Patents Assigned to Howard University
  • Patent number: 9675556
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: June 13, 2017
    Assignee: Howard University
    Inventors: Emmanuel Oyekanmi Akala, Simeon Kolawole Adesina
  • Patent number: 9644166
    Abstract: A nanolubricant composition is described where the lubricant composition includes a flowable oil or grease with nanoparticles dispersed in the flowable oil or grease. The nanoparticles are configured to polish a surface of a structure slowly over a period of time. The nanoparticles a hardness of at least about 7 Mohs and a diameter that is less than one half the arithmetic average roughness of the surface or a length that is less than one half of the arithmetic average roughness of the surface.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: May 9, 2017
    Assignee: Howard University
    Inventor: Mohsen Mosleh
  • Publication number: 20170008839
    Abstract: Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula: wherein, independent of each other, each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, n is an integer of 0, 1, 2, or 3, each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy,wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, m is an integer of 0, 1, 2, or 3, and R represents di-valent hydrocarbyl, substituted or unsubstituted.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 12, 2017
    Applicant: Howard University
    Inventor: Xiang Simon WANG
  • Patent number: 9511343
    Abstract: Methods and apparatus to control reaction rates of chemical reactions. Methods can include mixing chemical reactants to provide a reaction mixture, at least one chemical reactant being magnetic; and applying a magnetic field to the reaction mixture, the magnetic field being applied to effect a control of the rate of a chemical reaction between the reactants in the reaction mixture, the magnetic field being effective to change the reaction rate over a chemical reaction between the same reactants at the same pressure and temperature where the reaction mixture is not exposed to the magnetic field.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: December 6, 2016
    Assignee: Howard University
    Inventors: Reginald B. Little, James W. Mitchell
  • Publication number: 20160347739
    Abstract: A method for treating against HIV, such as by inhibiting HIV integrase, in target cells or in a patient involves administering to target cells or to a patient in need of treatment an effective amount of at least one compound having an N-indol heteroarylcarboxamide scaffold which compound is represented by the formula: wherein, independent of each other, R independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, R1 represents di-valent hydrocarbyl, substituted or unsubstituted, and R2 represents an ether moiety.
    Type: Application
    Filed: July 26, 2016
    Publication date: December 1, 2016
    Applicant: Howard University
    Inventor: Xiang Simon WANG
  • Publication number: 20160308996
    Abstract: The context of a first electronic device is automatically determined, and the first electronic device has a display unit. Information is displayed at the display unit based upon the context. The context is transmitted from the first electronic device to a second electronic device, and from the first electronic device and to a third electronic device. A first consistency of information is maintained between the first electronic device and a second electronic device based at least upon the context, and a second consistency is maintained between the first electronic device and a third electronic device based at least upon the context. The first consistency is greater than the second consistency.
    Type: Application
    Filed: June 22, 2016
    Publication date: October 20, 2016
    Applicant: Howard University
    Inventor: Legand L. Burge, III
  • Patent number: 9447047
    Abstract: Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: September 20, 2016
    Assignees: Howard University, The Board of Regents of the University of Texas System
    Inventors: Sergei Nekhai, Alexander Bukreyev
  • Publication number: 20160266148
    Abstract: The disclosure relates to the identification of salivary biomarkers for diagnosis and monitoring of type 2 diabetes in a subject. Also provided are methods for noninvasively diagnosing and monitoring type 2 diabetes in a subject. More particularly, the expression of salivary biomarkers, including MUC-1, MUC-2, MUC-4, and MUC-5B, are highly associated with A1C level in African American patients with type 2 diabetes.
    Type: Application
    Filed: March 10, 2016
    Publication date: September 15, 2016
    Applicant: Howard University
    Inventors: Xinbin Gu, Grace Robinson
  • Publication number: 20160258049
    Abstract: The present disclosure provides methods of applying a filtering coating to a substrate, comprising: depositing a solution on a surface of a substrate, wherein the solution comprises an organic solvent with nanorods dispersed within the solvent. Evaporation of the solution is allowed and/or controlled to increase a volume fraction of the nanorods in the solution as a function of the evaporation. Thus, an aligned deposit of the nanorods is provided as a function of the evaporation, wherein the aligned deposit of nanorods includes at least thousands of the nanorods with at least a majority of the nanorods aligned relative to a length of the nanorods.
    Type: Application
    Filed: March 1, 2016
    Publication date: September 8, 2016
    Applicant: Howard University
    Inventors: Kimani A. Stancil, James S. Hammonds
  • Patent number: 9433608
    Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition may include at least a benzodiazepine class material. In another form, the composition may include at least two components selected from the group consisting of an antagonist of the type 3 ryanodine receptor, an NMDA blocker (antagonist), and a benzodiazepine class material which can be administered for ischemic neuronal reperfusion injury. In one form, all three components may be used.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: September 6, 2016
    Assignee: Howard University
    Inventors: Harpal S. Mangat, Pradeep K. Karla
  • Patent number: 9434905
    Abstract: A nanolubricant composition is described where the lubricant composition includes a flowable oil or grease with a multi-component nanoparticle dispersed in the flowable oil or grease. The multi-component nanoparticle includes a first nanoparticle component which effects thermal conductivity at a part interface and a second nanoparticle component which effects shearing at a part interface.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 6, 2016
    Assignee: Howard University
    Inventor: Mohsen Mosleh
  • Publication number: 20160242718
    Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS-II) model can be applied, whereby estimating factor curves in the myocardium can be physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS-II model into a discrete-time K-FADS-II model and application of an iterative Improved Voxel-Resolution myocardial blood flow (IV-MBF) algorithm.
    Type: Application
    Filed: October 3, 2014
    Publication date: August 25, 2016
    Applicant: Howard University
    Inventor: John M. M. Anderson
  • Patent number: 9423443
    Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.
    Type: Grant
    Filed: April 25, 2014
    Date of Patent: August 23, 2016
    Assignee: Howard University
    Inventor: Charles J. Kim
  • Patent number: 9399708
    Abstract: A method is provided for synthesizing polylactide/calcium phosphate composites. In one aspect, an intermediate silanized calcium phosphate material calcium-phosphate/phosphonate is developed to improve the tensile strength of the composite.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: July 26, 2016
    Assignee: Howard University
    Inventors: Tongxin Wang, James W. Mitchell
  • Patent number: 9392073
    Abstract: A context of a mobile device is determined. A context preference of a user associated with the mobile device is determined. The context of the mobile device and the user context preference is transmitted to another node and responsively returned data is received. Available free space in the mobile device is determined. All data whose timestamp is within a predetermined threshold is cached. The data is cached in at least a portion of the free space.
    Type: Grant
    Filed: June 3, 2014
    Date of Patent: July 12, 2016
    Assignee: Howard University
    Inventor: Legand L. Burge, III
  • Publication number: 20160193237
    Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).
    Type: Application
    Filed: September 5, 2014
    Publication date: July 7, 2016
    Applicant: Howard University
    Inventor: Pradeep K. Karla
  • Patent number: 9358211
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: June 7, 2016
    Assignee: Howard University
    Inventors: Emmanuel Oyekanmi Akala, Oluyomi Modupe Okunola
  • Publication number: 20160143886
    Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
    Type: Application
    Filed: January 28, 2016
    Publication date: May 26, 2016
    Applicant: Howard University
    Inventors: Harpal S. Mangat, Pradeep K. Karla
  • Publication number: 20160113844
    Abstract: Described herein are compositions and methods which produce hydrolytically stable resin monomers, bioactive fillers, phosphorus coupling agent and surface coating method, which can be combined to produce new generation dental composites; compositions comprising the same, as well as methods of making and using the same are also described.
    Type: Application
    Filed: June 6, 2014
    Publication date: April 28, 2016
    Applicant: Howard University
    Inventors: Tongxin WANG, Lawrence C. CHOW
  • Patent number: 9248118
    Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
    Type: Grant
    Filed: February 19, 2015
    Date of Patent: February 2, 2016
    Assignee: Howard University
    Inventors: Harpal S. Mangat, Pradeep K. Karla