Patents Assigned to Incept
  • INTRAORAL DEVICE WITH SLIT
    Publication number: 20140212840
    Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.
    Type: Application
    Filed: March 27, 2014
    Publication date: July 31, 2014
    Applicant: Incept, Inc.
    Inventors: Thien Nguyen, Tam Thanh Pham
  • INTRAORAL DENTAL SUCTION AND ISOLATION SYSTEM
    Publication number: 20140162209
    Abstract: A dental mouthpiece is provided that may be attached to a high-suction dental adapter for the purpose of assisting the dental staff during dental procedures through chair-side, hands-free suction, and isolation. Such a mouthpiece may comprise a main body portion, a cheek retractor portion, and a suction connector portion. In some embodiments, the main body portion, cheek retractor portion, and suction connector portion (and sub-portions thereof) may be molded in one piece, preferably by injection molding. In an exemplary embodiment, the mouthpiece may be made of a material that is flexible, translucent, conducive to injection molding, high heat-resistant, and autoclavable. Such a material may include silicone. Because the mouthpiece may be made of a high heat-resistant and autoclavable material, such a mouthpiece may be reusable.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 12, 2014
    Applicant: Incept Incorporated
    Inventors: Thien Nguyen, Tam Thanh Pham
  • Steep-taper flared stents and apparatus and methods for delivering them
    Patent number: 8702777
    Abstract: A stent includes a first flaring portion including first and second sets of cells that flare outwardly when the stent is expanded from a contracted to a flared condition, and a second main portion connected to the first flaring portion. During use, the stent is introduced into a main vessel in the contracted condition and positioned with the first portion adjacent an ostium. The first portion is flared, causing first struts of the first set of cells to move from an axial towards a radial and partial circumferential orientation and causing second struts of the second set of cells to move from an axial towards a radial orientation. The second portion resists expansion when the first portion is flared. The stent is expanded further such that the second portion expands within the branch body lumen, and the first and second struts move towards a more circumferential orientation.
    Type: Grant
    Filed: August 22, 2006
    Date of Patent: April 22, 2014
    Assignee: Incept, LLC
    Inventors: Jeffrey A. Krolik, Eliot Kim, James H. Dreher, Farhad Khosravi
  • VASCULAR DEVICE FOR EMBOLI, THROMBUS AND FOREIGN BODY REMOVAL AND METHODS OF USE
    Publication number: 20140100598
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
    Type: Application
    Filed: December 16, 2013
    Publication date: April 10, 2014
    Applicant: Incept LLC
    Inventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
  • IMPLANTS AND BIODEGRADABLE FIDUCIAL MARKERS
    Publication number: 20140056816
    Abstract: Implantable materials may be used in an iatrogenic site. Applications include radioopaque materials for fiducial marking. Applications include a method of treating a patient with a pharmaceutically acceptable implant system comprising implanting a collection of pharmaceutically acceptable, covalently-crosslinked hydrogel particles, wherein the collection comprises a plurality of sets of the particles, with the sets having different rates of biodegradation.
    Type: Application
    Filed: January 25, 2013
    Publication date: February 27, 2014
    Applicant: INCEPT, LLC
    Inventors: Patrick Campbell, Amarpreet S. Sawhney
  • METHODS OF USING IN SITU HYDRATION OF HYDROGEL ARTICLES FOR SEALING OR AUGMENTATION OF TISSUE OR VESSELS
    Publication number: 20140052168
    Abstract: Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
    Type: Application
    Filed: October 29, 2013
    Publication date: February 20, 2014
    Applicant: Incept, LLC
    Inventor: Amarpreet S. Sawhney
  • Vascular device for emboli, thrombus and foreign body removal and methods of use
    Patent number: 8617201
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
    Type: Grant
    Filed: May 24, 2012
    Date of Patent: December 31, 2013
    Assignee: Incept LLC
    Inventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
  • Vascular filter having articulation region and methods of use in the ascending aorta
    Patent number: 8562639
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel such as the ascending aorta, wherein a vascular device comprises a support hoop having an articulation region connected near a distal end of an elongated member, a blood permeable sac affixed to the support hoop so that the support hoop forms a mouth of the blood permeable sac, a guide wire, and a delivery sheath. The articulation region comprises a reduced thickness region of the support hoop that prevents kinks from forming in the support hoop when the apparatus is contracted to its delivery state, and curved regions that close the mouth of the sac to prevent material escaping from the sac when the apparatus is collapsed for removal.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: October 22, 2013
    Assignee: Incept, LLC
    Inventors: Farhad Khosravi, Leo N. Hopkins, Amr Salahieh, Jackson F. Demond, Jeff A. Krolik
  • Drug delivery through hydrogel plugs
    Patent number: 8563027
    Abstract: An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
    Type: Grant
    Filed: February 26, 2013
    Date of Patent: October 22, 2013
    Assignee: Incept, LLC
    Inventors: Peter Jarrett, Michael Bassett, Charles D. Blizzard, Amarpreet S. Sawhney
  • Methods for preparation of platelet rich plasma
    Patent number: 8557535
    Abstract: A method of preparing a fibrinogen rich composition is disclosed. One embodiment of the method involves contacting plasma with a hydrogel capable of increasing in mass upon contact with said plasma; maintaining said contact for a period of time sufficient for said hydrogel to absorb a substantial amount of at least the water from said plasma to produce a swollen hydrogel and a fibrinogen rich phase; and separating said fibrinogen rich phase from said swollen hydrogel; whereby said fibrinogen rich composition is produced.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: October 15, 2013
    Assignee: Incept LLC
    Inventor: Chandrashekhar P. Pathak
  • METHODS FOR SEALING A VASCULAR PUNCTURE
    Publication number: 20130267996
    Abstract: Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture.
    Type: Application
    Filed: May 29, 2013
    Publication date: October 10, 2013
    Applicant: INCEPT, LLC
    Inventors: Amarpreet S. Sawhney, Farhad Khosravi, Suresh S. Pai
  • Biocompatible polymers and hydrogels and methods of use
    Patent number: 8535705
    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: September 17, 2013
    Assignee: Incept, LLC
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
  • VASCULAR DEVICE FOR EMBOLI, THROMBUS AND FOREIGN BODY REMOVAL AND METHODS OF USE
    Publication number: 20130238009
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
    Type: Application
    Filed: August 12, 2008
    Publication date: September 12, 2013
    Applicant: INCEPT LLC
    Inventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
  • Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
    Patent number: 8512749
    Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
    Type: Grant
    Filed: March 5, 2004
    Date of Patent: August 20, 2013
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, Peter G. Edelman, Steven L. Bennett
  • Vascular device for emboli and thrombi removal and methods of use
    Patent number: 8486105
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device disposed on a guidewire comprises a support hoop disposed from a suspension strut. Alternately, a support hoop having an articulation region may be directly connected to a region proximate the distal end of the guidewire. A blood permeable sac is affixed to the support hoop to form a mouth of the blood permeable sac. The support hoop is disposed obliquely relative to the longitudinal axis of the guidewire and is capable of being properly used in a wide range of vessel diameters. The vascular device collapses during removal to prevent material from escaping from the sac. A delivery sheath and introducer sheath for use with the vascular device of the present invention are also provided.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: July 16, 2013
    Assignee: Incept LLC
    Inventors: Jackson F. Demond, Farhad Khosravi, Jeff A. Krolik, Stephen Ramee, Richard J. Renati, Amr Salahieh, Kirk Hsueh-Kai Young
  • DRUG DELIVERY THROUGH HYDROGEL PLUGS
    Publication number: 20130172268
    Abstract: An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
    Type: Application
    Filed: February 26, 2013
    Publication date: July 4, 2013
    Applicant: INCEPT, LLC
    Inventor: Incept, LLC
  • MEDICAL ORGANOGEL PROCESSES AND COMPOSITIONS
    Publication number: 20130156752
    Abstract: Serial-solvent biomaterials are described. Embodiments include materials made in an organic solvent that are stripped of the solvent and used in a patient, where they imbibe water and form a hydrogel. These materials are useful for, among other things, delivering therapeutic agents, tissue augmentation, and radiological marking.
    Type: Application
    Filed: December 5, 2012
    Publication date: June 20, 2013
    Applicant: INCEPT, LLC
    Inventor: INCEPT, LLC
  • Systems and methods for vascular filter retrieval
    Patent number: 8460336
    Abstract: Apparatus and methods for retrieving a vascular filter from a vessel are provided wherein a retrieval adapter is delivered to a treatment site concurrently along with an interventional device to reduce the number of steps required to remove the vascular filter. The retrieval adapter also reduces the possibility of entangling the vascular filter with a stent disposed within the vessel during removal of the vascular filter. A separate retrieval catheter is also described for use in conjunction with the retrieval adapter.
    Type: Grant
    Filed: August 17, 2011
    Date of Patent: June 11, 2013
    Assignee: Incept LLC
    Inventors: Jeff A. Krolik, Amr Salahieh, Jackson F. Demond, Farhad Khosravi
  • Drug delivery through hydrogel plugs
    Patent number: 8409606
    Abstract: An embodiment is a medical prosthesis for blocking or reducing tear flow through a punctum or canaliculus of a human eye and delivering a drug to the eye that comprises a dehydrated covalently crosslinked synthetic hydrophilic polymer hydrogel with dimensions to pass through a puncta lacrimali, with the dehydrated hydrogel absorbing physiological water to swell to at least 1 mm in cross-sectional width and conformably fit a canaliculus, with the hydrogel comprising a therapeutic agent dispersed through the hydrogel for release to an eye, with the hydrogel having a water content of at least about 50% by weight or volume when allowed to fully hydrate in vitro in physiological saline.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: April 2, 2013
    Assignee: Incept, LLC
    Inventors: Amarpreet S. Sawhney, Peter Jarrett, Michael Bassett, Charles Blizzard
  • Radioopaque covalently crosslinked hydrogel particle implants
    Patent number: 8383161
    Abstract: A pharmaceutically acceptable implant system comprising a collection of pharmaceutically acceptable, covalently-crosslinked hydrogel particles having a radioopaque agent covalently attached to a plurality of the particles in the collection, with the radioopaque agent being present in the collection at a concentration of at least about 0.1% w/w. The implantable materials may be used, for instance, in an iatrogenic site and for fiducial marking.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: February 26, 2013
    Assignee: Incept, LLC
    Inventors: Patrick Campbell, Amarpreet S. Sawhney