Patents Assigned to Hisamitsu Pharmaceutical Co., Inc.
  • Publication number: 20210369637
    Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan ?) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.
    Type: Application
    Filed: September 25, 2019
    Publication date: December 2, 2021
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Masaki Yukuhiro, Yuka Takagi, Satoshi Amano
  • Publication number: 20210369638
    Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.
    Type: Application
    Filed: August 17, 2021
    Publication date: December 2, 2021
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Atsushi SONOBE, Takashi YASUKOCHI, Yasunori TAKADA
  • Patent number: 11166921
    Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: November 9, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke Tanaka, Masahiro Sato, Kentaro Nakashima, Takaaki Yoshinaga
  • Patent number: 11141576
    Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: October 12, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takuya Tajima, Naoki Yamamoto, Seiji Tokumoto
  • Patent number: 11130148
    Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.
    Type: Grant
    Filed: May 29, 2014
    Date of Patent: September 28, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Eiji Hashimoto, Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto
  • Patent number: 11123305
    Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: September 21, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada
  • Patent number: 11116955
    Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: September 14, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toru Kobayashi, Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto, Tetsuji Kuwahara
  • Patent number: 11077290
    Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: August 3, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toru Kobayashi, Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto, Tetsuji Kuwahara
  • Publication number: 20210228496
    Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent comprising free asenapine in a range of 2 to 5% by mass, isopropyl palmitate in a range of 5 to 12% by mass, styrene-isoprene-styrene block copolymer in a range of 10 to 20% by mass, polyisobutylene in a range of 3 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 50 to 70% by mass, and liquid paraffin in a range of 5 to 12% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch having an amount of the adhesive agent layer after drying in a range of 100 to 400 g/m2.
    Type: Application
    Filed: January 24, 2020
    Publication date: July 29, 2021
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yuka TAKAGI, Kazuya ISHIDA, Takao KUROKAWA, Yasunari MICHINAKA
  • Patent number: 11033511
    Abstract: The present invention provides a patch comprising a backing, and an adhesive layer on the backing, wherein the adhesive layer contains at least one drug selected from the group consisting of oxybutynin and a pharmaceutically acceptable salt thereof, a pressure-sensitive adhesive base, and diflucortolone valerate, and the content of the diflucortolone valerate is 0.0007 to 0.05% by mass based on the total mass of the adhesive layer.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: June 15, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Akira Shuto, Takao Kurokawa, Junya Horiuchi, Hidekazu Kuma, Satoshi Amano
  • Patent number: 11033458
    Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.
    Type: Grant
    Filed: December 1, 2016
    Date of Patent: June 15, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke Shirotani, Kazuki Kuriyama, Seiji Tokumoto
  • Patent number: 11020356
    Abstract: The patch of the present invention comprises a backing layer and an adhesive layer laminated on the backing layer, wherein a water vapor transmission rate of the backing layer is 400 g/m2·24 hours or more, and the adhesive layer comprises a drug, dimethylsulfoxide and an adhesive. Such a patch does not fall off easily even after long wear.
    Type: Grant
    Filed: December 26, 2017
    Date of Patent: June 1, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Ryo Tanaka, Hideaki Ohashi, Naruhide Miyoshi, Takito Shima, Naoko Fujita, Yasunari Michinaka
  • Patent number: 11007358
    Abstract: A microneedle sheet is disclosed that comprises a plurality of microneedles formed on a sheet generally along a principal surface of the sheet, wherein the microneedles contain a water-soluble polysaccharide and water, the water content is 1 mass % or more and less than 19 mass % based on the total mass of the microneedles, and the microneedles are raised from the principal surface by bending the sheet.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: May 18, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoki Yamamoto, Seiji Tokumoto
  • Patent number: 10987502
    Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: April 27, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Ryusuke Fudoji, Naoki Yamamoto
  • Patent number: 10940121
    Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.
    Type: Grant
    Filed: February 17, 2016
    Date of Patent: March 9, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiichiro Tsuru, Masayoshi Maki
  • Patent number: 10898448
    Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: January 26, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takito Shima, Toshiyuki Matsudo, Kenji Ishigaki
  • Patent number: 10888532
    Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: January 12, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoko Fujita, Takito Shima, Kazuya Kominami, Naoyuki Uchida
  • Publication number: 20200405654
    Abstract: A problem addressed by the present invention is to provide an adhesive patch, which contains an acrylic adhesive base material, is easy to handle, prevents cold flow independently of physical properties and concentrations while being kept in a packaging material or being adhered, and during storage, keeps the drug in the adhesive patch stable and maintains the suitable administration form of the drug over a long period so that the drug can provide sufficient medicinal effect for a long time. The present invention relates to an adhesive patch provided with a backing layer and an adhesive agent layer, the adhesive agent layer containing a drug, an acrylic adhesive base material, and calcium silicate. The present invention also relates to a method for producing the adhesive patch.
    Type: Application
    Filed: February 18, 2019
    Publication date: December 31, 2020
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Ryo Tanaka, Kazuya Kominami, Naoyuki Uchida, Takito Shima
  • Patent number: D926031
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: July 27, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kei Nishioka, Shigeo Kusumi
  • Patent number: D929871
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: September 7, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kei Kubota, Shintaro Takeda, Shigeo Kusumi