Patents Assigned to Howard University
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Patent number: 9675556Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monomer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.Type: GrantFiled: December 18, 2014Date of Patent: June 13, 2017Assignee: Howard UniversityInventors: Emmanuel Oyekanmi Akala, Simeon Kolawole Adesina
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Patent number: 9644166Abstract: A nanolubricant composition is described where the lubricant composition includes a flowable oil or grease with nanoparticles dispersed in the flowable oil or grease. The nanoparticles are configured to polish a surface of a structure slowly over a period of time. The nanoparticles a hardness of at least about 7 Mohs and a diameter that is less than one half the arithmetic average roughness of the surface or a length that is less than one half of the arithmetic average roughness of the surface.Type: GrantFiled: May 25, 2012Date of Patent: May 9, 2017Assignee: Howard UniversityInventor: Mohsen Mosleh
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Publication number: 20170008839Abstract: Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula: wherein, independent of each other, each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, n is an integer of 0, 1, 2, or 3, each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy,wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, m is an integer of 0, 1, 2, or 3, and R represents di-valent hydrocarbyl, substituted or unsubstituted.Type: ApplicationFiled: February 26, 2015Publication date: January 12, 2017Applicant: Howard UniversityInventor: Xiang Simon WANG
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Patent number: 9511343Abstract: Methods and apparatus to control reaction rates of chemical reactions. Methods can include mixing chemical reactants to provide a reaction mixture, at least one chemical reactant being magnetic; and applying a magnetic field to the reaction mixture, the magnetic field being applied to effect a control of the rate of a chemical reaction between the reactants in the reaction mixture, the magnetic field being effective to change the reaction rate over a chemical reaction between the same reactants at the same pressure and temperature where the reaction mixture is not exposed to the magnetic field.Type: GrantFiled: March 22, 2012Date of Patent: December 6, 2016Assignee: Howard UniversityInventors: Reginald B. Little, James W. Mitchell
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Publication number: 20160347739Abstract: A method for treating against HIV, such as by inhibiting HIV integrase, in target cells or in a patient involves administering to target cells or to a patient in need of treatment an effective amount of at least one compound having an N-indol heteroarylcarboxamide scaffold which compound is represented by the formula: wherein, independent of each other, R independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, R1 represents di-valent hydrocarbyl, substituted or unsubstituted, and R2 represents an ether moiety.Type: ApplicationFiled: July 26, 2016Publication date: December 1, 2016Applicant: Howard UniversityInventor: Xiang Simon WANG
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Publication number: 20160308996Abstract: The context of a first electronic device is automatically determined, and the first electronic device has a display unit. Information is displayed at the display unit based upon the context. The context is transmitted from the first electronic device to a second electronic device, and from the first electronic device and to a third electronic device. A first consistency of information is maintained between the first electronic device and a second electronic device based at least upon the context, and a second consistency is maintained between the first electronic device and a third electronic device based at least upon the context. The first consistency is greater than the second consistency.Type: ApplicationFiled: June 22, 2016Publication date: October 20, 2016Applicant: Howard UniversityInventor: Legand L. Burge, III
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Patent number: 9447047Abstract: Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.Type: GrantFiled: March 14, 2013Date of Patent: September 20, 2016Assignees: Howard University, The Board of Regents of the University of Texas SystemInventors: Sergei Nekhai, Alexander Bukreyev
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Publication number: 20160266148Abstract: The disclosure relates to the identification of salivary biomarkers for diagnosis and monitoring of type 2 diabetes in a subject. Also provided are methods for noninvasively diagnosing and monitoring type 2 diabetes in a subject. More particularly, the expression of salivary biomarkers, including MUC-1, MUC-2, MUC-4, and MUC-5B, are highly associated with A1C level in African American patients with type 2 diabetes.Type: ApplicationFiled: March 10, 2016Publication date: September 15, 2016Applicant: Howard UniversityInventors: Xinbin Gu, Grace Robinson
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Publication number: 20160258049Abstract: The present disclosure provides methods of applying a filtering coating to a substrate, comprising: depositing a solution on a surface of a substrate, wherein the solution comprises an organic solvent with nanorods dispersed within the solvent. Evaporation of the solution is allowed and/or controlled to increase a volume fraction of the nanorods in the solution as a function of the evaporation. Thus, an aligned deposit of the nanorods is provided as a function of the evaporation, wherein the aligned deposit of nanorods includes at least thousands of the nanorods with at least a majority of the nanorods aligned relative to a length of the nanorods.Type: ApplicationFiled: March 1, 2016Publication date: September 8, 2016Applicant: Howard UniversityInventors: Kimani A. Stancil, James S. Hammonds
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Patent number: 9433608Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition may include at least a benzodiazepine class material. In another form, the composition may include at least two components selected from the group consisting of an antagonist of the type 3 ryanodine receptor, an NMDA blocker (antagonist), and a benzodiazepine class material which can be administered for ischemic neuronal reperfusion injury. In one form, all three components may be used.Type: GrantFiled: May 8, 2014Date of Patent: September 6, 2016Assignee: Howard UniversityInventors: Harpal S. Mangat, Pradeep K. Karla
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Patent number: 9434905Abstract: A nanolubricant composition is described where the lubricant composition includes a flowable oil or grease with a multi-component nanoparticle dispersed in the flowable oil or grease. The multi-component nanoparticle includes a first nanoparticle component which effects thermal conductivity at a part interface and a second nanoparticle component which effects shearing at a part interface.Type: GrantFiled: May 25, 2012Date of Patent: September 6, 2016Assignee: Howard UniversityInventor: Mohsen Mosleh
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Publication number: 20160242718Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS-II) model can be applied, whereby estimating factor curves in the myocardium can be physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS-II model into a discrete-time K-FADS-II model and application of an iterative Improved Voxel-Resolution myocardial blood flow (IV-MBF) algorithm.Type: ApplicationFiled: October 3, 2014Publication date: August 25, 2016Applicant: Howard UniversityInventor: John M. M. Anderson
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Patent number: 9423443Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.Type: GrantFiled: April 25, 2014Date of Patent: August 23, 2016Assignee: Howard UniversityInventor: Charles J. Kim
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Patent number: 9399708Abstract: A method is provided for synthesizing polylactide/calcium phosphate composites. In one aspect, an intermediate silanized calcium phosphate material calcium-phosphate/phosphonate is developed to improve the tensile strength of the composite.Type: GrantFiled: March 8, 2013Date of Patent: July 26, 2016Assignee: Howard UniversityInventors: Tongxin Wang, James W. Mitchell
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Patent number: 9392073Abstract: A context of a mobile device is determined. A context preference of a user associated with the mobile device is determined. The context of the mobile device and the user context preference is transmitted to another node and responsively returned data is received. Available free space in the mobile device is determined. All data whose timestamp is within a predetermined threshold is cached. The data is cached in at least a portion of the free space.Type: GrantFiled: June 3, 2014Date of Patent: July 12, 2016Assignee: Howard UniversityInventor: Legand L. Burge, III
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Publication number: 20160193237Abstract: Methods and compositions are provided for reducing transmission and/or infection of HIV in a subject by increasing the bioavailability of a drug in the subject. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for reducing the transmission and/or infection of HIV in a subject. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).Type: ApplicationFiled: September 5, 2014Publication date: July 7, 2016Applicant: Howard UniversityInventor: Pradeep K. Karla
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Patent number: 9358211Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alkylene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.Type: GrantFiled: May 30, 2014Date of Patent: June 7, 2016Assignee: Howard UniversityInventors: Emmanuel Oyekanmi Akala, Oluyomi Modupe Okunola
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Publication number: 20160143886Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.Type: ApplicationFiled: January 28, 2016Publication date: May 26, 2016Applicant: Howard UniversityInventors: Harpal S. Mangat, Pradeep K. Karla
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Publication number: 20160113844Abstract: Described herein are compositions and methods which produce hydrolytically stable resin monomers, bioactive fillers, phosphorus coupling agent and surface coating method, which can be combined to produce new generation dental composites; compositions comprising the same, as well as methods of making and using the same are also described.Type: ApplicationFiled: June 6, 2014Publication date: April 28, 2016Applicant: Howard UniversityInventors: Tongxin WANG, Lawrence C. CHOW
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Patent number: 9248118Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.Type: GrantFiled: February 19, 2015Date of Patent: February 2, 2016Assignee: Howard UniversityInventors: Harpal S. Mangat, Pradeep K. Karla