Patents Assigned to Hisamitsu Pharmaceutical Co., Inc.
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Publication number: 20220257528Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, and the adhesive agent layer further contains an alicyclic saturated hydrocarbon resin and at least one aliphatic alcohol selected from the group consisting of lauryl alcohol, octyldodecanol, oleyl alcohol, and myristyl alcohol.Type: ApplicationFiled: June 5, 2020Publication date: August 18, 2022Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Hiroyuki ARAKI, Yuka TAKAGI, Yoko FUJIWARA, Hiroaki KOBAYASHI, Takao KUROKAWA
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Patent number: 11400053Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide and aluminum hydroxide, a content of nonylic acid vanillylamide in the adhesive agent layer is 0.01 to 0.025% by mass based on a total mass of the adhesive agent layer, a content of aluminum hydroxide in the adhesive agent layer is 0.55 to 1.5% by mass based on the total mass of the adhesive agent layer, and a mass ratio of the content of nonylic acid vanillylamide to the content of aluminum hydroxide ((content of nonylic acid vanillylamide):(content of aluminum hydroxide)) in the adhesive agent layer is 1:27 to 1:150.Type: GrantFiled: January 23, 2019Date of Patent: August 2, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yusuke Tanaka, Masahiro Sato, Takaaki Yoshinaga
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Patent number: 11364207Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.Type: GrantFiled: February 19, 2018Date of Patent: June 21, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Hideaki Ohashi, Takito Shima, Kenji Ishigaki, Yasunari Michinaka
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Publication number: 20220125626Abstract: A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.Type: ApplicationFiled: February 14, 2020Publication date: April 28, 2022Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.Inventors: Kentaro NAKASHIMA, Keiichiro TSURUSHIMA, Takaaki YOSHINAGA
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Publication number: 20220117906Abstract: The problem addressed by the present invention is to provide a method for suppressing cold flow during packaging or application, regardless of the properties or concentration of a drug, in a patch containing a drug and an acrylic adhesive base in an adhesive layer. The present invention relates to a method for suppressing cold flow of a patch equipped with a support layer and an adhesive layer containing a drug and an acrylic adhesive base, wherein the method causes calcium silicate to be contained in the adhesive layer.Type: ApplicationFiled: January 23, 2020Publication date: April 21, 2022Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Ryo Tanaka, Kazuya Kominami, Naoyuki Uchida, Takito Shima
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Publication number: 20220117934Abstract: The present invention provides a rotigotine stabilization method for stabilizing rotigotine and/or a pharmaceutically acceptable salt thereof in a rotigotine-containing patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer containing the rotigotine and/or the pharmaceutically acceptable salt thereof and a styrene-based thermoplastic elastomer, the method comprising further incorporating cross-linked polyvinylpyrrolidone in the adhesive agent layer in a content of 3 to 25% by mass in the adhesive agent layer.Type: ApplicationFiled: January 23, 2020Publication date: April 21, 2022Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takao KUROKAWA, Hiroyuki ARAKI, Kimiko KOMATANI
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Publication number: 20220079879Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: ApplicationFiled: November 29, 2021Publication date: March 17, 2022Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya MATSUMURA, Toshihiro NAKANISHI, Yasuhisa KOSE
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Publication number: 20220062236Abstract: A method for suppressing a plasma concentration of an asenapine metabolite includes applying to a subject a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer includes asenapine and/or a pharmaceutically acceptable salt thereof, and an adhesive base agent.Type: ApplicationFiled: November 10, 2021Publication date: March 3, 2022Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
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Patent number: 11246830Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: GrantFiled: February 19, 2019Date of Patent: February 15, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
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Patent number: 11219601Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.Type: GrantFiled: February 19, 2019Date of Patent: January 11, 2022Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
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Publication number: 20210393587Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.Type: ApplicationFiled: September 25, 2019Publication date: December 23, 2021Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
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Patent number: 11202764Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.Type: GrantFiled: April 19, 2018Date of Patent: December 21, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kazuya Kominami, Takito Shima, Naoyuki Uchida, Naoko Fujita, Shigeo Suzuki, Terumitsu Kaiho
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Publication number: 20210369637Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan ?) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.Type: ApplicationFiled: September 25, 2019Publication date: December 2, 2021Applicant: Hisamitsu Pharmaceutical Co., Inc.Inventors: Masaki Yukuhiro, Yuka Takagi, Satoshi Amano
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Publication number: 20210369638Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: ApplicationFiled: August 17, 2021Publication date: December 2, 2021Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi SONOBE, Takashi YASUKOCHI, Yasunori TAKADA
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Patent number: 11166921Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.Type: GrantFiled: January 23, 2019Date of Patent: November 9, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Yusuke Tanaka, Masahiro Sato, Kentaro Nakashima, Takaaki Yoshinaga
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Patent number: 11141576Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.Type: GrantFiled: December 15, 2017Date of Patent: October 12, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Takuya Tajima, Naoki Yamamoto, Seiji Tokumoto
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Patent number: 11130148Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.Type: GrantFiled: May 29, 2014Date of Patent: September 28, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Eiji Hashimoto, Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto
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Patent number: 11123305Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.Type: GrantFiled: June 14, 2018Date of Patent: September 21, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Atsushi Sonobe, Takashi Yasukochi, Yasunori Takada
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Patent number: 11116955Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.Type: GrantFiled: February 20, 2018Date of Patent: September 14, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Toru Kobayashi, Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto, Tetsuji Kuwahara
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Patent number: D929871Type: GrantFiled: February 5, 2020Date of Patent: September 7, 2021Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Kei Kubota, Shintaro Takeda, Shigeo Kusumi