Abstract: Compositions and methods for the development and use of a vaccine that includes one or more FusM antigens in a carrier adapted to trigger a FusM-specific immune response in the human blood stream are disclosed herein.

Abstract: An estimator training method and a pose estimating method using a depth image are disclosed, in which the estimator training method may train an estimator configured to estimate a pose of an object, based on an association between synthetic data and real data, and the pose estimating method may estimate the pose of the object using the trained estimator.

Abstract: An implant system for implantation at a joint, the implant system including an implant device (10), the implant device comprising a body portion (20) having first (15) and second (16) ends, and a first elongate member (40), extending from the first or second end of the body portion, the implant system further comprising a corresponding fixation device (70) for securing the first elongate member to a subject, the fixation device comprising at least one latching element, the first elongate member comprising at least one cooperating element, the at least one cooperating element being capable of cooperating with said at least one latching element of the fixation device in use.

Abstract: The present invention concerns nanoparticle formulations suitable for the delivery of one or more therapeutic agents, the formulations comprising: a cationic cholesterol derivative; a neutral phospholipid; cholesterol or a neutral cholesterol derivative; and a saturated fatty acid, PEGylated neutral derivative of phosphatidylethanolamine or phosphatidylcholine.

Abstract: A liquid chromatography device comprises one or more liquid reservoirs for a liquid medium, a sample reservoir for a sample to be analysed and a chromatography column in fluid communication with the liquid reservoir and the sample reservoir. The device comprises a monitoring mechanism for monitoring the number of times a sample is released from the sample reservoir into the chromatography column.

Abstract: A device for use in facilitating alignment of an acetabular component relative to the pelvis of a subject, the device having a device body and at least a first locator for placement on a first predetermined mounting location on the acetabular rim of a subject, the device defining an orientation and/or position with respect to said subject when installed for facilitating alignment of an acetabular component.

Abstract: An actuatable joint is disclosed having a transmission member, for example a ring gear, associated with a member of a joint and rotatable about a longitudinal axis through the member. In particular a two degree of freedom actuatable joint is disclosed comprising tendon driven joint arrangements having a transmission member disposed around or inside a body of the joint arrangement, to provide transmission of a force from a driving means to two tendons actuating a rotational degree of freedom of the joint arrangement. Further disclosed is a segmented device, for example an endoscope, comprising a plurality of such joints, for example to define a flexible and steerable conduit for an instrument.

Abstract: The present disclosure relates to a method of treating pain, in particular neuropathic pain, comprising administering a therapeutically effective amount of an inhibitor of VGF activity resulting from binding of VGF or a peptide of the type TLQP-21 to the receptor qC1qR. The disclosure also relates to and methods of screening for said inhibitors.

Abstract: In some embodiments, the inventions described herein relate to a composition of matter comprising a molecule having the structure: wherein: independently at each occurrence, R1 is a halogen, a alkyl group, a heteroalkyl group, an aryl group, or a heteroaryl group; R2 comprises from 3 to 30 CH2— groups, n=0-5, m=0-5, q=1-3, and R2 comprises at least one ether linkage.

Abstract: An implant system for implantation at a joint, the implant system including an implant device (10), the implant device comprising a body portion (20) having first (15) and second (16) ends, and a first elongate member (40), extending from the first or second end of the body portion, the implant system further comprising a corresponding fixation device (70) for securing the first elongate member to a subject, the fixation device comprising at least one latching element, the first elongate member comprising at least one cooperating element, the at least one cooperating element being capable of cooperating with said at least one latching element of the fixation device in use.

Abstract: A fluid flow modification apparatus (10) has a surface (15), the surface having an edge (65) of length Y over or past which a fluid can flow in use. The edge (65) has a virtual boundary (30) of length X where Y is greater than X. At least a first portion of the apparatus (10) within the virtual boundary (30) comprises an opening (55) and at least a second portion of the apparatus (10) comprises a projection (60) which extends beyond the virtual boundary (30) to provide the edge (65). The edge (65) is multi-scale.

Abstract: The present invention relates to a method for treating a lignocellulose biomass in order to dissolve the lignin therein, while the cellulose does not dissolve. The cellulose pulp obtained can be used to produce glucose. In addition the lignin can be isolated for subsequent use in the renewable chemical industry as a source for aromatic platform chemicals.

Abstract: Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means 51, 61 arranged to locate at least one reference surface 4 of the bone and guide means 53, 54 arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.

Abstract: A liquid chromatography device comprises one or more liquid reservoirs (3) for a liquid medium, a sample reservoir for a sample to be analysed and a chromatography column (4) in fluid communication with the liquid reservoir (3) and the sample reservoir (5). The device further comprises a gas reservoir (1) for containing a volume of gas under pressure to force liquid from the liquid reservoir (3) through the chromatography column (4), in use.

Abstract: A method for dispersing carbon nanotubes, wherein the nanotubes are contacted with an electronic liquid wherein the ratio to metal atoms in the electronic liquid to carbon atoms in the carbon nanotubes is controlled and a solution of carbon nanotubes obtainable by such a method is described.

Abstract: A fluid flow modification apparatus ( 10 ) has a surface ( 15 ), the surface having an edge ( 65 ) of length Y over or past which a fluid can flow in use. The edge ( 65 ) has a virtual boundary ( 30 ) of length X where Y is greater than X. At least a first portion of the apparatus ( 10 ) within the virtual boundary ( 30 ) comprises an opening ( 55 ) and at least a second portion of the apparatus ( 10 ) comprises a projection ( 60 ) which extends beyond the virtual boundary ( 30 ) to provide the edge ( 65 ). The edge ( 65 ) is multi-scale.

Abstract: Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means (51, 61) arranged to locate at least one reference surface (4) of the bone and guide means (53, 54) arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.

Abstract: There is provided a compound of formula (I) wherein R1a, R2a, R3, X1 to X6, a, b and c have meanings given in the description, which compounds are useful as, or are useful as prodrugs of, inhibitors of HDAC enzyme activity, and thus, in particular, in the treatment of conditions where inhibition of HDAC enzyme activity is required.

Abstract: A method of locating an acetabular cup implant (100) in a pelvis comprises locating a plurality of reference points on the pelvis, defining a target location of the implant relative to the reference points, and placing the implant at the target location. A method of locating a femoral head implant (102) is also disclosed, together with associated guidance systems.

Abstract: A method for dispersing nanotubes, comprising contacting the nanotubes with an electronic liquid comprising a metal and an amine solvent, a solution of dispersed nanotuhes, comprising individual nanotuhes at a concentration of greater than about 0.01 mgml?1 and a solvent and a nanotube crystal comprising a close packed array of nanotubes, wherein the crystal has a thickness of 100 nm or more are described.