Patents Assigned to ICAgen
-
Publication number: 20080058376Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.Type: ApplicationFiled: June 15, 2007Publication date: March 6, 2008Applicant: Icagen, Inc.Inventors: Michael Gross, Robert Atkinson, Matthew Johnson
-
Publication number: 20080058319Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.Type: ApplicationFiled: April 26, 2007Publication date: March 6, 2008Applicant: Icagen, Inc.Inventors: Grant McNaughton-Smith, George Amato, James Thomas
-
Publication number: 20080004430Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.Type: ApplicationFiled: October 23, 2006Publication date: January 3, 2008Applicant: Icagen, Inc.Inventors: Christopher Creech, Timothy Jegla
-
Patent number: 7309772Abstract: The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.Type: GrantFiled: February 3, 2006Date of Patent: December 18, 2007Assignee: Icagen, Inc.Inventor: Timothy James Jegla
-
Publication number: 20070197523Abstract: The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.Type: ApplicationFiled: December 20, 2006Publication date: August 23, 2007Applicant: ICAGEN, INC.Inventors: Gregory Pacofsky, Mark Suto, Paul Fritch
-
Publication number: 20070185209Abstract: The use of novel inhibitors of potassium flux is disclosed for the treatment of inflammatory processes, such as multiple sclerosis, insulin-dependent (type I) diabetes mellitus, rheumatoid arthritis, peripheral neuritis and pulmonary hypertension. The compounds are also of use in treating and preventing stroke. These inhibitors have a high specificity for the IK1 channel and greater stability relative to non-fluorine substituted homologues.Type: ApplicationFiled: December 20, 2006Publication date: August 9, 2007Applicant: Icagen, Inc.Inventors: Neil Castle, Gregory Rigdon, Douglas Krafte
-
Publication number: 20070173504Abstract: The present invention provides novel calcium channel antagonists, and methods of treating disease sates using the novel antagonists.Type: ApplicationFiled: December 20, 2006Publication date: July 26, 2007Applicant: ICAGEN, INC.Inventors: Gregory Pacofsky, Mark Suto, Paul Fritch
-
Patent number: 7244744Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.Type: GrantFiled: November 1, 2002Date of Patent: July 17, 2007Assignee: Icagen, Inc.Inventors: Michael F. Gross, Robert N. Atkinson, Matthew S. Johnson
-
Publication number: 20070135493Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.Type: ApplicationFiled: November 2, 2006Publication date: June 14, 2007Applicant: IcagenInventors: Xiaodong Wang, Alan Fulp, Brian Marron, Serge Beaudoin, Darrick Seconi, Mark Suto
-
Publication number: 20070128653Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.Type: ApplicationFiled: January 19, 2007Publication date: June 7, 2007Applicant: ICAGEN, INCORPORATEDInventor: Timothy Jegla
-
Patent number: 7223768Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.Type: GrantFiled: September 10, 2004Date of Patent: May 29, 2007Assignee: Icagen, Inc.Inventors: Grant Andrew McNaughton-Smith, George Salvatore Amato, James Barnwell Thomas, Jr.
-
Patent number: 7223782Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.Type: GrantFiled: November 1, 2002Date of Patent: May 29, 2007Assignee: Icagen, Inc.Inventors: Robert N. Atkinson, Michael F. Gross
-
Patent number: 7205307Abstract: The present invention provides a genus of pyrimidine amides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.Type: GrantFiled: November 27, 2002Date of Patent: April 17, 2007Assignee: Icagen, Inc.Inventors: Grant A. McNaughton-Smith, George S. Amato, Paul C. Fritch
-
Patent number: 7202253Abstract: Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the Kv1 subfamily of voltage gated K+ channels, especially inhibitors Kv1.5 which has been linked to the ultra-rapidly activating delayed rectifier K+ current IKur), methods of using such compounds in the prevention and treatment of arrhythmia and IKur-associated conditions, and pharmaceutical compositions containing such compounds.Type: GrantFiled: November 24, 2004Date of Patent: April 10, 2007Assignees: Bristol-Myers Squibb Company, Icagen, Inc.Inventors: John Lloyd, Yoon T. Jeon, Heather Finlay, Lin Yan, Michael F. Gross, Serge Beaudoin
-
Publication number: 20070078145Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides heterocyclic aryl sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.Type: ApplicationFiled: August 11, 2006Publication date: April 5, 2007Applicant: IcagenInventors: Alan Fulp, Brian Marron, Mark Suto, Xiaodong Wang
-
Publication number: 20070027200Abstract: The present invention provides a genus of bis-benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: September 29, 2006Publication date: February 1, 2007Applicant: ICAGEN, INC.Inventors: Xiaodong Wang, Alan Fulp, Albert van Rhee, Kerry Spear
-
Patent number: 7169893Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.Type: GrantFiled: January 22, 2001Date of Patent: January 30, 2007Assignee: Icagen, IncorporatedInventor: Timothy J. Jegla
-
Publication number: 20070004784Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides sulfonamides, and compositions and methods utilizing sulfonamides that are useful in the treatment of diseases by blocking potassium channels associated with the onset or recurrence of the indicated conditions. Exemplary diseases treatable with the compounds, compositions and methods of the invention include sickle cell disease and glaucoma.Type: ApplicationFiled: September 7, 2006Publication date: January 4, 2007Applicant: Icagen, Inc.Inventors: Grant McNaughton-Smith, Aimee Reed, Robert Atkinson
-
Patent number: 7153668Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.Type: GrantFiled: April 13, 2000Date of Patent: December 26, 2006Assignee: Icagen, IncorporatedInventor: Timothy J. Jegla
-
Publication number: 20060275790Abstract: The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.Type: ApplicationFiled: February 3, 2006Publication date: December 7, 2006Applicant: ICAGEN, INC.Inventor: Timothy Jegla