Patents Assigned to Hisamitsu Pharmaceutical Co., Inc.
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Patent number: 10806705Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.Type: GrantFiled: July 21, 2016Date of Patent: October 20, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takashi Yasukochi, Atsushi Sonobe, Satoshi Amano
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Publication number: 20200306203Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.Type: ApplicationFiled: December 14, 2018Publication date: October 1, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hiroyuki ARAKI, Yuka TAKAGI, Yoko FUJIWARA, Hiroaki KOBAYASHI, Takao KUROKAWA
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Patent number: 10716763Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.Type: GrantFiled: April 15, 2016Date of Patent: July 21, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naoyuki Uchida, Yasunari Michinaka
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Patent number: 10632065Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.Type: GrantFiled: October 19, 2015Date of Patent: April 28, 2020Assignees: HISAMITSU PHARMACEUTICAL CO., INC., ASKA PHARMACEUTICAL CO., LTD.Inventors: Shinpei Nishimura, Seiji Tokumoto, Takeshi Ito, Hajime Asada
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Publication number: 20200121613Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.Type: ApplicationFiled: April 19, 2018Publication date: April 23, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kazuya KOMINAMI, Takito SHIMA, Naoyuki UCHIDA, Naoko FUJITA, Shigeo SUZUKI, Terumitsu KAIHO
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Publication number: 20200121611Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.Type: ApplicationFiled: February 19, 2018Publication date: April 23, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hideaki OHASHI, Takito SHIMA, Kenji ISHIGAKI, Yasunari MICHINAKA
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Patent number: 10589077Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.Type: GrantFiled: December 4, 2015Date of Patent: March 17, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Makoto Ogura, Naoki Yamamoto, Takashi Kumon
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Patent number: 10583121Abstract: A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.Type: GrantFiled: March 9, 2017Date of Patent: March 10, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
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Publication number: 20200054575Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.Type: ApplicationFiled: April 19, 2018Publication date: February 20, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takito SHIMA, Toshiyuki MATSUDO, Kenji ISHIGAKI
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Patent number: 10537723Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.Type: GrantFiled: September 10, 2015Date of Patent: January 21, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinpei Nishimura, Seiji Tokumoto
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Publication number: 20200009075Abstract: A patch base comprises gelatin, polyvinyl alcohol, a methyl acrylate/2-ethylhexyl acrylate copolymer, and L-menthyl glyceryl ether, wherein relative to the total mass of the base, the content of the gelatin is 1.5 to 6% by mass, the content of the polyvinyl alcohol is 0.5 to 8% by mass, and the content of the methyl acrylate/2-ethylhexyl acrylate copolymer is 0.5 to 13% by mass.Type: ApplicationFiled: February 15, 2018Publication date: January 9, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Keiichiro TSURUSHIMA, Masakazu SAEKI, Takaaki YOSHINAGA
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Patent number: 10525132Abstract: The present invention provides a topical preparation for treating hyperhidrosis, comprising water, an anticholinergic drug, and one or more salts selected from the group consisting of lactate, tartrate, acetate and phosphate. Such a topical preparation comprises the above certain salt, thereby facilitating the accumulation of the anticholinergic drug in skin appendages.Type: GrantFiled: April 27, 2016Date of Patent: January 7, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kana Imamura, Tomohiro Shinoda, Shingo Somekawa, Yasunari Michinaka
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Publication number: 20200000737Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.Type: ApplicationFiled: December 21, 2017Publication date: January 2, 2020Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naoko FUJITA, Takito SHIMA, Kazuya KOMINAMI, Naoyuki UCHIDA
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Patent number: 10493156Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 ?m, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 ?m or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.Type: GrantFiled: August 7, 2018Date of Patent: December 3, 2019Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
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Publication number: 20190343800Abstract: A method for suppressing a plasma concentration of an asenapine metabolite includes applying to a subject a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer includes asenapine and/or a pharmaceutically acceptable salt thereof, and an adhesive base agent.Type: ApplicationFiled: July 24, 2019Publication date: November 14, 2019Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
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Patent number: 10441551Abstract: A patch comprises a backing and an adhesive layer laminated on at least one surface of the backing, in which the adhesive layer contains at least one selected from the group consisting of fentanyl and salts thereof, and contains an adhesive base material and an antioxidant having a sulfur atom in its molecule.Type: GrantFiled: October 24, 2016Date of Patent: October 15, 2019Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Akio Takeuchi, Yasunori Takada
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Patent number: D881710Type: GrantFiled: January 17, 2019Date of Patent: April 21, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Sayaka Mochizuki, Shigeo Kusumi
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Patent number: D882407Type: GrantFiled: January 17, 2019Date of Patent: April 28, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Sayaka Mochizuki, Shigeo Kusumi
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Patent number: D887842Type: GrantFiled: January 17, 2019Date of Patent: June 23, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takuya Ikaida, Sayaka Mochizuki, Hiroyuki Kinoshita
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Patent number: D888570Type: GrantFiled: January 17, 2019Date of Patent: June 30, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hiroyuki Nagashima, Hiroyuki Kinoshita, Shigeo Kusumi