Abstract: A method for screening compounds for biological activity is disclosed. A test library of compounds is selected. Then, a first analytical model is formed using a first recursive partitioning process. The first recursive partitioning process is performed on at least some of the compounds in the test library of compounds and uses a first descriptor set. Subsequent analytical models are formed using subsequent recursive partitioning processes using the digital computer and use multiple descriptor sets. A consensus compound set is determined using the first analytical model and one or more of the subsequent analytical models.
Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
Abstract: The present invention provides a genus of polycyclic thiazoles that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
Abstract: The present invention provides a genus of polycyclic pyridines that are useful as modulators of potassium ion channels. The modulators of the invention are of use in both therapeutic and diagnostic methods.
Type:
Application
Filed:
April 13, 2005
Publication date:
October 13, 2005
Applicant:
ICAgen, Inc.
Inventors:
Xiaodong Wang, Kerry Spear, Alan Fulp, Darrick Seconi
Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
Abstract: This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux through a calcium-activated potassium channel.
Type:
Application
Filed:
April 27, 2005
Publication date:
September 29, 2005
Applicants:
Oregon Health Sciences University, Icagen, Incorporated
Inventors:
John Adelman, James Maylie, Chris Bond, Christopher Silvia
Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
Type:
Application
Filed:
November 12, 2004
Publication date:
September 29, 2005
Applicant:
Icagen, Inc.
Inventors:
Robert Atkinson, Michael Gross, Albert van Rhee
Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
Type:
Grant
Filed:
August 10, 2001
Date of Patent:
August 23, 2005
Assignee:
ICAgen, Inc.
Inventors:
Christopher D. Creech, Timothy J. Jegla
Abstract: Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.
Type:
Application
Filed:
October 29, 2004
Publication date:
May 26, 2005
Applicant:
Icagen, Inc.
Inventors:
Andrew Miller, Ping Hu, Mark Curran, Marc Rutter, Jian-Yang Wang
Abstract: Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.
Type:
Application
Filed:
October 29, 2004
Publication date:
May 26, 2005
Applicant:
Icagen, Inc.
Inventors:
Andrew Miller, Ping Hu, Mark Curran, Marc Rutter, Wang Jian-Yang
Abstract: The invention provides isolated nucleic acid and amino acid sequences of Slo3, a pH sensitive potassium channel expressed in sperm; antibodies to Slo3; methods of screening for Slo3 inhibitors; and methods of screening for Slo3 homologs.
Type:
Grant
Filed:
March 6, 2000
Date of Patent:
May 24, 2005
Assignees:
Icagen, Incorporated, The Washington University
Inventors:
Lawrence Salkoff, Matthew Schreiber, Chris Silvia
Abstract: This invention relates to small and intermediate conductance, calcium-activated potassium channel proteins. More specifically, the invention relates to compositions and methods for making and detecting calcium-activated potassium channel proteins and the nucleic acids encoding calcium-activated potassium channel proteins. The invention also provides methods and compositions for assaying compounds which increase or decrease potassium ion flux though a calcium-activated potassium channel.
Type:
Grant
Filed:
April 3, 2002
Date of Patent:
May 17, 2005
Assignees:
Oregon Health Sciences University, Icagen, Inc.
Inventors:
John P. Adelman, James Maylie, Chris T. Bond, Christopher P. Silvia
Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions.
Type:
Application
Filed:
September 10, 2004
Publication date:
March 17, 2005
Applicant:
Icagen, Inc.
Inventors:
Grant McNaughton-Smith, George Amato, James Thomas
Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.
Type:
Grant
Filed:
March 19, 2003
Date of Patent:
February 22, 2005
Assignee:
Icagen, Inc.
Inventors:
Aimee Dolores Reed, Michael Francis Gross, Serge Beaudoin
Abstract: Compounds as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
Type:
Grant
Filed:
August 2, 2002
Date of Patent:
February 22, 2005
Assignee:
ICAgen, Inc.
Inventors:
Michael Gross, Serge Beaudoin, Aimee D. Reed
Abstract: The present invention provides a genus of asymmetric benzimidazole compounds, methods and pharmaceutical compositions that are useful as modulators of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.
Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.
Type:
Grant
Filed:
December 7, 2001
Date of Patent:
February 1, 2005
Assignee:
ICAgen
Inventors:
Serge Beaudoin, Aimee D. Reed, Michael F. Gross
Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.
Type:
Grant
Filed:
November 1, 2002
Date of Patent:
December 21, 2004
Assignee:
Icagen, Inc.
Inventors:
Robert N. Atkinson, Michael F. Gross, Albert M. van Rhee