Patents Assigned to Hokkaido
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Patent number: 11697686Abstract: The present invention provides an anti-PD-L1 antibody capable of staining tumor cells such as melanoma cells. An anti-PD-L1 antibody comprising (a) a light chain comprising CDR1 having the amino acid sequence of KSISKY (SEQ ID NO: 1), CDR2 having the amino acid sequence of SGS and CDR3 having the amino acid sequence of QQHNEYPLT (SEQ ID NO: 2) and (b) a heavy chain comprising CDR1 having the amino acid sequence of GYTFTDYI (SEQ ID NO: 3), CDR2 having the amino acid sequence of INPDSGGN (SEQ ID NO: 4) and CDR3 having the amino acid sequence of ARGITMMVVISHWKFDP (SEQ ID NO: 5). A composition for detecting PD-L1, comprising the above antibody as an active ingredient. A method for preparing the above antibody is also provided.Type: GrantFiled: October 28, 2020Date of Patent: July 11, 2023Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FUSO PHARMACEUTICAL INDUSTRIES, LTD.Inventors: Satoru Konnai, Kazuhiko Ohashi, Shiro Murata, Tomohiro Okagawa, Asami Nishimori, Naoya Maekawa, Satoshi Takagi, Yumiko Kagawa, Yasuhiko Suzuki, Chie Nakajima
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Publication number: 20230211325Abstract: A catalyst structure for synthesis gas production of a synthesis gas that contains carbon monoxide and hydrogen, the catalyst structure being provided with a carrier that has a porous structure, while being configured from a zeolite type compound; first catalyst particles that contain one or more iron group elements which are selected from the group consisting of nickel (Ni), iron (Fe) and cobalt (Co); and second catalyst particles that contain one or more platinum group elements which are selected from the group consisting of platinum (Pt), palladium (Pd), rhodium (Rh) and ruthenium (Ru). The catalyst structure for synthesis gas production has passages in communication with each other within the carrier. The first catalyst particles are present at least in the passages of the carrier; and the second catalyst particles are present at least either inside the carrier or on the outer surface of the carrier.Type: ApplicationFiled: June 1, 2021Publication date: July 6, 2023Applicants: FURUKAWA ELECTRIC CO., LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yuichiro BANBA, Masayuki FUKUSHIMA, Takahiro UENO, Tomohiko MORI, Mai NISHII, Takao MASUDA, Yuta NAKASAKA, Takuya YOSHIKAWA
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Publication number: 20230210925Abstract: A composition for activating cytotoxic T lymphocytes (CTLs) containing a spirulina extract is provided. A composition for CTL activation for proliferation of cytotoxic T lymphocytes (CTLs) containing a spirulina extract is provided. Moreover, a pharmaceutical composition for CTL activation or a food or a drink for CTL activation containing the composition for CTL activation is provided.Type: ApplicationFiled: July 9, 2021Publication date: July 6, 2023Applicants: DIC Corporation, National University Corporation Hokkaido UniversityInventors: Yasuyuki Imai, Tomohiro Hirahashi, Masanori Kasahara, Aya Miyazaki, Tsukasa Seya, Misako Matsumoto, Utano Tomaru
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Publication number: 20230212154Abstract: The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula: , or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: April 29, 2022Publication date: July 6, 2023Applicants: Shionogi & Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yuki TACHIBANA, Shota UEHARA, Yuto UNOH, Kenji NAKAHARA, Yoshiyuki TAODA, Yukiko YAMATSU, Shigeru ANDO, Michihito SASAKI
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Publication number: 20230201108Abstract: It is an object of the present invention to provide a Japanese encephalitis preventive agent and a Japanese encephalitis vaccine agent, which are capable of imparting sufficient immunity to humans, even if these agents are used at a lower dose than the dose of a Japanese encephalitis vaccine for subcutaneous injection, or at a smaller number of administrations than the number of administrations of a Japanese encephalitis vaccine for subcutaneous injection. According to the present invention, provided is a Japanese encephalitis preventive agent, comprising a microneedle array having a sheet portion and a plurality of needle portions present on the upper surface of the sheet portion, wherein the aforementioned needle portions contain or carry an inactivated Japanese encephalitis virus.Type: ApplicationFiled: January 13, 2023Publication date: June 29, 2023Applicants: FUJIFILM Corporation, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Takayoshi OYAMADA, Toshio SHIMADA, Kosuke KAKITA, Hiroaki IWATA
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Publication number: 20230201814Abstract: To provide a functional structural body that can realize a long life time by suppressing the decline in function of the functional substance and that can attempt to save resources without requiring a complicated replacement operation, and to provide a method for making the functional structural body. The functional structural body (1) includes a skeletal body (10) of a porous structure composed of a zeolite-type compound, and at least one functional substance (20) present in the skeletal body (10), the skeletal body (10) has channels (11) connecting with each other, and the functional substance is present at least in the channels (11) of the skeletal body (10).Type: ApplicationFiled: February 17, 2023Publication date: June 29, 2023Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FURUKAWA ELECTRIC CO., LTD.Inventors: Takao MASUDA, Yuta NAKASAKA, Takuya YOSHIKAWA, Sadahiro KATO, Masayuki FUKUSHIMA, Kojiro INAMORI, Hiroko TAKAHASHI, Yuichiro BANBA, Kaori SEKINE
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Patent number: 11683944Abstract: A laminate which allows to obtain an organic thin-film solar cell having excellent output characteristics and transparency is provided. The laminate as above has a titanium oxide layer that is disposed on the member serving as a light-transmissive electrode layer and serves as an electron transport layer. The titanium oxide layer has a thickness of not less than 1.0 nm and not more than 200.0 nm. The titanium oxide layer contains indium oxide and metallic indium, InOx/Ti is not less than 0.50 and not more than 20.00 in atomic ratio, and InM/Ti is less than 0.100 in atomic ratio, where an elemental titanium content is represented by Ti, an indium oxide content is represented by InOx, and a metallic indium content is represented by InM.Type: GrantFiled: September 28, 2020Date of Patent: June 20, 2023Assignees: JFE Steel Corporation, National University Corporation Hokkaido UniversityInventors: Mikito Suto, Hiroyuki Masuoka, Akira Matsuzaki, Hiroki Habazaki, Hikaru Kobayashi
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Publication number: 20230173578Abstract: Disclosed is oxide-containing copper fine particles including Cu64O and optionally Cu2O and coated with a carboxylic acid, wherein a mass ratio of Cu64O to a total mass of Cu, Cu64O and Cu2O is 0.5 to 2.0% by mass.Type: ApplicationFiled: August 26, 2021Publication date: June 8, 2023Applicant: National University Corporation Hokkaido UniversityInventor: Tetsu Yonezawa
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Publication number: 20230173268Abstract: A treatment device that shortens the time period until healing is determined even when a bone defect or a root apex lesion is generated in an apical area. The treatment device includes a file holder, a high-frequency signal generating circuit, and a control circuit. The file holder holds a file to be located in the site to be treated. The high-frequency signal generating circuit passes a high frequency current through the file. The control circuit controls a frequency of the high frequency current to be passed through the file from the high-frequency signal generating circuit. The control circuit controls the frequency of the high frequency current to be passed through the file within a range of 1.001 MHz to 11.700 MHz.Type: ApplicationFiled: November 2, 2022Publication date: June 8, 2023Applicants: J. MORITA MFG. CORP., National University Corporation Hokkaido UniversityInventors: Tsutomu SUGAYA, Keita YAMADA, Shingo BAN, Kei DOKAI, Tomoaki UEDA, Shunsuke YAMAGUCHI, Kazunari MATOBA
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Patent number: 11660471Abstract: The present invention makes it possible to provide a radiation therapy system capable of not only inhibiting treatment time from increasing more effectively than before but also reducing the loads of fluoroscopic radiation photographing apparatuses.Type: GrantFiled: November 27, 2018Date of Patent: May 30, 2023Assignees: HITACHI, LTD., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Koichi Miyazaki, Naoki Miyamoto
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Patent number: 11655157Abstract: A functional structural body that can realize a prolonged life time by suppressing the decrease in function and that can fulfill resource saving without requiring a complicated replacement operation is provided. A functional structural body includes a skeletal body of a porous structure composed of a zeolite-type compound; and at least one solid acid present in the skeletal body, the skeletal body has channels connecting with each other, and the solid acid is present at least in the channels of the skeletal body.Type: GrantFiled: November 27, 2019Date of Patent: May 23, 2023Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FURUKAWA ELECTRIC CO., LTD.Inventors: Takao Masuda, Yuta Nakasaka, Takuya Yoshikawa, Sadahiro Kato, Masayuki Fukushima, Kojiro Inamori, Hiroko Takahashi, Yuichiro Banba, Kaori Sekine
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Publication number: 20230150919Abstract: Disclosed is a method for producing a mono-cross-coupled aromatic compound (3-1) having one less leaving group than an aromatic compound (1) having at least two leaving groups, the method comprising: preparing the aromatic compound (1) having at least two leaving groups; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic boronic acid (2-1), an aromatic amino compound (2-2), a diboronic acid ester (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the aromatic compound (1) having at least two leaving groups with the compound (2) in the presence of a palladium catalyst and a base, in the absence of a solvent.Type: ApplicationFiled: March 2, 2021Publication date: May 18, 2023Applicant: National University Corporation Hokkaido UniversityInventors: Hajime Ito, Koji Kubota
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Patent number: 11648542Abstract: To provide a functional structural body that can realize ong life time by suppressing the decline in function of the functional substance and that can attempt to save resources without requiring a complicated replacement operation, and to provide a method for making the functional structural body. The functional structural body (1) includes a skeletal body (10) of a porous structure composed of a zeolite-type compound, and at least one functional substance (20) present in the skeletal body (10), the skeletal body (10) has channels (11) connecting with each other, and the functional substance is present at least the channels (11) of the skeletal body (10).Type: GrantFiled: November 27, 2019Date of Patent: May 16, 2023Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FURUKAWA ELECTRIC CO., LTD.Inventors: Takao Masuda, Yuta Nakasaka, Takuya Yoshikawa, Sadahiro Kato, Masayuki Fukushima, Kojiro Inamori, Hiroko Takahashi, Yuichiro Banba, Kaori Sekine
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Patent number: 11648538Abstract: A functional structural body includes a skeletal body of a porous structure composed of a zeolite-type compound, and at least one type of metallic nanoparticles present in the skeletal body, the skeletal body having channels connecting with each other, the metallic nanoparticles being present at least in the channels of the skeletal body.Type: GrantFiled: November 27, 2019Date of Patent: May 16, 2023Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FURUKAWA ELECTRIC CO., LTD.Inventors: Takao Masuda, Yuta Nakasaka, Takuya Yoshikawa, Sadahiro Kato, Masayuki Fukushima, Kojiro Inamori, Hiroko Takahashi, Yuichiro Banba, Kaori Sekine
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Patent number: 11648543Abstract: Provide is a functional structural body that can suppress aggregation of metal oxide nanoparticles and prevent functional loss of metal oxide nanoparticles, and thus exhibit a stable function over a long period of time. A functional structural body (1) includes: a skeletal body (10) of a porous structure composed of a zeolite-type compound; and at least one type of metal oxide nanoparticles (20) containing a perovskite-type oxide present in the skeletal body (10), the skeletal body (10) having channels (11) that connect with each other, and the metal oxide nanoparticles (20) being present at least in the channels (11) of the skeletal body (10).Type: GrantFiled: November 27, 2019Date of Patent: May 16, 2023Assignees: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, FURUKAWA ELECTRIC CO., LTD.Inventors: Takao Masuda, Yuta Nakasaka, Takuya Yoshikawa, Sadahiro Kato, Masayuki Fukushima, Kojiro Inamori, Hiroko Takahashi, Yuichiro Banba, Kaori Sekine
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Publication number: 20230132645Abstract: A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): [in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R1 and R2 each independently represents a linear hydrocarbon group that may have —CO—O—; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R3 and R4 each independently represents a C1-4 alkyl group or a C2-4 alkenyl group, where, R3 and R4 may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C1-4 alkyl groups or C2-4 alkenyl groups may be substituted on the ring)].Type: ApplicationFiled: November 17, 2022Publication date: May 4, 2023Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Hideyoshi Harashima, Yusuke Sato
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Publication number: 20230128797Abstract: A freshness/degree of maturation evaluating device for evaluating freshness and/or degree of maturation of food animal, freshness/degree of maturation evaluating device provided with: temperature parameter calculation unit that calculates temperature parameter regarding storage time and temperature in arbitrary area inside food animal, parameter based on temperature in arbitrary area inside food animal, determined by storage time and unsteady heat conduction equation; rate constant parameter calculation unit that calculates rate constant parameter regarding sequential decomposition reactions of various ATP-associated compounds contained infood animal, parameter being set based on rate constants in food animal determined by using relation based on storage time of food animal and measured values of ATP-associated compound concentrations; ATP-associated compound concentration calculation unit that calculates ATP-associated compound concentrations by sequential decomposition reaction calculation model using tempeType: ApplicationFiled: March 5, 2021Publication date: April 27, 2023Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Takaaki INADA, Hiroshi NAGAISHI, Naoto TSUBOUCHI, Yuji SHINOHARA
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Publication number: 20230128162Abstract: The present invention provides a compound exhibiting coronavirus 3CL protease inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. Furthermore, the present invention provides a crystalline form useful as an active pharmaceutical ingredient, and a pharmaceutical composition comprising the same. A compound represented by Formula (I): wherein Y is N or the like; R1 is substituted or unsubstituted aromatic heterocyclyl or the like; R2 is substituted or unsubstituted aromatic carbocyclyl or the like; R3 is substituted or unsubstituted aromatic heterocyclyl or the like; —X— is —NH— or the like; m is 1 or the like; R5a is each independently a hydrogen atom or the like; R5b is each independently a hydrogen atom or the like; n is 1 or the like; R4a is each independently a hydrogen atom or the like; and R4b is each independently a hydrogen atom or the like, or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: February 17, 2022Publication date: April 27, 2023Applicants: Shionogi & Co., Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventors: Yuki TACHIBANA, Shota UEHARA, Yuto UNOH, Kenji NAKAHARA, Yoshiyuki TAODA, Koji KASAMATSU, Yukiko YAMATSU, Shigeru ANDO, Atsuhiro IIMURO, Takahiro SUTO, Michihito SASAKI
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Publication number: 20230117695Abstract: The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound. An arenavirus proliferation inhibitor comprising a compound represented by Formula (I) or a prodrug thereof or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: September 30, 2022Publication date: April 20, 2023Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY, Shionogi & Co., Ltd.Inventors: Akihiro ISHII, Akihiko SATO, Makoto KAWAI, Yoshiyuki TAODA
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Patent number: 11625593Abstract: A neural network circuit is provided with which it is possible to significantly reduce the area occupied by the connection unit of a full connection (FC)-type neural network circuit. An analog-type neural network circuit constitute a learning apparatus having a self-learning function and corresponding to a brain function, wherein the neural network comprises: a plurality (n) of input-side neurons; a plurality (m, and including cases when n=m) of output-side neurons; (n×m) connection units each connecting one input-side neuron and one output-side neuron; and a self-learning control unit, the (n×m) connection units being constituted from connection units corresponding to only the positive weighting function as a brain function, and connection units corresponding to only the negative weighting function as the brain function.Type: GrantFiled: February 13, 2018Date of Patent: April 11, 2023Assignee: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITYInventor: Tetsuya Asai