Patents Assigned to ICAgen
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Publication number: 20030211529Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.Type: ApplicationFiled: April 22, 2003Publication date: November 13, 2003Applicant: ICAgen, IncorporatedInventors: Timothy J. Jegla, Yi Liu
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Publication number: 20030181465Abstract: The present invention provides a genus of pyrimidine amides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.Type: ApplicationFiled: November 27, 2002Publication date: September 25, 2003Applicant: Icagen, Inc.Inventors: Grant A. McNaughton-Smith, George S. Amato, Paul C. Fritch
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Publication number: 20030176450Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazolopyrimidines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.Type: ApplicationFiled: November 1, 2002Publication date: September 18, 2003Applicant: Icagen, Inc.Inventors: Robert N. Atkinson, Michael F. Gross, Albert M. van Rhee
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Publication number: 20030171360Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides substituted piperidines, and compositions containing these compounds. Also provided are methods using the compounds of the invention for the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.Type: ApplicationFiled: November 1, 2002Publication date: September 11, 2003Applicant: Icagen, Inc.Inventors: Michael F. Gross, Robert N. Atkinson, Matthew S. Johnson
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Patent number: 6605725Abstract: Benzanilides are provided which are voltage-dependent potassium channel openers. Methods of using the benzanilides of the invention are also provided.Type: GrantFiled: November 2, 2001Date of Patent: August 12, 2003Assignee: ICAgen, Inc.Inventors: Grant A. McNaughton-Smith, Michael F. Gross, Alan D. Wickenden
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Patent number: 6593349Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides bisarylamines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by opening potassium channels associated with the onset or recurrence of the indicated conditions.Type: GrantFiled: March 11, 2002Date of Patent: July 15, 2003Assignee: ICAgen, Inc.Inventors: Grant Andrew McNaughton-Smith, George Salvatore Amato
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Patent number: 6586179Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.Type: GrantFiled: July 10, 2000Date of Patent: July 1, 2003Assignee: ICAgen, IncorporatedInventors: Timothy J. Jegla, Yi Liu
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Publication number: 20030120430Abstract: Methods and compositions for enhancing chemical libraries with biologically active molecules are taught. Relevant physicochemical descriptors that correlate with biological activity are calculated and selected. Database descriptors are identified using the physicochemical descriptors and an electronic database can be formed.Type: ApplicationFiled: December 2, 2002Publication date: June 26, 2003Applicant: ICAgen, Inc.Inventor: Albert Michiel van Rhee
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Patent number: 6566380Abstract: Compounds which are useful as potassium channel inhibitors and which because of their slow off-rates are especially useful for the treatment of cardiac arrhythmias are described.Type: GrantFiled: July 24, 2001Date of Patent: May 20, 2003Assignee: ICAgen, Inc.Inventors: Aimee Dolores Reed, Michael Francis Gross, Serge Beaudoin
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Publication number: 20030077731Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.Type: ApplicationFiled: May 28, 2002Publication date: April 24, 2003Applicant: ICAgen, IncorporatedInventors: Timothy J. Jegla, Alan Wickenden
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Publication number: 20030036648Abstract: Methods for isolating K+Hnov genes are provided. The K+Hnov nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as identification of cell type based on expression, and the like.Type: ApplicationFiled: April 11, 2002Publication date: February 20, 2003Applicant: ICAgen, Inc.Inventors: Andrew P. Miller, Ping Hu, Mark Edward Curran, Marc Rutter, Jian-Yang Wang
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Publication number: 20030017533Abstract: The invention provides isolated nucleic acid and amino acid sequences of Slo2 and Slo4, members of the Slo family of potassium channel proteins, also known as “maxi” or BK potassium channel proteins. Also provided herein are antibodies to Slo2 and Slo 4, methods of detecting Slo2 and Slo 4, methods of screening for potassium channel activators and inhibitors using biologically active Slo2 and Slo 4, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Slo2 and Slo 4.Type: ApplicationFiled: August 1, 2001Publication date: January 23, 2003Applicant: ICAgen, Inc.Inventors: Timothy James Jegla, Julie Dickson Witzel
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Publication number: 20030013706Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.Type: ApplicationFiled: August 2, 2002Publication date: January 16, 2003Applicant: ICAgenInventors: Michael Gross, Serge Beaudoin, Aimee D. Reed
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Publication number: 20020193597Abstract: Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides bisarylamines, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases) and as neuroprotective agents (e.g., to prevent stroke and the like) by opening potassium channels associated with the onset or recurrence of the indicated conditions.Type: ApplicationFiled: March 11, 2002Publication date: December 19, 2002Applicant: ICAgen, Inc.Inventors: Grant Andrew McNaughton-Smith, George Salvatore Amato
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Patent number: 6495550Abstract: The present invention provides a genus of pyridine-substituted benzanilides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and diagnostic methods.Type: GrantFiled: February 2, 2001Date of Patent: December 17, 2002Assignee: ICAgen, Inc.Inventors: Grant McNaughton-Smith, Paul Christopher Fritch, George Salvatore Amato
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Publication number: 20020182691Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.Type: ApplicationFiled: August 10, 2001Publication date: December 5, 2002Applicant: ICAgen, Inc.Inventors: Christopher D. Creech, Timothy J. Jegla
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Publication number: 20020161011Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.Type: ApplicationFiled: December 7, 2001Publication date: October 31, 2002Applicant: ICAgenInventors: Serge Beaudoin, Aimee D. Reed, Michael F. Gross
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Publication number: 20020156586Abstract: A method for screening compounds for biological activity is disclosed. The method may include selecting a test set of compounds and selecting a training set of compounds. An assay is performed on the training set of compounds and training set data are formed. This data are entered into a digital computer, and an analytical model is formed. A subset of compounds is identified using the analytical model.Type: ApplicationFiled: February 15, 2002Publication date: October 24, 2002Applicant: ICAgen, Inc.Inventors: Albert Michiel van Rhee, Kerry L. Spear, P. Kay Wagoner
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Patent number: 6458794Abstract: Compounds useful as potassium channel inhibitors and especially useful for the treatment of cardiac arrhythmias and cell proliferative disorders are described.Type: GrantFiled: December 21, 2000Date of Patent: October 1, 2002Assignee: Icagen, Inc.Inventors: Michael Gross, Serge Beaudoin, Aimee D. Reed
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Patent number: 6432645Abstract: The invention provides isolated nucleic acid and amino acid sequences of BK beta 2, BK beta 3, and BK beta 4, antibodies to the BK beta subunits, methods of detecting the BK beta subunits, methods of screening for modulators of Slo potassium channels comprising BK beta subunits, and kits for screening for activators and inhibitors of the Slo family potassium channels comprising BK beta subunits.Type: GrantFiled: February 22, 2000Date of Patent: August 13, 2002Assignee: ICAgen Inc.Inventors: Timothy J. Jegla, Alan Wickenden, Yi Liu