Patents Assigned to Hisamitsu Pharmaceutical Co., Inc.
  • Publication number: 20230034383
    Abstract: A method for reducing skin sensitization of an asenapine-containing patch comprising a backing layer and an adhesive agent layer, the method comprising: using an adhesive agent for preparing the adhesive agent layer, the adhesive agent containing free asenapine in a range of 2 to 5% by mass, styrene-isoprene-styrene block copolymer (SIS) in a range of 7 to 18% by mass, polyisobutylene (PIB) in a range of 0.5 to 10% by mass, alicyclic saturated hydrocarbon resin in a range of 30 to 70% by mass, and liquid paraffin in a range of 5 to 10% by mass, relative to a total amount of the adhesive agent; and preparing the asenapine-containing patch whose average cumulative amount of skin permeation of asenapine (24 hours) after applying the asenapine-containing patch to skin of a dorsal scapular region of a 5-week-old Hartley white female guinea pig and holding the asenapine-containing patch with an occlusive dressing for 24 hours is in a range of 90 to 300 ?g/cm2 in terms of free form.
    Type: Application
    Filed: July 21, 2021
    Publication date: February 2, 2023
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yuka TAKAGI, Kazuya ISHIDA, Ryoma TAMURA, Takao KUROKAWA, Yasunari MICHINAKA
  • Publication number: 20230015492
    Abstract: A method for improving holding power of an adhesive agent layer in a ropinirole-containing patch comprising a backing layer and the adhesive agent layer, wherein the adhesive agent layer contains at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof and an adhesive agent, the method comprising: causing the adhesive agent layer to further contain a sodium salt of carbonic acid.
    Type: Application
    Filed: November 20, 2020
    Publication date: January 19, 2023
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoyuki UCHIDA, Satoshi AMANO
  • Publication number: 20220362214
    Abstract: A ropinirole-containing patch comprising an adhesive agent layer and a backing layer, wherein the adhesive agent layer containing: at least one selected from the group consisting of ropinirole and a pharmaceutically acceptable salt thereof; a fatty acid metal salt having 7 or more carbon atoms; and an adhesive agent.
    Type: Application
    Filed: September 11, 2020
    Publication date: November 17, 2022
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Naoyuki UCHIDA, Satoshi AMANO
  • Patent number: 11464956
    Abstract: A microneedle device of the present invention comprises a substrate, microneedles disposed on the substrate, and a coating layer formed on the microneedles, wherein a length of the microneedles is 300 to 500 ?m, the microneedles are disposed on the substrate at a density of 28 to 80 needles/cm2, and the coating layer comprises a biologically active substance. The microneedle device allows the skin irritation caused by administration of an agent to be reduced.
    Type: Grant
    Filed: February 20, 2018
    Date of Patent: October 11, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kazuya Machida, Shinpei Nishimura, Seiji Tokumoto
  • Publication number: 20220257528
    Abstract: The present invention provides a rotigotine-containing patch comprising: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer contains rotigotine and/or a pharmaceutically acceptable salt thereof, and the adhesive agent layer further contains an alicyclic saturated hydrocarbon resin and at least one aliphatic alcohol selected from the group consisting of lauryl alcohol, octyldodecanol, oleyl alcohol, and myristyl alcohol.
    Type: Application
    Filed: June 5, 2020
    Publication date: August 18, 2022
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Hiroyuki ARAKI, Yuka TAKAGI, Yoko FUJIWARA, Hiroaki KOBAYASHI, Takao KUROKAWA
  • Patent number: 11400053
    Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide and aluminum hydroxide, a content of nonylic acid vanillylamide in the adhesive agent layer is 0.01 to 0.025% by mass based on a total mass of the adhesive agent layer, a content of aluminum hydroxide in the adhesive agent layer is 0.55 to 1.5% by mass based on the total mass of the adhesive agent layer, and a mass ratio of the content of nonylic acid vanillylamide to the content of aluminum hydroxide ((content of nonylic acid vanillylamide):(content of aluminum hydroxide)) in the adhesive agent layer is 1:27 to 1:150.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: August 2, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke Tanaka, Masahiro Sato, Takaaki Yoshinaga
  • Patent number: 11364207
    Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains a mixture of a pharmaceutically acceptable acid addition salt of ropinirole and potassium hydrogen carbonate, and the mixture contains at least one selected from the group consisting of ropinirole and pharmaceutically acceptable acid addition salts thereof and potassium hydrogen carbonate.
    Type: Grant
    Filed: February 19, 2018
    Date of Patent: June 21, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Hideaki Ohashi, Takito Shima, Kenji Ishigaki, Yasunari Michinaka
  • Publication number: 20220125626
    Abstract: A cooling sheet comprising: a backing layer; an adhesive agent layer; and a liner layer for protecting the adhesive agent layer, wherein the adhesive agent layer contains water at 65 to 85% by mass based on a total mass of the adhesive agent layer, polyalkylene glycol monooleate at 0.12 to 0.7% by mass based on the total mass of the adhesive agent layer, polyvinyl alcohol at 3 to 10% by mass based on the total mass of the adhesive agent layer, polyacrylic acid at 0.5 to 5% by mass based on the total mass of the adhesive agent layer, and a parahydroxybenzoate at 0.01 to 1% by mass based on the total mass of the adhesive agent layer, and a mass ratio of a content of the polyvinyl alcohol to a content of the polyacrylic acid is in a range of 1.2:1 to 5:1.
    Type: Application
    Filed: February 14, 2020
    Publication date: April 28, 2022
    Applicant: HISAMITSU PHARMACEUTICAL CO.,INC.
    Inventors: Kentaro NAKASHIMA, Keiichiro TSURUSHIMA, Takaaki YOSHINAGA
  • Publication number: 20220117934
    Abstract: The present invention provides a rotigotine stabilization method for stabilizing rotigotine and/or a pharmaceutically acceptable salt thereof in a rotigotine-containing patch comprising a backing layer and an adhesive agent layer, the adhesive agent layer containing the rotigotine and/or the pharmaceutically acceptable salt thereof and a styrene-based thermoplastic elastomer, the method comprising further incorporating cross-linked polyvinylpyrrolidone in the adhesive agent layer in a content of 3 to 25% by mass in the adhesive agent layer.
    Type: Application
    Filed: January 23, 2020
    Publication date: April 21, 2022
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takao KUROKAWA, Hiroyuki ARAKI, Kimiko KOMATANI
  • Publication number: 20220117906
    Abstract: The problem addressed by the present invention is to provide a method for suppressing cold flow during packaging or application, regardless of the properties or concentration of a drug, in a patch containing a drug and an acrylic adhesive base in an adhesive layer. The present invention relates to a method for suppressing cold flow of a patch equipped with a support layer and an adhesive layer containing a drug and an acrylic adhesive base, wherein the method causes calcium silicate to be contained in the adhesive layer.
    Type: Application
    Filed: January 23, 2020
    Publication date: April 21, 2022
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Ryo Tanaka, Kazuya Kominami, Naoyuki Uchida, Takito Shima
  • Publication number: 20220079879
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Application
    Filed: November 29, 2021
    Publication date: March 17, 2022
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya MATSUMURA, Toshihiro NAKANISHI, Yasuhisa KOSE
  • Publication number: 20220062236
    Abstract: A method for suppressing a plasma concentration of an asenapine metabolite includes applying to a subject a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer includes asenapine and/or a pharmaceutically acceptable salt thereof, and an adhesive base agent.
    Type: Application
    Filed: November 10, 2021
    Publication date: March 3, 2022
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Masayuki SUZUKI, Hiroaki OKUTSU, Takashi YASUKOCHI, Yasunori TAKADA
  • Patent number: 11246830
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: February 15, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
  • Patent number: 11219601
    Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: January 11, 2022
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
  • Publication number: 20210393587
    Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
    Type: Application
    Filed: September 25, 2019
    Publication date: December 23, 2021
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Masaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
  • Patent number: 11202764
    Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains a rubber-based adhesive base and a silicone-based adhesive base, and a mass ratio of the rubber-based adhesive base to the silicone-based adhesive base (the mass of the rubber-based adhesive base:the mass of silicone-based adhesive base) in the adhesive layer is 9.5:0.5 to 1.9:8.1.
    Type: Grant
    Filed: April 19, 2018
    Date of Patent: December 21, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Kazuya Kominami, Takito Shima, Naoyuki Uchida, Naoko Fujita, Shigeo Suzuki, Terumitsu Kaiho
  • Publication number: 20210369637
    Abstract: An object of the present invention is to provide an asenapine-containing patch having excellent adhesiveness and handleability, which can persistently provide sufficient medicinal effects by suppressing cold flow during storage or application while enhancing skin permeability using a silicone-based pressure-sensitive adhesive base, and thereby maintaining the stability of the drug in the patch during storage, and maintaining an appropriate administration form for a long period of time. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and a silicone-based pressure-sensitive adhesive base, and the loss tangent (tan ?) of the pressure-sensitive adhesive layer is 0.75 to 1.5 at 1.0 Hz.
    Type: Application
    Filed: September 25, 2019
    Publication date: December 2, 2021
    Applicant: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Masaki Yukuhiro, Yuka Takagi, Satoshi Amano
  • Publication number: 20210369638
    Abstract: In a patch comprising a support layer and an adhesive agent layer, the adhesive agent layer comprises free asenapine, a maleic acid alkali salt, and a rubber-based adhesive agent.
    Type: Application
    Filed: August 17, 2021
    Publication date: December 2, 2021
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Atsushi SONOBE, Takashi YASUKOCHI, Yasunori TAKADA
  • Patent number: 11166921
    Abstract: The present invention provides a patch comprising a backing layer and an adhesive agent layer, wherein the adhesive agent layer is non-aqueous, the adhesive agent layer contains nonylic acid vanillylamide, terpene-based resin, rosin-based resin, styrene-isoprene-styrene block copolymer, and liquid paraffin, a mass ratio of a content of the terpene-based resin to a content of the rosin-based resin ((content of the terpene-based resin)/(content of the rosin-based resin)) in the adhesive agent layer is 0.45 to 1.3, and a mass ratio of a content of the styrene-isoprene-styrene block copolymer to a content of the liquid paraffin ((content of the styrene-isoprene-styrene block copolymer)/(content of the liquid paraffin)) in the adhesive agent layer is 0.45 to 1.2.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: November 9, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Yusuke Tanaka, Masahiro Sato, Kentaro Nakashima, Takaaki Yoshinaga
  • Patent number: 11141576
    Abstract: An applicator of one embodiment is for applying a sheet member to skin. The applicator includes: a body including a bottom plate configured to face the skin and a bending portion provided to the bottom plate; a cap being movable along a slide direction substantially orthogonal to the bottom plate; and an elastic member configured to extend along the slide direction between the body and the cap. The elastic member applies, to the cap, elastic force that acts in a direction away from the bottom plate, the cap being movable toward the bottom plate against the elastic force. The bending portion bends the sheet member that has advanced thereto in a pressed state in which the cap has been moved toward the bottom plate, thereby applying the sheet member to the skin.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: October 12, 2021
    Assignee: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Takuya Tajima, Naoki Yamamoto, Seiji Tokumoto