outlet opening, and further wherein the valve can be transitioned from a closed position to an open position through a rotation of the valve.

Abstract: An initiator system for self-curing plastic material comprises a) at least one salt of a dialklylbarbituric acid and/or an alkylcycloalkylbarbituric acid and/or alkylarylbarbituric acid and/or a cycloalkylarylbarbituric acid that is insoluble in methacrylate monomers; b) at least one heavy metal salt that is insoluble in methacrylate monomers; c) at least one halogenide ion donor that is insoluble in methacrylate monomers; and d) at least one acid that is soluble in methacrylate monomers. The initiator system can be used for the preparation of paste/paste, paste/powder, paste/liquid, powder/liquid, and liquid/liquid combinations for the production of medical plastic material and dental materials. Additionally, a bone cement composition containing the initiator system is described.

Abstract: A device is provided with which it is possible to produce poly(methyl methacrylate) bone-cement paste, which is degassed to the greatest extent possible, while avoiding large-volume mixing containers and large cement volumes contained therein. The device includes a tubular hollow body (10) having a first opening (30) on the input side and a second opening (20) on the output side, at least one rotatably-mounted shaft (40) arranged in the axial direction in the tubular hollow body (10), thread turns (50) arranged axially along the outer side of the shaft (40), wherein the shaft (40) has at least one section with thread turns (50) whose pitch decreases in the direction of the second opening (20), at least one stirring blade (60) arranged on the shaft (40), and rigid mixing elements (70) arranged on the inner side of the tubular hollow body (10).

Abstract: A paste is provided from which bone cement can be formed, which is to the largest extent possible bubble-free and has a high impact strength. The paste includes (i) 15-50 weight percent of at least one mono-functional, hydrophobic methacrylic acid ester, (ii) 40-85 weight percent of at least one filler, (iii) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having at least one peroxide group, (iv) 0.01-4 weight percent of at least one radical initiator soluble in the methacrylic acid ester (i) and having no peroxide groups, (v) 0.000001-3 weight percent of at least one accelerator soluble in the methacrylic acid ester (i) and capable of forming radicals from the radical initiators according to (iii) and (iv), (vi) 0.001-5 weight percent of at least one halide salt, and (vii) 0.2-3 weight percent of at least one cross-linking agent.

Abstract: A PMMA paste is made from a mixture of (A) methyl methacrylate having a methacrylic acid content of less than 1% and a water content of less than 1% and (B) at least one polymethyl methacrylate having a Tg of more than 65° C. and a molar mass of greater than or equal to 200,000 g/mol. The methyl methacrylate fraction is sufficient for the PMMA paste to be autosterile, the weight ratio of (B) to (A) preferably being 10-50% (B) to 50-90% (A). The PMMA paste can be used to produce paste-like one-component bone cements and two-component bone cements.