Patents Assigned to ICOS
  • Patent number: 10398695
    Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.
    Type: Grant
    Filed: May 30, 2018
    Date of Patent: September 3, 2019
    Assignee: ICOS CORPORATION
    Inventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
  • Patent number: 10336756
    Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of preparing such compounds are also disclosed, including the use of (S)-2-(1-aminopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one as a precursor to synthesize an exemplary compound disclosed in this application, (S)-2-(1-((9H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: July 2, 2019
    Assignee: ICOS CORPORATION
    Inventors: Edward A. Kesicki, Kerry W. Fowler, Danwen Huang, Hua Chee Ooi, Amy Oliver, Kamal Deep Puri, Fuqiang Ruan, Jennifer Treiberg
  • Patent number: 10286096
    Abstract: Device for discharging loose products includes a conveyor body attachable with its first end to a treatment machine for the loose products. The conveyor body, in correspondence to its second end, comprises a wall in which a collection aperture is made, selectively openable/closable by means of an opening/closing member to allow the discharge of said loose products. The discharge device for loose products further includes a pneumatic deliverer located in the conveyor body and configured to deliver a stream of gas at least toward the wall and determine the discharge, through the collection aperture, at least of the loose products that are deposited on the wall.
    Type: Grant
    Filed: September 24, 2015
    Date of Patent: May 14, 2019
    Assignee: ICOS PHARMA S.P.A.
    Inventor: Ottorino Casonato
  • Patent number: 10066231
    Abstract: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: September 4, 2018
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard Robert Grahame Clarke
  • Patent number: 10010550
    Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: July 3, 2018
    Assignee: ICOS Corporation
    Inventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
  • Patent number: 9957525
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: May 1, 2018
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • Patent number: 9943405
    Abstract: Advances in filling apparatus, handheld tools, surgical techniques and intraoperative biometry for implanting and adjusting an accommodative liquid lens are disclosed. The lens may be attached to or retained within a handheld surgical tool, which can be fluidly connectable to a filling console to fill the lens with a liquid. In various embodiments, a filling console facilitates aspirating liquid out of the lens in order to ensure the absence of residual bubbles and filling of the lens with fluid during surgery, as well as during post-operative adjustments to the lens. Actuated by the surgeon, the filling console can aspirate fluid from the lens and inject fluid into the lens following insertion thereof.
    Type: Grant
    Filed: May 16, 2012
    Date of Patent: April 17, 2018
    Assignee: ICO, INC.
    Inventors: Sean Caffey, Charles DeBoer, Mark Humayun, Yu-Chong Tai
  • Publication number: 20180052164
    Abstract: The present invention corresponds to the field of cancer and is related to predicting cancer detection, diagnosis, monitoring and prediction of response to treatment, in particular platelet derived-endothelial cell growth factor (PD-ECGF) levels for their use as a potential value in monitoring disease evolution and predicting response to anti-angiogenic treatment.
    Type: Application
    Filed: March 10, 2016
    Publication date: February 22, 2018
    Applicants: FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL), INSTITUT CATALÀ D'ONCOLOGIA (ICO)
    Inventors: Oriol CASANOVAS CASANOVAS, Gabriela JIMÉNEZ VALERIO, María OCHOA DE OLZA, Valentí NAVARRO PÉREZ, Nicklas BASSANI, Helena VERDAGUER
  • Patent number: 9814569
    Abstract: In various embodiments, implants including reservoirs, such as intraocular lenses, feature flexible membranes and valves integrated therewith, the valves having apertures that are normally closed.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: November 14, 2017
    Assignee: ICO, INC.
    Inventors: Wendian Shi, Charles DeBoer, Sean Caffey, Mark S. Humayun, Yu-Chong Tai
  • Publication number: 20170290939
    Abstract: Device for discharging loose products includes a conveyor body attachable with its first end to a treatment machine for the loose products. The conveyor body, in correspondence to its second end, comprises a wall in which a collection aperture is made, selectively openable/closable by means of an opening/closing member to allow the discharge of said loose products. The discharge device for loose products further includes a pneumatic deliverer located in the conveyor body and configured to deliver a stream of gas at least toward the wall and determine the discharge, through the collection aperture, at least of the loose products that are deposited on the wall.
    Type: Application
    Filed: September 24, 2015
    Publication date: October 12, 2017
    Applicant: ICOS PHARMA S.P.A.
    Inventor: Ottorino CASONATO
  • Publication number: 20170260677
    Abstract: Containing device for a treatment machine for loose products, provided internally with a treatment compartment that has at least an open side for loading the loose products to be treated, and for unloading the loose products that have been treated; the containing device comprises at least a first loading door for the loose products to be treated, positioned on a first portion of said open side and associated with at least a respective opening and closing unit, and at least a second unloading door for the loose products that have been treated, positioned on a second portion of said open side and associated with at least a respective opening and closing unit.
    Type: Application
    Filed: March 14, 2017
    Publication date: September 14, 2017
    Applicant: ICOS PHARMA S.P.A.
    Inventors: Ivone Capovilla, Ottorino Casonato, Fabio Zardini
  • Patent number: 9487772
    Abstract: Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation, in which PI3K? plays a role in leukocyte function are disclosed. Preferably, the methods employ active agents that selectively inhibit PI3K?, while not significantly inhibiting activity of other PI3K isoforms. Compounds are provided that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity. Methods of using PI3K? inhibitory compounds to inhibit cancer cell growth or proliferation are also provided. Accordingly, the invention provides methods of using PI3K? inhibitory compounds to inhibit PI3K?-mediated processes in vitro and in vivo.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: November 8, 2016
    Assignee: ICOS CORPORATION
    Inventors: Chanchal Sadhu, Ken Dick, Jennifer Treiberg, C. Gregory Sowell, Edward A. Kesicki, Amy Oliver
  • Patent number: 9297024
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: March 29, 2016
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • Patent number: 9212367
    Abstract: Materials and methods are provided which allowed for increased expression of a transfected gene of interest in a recombinant host cell.
    Type: Grant
    Filed: August 6, 2010
    Date of Patent: December 15, 2015
    Assignee: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke
  • Patent number: 9149477
    Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: October 6, 2015
    Assignee: ICOS Corporation
    Inventors: Edward A. Kesicki, Kerry W. Fowler, Danwen Huang, Hua Chee Ooi, Amy Oliver, Kamal Deep Puri, Fuqiang Ruan, Jennifer Treiberg
  • Publication number: 20150242104
    Abstract: Systems and methods for computer screen recording are described herein. In an embodiment, a web-based application includes a screen recorder, a video transcoder, and a video upload manager. The screen recorder records video tutorials, the video transcoder transcodes the recorded video tutorials, and the upload manager uploads the transcoded video tutorial to a server. The server analyzes the uploaded video tutorial to determine search terms that are relevant to the uploaded video tutorial, and associates the determined search terms with the uploaded video tutorial. The server also receives from users search queries containing search terms, searches for video tutorials related to the search terms, and returns a search query result containing links to the related video tutorials.
    Type: Application
    Filed: February 24, 2015
    Publication date: August 27, 2015
    Applicant: ICOS LLC
    Inventors: Nick Stokman, Sean Higgins
  • Patent number: 8993583
    Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: March 31, 2015
    Assignee: ICOS Corporation
    Inventors: Kerry W. Fowler, Danwen Huang, Edward A. Kesicki, Hua Chee Ooi, Amy Oliver, Fuqiang Ruan, Jennifer Treiberg, Kamal Deep Puri
  • Patent number: 8980901
    Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: March 17, 2015
    Assignee: Icos Corporation
    Inventors: Kerry W. Fowler, Danwen Huang, Edward A. Kesicki, Hua Chee Ooi, Amy Oliver, Fuqiang Ruan, Jennifer Treiberg, Kamal Deep Puri
  • Publication number: 20140378479
    Abstract: Compounds that inhibit PI3K? activity, including compounds that selectively inhibit PI3K? activity, are disclosed. Methods of inhibiting phosphatidylinositol 3-kinase delta isoform (PI3K?) activity, and methods of treating diseases, such as disorders of immunity and inflammation in which PI3K? plays a role in leukocyte function, using the compounds also are disclosed.
    Type: Application
    Filed: May 21, 2014
    Publication date: December 25, 2014
    Applicant: ICOS CORPORATION
    Inventors: Edward A. KESICKI, Kerry W. FOWLER, Danwen HUANG, Hua Chee OOI, Amy OLIVER, Kamal Deep PURI, Fuqiang RUAN, Jennifer TREIBERG
  • Publication number: 20140273208
    Abstract: The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster ovary elongation factor 1-? (CHEF1) transcriptional regulatory DNA elements and a cytomegalovirus (CMV) promoter and/or a human adenovirus tripartite leader (AdTPL) sequence. The invention achieves increased protein expression and better productivity of host cells compared to previously described expression systems.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: CMC ICOS BIOLOGICS, INC.
    Inventor: Howard R. Clarke