Abstract: In a satellie mobile telecommunications system based on the GSM standard, and using a TDMA frame structure, discontinuous transmission (DTX) mode is used to take advantage of the substantial silences which occur during normal speech. In this mode, traffic channel (TCH) data is not sent, but control of the link between a ground station and a user terminal is maintained by sending control channel data bursts (SACCH) together with silence descriptor (SID) frames. To avoid high peak to mean values of transmission power at the satellite, the emission time of the bursts is controlled so as to be uniform over the available sending opportunities. Conventional techniques for doing this cannot be used in a system which includes diversity operation. Therefore, the burst transmission time at the ground station is set in dependence on a reference provided by the user terminal which is a modified version of the reference generated for contention resolution of random access requests.
Abstract: Device for transferring electronic components (2) from a inclined gravity supply track (3) to another element, more particularly a receiving element (6), characterised in that it comprises at least one swing arm (14) fixed to an inclined rotating shaft (13) that is connected to driving means (15) and that is positioned between the supply track (3) and the receiving element (6), whereby the swing arm (14) forms an angle (C) with the rotating shaft (13) and is at least rotatable between a first position, whereby it is situated parallel to and above the supply track (3), and a second position whereby the swing arm (14) is situated above the receiving element (6), said device (1) further comprising suction means to suck up and to hold a concerned component (2) against the swing arm (14).
Abstract: A mobile station (4) in a satellite mobile telephone system predicts when it will move into another cell on the basis of one set of broadcast information thereby reducing the overall processing burden. The mobile station (4) can predict with a useful degree of certainty which broadcast control channel (BCCH) frequencies it should listen on when it wakes up on the basis of a stored map of the relative positions of cells. The broadcast information includes information about the current cell's (40) shape (V1, V2, V3, V4, V5, V6) and translational (T) and rotational (R) motion.
Abstract: Methods to treat secondary injury resulting from spinal cord injury using polypeptide compositions that specifically bind to CD11d are disclosed.
Type:
Application
Filed:
November 8, 2004
Publication date:
April 26, 2007
Applicant:
Icos Corporation
Inventors:
Lynne Weaver, Gregory Dekaban, Mark Oatway
Abstract: A method of treating symptoms of benign prostatic hypertrophy and a method of treating lower urinary tract symptoms, are disclosed. The method includes administering to a mammal about 1 to about 20 milligrams of an agent that inhibits cyclic guanosine 3,5-monophosphate specific phosphodiesterase type 5.
Type:
Application
Filed:
October 10, 2006
Publication date:
April 26, 2007
Applicant:
LILLY ICOS LLC
Inventors:
Bela Denes, Kenneth Ferguson, John Whitaker
Abstract: A method of reusing frequency bands between base stations of a terrestrial mobile communications network and a satellite communications network, comprising allocating the frequency bands using integrated resource management and other mitigation techniques in a such a way as to minimise interference between both the systems, thus making optimum usage of valuable frequency spectrum.
Type:
Application
Filed:
September 21, 2006
Publication date:
April 5, 2007
Applicant:
ICO Services Limited
Inventors:
Paul Regulinski, Govindan Nampoothiri, Patrick Chomet
Abstract: Formulations containing a PDE5 inhibitor, a water-soluble diluent, a lubricant, a hydrophilic binder, a disintegrant, and optional microcrystalline cellulose and/or a wetting agent, and their use in treating sexual dysfunction, are disclosed.
Type:
Grant
Filed:
April 26, 2000
Date of Patent:
February 27, 2007
Assignee:
Lilly Icos LLC.
Inventors:
Peter L. Oren, Neil R. Anderson, Martha A. Kral
Abstract: Compounds that inhibit DNA-dependent protein kinase, compositions comprising the compounds, methods to inhibit the DNA-PK biological activity, methods to sensitize cells the agents that cause DNA lesions, and methods to potentiate cancer treatment are disclosed.
Type:
Grant
Filed:
August 28, 2001
Date of Patent:
February 20, 2007
Assignee:
ICOS Corporation
Inventors:
James Halbrook, Edward A. Kesicki, Laurence E. Burgess, Stephen T. Schlachter, Charles T. Eary, Justin G. Schiro, Hongmei Huang, Michael Evans, Yongxin Han
Abstract: Novel pyrrolidine compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
Type:
Grant
Filed:
November 7, 2005
Date of Patent:
February 13, 2007
Assignee:
ICOS Corporation
Inventors:
Timothy J. Martins, Kerry W. Fowler, Joshua Odingo, Edward A. Kesicki, Amy Oliver, Laurence Edward Burgess, John Joseph Gaudino, Zachary S. Jones, Bradley J. Newhouse, Stephen T. Schlachter
Abstract: A method of reusing frequency bands between base stations of a terrestrial mobile communications network and a satellite communications network, comprising allocating the frequency bands using integrated resource management and other mitigation techniques in a such a way as to minimise interference between both the systems, thus making optimum usage of valuable frequency spectrum.
Type:
Grant
Filed:
May 26, 2005
Date of Patent:
December 26, 2006
Assignee:
ICO Services Limited
Inventors:
Paul Lucian Regulinski, Govindan Vishnu Nampoothiri, Patrick Chomet
Abstract: Methods to inhibit inflammation and macrophage infiltration following spinal cord injury are disclosed along with methods to modulate TNF? release from cells expressing ?d are disclosed.
Abstract: In a satellite mobile telecommunications system based on the GSM standard, and using a TDMA frame structure, discontinuous transmission (DTX) mode is used to take advantage of the substantial silences which occur during normal speech. In this mode, traffic channel (TCH) data is not sent, but control of the link between a ground station and a user terminal is maintained by sending control channel data bursts (SACCH) together with silence descriptor (SID) frames. To avoid high peak to mean values of transmission power at the satellite, the emission time of the bursts is controlled so as to be uniform over the available sending opportunities. Conventional techniques for doing this cannot be used in a system which includes diversity operation. Therefore, the burst transmission time at the ground station is set in dependence on a reference provided by the user terminal which is a modified version of the reference generated for contention resolution of random access requests.
Abstract: Compounds of general structural formula (I) and use of the compounds and salts and solvates thereof, as therapeutic agents as inhibitors of phosphodiesterase 5 cardiovascular disorders
Type:
Grant
Filed:
April 2, 2002
Date of Patent:
October 3, 2006
Assignee:
Lilly Icos LLC
Inventors:
Jason S. Sawyer, Mark W. Orme, James D. Copp
Abstract: The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
Type:
Application
Filed:
December 21, 2005
Publication date:
September 28, 2006
Applicants:
ICOS CORPORATION
Inventors:
Joseph Beavo, Jackie Corbin, Kenneth Ferguson, Sharron Francis, Ann Kadlecek, Kate Loughney, Linda McAllister-Lucas, William Sonnenburg, Melissa Thomas
Abstract: Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.
Type:
Grant
Filed:
April 18, 2003
Date of Patent:
August 8, 2006
Assignee:
ICOS Corporation
Inventors:
Timothy J. Martins, Kerry W. Fowler, Carmen C. Hertel, Amy Oliver
Abstract: Aryl- and heteroaryl-substituted urea compounds useful in the treatment of diseases and conditions related to DNA damage or lesions in DNA replication are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating cancer and other diseases characterized by defects in DNA replication, chromosome segregation, or cell division also are disclosed.
Type:
Grant
Filed:
March 1, 2002
Date of Patent:
June 27, 2006
Assignee:
ICOS Corporation
Inventors:
Kathleen S. Keegan, Edward A. Kesicki, John Joseph Gaudino, Adam Wade Cook, Scott Douglas Cowen, Laurence Edward Burgess
Abstract: The present invention relates to methods for making multimeric proteins comprising fusion of two or more cells expressing a single subunit of the multimeric protein to generate a single hybrid cell expressing the fully assembled multimeric protein.