Abstract: The present invention provides a method for assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease in a test subject, by using, as an indicator, the level of SYT17 protein in a urine-derived specimen collected from the test subject. The present invention also provides: a pharmaceutical composition for preventing and/or treating chronic kidney allograft rejection or chronic kidney disease, the pharmaceutical composition including at least one substance selected from the group consisting of a specific antibody to SYT17, a derivative of the specific antibody, and an inhibitory nucleic acid against SYT17; and a test kit for use in assessing the possibility of onset or progression of chronic kidney allograft rejection or chronic kidney disease, the test kit including a specific antibody to SYT17 or a derivative of the specific antibody.

Abstract: The present invention relates to a method for screening an anticancer agent by causing drosophila having the characteristics of a) expression of mutant Ras85D, b) deletion or suppressed expression of a p53 gene, c) overexpression of a cyclin E gene, and d) deletion or suppressed expression of a Med gene to ingest a test substance and comparing the survival rate thereof with the survival rate of drosophila that did not ingest the test substance. The present invention also relates to a combination drug of at least two kinase inhibitors for treatment of pancreatic cancer and to kinase inhibitors for use in said combination drug.

Abstract: A lipid membrane structure includes, as lipid components, a lipid compound represented by Formula (I): (R1)(R2)C(OH)—(CH3)a—(O—CO)b—X??(I) [in the formula, a represents an integer of 3 to 5; b represents an integer of 0 or 1; R1 and R2 each independently represents a linear hydrocarbon group that may have —CO—O—; and X represents a 5- to 7-membered non-aromatic heterocyclic group or a group represented by Formula (B) (in the formula, d represents an integer of 0 to 3, and R3 and R4 each independently represents a C1-4 alkyl group or a C2-4 alkenyl group, where, R3 and R4 may be bonded to each other to form a 5- to 7-membered non-aromatic heterocycle (where, one or two C1-4 alkyl groups or C2-4 alkenyl groups may be substituted on the ring)].

Abstract: A latent heat storage body microcapsule includes a core including gallium or gallium alloy; and a shell covering the core and including gallium oxide. A method for producing the same includes a particle-forming step of forming gallium or an alloy of gallium in a liquid state into particles; a water treatment step of heating the particles in distilled water to form a gallium hydrate on a surface of each of the particles; and an oxidation treatment step of oxidizing the gallium hydrate to form a shell including gallium oxide. The method includes a particle-forming step of forming gallium or an alloy of gallium in a liquid state into particles; a cooling step of cooling the particles to a solid state; and a pH treatment step of immersing the particles in an aqueous solution having a predetermined pH to form a shell including gallium hydrate.

Abstract: An object is to provide a composition and a method for eliminating undifferentiated pluripotent stem cells remaining in a cell group induced to differentiate from pluripotent stem cells. It has been found that while dihydroorotate dehydrogenase inhibitors exhibit cytotoxic activity against pluripotent stem cells, they do not exhibit significant cytotoxic activity against differentiated cells such as somatic stem cells.

Abstract: A rare earth complex including a rare earth ion and a ligand coordinated with the rare earth ion and having a condensed polycyclic aromatic group.

Abstract: A quantum key distribution device is provided with an encoding unit which encodes an optical pulse train; an intensity modulating unit which subjects the encoded optical pulse train to N (where N is an integer at least equal to 3) types of intensity modulation having mutually different intensities, with different timings; and a first key distillation processing unit which generates an encryption key on the basis of a data sequence obtained by removing data obtained from an optical pulse having a specific modulation pattern from a data sequence used by the encoding unit and the intensity modulating unit.

Abstract: The purpose of the present invention is to provide a method for detecting, in a selective and simple manner, an oxidized form of HD5 which is human ?-defensin, that is, HD5 having intramolecular disulfide bonds that function beneficially in the human body. [Solution] The present invention relates to: two kinds of novel monoclonal antibodies that contain amino acid sequences of SEQ ID NO: 1-6 or 7-12 as a CDR and that specifically bind to human ?-defensin HD5 having intramolecular disulfide bonds; an immunological detection method using the antibodies; and a kit containing the antibodies.

Abstract: A balanced-lattice-ledge nucleant having ledge inducing local densification of proteins and a balanced-lattice inducing self-organized crystal packing. Using this balanced-lattice-ledge nucleant enhances nucleation of protein crystals.

Abstract: The hydrogel includes a first network structure and a second network structure. The second network structure is entwined with the first network structure. The first network structure contains a polymer crosslinked with a first crosslinking agent. The second network structure contains a polymer crosslinked with a second crosslinking agent. 50 mol % or more of the first crosslinking agent does not contain a decomposable bond. 50 mol % or more of the second crosslinking agent does not contain a decomposable bond.

Abstract: The present invention provides a compound having antiviral activity, especially having arenavirus proliferation inhibitory activity, and/or a medicament comprising the compound. More preferably, the present invention provides a compound having proliferation inhibitory activity on the Old World arenaviruses such as Luna virus, Lassa virus, and lymphocytic choriomeningitis virus and/or the New World arenaviruses such as Junin virus, and/or a medicament comprising the compound.

Abstract: A laminate which allows to obtain an organic thin-film solar cell having excellent output characteristics and transparency is provided. The laminate as above has a titanium oxide layer that is disposed on the member serving as a light-transmissive electrode layer and serves as an electron transport layer. The titanium oxide layer has a thickness of not less than 1.0 nm and not more than 200.0 nm. The titanium oxide layer contains indium oxide and metallic indium, InOx/Ti is not less than 0.50 and not more than 20.00 in atomic ratio, and InM/Ti is less than 0.100 in atomic ratio, where an elemental titanium content is represented by Ti, an indium oxide content is represented by InOx, and a metallic indium content is represented by InM.

Abstract: In order to provide an antibody having high therapeutic and prophylactic effects against cancer and the like, three types of mouse monoclonal antibodies were prepared which exhibit high affinities for a human-derived Eva1 protein. Moreover, constant regions of these antibodies were substituted with human-derived constant regions to also prepare chimeric antibodies. Further, these mouse antibodies and chimeric antibodies were found to have high ADCC and/or CDC activities. Furthermore, it was also revealed that administering these antibodies to mice having been subjected to melanoma cell administration suppresses the metastasis and the like of the cells to the lungs.

Abstract: A heat-resistant alloy contains at least one element selected from a group consisting of Al, Ti, Ni, Cr, and Mo, O, and Y, and a ratio of a content of Y in terms of mass to a content of O in terms of mass is 0.5 or greater and 100 or less.

Abstract: A composition for forming a phase-separated structure contains a block copolymer having a block (b1) consisting of a repeating structure of a styrene unit and a block (b2) consisting of a repeating structure of a methyl methacrylate unit, in which the block (b2) is disposed at least at one terminal portion of the block copolymer, the block copolymer has a structure (e1) represented by General Formula (e1) at least at one main chain terminal, and the structure (e1) is bonded to the main chain terminal of the block (b2) disposed at a terminal portion of the block copolymer. Ree0 represents a hydrocarbon group containing a hetero atom, and Re1 represents a hydrogen atom or a halogen atom.

Abstract: Disclosed is a rare earth complex having a rare earth ion and a phosphine oxide ligand that is coordinated with the rare earth ion and is represented by the following formula (I): wherein R1, R2, R3, R4, R5, and R6 each independently represent an alkyl group which may have a substituent.

Abstract: Disclosed is a cross-coupling reaction method which forms a chemical bond selected from C—N, C—B, C—C, C—O and C—S bonds, the method comprising: preparing an aromatic compound (1) having a leaving group; preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic amino compound (2-1), a diboronic acid ester or the like (2-2), an aromatic boronic acid or the like (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; and performing a cross-coupling reaction of the compound (1) with the compound (2) in the presence of a palladium catalyst, a base and a compound (4) having a carbon-carbon double bond or a carbon-carbon triple bond, in the absence of a solvent.

Abstract: Through the present invention, three-dimensional coordinates of a tracking object moving in an irradiation object can be calculated from fluoroscopic X-ray images captured and acquired from various angles in a single fluoroscopic X-ray device mounted to a radiation therapy apparatus. The three-dimensional coordinates of the tracking object are calculated on a straight tracking object presence line connecting an X-ray generating device for fluoroscopy and the position in an X-ray plane detector of the tracking object on the fluoroscopic X-ray image acquired by the X-ray generating device for fluoroscopy and the X-ray plane detector, and using line segment information included in a movement region of the tracking object set in advance.

Abstract: A template matching is performed on two fluoroscopic images by using a template image prepared in advance and a position corresponding to a high matching score is listed as a candidate for the position of a marker 29. From two lists of the candidates of the position of the marker 29, the lengths of common vertical lines for all combinations are calculated. Then, the position of the marker 29 is detected based on the matching score and the common vertical line. Then, based on the detected position of the marker 29, an amount of a proton beam to be irradiated to a target is controlled. Therefore, a tracking target can be accurately detected even when the conditions for X-ray fluoroscopy is severe, e.g., a thick object.

Abstract: A processor of a fundus image processing device acquires a fundus image 50 photographed by a fundus image photographing device. The processor acquires blood vessel images 60A and 60B that indicate at least one of an arteriole and a venule in the fundus image 50 by inputting the fundus image 50 into a mathematical model trained by a machine learning algorithm. The processor acquires a blood vessel area that is an area of at least one of the arteriole and the venule in the whole of the blood vessel images 60A and 60B.