Patents Assigned to Hisamitsu Pharmaceutical Co., Inc.
  • Patent number: 10869998
    Abstract: An applicator according to one embodiment is an applicator for applying a sheet member to skin, and includes: a bottom plate facing the skin; a top plate facing the bottom plate and configured to be pressed toward the bottom plate; and a bending portion configured to apply the sheet member to the skin by bending the sheet member having advanced to the bending portion in a pressed state in which the top plate has been moved toward the bottom plate.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: December 22, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takuya Tajima, Naoki Yamamoto, Kazuki Kuriyama, Seiji Tokumoto
  • Publication number: 20200352872
    Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.
    Type: Application
    Filed: January 23, 2019
    Publication date: November 12, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke TANAKA, Masahiro SATO, Kentaro NAKASHIMA, Takaaki YOSHINAGA
  • Publication number: 20200352873
    Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide and aluminum hydroxide, a content of nonylic acid vanillylamide in the adhesive agent layer is 0.01 to 0.025% by mass based on a total mass of the adhesive agent layer, a content of aluminum hydroxide in the adhesive agent layer is 0.55 to 1.5% by mass based on the total mass of the adhesive agent layer, and a mass ratio of the content of nonylic acid vanillylamide to the content of aluminum hydroxide ((content of nonylic acid vanillylamide):(content of aluminum hydroxide)) in the adhesive agent layer is 1:27 to 1:150.
    Type: Application
    Filed: January 23, 2019
    Publication date: November 12, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke TANAKA, Masahiro SATO, Takaaki YOSHINAGA
  • Patent number: 10828480
    Abstract: An applicator according to one embodiment includes a housing having a tubular shape with one closed end, and configured to house an elastic member and a piston plate for transmitting biasing force of the elastic member to the microneedles, and release means configured to release the piston plate engaged in a manner resisting against the biasing force of the elastic member in the housing, to cause the piston plate to move toward an opening of the housing along an axial direction of the housing. The release means is configured, when the release means releases the engagement of the piston plate by moving toward the housing in the axial direction, to transmit force in a direction toward the opening to the housing.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: November 10, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinpei Nishimura, Seiji Tokumoto, Masafumi Ono
  • Patent number: 10814002
    Abstract: A method for producing a patch including a support layer, and an adhesive agent layer formed on the support layer and including sodium diacetate, a pressure-sensitive adhesive base agent, and asenapine and/or a pharmaceutically acceptable salt thereof. The sodium diacetate is generated from sodium acetate in the presence of the asenapine and/or salt thereof, a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is in range of 3.0 to 20 mg, and when a content of the asenapine and/or salt thereof in terms of free asenapine in the adhesive agent layer is 6.4 mg and the patch is in contact with skin for 24 hours, Cmax of free asenapine is in range of 0.5 to 6.0 ng/mL and tmax of free asenapine is in range of 8 to 28 hr.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: October 27, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
  • Patent number: 10806705
    Abstract: The present invention provides a patch comprising a backing and an adhesive layer laminated on one side of the backing, wherein the adhesive layer comprises asenapine or a pharmaceutically acceptable salt thereof, an adhesive base and a low molecular weight amine.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: October 20, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takashi Yasukochi, Atsushi Sonobe, Satoshi Amano
  • Publication number: 20200306203
    Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, the adhesive agent layer further contains a styrene-based thermoplastic elastomer, a petroleum-based resin and/or a terpene-based resin, an aliphatic alcohol, and a cross-linked polyvinylpyrrolidone, and in the adhesive agent layer, a mass ratio of a content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form and a content of the cross-linked polyvinylpyrrolidone (content of the rotigotine and/or the pharmaceutically acceptable salt thereof in terms of rotigotine free form:content of the cross-linked polyvinylpyrrolidone) is 10:3 to 1:3.
    Type: Application
    Filed: December 14, 2018
    Publication date: October 1, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Hiroyuki ARAKI, Yuka TAKAGI, Yoko FUJIWARA, Hiroaki KOBAYASHI, Takao KUROKAWA
  • Patent number: 10716763
    Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: July 21, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoyuki Uchida, Yasunari Michinaka
  • Patent number: 10632065
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; in which the coating layer comprises a recombinant follicle-stimulating hormone, arginine, and glycerin, in the coating layer, the mass of arginine is 0.07 to 0.75-fold of the mass of the recombinant follicle-stimulating hormone and the mass of glycerin is 0.1 to 2.75-fold of the mass of the recombinant follicle-stimulating hormone.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: April 28, 2020
    Assignees: HISAMITSU PHARMACEUTICAL CO., INC., ASKA PHARMACEUTICAL CO., LTD.
    Inventors: Shinpei Nishimura, Seiji Tokumoto, Takeshi Ito, Hajime Asada
  • Publication number: 20200121613
    Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.
    Type: Application
    Filed: April 19, 2018
    Publication date: April 23, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kazuya KOMINAMI, Takito SHIMA, Naoyuki UCHIDA, Naoko FUJITA, Shigeo SUZUKI, Terumitsu KAIHO
  • Publication number: 20200121611
    Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.
    Type: Application
    Filed: February 19, 2018
    Publication date: April 23, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Hideaki OHASHI, Takito SHIMA, Kenji ISHIGAKI, Yasunari MICHINAKA
  • Patent number: 10589077
    Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: March 17, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Makoto Ogura, Naoki Yamamoto, Takashi Kumon
  • Patent number: 10583121
    Abstract: A patch for administering asenapine includes a support layer, and an adhesive agent layer formed on the support layer and including an adhesive base agent and asenapine and/or a pharmaceutically acceptable salt thereof. The adhesive base agent has a content in a range of 10 to 90% by mass in the adhesive agent layer and includes a natural rubber, polyisobutylene, an alkyl vinyl ether(co)polymer, polyisoprene, polybutadiene, a styrene-butadiene copolymer, a styrene-isoprene copolymer, a styrene-isoprene-styrene block copolymer, or a combination thereof. When a content of the asenapine and/or pharmaceutically acceptable salt thereof in terms of free asenapine in the adhesive agent layer is 3.4 mg, an AUC2-120 for a period starting from the time when the patch is brought into contact with a skin for 24 hours is 27,000 pg·hr/mL or more, and an AUC2-120 of an asenapine metabolite is 20% or less of the AUC2-120 of the free asenapine.
    Type: Grant
    Filed: March 9, 2017
    Date of Patent: March 10, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Masayuki Suzuki, Hiroaki Okutsu, Takashi Yasukochi, Yasunori Takada
  • Publication number: 20200054575
    Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.
    Type: Application
    Filed: April 19, 2018
    Publication date: February 20, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takito SHIMA, Toshiyuki MATSUDO, Kenji ISHIGAKI
  • Patent number: 10537723
    Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: January 21, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinpei Nishimura, Seiji Tokumoto
  • Publication number: 20200009075
    Abstract: A patch base comprises gelatin, polyvinyl alcohol, a methyl acrylate/2-ethylhexyl acrylate copolymer, and L-menthyl glyceryl ether, wherein relative to the total mass of the base, the content of the gelatin is 1.5 to 6% by mass, the content of the polyvinyl alcohol is 0.5 to 8% by mass, and the content of the methyl acrylate/2-ethylhexyl acrylate copolymer is 0.5 to 13% by mass.
    Type: Application
    Filed: February 15, 2018
    Publication date: January 9, 2020
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Keiichiro TSURUSHIMA, Masakazu SAEKI, Takaaki YOSHINAGA
  • Patent number: D881710
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: April 21, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Sayaka Mochizuki, Shigeo Kusumi
  • Patent number: D882407
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: April 28, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Sayaka Mochizuki, Shigeo Kusumi
  • Patent number: D887842
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: June 23, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takuya Ikaida, Sayaka Mochizuki, Hiroyuki Kinoshita
  • Patent number: D888570
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: June 30, 2020
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Hiroyuki Nagashima, Hiroyuki Kinoshita, Shigeo Kusumi