Patents Assigned to Hitachi Software Engineering Co., Ltd.
  • Biochip reader and labeling reagent
    Patent number: 6787349
    Abstract: The present invention provides a high-sensitive, inexpensive biochip reader for reading a biochip as compared to a fluorescence method. The biochip reader is provided with an X-Y stage (3) for mounting a biochip (6) and scanning the biochip (6) in a two-dimensional manner, a controller (4) for the X-Y stage, a magnetic sensor (1) for reading the magnetic field strength, an ohmmeter (2), and a computer (5) for signal processing. As a result, a high-performance, inexpensive biochip reader can be provided without using an expensive laser or an expensive optical system, by employing a magnetic sensor and a disk driving mechanism generally used in a hard disk drive and the like.
    Type: Grant
    Filed: July 19, 2001
    Date of Patent: September 7, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Kenji Yamamoto, Mitsuhiro Tachibana, Katsuya Mizuno
  • Microarray, method for producing the same, and method for correcting inter-PIN spotting amount error of the same
    Publication number: 20040166522
    Abstract: The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality of pins.
    Type: Application
    Filed: February 24, 2004
    Publication date: August 26, 2004
    Applicant: Hitachi Software Engineering Co., Ltd.
    Inventors: Tomoyuki Yamamoto, Takuro Tamura
  • Hybridization detection method and biochips
    Publication number: 20040161801
    Abstract: The present invention provides a hybridization detection method capable of quantitatively determining the degree of the hybridization between a sample biopolymer and a probe biopolymer. In the method, the amount of a fluorescently labeled probe immobilized on a substrate as a spot is quantitatively determined by determining the fluorescence emitted from a fluorescent material labeling the probe, and the amount of a fluorescently labeled sample hybridized to the probe is quantitatively determined by determining the fluorescence emitted from the fluorescent material labeling the sample. The difference between the amount of the probe and the amount of the sample is normalized with the amount of the probe. Based on the normalized value, the amount of the sample hybridized to the probe can be determined relative to the amount of the probe spotted on the substrate.
    Type: Application
    Filed: February 19, 2004
    Publication date: August 19, 2004
    Applicant: Hitachi Software Engineering Co., Ltd.
    Inventors: Noriko Ban, Kenji Yamamoto, Toshiaki Ito, Toshimasa Watanabe
  • Degree of hybridization detection method
    Patent number: 6775621
    Abstract: The present invention provides a hybridization detection method capable of quantitatively determining the degree of the hybridization between a sample biopolymer and a probe biopolymer. In the method, the amount of a fluorescently labeled probe immobilized on a substrate as a spot is quantitatively determined by determining the fluorescence emitted from a fluorescent material labeling the probe, and the amount of a fluorescently labeled sample hybridized to the probe is quantitatively determined by determining the fluorescence emitted from the fluorescent material labeling the sample. The difference between the amount of the probe and the amount of the sample is normalized with the amount of the probe. Based on the normalized value, the amount of the sample hybridized to the probe can be determined relative to the amount of the probe spotted on the substrate.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: August 10, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Noriko Yurino, Kenji Yamamoto, Toshiaki Ito, Toshimasa Watanabe
  • Fault recovery method and a storage controller in an informatin processing apparatus
    Publication number: 20040153691
    Abstract: In a shared bus connection scheme or an individual path connection scheme, a fault caused at a part of a system affects the same in its entirety. Also, these schemes do not permit the determination of fault locations. Adapters 11, 12 are connected to shared memories 21, 22 with a plurality of individual paths 31 through 38. An address locking unit (not shown) is arranged in each of the shared memories 21, 22 to perform address lock check on memory access operations from the adapters 11, 12. If an address to be accessed is in the locked state, the access is held in the lock wait state until the address is unlocked. The access is made when the address locking is cleared.
    Type: Application
    Filed: June 23, 2003
    Publication date: August 5, 2004
    Applicants: Hitachi, Ltd., Hitachi Software Engineering Co., Ltd.
    Inventors: Takeo Fujimoto, Hisao Honma, Katsuhiro Okumoto, Osamu Sakaguchi
  • Functional beads, method for reading the same and bead-reading apparatus
    Publication number: 20040147031
    Abstract: A method for reading beads comprising the steps of: introducing into a flow path functional beads having a coating layer on the surface thereof and having nanoparticles present in the coating layer; enabling the functional beads to emit light specific to the nanoparticles by applying a voltage to the functional beads in the flow path; and identifying the functional beads based on the emission. A bead-reading apparatus employing the method is also disclosed. Since conventional fluorescent beads are excited with a laser for reading fluorescence, light leakage occurs, so that the influence of noise cannot be ignored. The invention eliminates this drawback.
    Type: Application
    Filed: January 14, 2004
    Publication date: July 29, 2004
    Applicant: Hitachi. Software Engineering Co., Ltd.
    Inventor: Motonao Nakao
  • Spotting pin, spotting device and method for spotting biomolecules
    Patent number: 6767748
    Abstract: The present invention enables the accurate management of the total number of spotting counts for each spotting pin. An IC chip is installed on the spotting pin to allow the IC chip to accumulate spotting-count information, and during each spotting time the information is loaded up and displayed.
    Type: Grant
    Filed: May 6, 2003
    Date of Patent: July 27, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Naoki Yokokawa, Mitsuhiro Tachibana, Hiroshi Kishida
  • Device for electrophoresis
    Patent number: 6755952
    Abstract: The present invention allows detection in short time while maintaining the level of the resolving power as high as when a capillary is utilized. The entire surface of an electrophoresis board 10, which is provided with a two-dimensional tubular electrophoresis pathway, is irradiated with excitation light so as to pick up fluorescence or luminescence from a sample with a two-dimensional sensor. By reading the entire electrophoresis pathway, the separated state of the sample may be confirmed during the electrophoresis. As a result, the electrophoresis may be ended when the sample is sufficiently separated and a molecular weight thereof may be determined based on the migration distance.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: June 29, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Kenji Yamamoto, Noriko Yurino
  • Parallel database record distribution method and parallel database management system
    Patent number: 6745191
    Abstract: A parallel database management system with a database divided into a plurality of external memory units is disclosed. A control CPU, upon receipt of a request for access to the database, decides whether the access request is for storing or searching a record. For a record storage request, the control CPU determines an external memory unit to store the record using a hash function. In the case of a record search request, on the other hand, all the external memory units are searched in parallel without using the hash function thereby to obtain the desired record. The hash function is altered upon addition of an external memory unit.
    Type: Grant
    Filed: April 29, 2003
    Date of Patent: June 1, 2004
    Assignees: Hitachi, Ltd., Hitachi Software Engineering Co., Ltd.
    Inventors: Hideaki Kasao, Keisuke Toda, Kota Yamaguchi, Kazuo Masai, Kiyomi Hirohata
  • Substrate for immobilization of a biological substance or chemical substance, method of immobilizing a biological substance or chemical substance, and method of coating a substrate
    Publication number: 20040091899
    Abstract: A coated substrate for immobilizing a biological substance etc. at high density with low background value. The substrate has a cross-linking reagent represented by general formula A—L—B (wherein, A and B represent an identical or different group which reacts with an active group of the coupling agent comprising an active group, selected from an active ester group, isothiocyanate group, isocyanate group, imidazole group, carbodiimide group or aldehyde group, and wherein L is a linking group linking A and B, selected from a straight chain alkyl group, aryl group, allyl group or alkyl group having an amide group) bound thereonto by means of a coupling agent comprising an active group. An biological substance or the like is immobilized on the substrate.
    Type: Application
    Filed: June 24, 2003
    Publication date: May 13, 2004
    Applicants: DNA Chip Research, Inc., Hitachi Software Engineering Co., Ltd.
    Inventors: Yasuo Komatsu, Kenichi Matsubara, Eiko Ohtsuka, Ken Nonaka, Noriko Yurino
  • Microarray, method for producing the same, and method for correcting inter-pin spotting amount error of the same
    Patent number: 6733968
    Abstract: The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality of pins. Upon microarray production, samples are immobilized on a microarray support using all pins as controls for correcting the inter-pin spotting amount errors. After the microarray experiments, luminescent intensities of the samples used as control spots for correcting the inter-pin spotting amount errors are measured and used to obtain correction parameters for the inter-pin spotting amount errors of respective pins. These parameters are used to correct luminescent intensities of other samples.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: May 11, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Tomoyuki Yamamoto, Takuro Tamura
  • Spotting pin
    Patent number: 6726883
    Abstract: Identically shaped spots can be formed sequentially and stably by a spotting pin comprising a bar-like plunger 20. Four projections each formed in the shape of a top portion of a quadrangular pyramid are formed on the head of the plunger 20. The apexes 21 of the quadrangular pyramids constituting the projections are located inside a virtual plane extending from the peripheral wall of the plunger.
    Type: Grant
    Filed: May 20, 2003
    Date of Patent: April 27, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Seiichiro Ito, Mitsuhiro Tachibana, Naoki Yokokawa
  • Semiconductor nanoparticles, method for producing the same, and fluorescence reagent comprising semiconductor nanoparticles
    Publication number: 20040072427
    Abstract: This invention provides semiconductor nanoparticles having fluorescence properties and comprising a modifying group represented by the following general formula bound to their surfaces, a method for producing the same, and a fluorescence reagent comprising semiconductor nanoparticles:
    Type: Application
    Filed: July 21, 2003
    Publication date: April 15, 2004
    Applicant: Hitachi Software Engineering Co., Ltd.
    Inventors: Keiichi Sato, Susumu Kuwabata
  • Method for converting directory data, and program and device therefor
    Patent number: 6715128
    Abstract: A method for converting directory data is executed to selectively reflect any entry of the directory data onto application data. The directory data converting method includes the steps of searching from the directory data the data of the directory entry specified by a filtering rule corresponding to the application data; converting the searched directory entry data according to the schema conversion rule compatible with the filtering rule used for searching the data; and reflecting the schema-converted entry data onto said application data.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: March 30, 2004
    Assignees: Hitachi, Ltd., Hitachi Software Engineering Co., Ltd.
    Inventors: Yoko Hirashima, Satoshi Kikuchi, Kenta Shiga, Hitoshi Yui, Masakazu Mitsuhashi
  • Solution for substrate spotting and spotting method
    Publication number: 20040058844
    Abstract: A solution for substrate spotting and spotting method for immobilizing a biological substance or various chemical substances on a substrate at high density. The solution for substrate spotting and the spotting method involve mixing a solution comprising a biological substance or chemical substance to be spotted with a solution to which an inorganic fine powder has been added as a surface tension regulating agent.
    Type: Application
    Filed: June 23, 2003
    Publication date: March 25, 2004
    Applicants: DNA Chip Research, Inc., Hitachi Software Engineering Co., Ltd.
    Inventors: Yasuo Komatsu, Kenichi Matsubara, Eiko Ohtsuka, Ken Nonaka, Noriko Yurino
  • Electronic board system and coordinates-inputting pen
    Patent number: 6700129
    Abstract: The present invention transmits, to an electronic board controller 14, click signals generated upon manipulating multiple switches provided on a coordinates-inputting pen 13, timing signals upon detecting infrared scanning beams 18a and 18b, and the like without using a connecting wire. Specifically, light-emitting elements are provided which can emit visible or infrared light to the coordinates-inputting pen 13. A timing signal upon detecting the infrared scanning beam with the pen and a click signal generated upon manipulating the switch on the pen are sent out on a modulated light 19 to be received by a light receiver 20 arranged at a fixed position and transmitted to the electronic board controller 14.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: March 2, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Yutaka Usuda, Yoshikazu Shinkai, Ichirou Takeuchi, Yuji Tsukamoto, Jun Namiki
  • Functional fluorescence reagent comprising semiconductor nanoparticles
    Publication number: 20040036085
    Abstract: This invention provides semiconductor nanoparticles having excellent fluorescence properties and capable of fusing with biopolymers. The semiconductor nanoparticles are encapsulated in a phospholipid bilayer membrane or phospholipid multi-layer membrane to impart functionality thereto. Thus, functional semiconductor nanoparticles can be produced while fluorescence properties of semiconductor nanoparticles are maintained.
    Type: Application
    Filed: August 6, 2003
    Publication date: February 26, 2004
    Applicant: Hitachi Software Engineering Co., Ltd.
    Inventors: Keiichi Sato, Susumu Kuwabata
  • Method for displaying microarray information
    Patent number: 6690461
    Abstract: A method for displaying microarray information by which unknown but useful information is extracted from a mass amount of sample information obtained with microarrays. Luminescent intensity information of sample spots obtained with the microarrays is standardized for each microarray and displayed as a graph as a difference from the standardized luminescent intensity of a sample spot of interest. Accordingly, information can be compared without being influenced by a difference of experiment status between the microarrays or a difference of physical properties between the samples. A three-dimensional graph is displayed by sorting the set of samples and the set of microarrays to which the sample spots belong, under predetermined conditions, and assigning the set of sorted samples and the set of sorted microarrays to X-axis and Y-axis, and the accumulated luminescence intensity to Z-axis.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: February 10, 2004
    Assignee: Hitachi Software Engineering Co., Ltd.
    Inventors: Takuro Tamura, Jyunji Yoshii, Katsuya Mizuno
  • Numerically controlled curved surface machining unit
    Patent number: 6675061
    Abstract: Performing NURBS (non-uniform rational B-spline) interpolation machining is performed by reading cutter location (CL) data consisting of a tool control point vector and a tool axis vector on a workpiece coordinate system, converting the CL data into a position vector of three linear axes and a rotation angle on a machine coordinate system in accordance with the machine configuration of a simultaneous multiple-axis NC machine, calculating knot vectors of a NURBS curve with the most suitable chord length on the basis of a position vector of the three linear axes and a rotation angle, calculating a NURBS curve of the three linear axes and one rotary axis using the knot vectors, converting the NURBS curve into NURBS interpolation NC data, converting the feed rate on a workpiece coordinate system into the feed rate per minute on a machine coordinate system, and transmitting NC data to a NC machine.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: January 6, 2004
    Assignees: Hitachi, Ltd., Hitachi Software Engineering Co., Ltd.
    Inventors: Junichi Hirai, Hiroshi Arai, Tamotsu Harihara, Osamu Chiba, Masaaki Takahashi, Nobuhisa Kanamaru
  • Database processing method, apparatus for carrying out the same and medium storing processing program
    Patent number: 6675160
    Abstract: A database processing system for analyzing a query issued to a database to generate a corresponding execution procedure for performing database processing in accordance therewith. A plurality of columns for storing data each constituted by a set of instances and conditions concerning the instances constituting the plurality of columns are entered. A query is inputted which contains a predicate for evaluating whether a set of instances which meet the designated conditions and which can be identified with the same subscript exists among the sets of instances stored in the plurality of columns. In response to the query, a decision is made as to whether or not an index has been generated for one or plural columns specified in the query predicate. When the index is generated, the index is accessed to acquire an identifier of table data which is “true” for a predicate.
    Type: Grant
    Filed: June 13, 2002
    Date of Patent: January 6, 2004
    Assignees: Hitachi, Ltd., Hitachi Software Engineering Co., Ltd.
    Inventors: Norihiro Hara, Nobuo Kawamura, Tomohiro Nakayama, Kiyomi Hirohata