Patents Assigned to Howard University
  • Patent number: 9215045
    Abstract: Signals are transmitted from at least one transmitter that is positioned in an electrical network. The signals that have been transmitted are received a single receiver positioned within the electrical network. At the single receiver, the received signals are analyzed and a determination from the analyzing the received signals is made as to whether a fault has occurred in the electrical network and the approximate location of the fault.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: December 15, 2015
    Assignee: Howard University
    Inventor: Charles J. Kim
  • Patent number: 9149244
    Abstract: A myocardial blood flow analysis scan includes incorporating a pharmacological kinetic model with the standard factor analysis model where each time activity curve is assumed to be a linear combination of factor curves. Pharmacological kinetics based factor analysis of dynamic structures (K-FADS) model can be applied, whereby a means for estimating factor curves in the myocardium that are physiologically meaningful is provided. Additional optional aspects include performing a discretization to transform continuous-time K-FADS model into a discretetime K-FADS model and application of an iterative Voxel-Resolution myocardial blood flow (V-MBF) algorithm. A V-MBF algorithm based on a model that accounts for the fact that the shape of TACs due to ischemic and normal tissue are different can be included.
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: October 6, 2015
    Assignee: Howard University
    Inventor: John M. M. Anderson
  • Publication number: 20150279082
    Abstract: A majorize-minimize (MM) mathematical principle is applied to least squares regularization estimation problems to effect efficient processing of image data sets to provide good quality images. In a ground penetrating radar application, these approaches can reduce processing time and memory use by accounting for a symmetric nature of a given radar pulse, accounting for similar discrete time delays between transmission of a given radar pulse and reception of reflections from the given radar pulse, and accounting for a short duration of the given radar pulse.
    Type: Application
    Filed: February 19, 2014
    Publication date: October 1, 2015
    Applicant: Howard University
    Inventors: John M. M. Anderson, Mandoye Ndoye
  • Patent number: 9101652
    Abstract: A method, apparatus and kit have been discovered which regenerate with the use of odorants the connections of the neurons of the brain and central nervous system in the treatment of such person afflicted neuro-disorders caused by disease or trauma.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: August 11, 2015
    Assignee: Howard University
    Inventor: Evaristus A. Nwulia
  • Publication number: 20150119429
    Abstract: The present invention relates to chelator compounds for chelating metal ions. In particular, the present invention relates to (thio)semicarbazone compounds and (thio)hydrazone compounds, such as PpYeT and PpYaT, which are chelators for metal ions, including iron ions. Therapeutic use of such compounds and/or their metal ion complexes, includes methods for treating and inhibiting HIV-1 replication, particularly in HIV-1 infected cells.
    Type: Application
    Filed: March 14, 2013
    Publication date: April 30, 2015
    Applicant: Howard University
    Inventors: Sergei Nekhai, Dmytro Borisovych Kovalskyy
  • Patent number: 9012490
    Abstract: Compounds having formulas (I) to (VIII), salts thereof, or combinations thereof and pharmaceutical compositions comprising one or more these compounds are described herein for the treatment of HIV and neurodegenerative effects caused by HIV. Also provided herein are methods and a kit for inhibiting HIV-1, treating latent HIV in the brain, and preventing HIV-mediated cognitive decline and HIV dementia comprising administering the compounds having the formulas (I) to (VIII) and pharmaceutical compositions comprising the compounds having these formulas. The compounds having formulas I through VIII are curcumin analogs which are advantageously characterized as having anti-retroviral, neuroprotective, anti-glucosidase, and anti-HIV integrase properties. In one aspect, the pharmaceutical composition is delivered intranasally.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: April 21, 2015
    Assignee: Howard University
    Inventors: Evaristus A. Nwulia, Amol Kulkarni
  • Patent number: 8993512
    Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: March 31, 2015
    Assignee: Howard University
    Inventors: Harpal S. Mangat, Pradeep K. Karla
  • Patent number: 8941387
    Abstract: An electrical waveform is received over an electrical power line. A plurality of nominal electrical parameters are determined for the electrical power network and the plurality of nominal electrical parameters are associated with a state of the electrical power network in the absence of at least one transitory electrical fault in the network. Subsequently, a plurality of electrical parameters of the electrical waveform are sampled when the at least one transitory electrical fault exists in the network. A plurality of inductances are determined based at least in part upon a comparison of the nominal electrical parameters and the plurality of sampled electrical parameters. The plurality of inductances are representative of inductances present in the network when the at least one transitory electrical fault exists in the network. The plurality of inductances are analyzed to determine a distance and/or direction to the at least one electrical fault.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: January 27, 2015
    Assignees: Howard University, San Diego Gas & Electric Company
    Inventor: Charles Kim
  • Patent number: 8921429
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-lactate) that is crosslinked by at least one hydrolysable monmer. Another embodiment of the present invention is a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent. Another embodiment of the present invention is a polymer particle comprising, a crosslinked copolymer comprises structures represented by Formulas (I), (II), and (III), where Formulas (I), (II) and (III) are defined in the specification. Yet other embodiments of the present invention include a method of preparing a methacrylate terminated macromonomer, a method of preparing a crosslinking agent, and a method of preparing a therapeutic agent loaded nanosphere by dispersion polymerization.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: December 30, 2014
    Assignee: Howard University
    Inventors: Emmanuel Akala, Simeon Adesina
  • Patent number: 8897635
    Abstract: A signal is conducted from a controller module onto a network via a first coupling. The signal is transmitted across the network and received at one or more receiver modules via one or more second couplings. At the one or more receiver modules, the received signal is analyzed and based upon the analysis, a determination is made as to whether a fault has occurred in the network and/or where the occurrence occurred.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: November 25, 2014
    Assignee: Howard University
    Inventor: Charles J Kim
  • Publication number: 20140336120
    Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
    Type: Application
    Filed: May 8, 2014
    Publication date: November 13, 2014
    Applicant: Howard University
    Inventors: Harpal S. Mangat, Pradeep K. Karla
  • Publication number: 20140289318
    Abstract: A context of a mobile device is determined. A context preference of a user associated with the mobile device is determined. The context of the mobile device and the user context preference is transmitted to another node and responsively returned data is received. Available free space in the mobile device is determined. All data whose timestamp is within a predetermined threshold is cached. The data is cached in at least a portion of the free space.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 25, 2014
    Applicant: Howard University
    Inventor: Legand L. Burge, III
  • Patent number: 8772355
    Abstract: The present invention is directed to a crosslinked or non-crosslinked polymer particle, wherein the crosslinked polymer particle comprises a copolymer of poly(alklyene glycol-graft-acrylate) that is crosslinked by at least one hydrolysable monomer or crosslinking agent. The present invention is also directed to a polymer particle comprising a crosslinked polymer particle that is a product of starting materials comprising (a) a hydrophilic monomer, (b) a hydrophobic monomer, and (c) a hydrolysable crosslinking agent (the crosslinking agent may be absent in the case of non-crosslinked particles). The present invention is still further directed to a polymer particle comprising a crosslinked copolymer, where the crosslinked copolymer includes structures represented by Formulas (I), (II), and (III), as defined in the specification. Other embodiments of the present invention also include methods of manufacturing polymer particles.
    Type: Grant
    Filed: November 23, 2010
    Date of Patent: July 8, 2014
    Assignee: Howard University
    Inventors: Emmanuel Akala, Oluyomi Okunola
  • Patent number: 8751743
    Abstract: A context of a mobile device is determined. A context preference of a user associated with the mobile device is determined. The context of the mobile device and the user context preference is transmitted to another node and responsively returned data is received. Available free space in the mobile device is determined. All data whose timestamp is within a predetermined threshold is cached. The data is cached in at least a portion of the free space.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: June 10, 2014
    Assignee: Howard University
    Inventor: Legand L. Burge, III
  • Patent number: 8711711
    Abstract: Data associated with at least one building condition or status is sensed by one or more sensors. The data from these sensors may be sent over a data bus and received by the central computer. In addition, a modulated signal may be transmitted by one or both of the transmitters across the data bus. The modulated signal is received at the receiver, which analyzes the received modulated signal, and determines whether an intermittent fault has occurred on the data bus based upon the analyzing. For example, the receiver may compare the received signal to an expected pattern and when a discrepancy exists, an intermittent fault is determined to exist. The receiver may also determine the location of the fault based upon the analysis.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: April 29, 2014
    Assignee: Howard University
    Inventor: Charles J. Kim
  • Patent number: 8525095
    Abstract: A nanothermocouple detector includes a nanowire coupled across two electrodes. The two electrodes are electrically connected to an amplifier. The two electrodes generally have a separation of about five micrometers to about thirty micrometers across which the nanowire is coupled. A focusing element is disposed to admit photons that fall on the focusing element onto the nanowire to heat it. A voltage change across the nanowire caused by the heating of the nanowire by the light is detected by the amplifier. The voltage change corresponds to the energy absorbed from the light by the nanowire. The color of a single photon can be detected using such device. An array of such devices can be used for sensing light on a two-dimensional scale, thereby providing an image showing small variances in the energies of the light impinging upon the detector array.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: September 3, 2013
    Assignee: Howard University
    Inventor: Tito E. Huber
  • Patent number: 8525421
    Abstract: A lighting element is disposed in an array of lighting elements. At the lighting element, a lighting status of at least one neighboring lighting element is sensed. Independent of any other lighting element, a lighting adjustment for the lighting element by applying the sensed lighting status to a predetermined rule is determined. The lighting adjustment is applied to the lighting element to adjust an illumination of the lighting element.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: September 3, 2013
    Assignee: Howard University
    Inventor: Charles J. Kim
  • Patent number: 8278326
    Abstract: Inhibitors of Protein Phosphatase-1 have been shown to slow replication of HIV-1. Inhibitors of PP 1 and their use for treatment or prevention of HIV-1 infections are disclosed.
    Type: Grant
    Filed: April 15, 2009
    Date of Patent: October 2, 2012
    Assignee: Howard University
    Inventors: Sergei Nekhai, Dmytro Borysovich Kovalskyy
  • Patent number: 8244406
    Abstract: The operation of a power distribution network is modeled. At least one quality of the operation of the power distribution network is measured. The future operational performance of the power distribution network is predicted based at least in part upon the modeling. When the at least one measure of the quality of the operation of the power distribution network or the predicted future operational performance do not meet the predetermined performance criteria, corrective action is taken with respect to the power distribution network.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: August 14, 2012
    Assignee: Howard University
    Inventor: James Momoh
  • Patent number: 8154028
    Abstract: An infrared external photoemissive detector can have an n-p heterojunction comprising an n-type semiconductor layer and a p-layer; the n-layer semiconductor comprising doped silicon embedded with nanoparticles forming Schottky barriers; and the p-layer is a p-type diamond film. The nanoparticles can be about 20-30 atomic percentage metal particles (such as silver) having an average particle size of about 5-10 nm. The p-layer can have a surface layer that has a negative electron affinity. The n-layer can be in the range of about 3 ?m to 10 ?m thick, and preferably about 3 ?m thick. The doped silicon can be doped with elements selected from the list consisting of phosphorus and antimony.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: April 10, 2012
    Assignee: Howard University
    Inventor: Clayton W. Bates, Jr.