Patents Assigned to IMAGINE
  • Patent number: 12071635
    Abstract: The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: August 27, 2024
    Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, FONDATION IMAGINE-INSTITUT DES MALADIES GÉNÉTIQUES, UNIVERSITÉCITÉ, INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE (INSERM)
    Inventors: Marina Cavazzana, Isabelle André, Chantal Lagresle-Peyrou, Salima Hacein-Bey-Abina, Christian Reimann, Corinne De Chappedelaine, Emmanuelle Six
  • Patent number: 12059306
    Abstract: An ultrasound imaging system includes an ultrasound probe including transducers, a digital acquisition board including electronic circuits adapted to control the transducers to emit ultrasound waves and to convert signals sensed by transducers into digital data; a real-time sequencer adapted to control the electronic circuits to drive the emission and reception of ultrasound signals, based on working parameters and sequence parameters; and a computer connected to the digital acquisition board and including a computer's memory, the parameters being stored in the computer's memory. The digital acquisition board further includes a DMA controller adapted to access the computer's memory in reading and writing by implementation of DMA protocols, and the sequencer is adapted to send requests to the DMA controller to recover the parameters from the computer's memory in real time.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: August 13, 2024
    Assignee: SUPERSONIC IMAGINE
    Inventors: François Maurice, Frédéric Giral
  • Publication number: 20240264296
    Abstract: Examples relate to a method for processing beamformed data of a medium. The beamformed data includes a first set of beamformed data associated with a first spatial region and a second set of beamformed data associated with a second spatial region, and the method includes estimating the clutter caused by the second spatial region at the first set.
    Type: Application
    Filed: April 2, 2024
    Publication date: August 8, 2024
    Applicant: SUPERSONIC IMAGINE
    Inventors: Christophe FRASCHINI, William LAMBERT
  • Publication number: 20240230536
    Abstract: According to one aspect, the present description relates to a device for analysing a wavefront, configured to be connected to a fluorescence microscopy imaging system with optical sectioning, equipped with a microscope objective comprising a pupil in a pupil plane, the analysis device comprising a two-dimensional detector comprising a detection plane; a two-dimensional arrangement of microlenses, arranged in an analysis plane, each microlens being configured to form, on the detection plane, when the analysis device is connected to the microscopic imaging system, an image of an object situated in a focal plane of the microscope objective, with a given analysis field; an optical relay system configured to optically conjugate the analysis plane and the pupil plane; a field diaphragm positioned in a plane optically conjugated with the plane of detection, and configured to define said analysis field; a processing unit configured to determine, based on the set of images formed by the microlenses, a two-dimensional
    Type: Application
    Filed: March 15, 2024
    Publication date: July 11, 2024
    Applicant: IMAGINE OPTIC
    Inventors: Fabrice Harms, Xavier Levecq
  • Patent number: 11995807
    Abstract: Method for ultrasound determination of a corrected image of a medium, the method comprising: determination of a temporal succession of images (Ik) of the medium, determination of the movement for each image of the medium, determination of a temporal succession of partial strain images (I??k) based on images of the medium, determination of corrected partial strain images (I??k*) by compensation of said partial strain images (I??k) based on preceding movements, and determination of a corrected strain image (I?k*) by summation of the preceding corrected partial strain images (I??k*).
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: May 28, 2024
    Assignee: SUPERSONIC IMAGINE
    Inventor: Mathieu Couade
  • Patent number: 11977189
    Abstract: Examples relate to a method for processing beamformed data of a medium. The beamformed data includes a first set of beamformed data associated with a first spatial region and a second set of beamformed data associated with a second spatial region, and the method includes estimating the clutter caused by the second spatial region at the first set.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: May 7, 2024
    Assignee: SUPERSONIC IMAGINE
    Inventors: Christophe Fraschini, William Lambert
  • Patent number: 11951090
    Abstract: FGFR3-related chondrodysplasias represent a group of rare diseases. Among them, achondroplasia, a nonlethal form of chondrodysplasia, is the most common type of dwarfism. The mutation, which produce an increase of FGFR3 function, affects many tissues, most strikingly the cartilaginous growth plate and bone in the growing skeleton, leading to a variety of manifestations and complications. In attempt to find a new therapeutic approach for FGFR3-related chondrodysplasia, the inventors purified (?)-epicatechin from T. cacao and showed that (?)-epicatechin treatment significantly increases the length of the Fgfr3Y367C/+ femurs comparing to Fgfr3+/+ femurs and improves the whole growth plate cartilage. The present invention thus relates to the use of (?)-epicatechin for the treatment of FGFR3-related chondrodysplasias.
    Type: Grant
    Filed: January 23, 2019
    Date of Patent: April 9, 2024
    Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ DE PARIS, FONDATION IMAGINE, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS, UNIVERSIDAD DE GRANADA
    Inventors: Laurence Legeai-Mallet, Antonio Segura Carretero, Maria De La Luz Cadiz Gurrea
  • Publication number: 20240032889
    Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r, ?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).
    Type: Application
    Filed: July 31, 2020
    Publication date: February 1, 2024
    Applicants: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William LAMBERT, Alexandre AUBRY, Mathias FINK, Laura COBUS
  • Publication number: 20240004064
    Abstract: Examples of this disclosure include a method for determining a physical characteristic of a medium, the method including processing ultrasound signal data of the medium associated to at least three emitted ultrasound pulses for respectively providing at least three in-phase and quadrature phase data sets, the at least three emitted ultrasound pulses including a first emitted pulse having a first intensity and at least two supplementary emitted pulses having each a second intensity, wherein a sum of the second intensities corresponds to the first intensity, determining the physical characteristic as a function of a first phase lag between the first IQ data set and a sum of the at least two further IQ data sets, or a second phase lag between the at least two further IQ data sets.
    Type: Application
    Filed: October 27, 2022
    Publication date: January 4, 2024
    Applicant: SUPERSONIC IMAGINE
    Inventor: William LAMBERT
  • Patent number: 11857532
    Abstract: Friedreich ataxia (FRDA) is caused by a GAA repeat expansion in FXN gene that encodes a mitochondrial protein, frataxin, involved in iron sulfur complex (ISC) assembly. Frataxin deficiency results in abnormal ISC containing proteins, namely respiratory chain complex I-III and aconitases and accumulation of iron in brain and heart of patients. Here, the inventors show that FRDA fibroblasts are unable to limit iron uptake inducing a massive cytosolic iron accumulation and to a lesser extent in mitochondria. The inventors also observed increased transferrin receptor (TfR1) steady state levels and membrane TfR1 accumulation that they ascribed to impaired post-translational modification by palmitoylation as well as delayed transferrin recycling. Finally, the inventors showed that artesunate, dichloroacetate and Coenzyme-A improved TfR1 palmitoylation and thus represent candidate molecules for the treatment of patients with Friedreich ataxia.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: January 2, 2024
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), FONDATION IMAGINE, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
    Inventors: Anne Agnès Rotig, Arnold Munnich, Floriane Petit
  • Patent number: 11828590
    Abstract: A geosynthetic sensor that incorporates an arrangement of a first layer of lengths of electrically conductive geosynthetic and a second layer of lengths of electrically conductive geosynthetic where each said length undergoes a change in electrical resistance or capacitance when subject to changes in any one or more of: pressure; strain; water content; or temperature.
    Type: Grant
    Filed: November 19, 2021
    Date of Patent: November 28, 2023
    Assignee: IMAGINE INTELLIGENT MATERIALS LTD
    Inventor: Phillip Aitchison
  • Patent number: 11786219
    Abstract: A method for determining a physical characteristic on a punctual location inside a medium, comprising the steps of: sending an emitted sequence comprising emitted pulses having different amplitudes, receiving a received sequence comprising received pulses corresponding to echoes of emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the bases of a phase difference.
    Type: Grant
    Filed: May 20, 2021
    Date of Patent: October 17, 2023
    Assignee: SUPERSONIC IMAGINE
    Inventors: Matthew Bruce, Charles Tremblay-Darveau
  • Publication number: 20230314823
    Abstract: The aim of the present description is a system for generating high peak power laser pulses including a light source for emitting initial nanosecond laser pulses, a fiber-based device for conveying laser pulses, including at least one first multimode fiber with a single core, a diffractive optical element and an optical system that generates, from each of said initial laser pulses, a laser pulse, the spatial intensity distribution of which on an input face of said first multimode fiber includes a “top hat” component summed with a speckle pattern. The system further includes a spatial shaping module that transforms a first electric field into a second electric field formed by a sum of N components that are at least partially spatially incoherent with one another, N?2, such that the contrast of said speckle pattern is limited compared to an initial contrast defined without a spatial shaping module.
    Type: Application
    Filed: August 6, 2021
    Publication date: October 5, 2023
    Applicant: IMAGINE OPTIC
    Inventors: Guillaume Gorju, Xavier Levecq, Adam Ayeb, Fahem Boudries
  • Patent number: 11776526
    Abstract: Method and system for ultrasonic characterization of a medium Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, determining a focused reflection matrix RFoc(rin, rout, at) of the medium between an input virtual transducer (Win) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay 6t relative to a time instant of the responses of the input virtual transducer (TVin).
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: October 3, 2023
    Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William Lambert, Thomas Frappart, Alexandre Aubry, Mathias Fink
  • Publication number: 20230304850
    Abstract: The invention relates to a method of evaluating an assumed wave propagation speed in a medium, the medium being associated with spatio-temporal signal data, wherein the method comprises: evaluating (e) the assumed wave propagation speed based on phase properties of the spatio-temporal signal data.
    Type: Application
    Filed: March 10, 2023
    Publication date: September 28, 2023
    Applicant: SUPERSONIC IMAGINE
    Inventor: Bo ZHANG
  • Patent number: 11768181
    Abstract: Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).
    Type: Grant
    Filed: September 13, 2021
    Date of Patent: September 26, 2023
    Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
    Inventors: William Lambert, Alexandre Aubry, Mathias Fink, Thomas Frappart
  • Publication number: 20230263856
    Abstract: The present invention provides a pharmaceutical formulation comprising a therapeutically effective amount of a polypeptide corresponding to SEQ ID No, 2 and uses thereof for treating at least one of diabetes, hyperglycemia, hypercholesterolemia, and hypertension in a subject.
    Type: Application
    Filed: August 22, 2022
    Publication date: August 24, 2023
    Applicant: IMAGINE PHARMA LLC
    Inventors: Ngoc THAI, Jonathan Pollett
  • Patent number: 11735883
    Abstract: The present description relates, according to one aspect, to a high-peak-power laser pulse generation system (10), comprising at least one first light source (101) for emitting first laser pulses (IL), a fiber device (110) for transporting said first laser pulses, comprising at least one first multimode fiber with a single core designed to receive said first laser pulses, and a module (102) for temporally shaping said first laser pulses, arranged upstream of the fiber device, configured so as to reduce the power spectral density of said pulses by reducing the temporal coherence.
    Type: Grant
    Filed: May 31, 2019
    Date of Patent: August 22, 2023
    Assignee: IMAGINE OPTIC
    Inventors: Guillaume Gorju, Adam Ayeb, Xavier Levecq
  • Patent number: D1000615
    Type: Grant
    Filed: January 25, 2023
    Date of Patent: October 3, 2023
    Assignee: SUPERSONIC IMAGINE
    Inventors: Etienne Rousseau, Matthieu Valentin
  • Patent number: D1013180
    Type: Grant
    Filed: September 22, 2021
    Date of Patent: January 30, 2024
    Assignee: SUPERSONIC IMAGINE
    Inventors: Etienne Rousseau, Matthieu Valentin, Jean-Pierre Henry