Abstract: An implant system for implantation at a joint, the implant system including an implant device, the implant device comprising a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion, the implant system further comprising a corresponding fixation device for securing the first elongate member to a subject, the fixation device comprising at least one latching element, the first elongate member comprising at least one cooperating element, the at least one cooperating element being capable of cooperating with said at least one latching element of the fixation device in use.

Abstract: An implant system for implantation at a joint, the implant system including an implant device, the implant device comprising a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion, the first elongate member being insertable in a bone tunnel in a subject's tibia.

Abstract: The method relates to a method of forming an Al-alloy sheet component. The method comprises heating an Al-alloy sheet blank to its Solution Heat Treatment temperature at a heating station and, in the case of alloys not in a pre age hardened temper, maintaining the SHT temperature until Solution Heat Treatment is complete. The sheet blank is then transferred to a set of cold dies and forming is initiated within 10 s of removal from the heating station so that heat loss from the sheet blank is minimised. The cold dies are closed to form the sheet blank into a shaped component, said forming occurring in less than 0.15 s, and the formed component is held in the closed dies during cooling of the formed component. The claimed method will find application for any Aluminium alloy with a microstructure and mechanical properties that can be usefully modified by solution treatment and age-hardening.

Abstract: A method of detecting active TB in the presence of a complicating factor, for example, latent TB and/or co-morbidities, such as those that present similar symptoms to TB. The disclosure also relates to a minimal gene signature employed in the said method and to a bespoke gene chip for use in the method. The disclosure further relates to use of gene chips and primer sets in the methods of the disclosure and kits comprising the elements required for performing the method. The disclosure also relates to use of the method to provide a composite expression score which can be used in the diagnosis of TB, particularly in a low resource setting.

Abstract: A method of identifying a subject having a bacterial infection, which includes discriminating said subject from a subject having a viral infection or an inflammatory disease. Also provided is a gene signature employed in the method and to a bespoke gene chip for use in the method. Further provided are probes and/or primers specific to genes in a signature of the present disclosure.

Abstract: An implant system for implantation at a joint, the implant system including an implant device, the implant device comprising a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion, the implant system further comprising a corresponding fixation device for securing the first elongate member to a subject, the fixation device comprising at least one latching element, the first elongate member comprising at least one cooperating element, the at least one cooperating element being capable of cooperating with said at least one latching element of the fixation device in use.

Abstract: A fluid flow modification apparatus has a plurality of flow modification elements each having a first surface portion against which a fluid (F) can flow and a second surface portion along which the fluid (F) can flow. The elements are arranged in a number of sets. A first set of elements comprises a plurality of fluid flow modification elements with a first surface portion. A second set of elements comprises a plurality of fluid flow modification elements with a first surface portion having a surface area different from that of the first set. The first set of elements includes first and second types of fluid flow modification elements. The depth of the second surface portion is different from the depth of the second surface portion.

Abstract: An implant system for implantation at a joint, the implant system including an implant device which includes a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion. The implant system also includes a corresponding fixation device for securing the first elongate member to a subject, and the fixation device includes at least one latching element, the first elongate member includes at least one cooperating element, the at least one cooperating element being capable of cooperating with the at least one latching element of the fixation device in use.

Abstract: Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means 51, 61 arranged to locate at least one reference surface 4 of the bone and guide means 53, 54 arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.

Abstract: The present disclosure an in vitro method of assaying the stimulation of a cytokine storm response comprising the steps of: a. co-culturing PBMCs and matched differentiated endothelial cells to provide a system representative of human responses in vivo, and b. exposing the co-cultured cell system to a test agent, c. analyzing the system for the presence of one or more cytokines released after exposing the co-culture system to said test agent, and d. optionally evaluating the response to the test agent in comparison to a response to one or more control agents.

Abstract: Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means 51, 61 arranged to locate at least one reference surface 4 of the bone and guide means 53, 54 arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.

Abstract: The present invention relates to a method for treating a lignocellulose biomass in order to dissolve the lignin therein, while the cellulose does not dissolve. The cellulose pulp obtained can be used to produce glucose. In addition the lignin can be isolated for subsequent use in the renewable chemical industry as a source for aromatic platform chemicals.

Abstract: The present disclosure relates to a method of treating pain, in particular neuropathic pain, comprising administering a therapeutically effective amount of an inhibitor of VGF activity resulting from binding of VGF or a peptide of the type TLQP-21 to the receptor qC1qR. The disclosure also relates to and methods of screening for said inhibitors.

Abstract: A method of locating an acetabular cup implant (100) in a pelvis comprises locating a plurality of reference points on the pelvis, defining a target location of the implant relative to the reference points, and placing the implant at the target location. A method of locating a femoral head implant (102) is also disclosed, together with associated guidance systems.

Abstract: A turbine is provided with a turbine rotor blade, and a turbine housing having a scroll part extending along a circumferential direction of the turbine rotor blade. The scroll part is configured such that an A/R ratio of a flow passage area A to a distance R between an axis of the turbine rotor blade and a flow passage center of the scroll part has a concave distribution at least in a part of a graph where an abscissa represents a circumferential position around the axis of the turbine rotor blade and an ordinate represents the A/R ratio.

Abstract: An estimator training method and a pose estimating method using a depth image are disclosed, in which the estimator training method may train an estimator configured to estimate a pose of an object, based on an association between synthetic data and real data, and the pose estimating method may estimate the pose of the object using the trained estimator.

Abstract: A method and an apparatus for use in a multiuser radio communication system for transmitting and receiving a signal in a Multiple Input and Multiple Output (MIMO) broadcast channel with an imperfect Channel State Information at the Transmitter (CSIT) are provided. The signal transmission/reception method includes receiving CSI from each of a plurality of receivers, determining a transmit power and a transmission rate based on the CSI qualities of the plurality of receivers calculated from the CSI from each of the plurality of receivers, and transmitting the signal using the transmit power and the transmission rate. The present disclosure is capable of maximizing system throughput in wireless communication system.

Abstract: An implant system for implantation at a joint, the implant system including an implant device, the implant device comprising a body portion having first and second ends, and a first elongate member, extending from the first or second end of the body portion, the implant system further comprising a corresponding fixation device for securing the first elongate member to a subject, the fixation device comprising at least one latching element, the first elongate member comprising at least one cooperating element, the at least one cooperating element being capable of cooperating with said at least one latching element of the fixation device in use.

Abstract: Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means 51, 61 arranged to locate at least one reference surface 4 of the bone and guide means 53, 54 arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.

Abstract: A liquid chromatography device comprises one or more liquid reservoirs (3) for a liquid medium, a sample reservoir for a sample to be analyzed and a chromatography column (4) in fluid communication with the liquid reservoir (3) and the sample reservoir (5). The device further comprises a gas reservoir (1) for containing a volume of gas under pressure to force liquid from the liquid reservoir (3) through the chromatography column (4), in use.