Abstract: Examples relate to a method for processing beamformed data of a medium. The beamformed data includes a first set of beamformed data associated with a first spatial region and a second set of beamformed data associated with a second spatial region, and the method includes estimating the clutter caused by the second spatial region at the first set.

Abstract: FGFR3-related chondrodysplasias represent a group of rare diseases. Among them, achondroplasia, a nonlethal form of chondrodysplasia, is the most common type of dwarfism. The mutation, which produce an increase of FGFR3 function, affects many tissues, most strikingly the cartilaginous growth plate and bone in the growing skeleton, leading to a variety of manifestations and complications. In attempt to find a new therapeutic approach for FGFR3-related chondrodysplasia, the inventors purified (?)-epicatechin from T. cacao and showed that (?)-epicatechin treatment significantly increases the length of the Fgfr3Y367C/+ femurs comparing to Fgfr3+/+ femurs and improves the whole growth plate cartilage. The present invention thus relates to the use of (?)-epicatechin for the treatment of FGFR3-related chondrodysplasias.

Abstract: According to some aspects, an x-ray apparatus for imaging and/or radiation therapy is provided, the x-ray apparatus comprises an electron source capable of generating electrons, at least one first target arranged to receive electrons from the electron source, the at least one first target comprising material that, in response to being irradiated by the electrons, emits broad spectrum x-ray radiation, at least one second target arranged to receive at least some of the broad spectrum x-ray radiation, the at least one second target comprising material that, in response to irradiation by broad spectrum x-ray radiation from the first target, emits monochromatic x-ray radiation, and at least one detector positioned to detect at least some of the monochromatic x-ray radiation emitted from the at least one second target.

Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r, ?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).

Abstract: A playout system for providing playout of fragmented video content is provided. The system includes a non-transitory data store and a processor. The processor is configured to playout content for video origination using a fragmented format. The processor can receive a playlist and generate a plurality of video fragments from source content. A transcoder can process video fragments based on one or more program scheduling requirements from the playlist to generate new video fragments. A manifest is updated to reference the new video fragments. The process can output a video stream based on the new video fragments.

Abstract: The invention relates to a probe (110, 210, 310, 410, 510) which has a sealed cooling chamber (140, 240, 340, 440, 540) arranged within a casing (112, 212, 312, 412, 512) of the probe. An interface unit (124, 224, 324, 424, 524) of the probe is at least partially arranged within the cooling chamber or in contact with the cooling chamber. The cooling chamber is at least partially filled with a heat transfer liquid (142, 242, 342, 442, 542).

Abstract: Examples of this disclosure include a method for determining a physical characteristic of a medium, the method including processing ultrasound signal data of the medium associated to at least three emitted ultrasound pulses for respectively providing at least three in-phase and quadrature phase data sets, the at least three emitted ultrasound pulses including a first emitted pulse having a first intensity and at least two supplementary emitted pulses having each a second intensity, wherein a sum of the second intensities corresponds to the first intensity, determining the physical characteristic as a function of a first phase lag between the first IQ data set and a sum of the at least two further IQ data sets, or a second phase lag between the at least two further IQ data sets.

Abstract: Friedreich ataxia (FRDA) is caused by a GAA repeat expansion in FXN gene that encodes a mitochondrial protein, frataxin, involved in iron sulfur complex (ISC) assembly. Frataxin deficiency results in abnormal ISC containing proteins, namely respiratory chain complex I-III and aconitases and accumulation of iron in brain and heart of patients. Here, the inventors show that FRDA fibroblasts are unable to limit iron uptake inducing a massive cytosolic iron accumulation and to a lesser extent in mitochondria. The inventors also observed increased transferrin receptor (TfR1) steady state levels and membrane TfR1 accumulation that they ascribed to impaired post-translational modification by palmitoylation as well as delayed transferrin recycling. Finally, the inventors showed that artesunate, dichloroacetate and Coenzyme-A improved TfR1 palmitoylation and thus represent candidate molecules for the treatment of patients with Friedreich ataxia.

Abstract: According to some aspects, a carrier configured for use with a broadband x-ray source comprising an electron source and a primary target arranged to receive electrons from the electron source to produce broadband x-ray radiation in response to electrons impinging on the primary target is provided. The carrier comprising a housing configured to be removeably coupled to the broadband x-ray source and configured to accommodate a secondary target capable of producing monochromatic x-ray radiation in response to incident broadband x-ray radiation, the housing comprising a transmissive portion configured to allow broadband x-ray radiation to be transmitted to the secondary target when present, and a blocking portion configured to absorb broadband x-ray radiation.

Abstract: A geosynthetic sensor that incorporates an arrangement of a first layer of lengths of electrically conductive geosynthetic and a second layer of lengths of electrically conductive geosynthetic where each said length undergoes a change in electrical resistance or capacitance when subject to changes in any one or more of: pressure; strain; water content; or temperature.

Abstract: A novel and advantageous system and method for return mail processing is provided. Particularly, the present disclosure relates to a novel and advantageous system and method for return mail processing and improving data hygiene. More particularly, the present disclosure relates to a novel and advantageous system and method for return mail processing that creates a database of addresses and continually or periodically updates the database using post-return revisions. In further embodiments, the system and method may apply business rules for making the revisions and/or for using addresses from the database. Further, the system and method may generate a scorecard of the addresses in the database that may be used in conjunction with business rules.

Abstract: A method for determining a physical characteristic on a punctual location inside a medium, comprising the steps of: sending an emitted sequence comprising emitted pulses having different amplitudes, receiving a received sequence comprising received pulses corresponding to echoes of emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the bases of a phase difference.

Abstract: The aim of the present description is a system for generating high peak power laser pulses including a light source for emitting initial nanosecond laser pulses, a fiber-based device for conveying laser pulses, including at least one first multimode fiber with a single core, a diffractive optical element and an optical system that generates, from each of said initial laser pulses, a laser pulse, the spatial intensity distribution of which on an input face of said first multimode fiber includes a “top hat” component summed with a speckle pattern. The system further includes a spatial shaping module that transforms a first electric field into a second electric field formed by a sum of N components that are at least partially spatially incoherent with one another, N?2, such that the contrast of said speckle pattern is limited compared to an initial contrast defined without a spatial shaping module.

Abstract: Method and system for ultrasonic characterization of a medium Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, determining a focused reflection matrix RFoc(rin, rout, at) of the medium between an input virtual transducer (Win) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay 6t relative to a time instant of the responses of the input virtual transducer (TVin).

Abstract: The invention relates to a method of evaluating an assumed wave propagation speed in a medium, the medium being associated with spatio-temporal signal data, wherein the method comprises: evaluating (e) the assumed wave propagation speed based on phase properties of the spatio-temporal signal data.

Abstract: Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).

Abstract: The invention relates to an in vitro method to generate T cell progenitors, comprising the step of culturing CD34+ cells in a medium containing TNF-alpha and/or an antagonist of the Aryl hydrocarbon/Dioxin receptor, in particular StemRegenin 1 (SR1), in presence of a Notch ligand and optionally a fibronectin fragment.

Abstract: A flexible pet protective collar having stays formed of a more rigid material than flexible sheets of the collar, the stays being disposed inside channels located at seams of the collar.