Patents Assigned to Incept
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Publication number: 20080300621Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.Type: ApplicationFiled: August 12, 2008Publication date: December 4, 2008Applicant: INCEPT LLCInventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
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Patent number: 7413752Abstract: Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.Type: GrantFiled: August 12, 2003Date of Patent: August 19, 2008Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 7410491Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device comprises one or more support hoops connected near a distal end of a guide wire, each support hoop having an articulation region, and a blood permeable sac affixed to the support hoop or hoops to form a mouth of the blood permeable sac. The mouth of the sac closes when the apparatus is collapsed for removal to prevent material from escaping from the sac.Type: GrantFiled: November 22, 2002Date of Patent: August 12, 2008Assignee: Incept LLCInventors: Leo N. Hopkins, Farhad Khosravi, Amr Salahieh, Jackson F. Demond, Jonah Lepak, Stephen Ramee, Jeff A. Krolik, Richard Renati
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Patent number: 7347850Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use with minimally invasive surgery applicators are disclosed. The disclosure includes compositions and methods for in situ formation of hydrogels using minimally invasive surgical techniques.Type: GrantFiled: December 13, 2002Date of Patent: March 25, 2008Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Publication number: 20080058860Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device disposed on a guidewire comprises a support hoop disposed from a suspension strut. Alternately, a support hoop having an articulation region may be directly connected to a region proximate the distal end of the guidewire. A blood permeable sac is affixed to the support hoop to form a mouth of the blood permeable sac. The support hoop is disposed obliquely relative to the longitudinal axis of the guidewire and is capable of being properly used in a wide range of vessel diameters. The vascular device collapses during removal to prevent material from escaping from the sac. A delivery sheath and introducer sheath for use with the vascular device of the present invention are also provided.Type: ApplicationFiled: November 7, 2007Publication date: March 6, 2008Applicant: INCEPT LLCInventors: Jackson Demond, Farhad Khosravi, Jeff Krolik, Stephen Ramee, Richard Renati, Amr Salahieh, Kirk Young
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Patent number: 7332566Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.Type: GrantFiled: December 2, 2005Date of Patent: February 19, 2008Assignee: Incept LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Patent number: 7306618Abstract: Apparatus and methods are provided for use in filtering emboli from a vessel and/or performing thrombectomy and embolectomy, wherein a vascular device disposed on a guidewire comprises a support hoop disposed from a suspension strut. Alternately, a support hoop having an articulation region may be directly connected to a region proximate the distal end of the guidewire. A blood permeable sac is affixed to the support hoop to form a mouth of the blood permeable sac. The support hoop is disposed obliquely relative to the longitudinal axis of the guidewire and is capable of being properly used in a wide range of vessel diameters. The vascular device collapses during removal to prevent material from escaping from the sac. A delivery sheath and introducer sheath for use with the vascular device of the present invention are also provided.Type: GrantFiled: March 21, 2002Date of Patent: December 11, 2007Assignee: Incept LLCInventors: Jackson F. Demond, Farhad Khosravi, Jeff A. Krolik, Stephen Ramee, Richard J. Renati, Amr Salahieh, Kirk Hsueh-kai Young
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Patent number: 7220270Abstract: Methods and apparatus of forming hydrogel systems in situ are provided using a delivery system configured to deliver two or more fluent prepolymer solutions without premature crosslinking. The delivery system comprises separate first and second lumens coupling first and second inlet ports and first and second outlet ports, respectively, and may include a balloon, flexible distal region, mixing chamber or steerable distal end. Multi-component hydrogel systems suitable for use with the inventive methods and apparatus are also described.Type: GrantFiled: January 13, 2004Date of Patent: May 22, 2007Assignee: Incept LLCInventors: Amarpreet S. Sawhney, John Spiridigliozzi
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Patent number: 7211651Abstract: Proteinaceous gels having visualization agents and methods of use thereof are disclosed herein. Further, polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be flanked at each end with a biodegradable component which is flanked at each end with a protein reactive functional component. A polymeric crosslinking agent is disclosed having a biodegradable component, polyalkylene oxide, and at least three reactive functional groups that are each capable of forming a covalent bond in water with at least one functional group such as an amine, thiol, or carboxylic acid.Type: GrantFiled: November 13, 2002Date of Patent: May 1, 2007Assignee: Incept LLCInventor: Chandrashekhar P. Pathak
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Patent number: 7057019Abstract: Materials, methods, and compositions for making crosslinked albumin hydrogels are included in the application. Embodiments include a biocompatible material of albumin crosslinked with an n-functional crosslinking agent wherein n is at least 3. Other embodiments include a cross-linking agent having a polyalkylene oxide member. Other embodiments include a system for administering an albumin material, the system having albumin and a crosslinking agent that reacts with the albumin to form a crosslinked material made of crosslinked albumin. Another embodiment is a method of making a biocompatible material that includes a step of mixing albumin with an n-functional crosslinking agent wherein n is at least 3.Type: GrantFiled: February 11, 2003Date of Patent: June 6, 2006Assignee: Incept LLCInventor: Chandrashekhar P. Pathak
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Patent number: 7025990Abstract: Methods are provided for forming hydrogel barriers in situ that adhere to tissue and prevent the formation of post-surgical adhesions or deliver drugs or other therapeutic agents to a body cavity. The hydrogels are crosslinked, resorb or degrade over a period of time, and may be formed by free radical polymerization initiated by a redox system or thermal initiation, or electrophilic-neutrophilic mechanism, wherein two components of an initiating system are simultaneously or sequentially poured into a body cavity to obtain widespread dispersal and coating of all or most visceral organs within that cavity prior to gelation and polymerization of the regional barrier. The hydrogel materials are selected to have a low stress at break in tension or torsion, and so as to have a close to equilibrium hydration level when formed.Type: GrantFiled: October 8, 2002Date of Patent: April 11, 2006Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Patent number: 7009034Abstract: Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers.Type: GrantFiled: November 9, 2001Date of Patent: March 7, 2006Assignee: Incept, LLCInventors: Chandrashekhar P. Pathak, Amarpreet S. Sawhney, Peter G. Edelman
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Patent number: 6887974Abstract: Polymeric crosslinking agents are disclosed that have an inert water soluble polymeric component, biodegradable components, functional components reactive with chemical groups on a protein, for example, amine or thiol groups. The inert polymeric component may be flanked at each end with a biodegradable component which is flanked at each end with a protein reactive functional component. A polymeric crosslinking agent is disclosed having a biodegradable component, polyalkylene oxide, and at least three reactive functional groups that are each capable of forming a covalent bond in water with at least one functional group such as an amine, thiol, or carboxylic acid.Type: GrantFiled: February 5, 2002Date of Patent: May 3, 2005Assignee: Incept LLCInventor: Chandrashekhar P. Pathak
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Patent number: 6887257Abstract: Vascular embolic filtering systems, as well as methods for using the same, are provided. In general, the subject invention includes a system comprised of an embolic filter assembly and a multiple lumen delivery and retrieval sheath, where the embolic filter assembly includes a guide wire with an embolic filter operatively coupled to the distal end of the guide wire for capturing emboli created during interventional procedures within a target vessel. Features of the subject invention provide for the rapid exchange and deployment of embolic filters in a patient's vasculature.Type: GrantFiled: October 19, 2001Date of Patent: May 3, 2005Assignee: Incept LLCInventors: Amr Salahieh, Jackson Demond, Jeff Krolik
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Patent number: 6818018Abstract: Compositions and methods for forming hydrogels in situ through a combination of physical and chemical crosslinking processes are provided in which physical crosslinking is mediated by one or more natural or synthetic components that stabilize the a hydrogel-forming precursor solutions at a deposition site for a period of time sufficient for more resilient chemical crosslinks to form. Methods of using such hydrogels as tissue coatings to prevent postsurgical adhesion formation, as tissue augmentation or luminal occlusion aids, as matrices for carrying cells, drugs or other bioactive species, as tissue sealants or adhesives, and as medical device coatings also are provided.Type: GrantFiled: August 14, 1998Date of Patent: November 16, 2004Assignee: Incept LLCInventor: Amarpreet S. Sawhney
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Publication number: 20040191277Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other usefull medical and surgical purposes.Type: ApplicationFiled: March 5, 2004Publication date: September 30, 2004Applicant: Incept LLCInventors: Amarpreet S. Sawhney, Peter G. Edelman, Steven L. Bennett
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Publication number: 20040082968Abstract: Apparatus and methods for retrieving a vascular filter from a vessel are provided wherein a retrieval adapter is delivered to a treatment site concurrently along with an interventional device to reduce the number of steps required to remove the vascular filter. The retrieval adapter also reduces the possibility of entangling the vascular filter with a stent disposed within the vessel during removal of the vascular filter. A separate retrieval catheter is also described for use in conjunction with the retrieval adapter.Type: ApplicationFiled: October 14, 2003Publication date: April 29, 2004Applicant: INCEPT LLCInventors: Jeff A. Krolik, Amr Salahieh, Jackson F. Demond, Farhad Khosravi
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Patent number: 6703047Abstract: Compositions and methods are provided for forming tissue-adherent hydrogels using substantially dry precursors. The dehydrated precursors are premixed prior to in situ therapy and utilize naturally-occurring body fluids as an aqueous environment that initiates transformation, which causes dissolution and nearly simultaneous crosslinking of the precursors, thus forming an insoluble hydrogel implant. The dehydrated precursor-based hydrogels may be used as sealants for fluid leaks from tissue, as adherent drug delivery depots, as means for augmenting and/or supporting tissue, and as means for serving a variety of other useful medical and surgical purposes.Type: GrantFiled: February 2, 2001Date of Patent: March 9, 2004Assignee: Incept LLCInventors: Amarpreet S. Sawhney, Peter G. Edelman
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Publication number: 20040044359Abstract: An embolic protection filter delivery and/or retrieval assembly. In one embodiment the assembly includes a shaft having a filter coupled thereto, a sheath, and a tapering member.Type: ApplicationFiled: September 4, 2002Publication date: March 4, 2004Applicant: INCEPT LLCInventors: Richard J. Renati, Jackson F. Demond, Jeff A. Krolik
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Publication number: 20040033264Abstract: Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.Type: ApplicationFiled: August 12, 2003Publication date: February 19, 2004Applicant: Incept LLCInventor: Amarpreet S. Sawhney