Abstract: A method for fluorescence microscopic imaging of an object may be performed by means of a fluorescence microscopic imaging system with light sheet illumination. The method includes generating a line of light and scanning the line of light to generate a light sheet and further includes performing a wavefront analysis on an analysis field of the object. The method further includes applying spatial filtering of the fluorescence light, where the spatial filtering includes scanning a filtering element with respect to a fluorescence image of the line of light formed in a filtering plane of the filtering element. The scanning of the filtering element may be synchronized with the scanning of the line of light such as to obtain a superposition, at each instant, of the filtering element and the fluorescence image of the line of light.

Abstract: This disclosure relates to a method for characterising a target object in a medium. The method comprises: obtaining a reference matrix F(q) associated with the target object, measuring a reflection matrix R associated with the probed medium, and projecting the reflection matrix R onto the reference matrix F(q) to estimate a probability P(q) that the object is in a state q.

Abstract: An ultrasound characterisation method of a medium comprising the steps of generating a series of incident ultrasound waves, measuring a canonical reflection matrix defined between the input emission base and an output reception base, determining a set of responses of the medium obtained from the canonical reflection matrix, at a plurality of frequencies and for several points in a region around a reference point, determination of a frequency correction law from the responses of the medium at the various points, the frequency correction law being adapted to the reference point and being determined at frequencies, determination of the corrected responses of the medium by applying the frequency correction law to the responses of the medium around the reference point and for the plurality of frequencies.

Abstract: A method for analyzing the surface quality of a substrate may include emitting a first light beam incident on a first face of said substrate, receiving a first reflected beam resulting from the reflection of the first beam by the first face and a second reflected beam resulting from a reflection by a second face of the substrate in order to generate at least a first measurement signal characteristic of a combination of the wavefronts of the first and second reflected beams, receiving a transmission beam resulting from transmission of the substrate by a second light beam in order to generate a second measurement signal, and calculating, from the first and second measurement signals, a first signal and a second signal representative of a deformation of the first face and the second face respectively.

Abstract: A medical diagnostic imaging system and method for adjusting image gain compensation when changing from a first imaging state to a second imaging state, where a first image power value is determined from an image acquired in a first imaging state with a first image gain compensation, a second image power value is determined from an image acquired in a second imaging state with an initial second image gain compensation, an image power change value is determined from the first image power value and the second image power value, and an adjusted second image gain compensation calculated from the initial second image gain compensation and the image power change value.

Abstract: A shear wave elastography method for imaging an observation field in an anisotropic medium, including an initial ultrasonic acquisition step during which initial physical parameters are acquired in at least one region of interest; a spatial characterization step during which a set of spatial characteristics of the anisotropic medium is determined on the basis of the initial physical parameter; an excitation substep during which an shear wave is generated inside the anisotropic medium on the basis of the set of spatial characteristics; and an observation substep during which the propagation of the shear wave is observed simultaneously at a multitude of points in the observation field.

Abstract: Examples of this disclosure include a medical imaging system having a control module, a foldable touchscreen with at least a first touchscreen section and a second touchscreen section extending from the first section and being tiltable relative to the first section. The control module has a watertight surface resistant to liquids and configured to be cleanable by disinfectant liquid on the first and second sections, and between the two sections. Other examples include a method for medical imaging that includes displaying a first image generated by the imaging system on the third section of the system, duplicating the first image, displaying the first duplicated image on at least one of the first section and the second section such that a user can at least one of mark an area on the latter and have annotation options, and in response, processing the first image using a predefined algorithm.

Abstract: An ultrasonic method for quantifying the nonlinear shear wave elasticity of a medium, the method comprising the following steps: A1.—collecting a temporal succession of shear wave elasticity data from the medium, A2.—applying, to the medium, a deformation that successively changes according to a predetermined sequence of deformations, during the collection of the shear waves, A3.—observing the actual evolution of deformation, and B.—quantifying the nonlinear elasticity of the medium depending on the temporal succession of data and the evolution of deformation.

Abstract: Examples relate to a method for processing beamformed data of a medium. The beamformed data includes a first set of beamformed data associated with a first spatial region and a second set of beamformed data associated with a second spatial region, and the method includes estimating the clutter caused by the second spatial region at the first set.

Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r,?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).

Abstract: FGFR3-related chondrodysplasias represent a group of rare diseases. Among them, achondroplasia, a nonlethal form of chondrodysplasia, is the most common type of dwarfism. The mutation, which produce an increase of FGFR3 function, affects many tissues, most strikingly the cartilaginous growth plate and bone in the growing skeleton, leading to a variety of manifestations and complications. In attempt to find a new therapeutic approach for FGFR3-related chondrodysplasia, the inventors purified (?)-epicatechin from T. cacao and showed that (?)-epicatechin treatment significantly increases the length of the Fgfr3Y367C/+ femurs comparing to Fgfr3+/+ femurs and improves the whole growth plate cartilage. The present invention thus relates to the use of (?)-epicatechin for the treatment of FGFR3-related chondrodysplasias.

Abstract: Examples of the disclosure relate to a computer-implemented method, the method including quantifying a posterior confidence of an output of a layer of an artificial intelligence (AI) model for a set of input data samples using a mixture model, the AI model being a classifier model, providing an assumed prevalence prior on a class distribution, and calibrating the quantified posterior confidence based on the prevalence prior.

Abstract: An ultrasound imaging system (10) comprising probe (20), a processing unit (30) for processing an image, a display (50) for visualizing the image, and a control panel (40) for configuring and controlling the processing unit. The control panel comprises input control elements (41) and a touch pad (42). The touch pad is a multi-touch device providing multi-touch information of at least two or more touch of user on the touch pad for determining a gesture and an associated system function.

Abstract: A method for measuring a mean visco-elasticity value for a soft material using a single probe carrying at least one transducer includes inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from the constraint zone into the tissue, measuring, with the transducer, transient tissue displacements in at least one first measurement zone in the tissue, the first measurement zone being located away from the constraint zone, and estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from the measured transient tissue displacements of the tissue in the first measurement zone.

Abstract: According to one aspect, the present description relates to a device for analysing a wavefront, configured to be connected to a fluorescence microscopy imaging system with optical sectioning, equipped with a microscope objective comprising a pupil in a pupil plane, the analysis device comprising a two-dimensional detector comprising a detection plane; a two-dimensional arrangement of microlenses, arranged in an analysis plane, each microlens being configured to form, on the detection plane, when the analysis device is connected to the microscopic imaging system, an image of an object situated in a focal plane of the microscope objective, with a given analysis field; an optical relay system configured to optically conjugate the analysis plane and the pupil plane; a field diaphragm positioned in a plane optically conjugated with the plane of detection, and configured to define said analysis field; a processing unit configured to determine, based on the set of images formed by the microlenses, a two-dimensional

Abstract: An ultrasound imaging method for generating a visualization image includes an emission and reception step of interleaved ultrasound waves, a processing step during which the received sequences are processed for generating three images via three different process, an image combining step during which the visualization image is determined by combining the three images for simultaneously visualizing the results of all images process.

Abstract: Method for ultrasonic characterization of a medium, including generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).

Abstract: This invention relates to recombinant lentiviral vectors, compositions thereof, the use of the vectors or the compositions thereof, kits of parts comprising said vectors or compositions thereof and a catalytically active Cas9 or Cpf1 protein, methods for modifying the genome of a hematopoietic stem/progenitor cell (HSPC), and the HSPC obtainable by such methods.

Abstract: A method for estimating an ultrasonic attenuation parameter of a region in a medium includes a transmission step in which at least one pulse is transmitted in the medium by a transducer, and a reception step in which data is acquired by a transducer in response to the pulse. The method includes a processing step in which the data is processed by the processing unit for providing backscattered acquisition data of the region, and a function determination step in which an auto-correlation function of the backscattered acquisition data is determined which is a function of depth in the spatio-temporal domain, the autocorrelation function being determined at a lag of zero. The method includes an attenuation estimation step in which an ultrasonic attenuation parameter is estimated based on said auto-correlation function. The method is implemented by a processing unit associated to at least one ultrasound transducer.

Abstract: A device for analysing a wavefront may be connected to a fluorescence microscopy imaging system with optical sectioning, equipped with a microscope objective including a pupil in a pupil plane, the analysis device including a two-dimensional detector including a detection plane; a two-dimensional arrangement of microlenses, arranged in an analysis plane, each microlens forming, on the detection plane, when the analysis device is connected to the microscopic imaging system, an image of an object situated in a focal plane of the microscope objective, with a given analysis field; an optical relay system optically conjugating the analysis plane and the pupil plane; a field diaphragm positioned in a plane optically conjugated with the plane of detection, and defining said analysis field; a processing unit that determines, based on the set of images formed by the microlenses, a two-dimensional map of a characteristic parameter of the wavefront in said analysis plane.