Patents Assigned to Incept
  • Patent number: 10441745
    Abstract: A neurovascular catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible tubular body, having a proximal end, a distal end and a side wall defining a central lumen. A distal zone of the tubular body includes a tubular inner liner, a tie layer separated from the lumen by the inner liner, a helical coil surrounding the tie layer, an outer jacket surrounding the helical coil, and an opening at the distal end. Adjacent windings of the helical coil are spaced progressively further apart in the distal direction. The opening at the distal end of the tubular body is enlargeable from a first inside diameter for transluminal navigation to a second, larger inside diameter to facilitate aspiration of thrombus into the lumen.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: October 15, 2019
    Assignee: INCEPT, LLC
    Inventors: Yi Yang, Farhad Khosravi, Lisa M. Young
  • Patent number: 10420724
    Abstract: Drug delivery using bio-affecting drugs, particularly with shape changing drug delivery devices. Embodiments are included for depots for delivery of a therapeutic agent that change from an elongated state ex vivo to a coil in vivo where the agent is released.
    Type: Grant
    Filed: November 23, 2016
    Date of Patent: September 24, 2019
    Assignee: Incept, LLC
    Inventors: Peter Jarrett, Michael J. McGrath, Timothy S. Jarrett, Rami El-Hayek, Andrew C. Vanslette, Courtney A. Rosales, Charles D. Blizzard, Amarpreet S. Sawhney
  • Patent number: 10321924
    Abstract: An apparatus and method for capturing material within a body lumen are disclosed. The apparatus includes a core wire extending from a proximal end to a distal tip, an actuator member defining a lumen for receiving at least a portion of the core wire, and a distal basket having a distal enclosed end fixed relative to the core wire and one or more elements extending from a proximal open end to a collar slidable on the core wire. The collar is slidable on the core wire within an interior of the distal basket such that, when the collar contacts the actuator member, the collar applies an inward force to direct the proximal open end of the distal basket radially inwardly.
    Type: Grant
    Filed: November 13, 2016
    Date of Patent: June 18, 2019
    Assignee: INCEPT, LLC
    Inventors: Jeffrey A. Krolik, Gwendolyn Watanabe, James H. Dreher
  • Patent number: 10272164
    Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: April 30, 2019
    Assignee: Incept, LLC
    Inventors: Patrick Campbell, Amarpreet S. Sawhney
  • Patent number: 10251954
    Abstract: Some aspects of this disclosure relate to a method of treating an ophthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel for controlled release of a therapeutic agent.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: April 9, 2019
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, William H. Ransone, II
  • Publication number: 20190021759
    Abstract: An apparatus and method are provided for accessing and/or removing material from a body lumen. The apparatus includes a tubular sheath including a shaft having a proximal end and an expandable distal end that is expandable between a collapsed configuration and an expanded, tapered configuration. A treatment member can be introduced into the body lumen through the tubular sheath. The treatment member includes one or more expandable members to interact with the material to be removed from the body lumen.
    Type: Application
    Filed: September 26, 2018
    Publication date: January 24, 2019
    Applicant: Incept, Inc.
    Inventors: Jeffrey A. KROLIK, James H. DREHER, Gwendolyn A. WATANABE
  • Patent number: 10183145
    Abstract: A catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible body, having a proximal end, a distal end and a side wall defining a central lumen. A distal zone of the side wall includes a tubular inner liner, a tie layer separated from the lumen by the inner liner, a helical coil surrounding the tie layer, adjacent windings of the coil spaced progressively further apart in the distal direction. An outer jacket surrounds the helical coil. The outer jacket is formed from a plurality of tubular segments positioned end to end, coaxially about the coil. The flexural load profile of the catheter as a function of catheter length is configured to provide enhanced distal flexibility while maintaining high backup support.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: January 22, 2019
    Assignee: Incept, LLC
    Inventors: Yi Yang, Fred Khosravi, Lisa M. Young
  • Patent number: 10183146
    Abstract: A method of making a high flexibility distal zone on a neurovascular catheter is provided. The method includes the steps of dip coating a removable mandrel to form a tubular inner layer on the mandrel, coating the tubular inner layer with a soft tie layer, applying a helical coil to the outside of the tie layer, positioning a plurality of tubular segments on the helical coil, heating the tubular segments to form the high flexibility distal zone on the neurovascular catheter; and removing the mandrel. The plurality of segments have durometers that decrease in a distal direction. The flexural load profile of the catheter as a function of catheter length is configured to provide enhanced distal flexibility while maintaining high backup support.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 22, 2019
    Assignee: Incept, LLC
    Inventors: Yi Yang, Fred Khosravi, Lisa M. Young
  • Patent number: 10183147
    Abstract: A neurovascular catheter extension segment is provided, such as for distal neurovascular access or aspiration. The neurovascular catheter extension segment includes 1) an elongate flexible control wire having a proximal end and a distal end and 2) a tubular extension segment having a side wall defining a central lumen carried by the distal end of the control wire. The side wall of the tubular extension segment includes a tubular inner liner, a tie layer separated from the lumen by the inner liner, a helical coil surrounding the tie layer, and an outer jacket surrounding the helical coil. The extension segment may be introduced into the proximal end of a neurovascular catheter and advanced distally to extend beyond the catheter and thereby extend the reach of the catheter.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 22, 2019
    Assignee: Incept, LLC
    Inventors: Yi Yang, Fred Khosravi, Lisa M. Young
  • Patent number: 10179224
    Abstract: An enhanced flexibility neurovascular catheter is provided, such as for distal neurovascular access or aspiration. The catheter includes an elongate flexible body, having a proximal end, a distal end and a side wall defining a central lumen. A distal zone of the side wall includes an outer jacket surrounding a helical coil, and the outer jacket is formed from a plurality of tubular segments positioned coaxially about the coil. A proximal one of the tubular segments has a durometer of at least about 60D, and a distal one of the tubular segments has a durometer of no more than about 35D. An axially extending filament within the side wall extends at least about the most distal 10 cm of the length of the catheter. The axially extending filament serves as a tension support and resists elongation of the catheter wall under tension, such as when the catheter is being proximally retracted through tortuous vasculature.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: January 15, 2019
    Assignee: Incept, LLC
    Inventors: Yi Yang, Fred Khosravi, Lisa M. Young
  • Patent number: 10092429
    Abstract: Flared stents are disclosed, and apparatus and methods for delivering such stents into a bifurcation between a main vessel and a branch vessel. The stent includes a first tubular portion a second flaring portion that may be flared radially outwardly to contact the ostium. The stent may include variable mechanical properties along its length. The stent may be delivered using a catheter including proximal and distal ends, the stent overlying first and second balloons on the distal end. During use, the catheter is advanced through an ostium into the branch to place the stent within the branch. The first balloon is expanded to flare the stent to contact a wall of the ostium, thereby causing the stent to migrate partially into the ostium. The second balloon is expanded to fully expand the stent within the ostium and branch.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: October 9, 2018
    Assignee: INCEPT, LLC
    Inventors: Jeffrey A. Krolik, Eliot Kim, James Howard Dreher
  • Patent number: 10085765
    Abstract: An apparatus and method are provided for accessing and/or removing material from a body lumen. The apparatus includes a tubular sheath including a shaft having a proximal end and an expandable distal end that is expandable between a collapsed configuration and an expanded, tapered configuration. A treatment member can be introduced into the body lumen through the tubular sheath. The treatment member includes one or more expandable members to interact with the material to be removed from the body lumen.
    Type: Grant
    Filed: September 8, 2015
    Date of Patent: October 2, 2018
    Assignee: Incept, Inc.
    Inventors: Jeffrey A. Krolik, James H. Dreher, Gwendolyn A. Watanabe
  • Publication number: 20180193026
    Abstract: Disclosed are coating compositions, processes, and designs for endowing vascular devices with thromboresistant and endothelializing properties. Also disclosed are designs of vascular devices used as aneurysm treating devices for assisting in the delivery, packing, and maintenance of embolization coils within an aneurysm, particularly a neurovascular aneurysm.
    Type: Application
    Filed: January 4, 2018
    Publication date: July 12, 2018
    Applicant: Incept, LLC
    Inventors: Yi Yang, Tiffany C. Suekama, Syed Hossainy, Viet Ton, Fred Khosravi, Alex Jared Rowson, Benjamin Robert Palone, Henry Lao
  • Patent number: 9775906
    Abstract: Some aspects of this disclosure relate to a method of treating an opthalmic disease affecting an eye of a patient comprising forming a covalently-crosslinked hydrogel in situ at a peri-ocular, intra-ocular, or intra-vitreal site for controlled release of a therapeutic agent.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: October 3, 2017
    Assignee: Incept LLC
    Inventors: Amarpreet S. Sawhney, William H. Ransone, II
  • Patent number: 9687216
    Abstract: Apparatus and methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least one of first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: June 27, 2017
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, Farhad Khosravi, Suresh S. Pai
  • Patent number: 9675457
    Abstract: Methods and devices are disclosed for treating neurovascular venous outflow obstructions, with or without implantation of a prosthetic valve. The valve may be carried by a support, such as a stent, which may be self-expandable or balloon expandable. Both transvascular and direct surgical access is contemplated.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: June 13, 2017
    Assignee: Incept, LLC
    Inventors: Fred Khosravi, Gerard von Hoffmann
  • Patent number: 9669117
    Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: June 6, 2017
    Assignee: Incept, LLC
    Inventors: Patrick Campbell, Amarpreet S. Sawhney
  • Patent number: 9498557
    Abstract: Some aspects of this disclosure relate to a method for forming a biomaterial in situ comprising: combining a solution of a crosslinker in a water soluble organic solvent with a precursor to covalently crosslink the precursor to form a crosslinked gel, with the crosslinker comprising a plurality of first functional groups and the precursor comprising a plurality of second functional groups, with the first functional groups chemically reacting with the second functional groups in situ to form covalent bonds and thereby form the crosslinked gel.
    Type: Grant
    Filed: August 24, 2009
    Date of Patent: November 22, 2016
    Assignee: Incept, LLC
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, James H. Dreher
  • Patent number: 9492263
    Abstract: An apparatus for capturing material within a body lumen includes a shaft carrying an expandable basket device on a distal end thereof. The basket device includes a distal basket carried and a proximal basket carried on the shaft such that the proximal basket is proximal to and spaced apart from the distal basket. Each basket includes an open end communicating with an interior of the respective basket and oriented towards one another. In one embodiment, a tubular middle portion extends between the baskets. In another embodiment, the distal basket includes an actuator coupled to the distal basket open end such that movement of the baskets towards one another causes the actuator to direct the distal basket open end inwardly to allow the open end to be received within the proximal basket to facilitate removal of the apparatus after capturing material within the baskets.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: November 15, 2016
    Assignee: Incept, LLC
    Inventors: Jeffrey A. Krolik, James H. Dreher, Gwendolyn Watanabe
  • Patent number: 9463004
    Abstract: Embodiments include coatings for adherence of biomaterials to a tissue. Systems and methods for adapting such coated materials to vascular access closure are further proved.
    Type: Grant
    Filed: May 4, 2010
    Date of Patent: October 11, 2016
    Assignee: Incept, LLC.
    Inventors: Patrick Campbell, Amarpreet S. Sawhney