Patents Assigned to IMAGINE
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Patent number: 12071635Abstract: The invention relates to the field of cell therapy and to an in vitro method for generating T-cell progenitors, comprising the step of exposing CD34+ cells in a medium containing a Notch ligand, a soluble domain of the Delta-like ligand 4, joined to an Fc region of a protein IgG, in the presence of a fragment of fibronectin comprising the motifs RGDS and CS-1 and a heparin-binding domain.Type: GrantFiled: October 5, 2015Date of Patent: August 27, 2024Assignees: ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, FONDATION IMAGINE-INSTITUT DES MALADIES GÉNÉTIQUES, UNIVERSITÉCITÉ, INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE (INSERM)Inventors: Marina Cavazzana, Isabelle André, Chantal Lagresle-Peyrou, Salima Hacein-Bey-Abina, Christian Reimann, Corinne De Chappedelaine, Emmanuelle Six
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Patent number: 12059306Abstract: An ultrasound imaging system includes an ultrasound probe including transducers, a digital acquisition board including electronic circuits adapted to control the transducers to emit ultrasound waves and to convert signals sensed by transducers into digital data; a real-time sequencer adapted to control the electronic circuits to drive the emission and reception of ultrasound signals, based on working parameters and sequence parameters; and a computer connected to the digital acquisition board and including a computer's memory, the parameters being stored in the computer's memory. The digital acquisition board further includes a DMA controller adapted to access the computer's memory in reading and writing by implementation of DMA protocols, and the sequencer is adapted to send requests to the DMA controller to recover the parameters from the computer's memory in real time.Type: GrantFiled: July 10, 2017Date of Patent: August 13, 2024Assignee: SUPERSONIC IMAGINEInventors: François Maurice, Frédéric Giral
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Publication number: 20240264296Abstract: Examples relate to a method for processing beamformed data of a medium. The beamformed data includes a first set of beamformed data associated with a first spatial region and a second set of beamformed data associated with a second spatial region, and the method includes estimating the clutter caused by the second spatial region at the first set.Type: ApplicationFiled: April 2, 2024Publication date: August 8, 2024Applicant: SUPERSONIC IMAGINEInventors: Christophe FRASCHINI, William LAMBERT
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Publication number: 20240230536Abstract: According to one aspect, the present description relates to a device for analysing a wavefront, configured to be connected to a fluorescence microscopy imaging system with optical sectioning, equipped with a microscope objective comprising a pupil in a pupil plane, the analysis device comprising a two-dimensional detector comprising a detection plane; a two-dimensional arrangement of microlenses, arranged in an analysis plane, each microlens being configured to form, on the detection plane, when the analysis device is connected to the microscopic imaging system, an image of an object situated in a focal plane of the microscope objective, with a given analysis field; an optical relay system configured to optically conjugate the analysis plane and the pupil plane; a field diaphragm positioned in a plane optically conjugated with the plane of detection, and configured to define said analysis field; a processing unit configured to determine, based on the set of images formed by the microlenses, a two-dimensionalType: ApplicationFiled: March 15, 2024Publication date: July 11, 2024Applicant: IMAGINE OPTICInventors: Fabrice Harms, Xavier Levecq
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Patent number: 11995807Abstract: Method for ultrasound determination of a corrected image of a medium, the method comprising: determination of a temporal succession of images (Ik) of the medium, determination of the movement for each image of the medium, determination of a temporal succession of partial strain images (I??k) based on images of the medium, determination of corrected partial strain images (I??k*) by compensation of said partial strain images (I??k) based on preceding movements, and determination of a corrected strain image (I?k*) by summation of the preceding corrected partial strain images (I??k*).Type: GrantFiled: May 14, 2020Date of Patent: May 28, 2024Assignee: SUPERSONIC IMAGINEInventor: Mathieu Couade
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Patent number: 11977189Abstract: Examples relate to a method for processing beamformed data of a medium. The beamformed data includes a first set of beamformed data associated with a first spatial region and a second set of beamformed data associated with a second spatial region, and the method includes estimating the clutter caused by the second spatial region at the first set.Type: GrantFiled: December 9, 2022Date of Patent: May 7, 2024Assignee: SUPERSONIC IMAGINEInventors: Christophe Fraschini, William Lambert
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Patent number: 11951090Abstract: FGFR3-related chondrodysplasias represent a group of rare diseases. Among them, achondroplasia, a nonlethal form of chondrodysplasia, is the most common type of dwarfism. The mutation, which produce an increase of FGFR3 function, affects many tissues, most strikingly the cartilaginous growth plate and bone in the growing skeleton, leading to a variety of manifestations and complications. In attempt to find a new therapeutic approach for FGFR3-related chondrodysplasia, the inventors purified (?)-epicatechin from T. cacao and showed that (?)-epicatechin treatment significantly increases the length of the Fgfr3Y367C/+ femurs comparing to Fgfr3+/+ femurs and improves the whole growth plate cartilage. The present invention thus relates to the use of (?)-epicatechin for the treatment of FGFR3-related chondrodysplasias.Type: GrantFiled: January 23, 2019Date of Patent: April 9, 2024Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, UNIVERSITÉ DE PARIS, FONDATION IMAGINE, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS, UNIVERSIDAD DE GRANADAInventors: Laurence Legeai-Mallet, Antonio Segura Carretero, Maria De La Luz Cadiz Gurrea
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Publication number: 20240032889Abstract: Method for non-invasively characterizing a heterogeneous medium using ultrasound, comprising a step of generating a series of incident ultrasonic waves, a step of recording an experimental reflection matrix Rui(t) defined between the input emission basis (i) and an output reception basis (u), a step of determining a response REP(r, ?r) of the medium between an input virtual transducer (TVin) calculated based on an input focusing of the experimental reflection matrix that creates an input focal spot around a first point (P1), and an output virtual transducer (TVout) calculated based on an output focusing of the experimental reflection matrix that creates an output focal spot around a second point (P2), said response being expressed as a function of a central point (PC) of spatial position (r) in the medium located midway between the first and second points (P1, P2).Type: ApplicationFiled: July 31, 2020Publication date: February 1, 2024Applicants: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William LAMBERT, Alexandre AUBRY, Mathias FINK, Laura COBUS
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Publication number: 20240004064Abstract: Examples of this disclosure include a method for determining a physical characteristic of a medium, the method including processing ultrasound signal data of the medium associated to at least three emitted ultrasound pulses for respectively providing at least three in-phase and quadrature phase data sets, the at least three emitted ultrasound pulses including a first emitted pulse having a first intensity and at least two supplementary emitted pulses having each a second intensity, wherein a sum of the second intensities corresponds to the first intensity, determining the physical characteristic as a function of a first phase lag between the first IQ data set and a sum of the at least two further IQ data sets, or a second phase lag between the at least two further IQ data sets.Type: ApplicationFiled: October 27, 2022Publication date: January 4, 2024Applicant: SUPERSONIC IMAGINEInventor: William LAMBERT
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Patent number: 11857532Abstract: Friedreich ataxia (FRDA) is caused by a GAA repeat expansion in FXN gene that encodes a mitochondrial protein, frataxin, involved in iron sulfur complex (ISC) assembly. Frataxin deficiency results in abnormal ISC containing proteins, namely respiratory chain complex I-III and aconitases and accumulation of iron in brain and heart of patients. Here, the inventors show that FRDA fibroblasts are unable to limit iron uptake inducing a massive cytosolic iron accumulation and to a lesser extent in mitochondria. The inventors also observed increased transferrin receptor (TfR1) steady state levels and membrane TfR1 accumulation that they ascribed to impaired post-translational modification by palmitoylation as well as delayed transferrin recycling. Finally, the inventors showed that artesunate, dichloroacetate and Coenzyme-A improved TfR1 palmitoylation and thus represent candidate molecules for the treatment of patients with Friedreich ataxia.Type: GrantFiled: December 27, 2019Date of Patent: January 2, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), FONDATION IMAGINE, ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)Inventors: Anne Agnès Rotig, Arnold Munnich, Floriane Petit
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Patent number: 11828590Abstract: A geosynthetic sensor that incorporates an arrangement of a first layer of lengths of electrically conductive geosynthetic and a second layer of lengths of electrically conductive geosynthetic where each said length undergoes a change in electrical resistance or capacitance when subject to changes in any one or more of: pressure; strain; water content; or temperature.Type: GrantFiled: November 19, 2021Date of Patent: November 28, 2023Assignee: IMAGINE INTELLIGENT MATERIALS LTDInventor: Phillip Aitchison
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Patent number: 11786219Abstract: A method for determining a physical characteristic on a punctual location inside a medium, comprising the steps of: sending an emitted sequence comprising emitted pulses having different amplitudes, receiving a received sequence comprising received pulses corresponding to echoes of emitted pulses, calculating a phase difference between the received pulses relative to the emitted pulses, and determining the physical characteristic on the bases of a phase difference.Type: GrantFiled: May 20, 2021Date of Patent: October 17, 2023Assignee: SUPERSONIC IMAGINEInventors: Matthew Bruce, Charles Tremblay-Darveau
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Publication number: 20230314823Abstract: The aim of the present description is a system for generating high peak power laser pulses including a light source for emitting initial nanosecond laser pulses, a fiber-based device for conveying laser pulses, including at least one first multimode fiber with a single core, a diffractive optical element and an optical system that generates, from each of said initial laser pulses, a laser pulse, the spatial intensity distribution of which on an input face of said first multimode fiber includes a “top hat” component summed with a speckle pattern. The system further includes a spatial shaping module that transforms a first electric field into a second electric field formed by a sum of N components that are at least partially spatially incoherent with one another, N?2, such that the contrast of said speckle pattern is limited compared to an initial contrast defined without a spatial shaping module.Type: ApplicationFiled: August 6, 2021Publication date: October 5, 2023Applicant: IMAGINE OPTICInventors: Guillaume Gorju, Xavier Levecq, Adam Ayeb, Fahem Boudries
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Patent number: 11776526Abstract: Method and system for ultrasonic characterization of a medium Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, determining a focused reflection matrix RFoc(rin, rout, at) of the medium between an input virtual transducer (Win) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay 6t relative to a time instant of the responses of the input virtual transducer (TVin).Type: GrantFiled: September 13, 2021Date of Patent: October 3, 2023Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William Lambert, Thomas Frappart, Alexandre Aubry, Mathias Fink
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Publication number: 20230304850Abstract: The invention relates to a method of evaluating an assumed wave propagation speed in a medium, the medium being associated with spatio-temporal signal data, wherein the method comprises: evaluating (e) the assumed wave propagation speed based on phase properties of the spatio-temporal signal data.Type: ApplicationFiled: March 10, 2023Publication date: September 28, 2023Applicant: SUPERSONIC IMAGINEInventor: Bo ZHANG
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Patent number: 11768181Abstract: Method for ultrasonic characterization of a medium, comprising generating a series of incident ultrasonic waves, generating an experimental reflection matrix Rui(t) defined between the emission basis (i) as input and a reception basis (u) as output, and determining a focused reflection matrix RFoc(rin, rout, ?t) of the medium between an input virtual transducer (TVin) calculated based on a focusing as input to the experimental reflection matrix and an output virtual transducer (TVout) calculated based on a focusing as output from the experimental reflection matrix, the responses of the output virtual transducer (TVout) being obtained at a time instant that is shifted by an additional delay ?t relative to a time instant of the responses of the input virtual transducer (TVin).Type: GrantFiled: September 13, 2021Date of Patent: September 26, 2023Assignees: SUPERSONIC IMAGINE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de ParisInventors: William Lambert, Alexandre Aubry, Mathias Fink, Thomas Frappart
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Publication number: 20230263856Abstract: The present invention provides a pharmaceutical formulation comprising a therapeutically effective amount of a polypeptide corresponding to SEQ ID No, 2 and uses thereof for treating at least one of diabetes, hyperglycemia, hypercholesterolemia, and hypertension in a subject.Type: ApplicationFiled: August 22, 2022Publication date: August 24, 2023Applicant: IMAGINE PHARMA LLCInventors: Ngoc THAI, Jonathan Pollett
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Patent number: 11735883Abstract: The present description relates, according to one aspect, to a high-peak-power laser pulse generation system (10), comprising at least one first light source (101) for emitting first laser pulses (IL), a fiber device (110) for transporting said first laser pulses, comprising at least one first multimode fiber with a single core designed to receive said first laser pulses, and a module (102) for temporally shaping said first laser pulses, arranged upstream of the fiber device, configured so as to reduce the power spectral density of said pulses by reducing the temporal coherence.Type: GrantFiled: May 31, 2019Date of Patent: August 22, 2023Assignee: IMAGINE OPTICInventors: Guillaume Gorju, Adam Ayeb, Xavier Levecq
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Patent number: D1000615Type: GrantFiled: January 25, 2023Date of Patent: October 3, 2023Assignee: SUPERSONIC IMAGINEInventors: Etienne Rousseau, Matthieu Valentin
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Patent number: D1013180Type: GrantFiled: September 22, 2021Date of Patent: January 30, 2024Assignee: SUPERSONIC IMAGINEInventors: Etienne Rousseau, Matthieu Valentin, Jean-Pierre Henry