Patents Assigned to Incept
  • Publication number: 20080300621
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
    Type: Application
    Filed: August 12, 2008
    Publication date: December 4, 2008
    Applicant: INCEPT LLC
    Inventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
  • Patent number: 7413752
    Abstract: Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
    Type: Grant
    Filed: August 12, 2003
    Date of Patent: August 19, 2008
    Assignee: Incept LLC
    Inventor: Amarpreet S. Sawhney
  • Patent number: 7410491
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: August 12, 2008
    Assignee: Incept LLC
    Inventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
  • Patent number: 7347850
    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use with minimally invasive surgery applicators are disclosed. The disclosure includes compositions and methods for in situ formation of hydrogels using minimally invasive surgical techniques.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: March 25, 2008
    Assignee: Incept LLC
    Inventor: Amarpreet S. Sawhney
  • Publication number: 20080058860
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device disposed on a guidewire comprises a support hoop disposed from a suspension strut. Alternately, a support hoop having an articulation region may be directly connected to a region proximate the distal end of the guidewire. A blood permeable sac is affixed to the support hoop to form a mouth of the blood permeable sac. The support hoop is disposed obliquely relative to the longitudinal axis of the guidewire and is capable of being properly used in a wide range of vessel diameters. The vascular device collapses during removal to prevent material from escaping from the sac. A delivery sheath and introducer sheath for use with the vascular device of the present invention are also provided.
    Type: Application
    Filed: November 7, 2007
    Publication date: March 6, 2008
    Applicant: INCEPT LLC
    Inventors: Jackson Demond, Farhad Khosravi, Jeff Krolik, Stephen Ramee, Richard Renati, Amr Salahieh, Kirk Young
  • Patent number: 7332566
    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
    Type: Grant
    Filed: December 2, 2005
    Date of Patent: February 19, 2008
    Assignee: Incept LLC
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
  • Patent number: 7306618
    Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device disposed on a guidewire comprises a support hoop disposed from a suspension strut. Alternately, a support hoop having an articulation region may be directly connected to a region proximate the distal end of the guidewire. A blood permeable sac is affixed to the support hoop to form a mouth of the blood permeable sac. The support hoop is disposed obliquely relative to the longitudinal axis of the guidewire and is capable of being properly used in a wide range of vessel diameters. The vascular device collapses during removal to prevent material from escaping from the sac. A delivery sheath and introducer sheath for use with the vascular device of the present invention are also provided.
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: December 11, 2007
    Assignee: Incept LLC
    Inventors: Jackson F. Demond, Farhad Khosravi, Jeff A. Krolik, Stephen Ramee, Richard J. Renati, Amr Salahieh, Kirk Hsueh-kai Young
  • Patent number: 7220270
    Abstract: Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.
    Type: Grant
    Filed: January 13, 2004
    Date of Patent: May 22, 2007
    Assignee: Incept LLC
    Inventors: Amarpreet S. Sawhney, John Spiridigliozzi
  • Patent number: 7211651
    Abstract: Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be flanked at each end with a biodegradable component which is flanked at each end with a protein reactive functional component. A polymeric crosslinking agent is disclosed having a biodegradable component, polyalkylene oxide, and at least three reactive functional groups that are each capable of forming a covalent bond in water with at least one functional group such as an amine, thiol, or carboxylic acid.
    Type: Grant
    Filed: November 13, 2002
    Date of Patent: May 1, 2007
    Assignee: Incept LLC
    Inventor: Chandrashekhar P. Pathak
  • Patent number: 7057019
    Abstract: Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments include a cross-linking agent having a polyalkylene oxide member. Other embodiments include a system for administering an albumin material, the system having albumin and a crosslinking agent that reacts with the albumin to form a crosslinked material made of crosslinked albumin. Another embodiment is a method of making a biocompatible material that includes a step of mixing albumin with an n-functional crosslinking agent wherein n is at least 3.
    Type: Grant
    Filed: February 11, 2003
    Date of Patent: June 6, 2006
    Assignee: Incept LLC
    Inventor: Chandrashekhar P. Pathak
  • Patent number: 7025990
    Abstract: Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-neutrophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.
    Type: Grant
    Filed: October 8, 2002
    Date of Patent: April 11, 2006
    Assignee: Incept LLC
    Inventor: Amarpreet S. Sawhney
  • Patent number: 7009034
    Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.
    Type: Grant
    Filed: November 9, 2001
    Date of Patent: March 7, 2006
    Assignee: Incept, LLC
    Inventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
  • Patent number: 6887974
    Abstract: Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be flanked at each end with a biodegradable component which is flanked at each end with a protein reactive functional component. A polymeric crosslinking agent is disclosed having a biodegradable component, polyalkylene oxide, and at least three reactive functional groups that are each capable of forming a covalent bond in water with at least one functional group such as an amine, thiol, or carboxylic acid.
    Type: Grant
    Filed: February 5, 2002
    Date of Patent: May 3, 2005
    Assignee: Incept LLC
    Inventor: Chandrashekhar P. Pathak
  • Patent number: 6887257
    Abstract: Vascular embolic filtering systems, as well as methods for using the same, are provided. In general, the subject invention includes a system comprised of an embolic filter assembly and a multiple lumen delivery and retrieval sheath, where the embolic filter assembly includes a guide wire with an embolic filter operatively coupled to the distal end of the guide wire for capturing emboli created during interventional procedures within a target vessel. Features of the subject invention provide for the rapid exchange and deployment of embolic filters in a patient's vasculature.
    Type: Grant
    Filed: October 19, 2001
    Date of Patent: May 3, 2005
    Assignee: Incept LLC
    Inventors: Amr Salahieh, Jackson Demond, Jeff Krolik
  • Patent number: 6818018
    Abstract: Compositions and methods for forming hydrogels in situ through a combination of physical and chemical crosslinking processes are provided in which physical crosslinking is mediated by one or more natural or synthetic components that stabilize the a hydrogel-forming precursor solutions at a deposition site for a period of time sufficient for more resilient chemical crosslinks to form. Methods of using such hydrogels as tissue coatings to prevent postsurgical adhesion formation, as tissue augmentation or luminal occlusion aids, as matrices for carrying cells, drugs or other bioactive species, as tissue sealants or adhesives, and as medical device coatings also are provided.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: November 16, 2004
    Assignee: Incept LLC
    Inventor: Amarpreet S. Sawhney
  • Publication number: 20040191277
    Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other usefull medical and surgical purposes.
    Type: Application
    Filed: March 5, 2004
    Publication date: September 30, 2004
    Applicant: Incept LLC
    Inventors: Amarpreet S. Sawhney, Peter G. Edelman, Steven L. Bennett
  • Publication number: 20040082968
    Abstract: Apparatus and methods for retrieving a vascular filter from a vessel are provided wherein a retrieval adapter is delivered to a treatment site concurrently along with an interventional device to reduce the number of steps required to remove the vascular filter. The retrieval adapter also reduces the possibility of entangling the vascular filter with a stent disposed within the vessel during removal of the vascular filter. A separate retrieval catheter is also described for use in conjunction with the retrieval adapter.
    Type: Application
    Filed: October 14, 2003
    Publication date: April 29, 2004
    Applicant: INCEPT LLC
    Inventors: Jeff A. Krolik, Amr Salahieh, Jackson F. Demond, Farhad Khosravi
  • Patent number: 6703047
    Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: March 9, 2004
    Assignee: Incept LLC
    Inventors: Amarpreet S. Sawhney, Peter G. Edelman
  • Publication number: 20040044359
    Abstract: An embolic protection filter delivery and/or retrieval assembly. In one embodiment the assembly includes a shaft having a filter coupled thereto, a sheath, and a tapering member.
    Type: Application
    Filed: September 4, 2002
    Publication date: March 4, 2004
    Applicant: INCEPT LLC
    Inventors: Richard J. Renati, Jackson F. Demond, Jeff A. Krolik
  • Publication number: 20040033264
    Abstract: Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
    Type: Application
    Filed: August 12, 2003
    Publication date: February 19, 2004
    Applicant: Incept LLC
    Inventor: Amarpreet S. Sawhney